Page last updated: 2024-10-30

metformin and Hypertrophy

metformin has been researched along with Hypertrophy in 5 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).

Research Excerpts

ExcerptRelevanceReference
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."7.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."3.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
" Therefore, we investigated the role of AMPK activation in regulating protein synthesis during both phenylephrine- and Akt-induced cardiac hypertrophy."3.72Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. ( Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME, 2004)
"Renal hypertrophy in rats with Type 1 diabetes was associated with reduction in AMPK phosphorylation and increased mTOR activity."1.34A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. ( Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM, 2007)
"Obesity has been associated with alterations in glucocorticoid metabolism in both man and rodents, but the underlying mechanisms remain undefined."1.31Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. ( Kenyon, CJ; Livingstone, DE; Walker, BR, 2000)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Su, M1
Sun, L1
Li, W1
Liu, H1
Liu, Y1
Wei, Y1
Yuan, Y1
Zheng, L1
Yin, S1
Dai, C1
Zhao, C1
Pan, Z1
Li, Y1
Malekpour-Dehkordi, Z1
Teimourian, S1
Nourbakhsh, M1
Naghiaee, Y1
Sharifi, R1
Mohiti-Ardakani, J1
Chan, AY1
Soltys, CL1
Young, ME1
Proud, CG1
Dyck, JR1
Lee, MJ1
Feliers, D1
Mariappan, MM1
Sataranatarajan, K1
Mahimainathan, L1
Musi, N1
Foretz, M1
Viollet, B1
Weinberg, JM1
Choudhury, GG1
Kasinath, BS1
Livingstone, DE1
Kenyon, CJ1
Walker, BR1

Other Studies

5 other studies available for metformin and Hypertrophy

ArticleYear
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging.
    Clinical science (London, England : 1979), 2020, 06-26, Volume: 134, Issue:12

    Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipose Tissue, Beige; Adipose Tissue, White; Adult; Ani

2020
Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction.
    Life sciences, 2019, Sep-15, Volume: 233

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Collagen Type IV; Extracellular

2019
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
    The Journal of biological chemistry, 2004, Jul-30, Volume: 279, Issue:31

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, A

2004
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Culture

2007
Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats.
    The Journal of endocrinology, 2000, Volume: 167, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adipose Tissue; Adrenal Glands; Adrenalectomy; Analysis of Va

2000