metformin has been researched along with Hypoxia-Ischemia, Brain in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice." | 5.72 | Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022) |
| "Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice." | 1.72 | Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bourget, C | 1 |
| Adams, KV | 1 |
| Morshead, CM | 1 |
| Qi, B | 1 |
| Hu, L | 1 |
| Zhu, L | 1 |
| Shang, L | 1 |
| Sheng, L | 1 |
| Wang, X | 1 |
| Liu, N | 1 |
| Wen, N | 1 |
| Yu, X | 1 |
| Wang, Q | 1 |
| Yang, Y | 1 |
2 other studies available for metformin and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; Metformin; Mice | 2022 |
Metformin Attenuates Cognitive Impairments in Hypoxia-Ischemia Neonatal Rats via Improving Remyelination.
Topics: Animals; Animals, Newborn; Cognitive Dysfunction; Hypoxia-Ischemia, Brain; Maze Learning; Metformin; | 2017 |