metformin has been researched along with Hypertrophy in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro." | 7.91 | Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019) |
| "Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro." | 3.91 | Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019) |
| " Therefore, we investigated the role of AMPK activation in regulating protein synthesis during both phenylephrine- and Akt-induced cardiac hypertrophy." | 3.72 | Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. ( Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME, 2004) |
| "Renal hypertrophy in rats with Type 1 diabetes was associated with reduction in AMPK phosphorylation and increased mTOR activity." | 1.34 | A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. ( Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM, 2007) |
| "Obesity has been associated with alterations in glucocorticoid metabolism in both man and rodents, but the underlying mechanisms remain undefined." | 1.31 | Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. ( Kenyon, CJ; Livingstone, DE; Walker, BR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, M | 1 |
| Sun, L | 1 |
| Li, W | 1 |
| Liu, H | 1 |
| Liu, Y | 1 |
| Wei, Y | 1 |
| Yuan, Y | 1 |
| Zheng, L | 1 |
| Yin, S | 1 |
| Dai, C | 1 |
| Zhao, C | 1 |
| Pan, Z | 1 |
| Li, Y | 1 |
| Malekpour-Dehkordi, Z | 1 |
| Teimourian, S | 1 |
| Nourbakhsh, M | 1 |
| Naghiaee, Y | 1 |
| Sharifi, R | 1 |
| Mohiti-Ardakani, J | 1 |
| Chan, AY | 1 |
| Soltys, CL | 1 |
| Young, ME | 1 |
| Proud, CG | 1 |
| Dyck, JR | 1 |
| Lee, MJ | 1 |
| Feliers, D | 1 |
| Mariappan, MM | 1 |
| Sataranatarajan, K | 1 |
| Mahimainathan, L | 1 |
| Musi, N | 1 |
| Foretz, M | 1 |
| Viollet, B | 1 |
| Weinberg, JM | 1 |
| Choudhury, GG | 1 |
| Kasinath, BS | 1 |
| Livingstone, DE | 1 |
| Kenyon, CJ | 1 |
| Walker, BR | 1 |
5 other studies available for metformin and Hypertrophy
| Article | Year |
|---|---|
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipose Tissue, Beige; Adipose Tissue, White; Adult; Ani | 2020 |
Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Collagen Type IV; Extracellular | 2019 |
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, A | 2004 |
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Culture | 2007 |
Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adipose Tissue; Adrenal Glands; Adrenalectomy; Analysis of Va | 2000 |