metformin has been researched along with Idiopathic Pulmonary Fibrosis in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Idiopathic Pulmonary Fibrosis: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is a biguanide antidiabetic medication and its pharmacological action is mediated through the activation of AMP-activated protein kinase (AMPK), which regulates not only energy homeostasis but also stress responses, including ROS." | 1.43 | Metformin attenuates lung fibrosis development via NOX4 suppression. ( Araya, J; Fujita, Y; Hara, H; Hashimoto, M; Ito, S; Kadota, T; Kaneko, Y; Kobayashi, K; Kohrogi, H; Kojima, J; Kurita, Y; Kuwano, K; Minagawa, S; Morikawa, T; Nakayama, K; Numata, T; Odaka, M; Saito, N; Sato, N; Takasaka, N; Tsubouchi, K; Utsumi, H; Wakui, H; Yanagisawa, H; Yoshida, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Teague, TT | 1 |
| Payne, SR | 1 |
| Kelly, BT | 1 |
| Dempsey, TM | 1 |
| McCoy, RG | 1 |
| Sangaralingham, LR | 1 |
| Limper, AH | 1 |
| Rangarajan, S | 1 |
| Bone, NB | 1 |
| Zmijewska, AA | 1 |
| Jiang, S | 1 |
| Park, DW | 1 |
| Bernard, K | 1 |
| Locy, ML | 1 |
| Ravi, S | 1 |
| Deshane, J | 1 |
| Mannon, RB | 1 |
| Abraham, E | 1 |
| Darley-Usmar, V | 1 |
| Thannickal, VJ | 1 |
| Zmijewski, JW | 1 |
| Tzouvelekis, A | 1 |
| Tzilas, V | 1 |
| Dassiou, M | 1 |
| Bouros, D | 1 |
| Dos Santos, CC | 1 |
| Gopal, B | 1 |
| Verma, S | 1 |
| Manning, EP | 1 |
| Losier, A | 1 |
| Emeagwali, N | 1 |
| Ryu, C | 1 |
| Honiden, S | 1 |
| Kheirollahi, V | 1 |
| Wasnick, RM | 1 |
| Biasin, V | 1 |
| Vazquez-Armendariz, AI | 1 |
| Chu, X | 1 |
| Moiseenko, A | 1 |
| Weiss, A | 1 |
| Wilhelm, J | 1 |
| Zhang, JS | 1 |
| Kwapiszewska, G | 1 |
| Herold, S | 1 |
| Schermuly, RT | 1 |
| Mari, B | 1 |
| Li, X | 1 |
| Seeger, W | 1 |
| Günther, A | 1 |
| Bellusci, S | 1 |
| El Agha, E | 1 |
| Sato, N | 1 |
| Takasaka, N | 1 |
| Yoshida, M | 1 |
| Tsubouchi, K | 1 |
| Minagawa, S | 1 |
| Araya, J | 1 |
| Saito, N | 1 |
| Fujita, Y | 1 |
| Kurita, Y | 1 |
| Kobayashi, K | 1 |
| Ito, S | 1 |
| Hara, H | 1 |
| Kadota, T | 1 |
| Yanagisawa, H | 1 |
| Hashimoto, M | 1 |
| Utsumi, H | 1 |
| Wakui, H | 1 |
| Kojima, J | 1 |
| Numata, T | 1 |
| Kaneko, Y | 1 |
| Odaka, M | 1 |
| Morikawa, T | 1 |
| Nakayama, K | 1 |
| Kohrogi, H | 1 |
| Kuwano, K | 1 |
7 other studies available for metformin and Idiopathic Pulmonary Fibrosis
| Article | Year |
|---|---|
Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis.
Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Idiopathic Pulmonary Fibrosis; Insurance C | 2022 |
Metformin reverses established lung fibrosis in a bleomycin model.
Topics: Adenylate Kinase; Animals; Bleomycin; Disease Models, Animal; Enzyme Activation; Extracellular Matri | 2018 |
Metformin in Idiopathic Pulmonary Fibrosis "Seeking the Holy-Grail through Drug-Repositioning".
Topics: Humans; Idiopathic Pulmonary Fibrosis; Metformin | 2018 |
Metformin: An Old Dog with a New Trick?
Topics: Bleomycin; Humans; Idiopathic Pulmonary Fibrosis; Metformin; Myofibroblasts; Signal Transduction | 2018 |
New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone.
Topics: Bleomycin; Humans; Hydroxychloroquine; Idiopathic Pulmonary Fibrosis; Metformin; Thyroid Hormones | 2019 |
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.
Topics: AMP-Activated Protein Kinases; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, C | 2019 |
Metformin attenuates lung fibrosis development via NOX4 suppression.
Topics: AMP-Activated Protein Kinases; Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Cytoprotec | 2016 |