metformin has been researched along with Hypertriglyceridemia in 25 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hypertriglyceridemia: A condition of elevated levels of TRIGLYCERIDES in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this context, metformin has been shown to not only contribute to a better glycaemic control but also to induce some weight loss (especially in the visceral depot) which may contribute to the improvement of the features of the metabolic syndrome." | 8.82 | Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes. ( Després, JP, 2003) |
| " This study is to investigate the role of apoA5 in obesity-associated hypertriglyceridemia and metformin-related hypotriglyceridemic actions." | 7.83 | Metformin ameliorates obesity-associated hypertriglyceridemia in mice partly through the apolipoprotein A5 pathway. ( Chen, LZ; Huang, XS; Li, R; Zhao, SP; Zhao, W, 2016) |
| "Metformin alone reduced hyperinsulinemia and circulating c-reactive protein, but exacerbated nephropathy." | 5.72 | Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice. ( Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC, 2022) |
| "Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0." | 5.48 | Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia. ( Haluzik, M; Kazdova, L; Malinska, H; Markova, I; Škop, V; Svoboda, P; Trnovska, J, 2018) |
| "Metformin treatment increases serum cartonectin levels in these women and in omental AT explants." | 5.39 | Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. ( Adya, R; Amar, O; Chen, J; Hu, J; Lehnert, H; Mattu, HS; Patel, V; Ramanjaneya, M; Randeva, HS; Tan, BK, 2013) |
| "Metformin has been proposed as a potential drug treatment to reduce liver steatosis." | 5.35 | Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver. ( Tessari, P; Tiengo, A, 2008) |
| "Hypertension was present in 30% of participants at study entry and then increased in the placebo and metformin groups, although it significantly decreased with intensive lifestyle intervention." | 5.11 | Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. ( Fowler, S; Goldberg, R; Haffner, S; Marcovina, S; Orchard, T; Ratner, R; Temprosa, M, 2005) |
| " In this context, metformin has been shown to not only contribute to a better glycaemic control but also to induce some weight loss (especially in the visceral depot) which may contribute to the improvement of the features of the metabolic syndrome." | 4.82 | Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes. ( Després, JP, 2003) |
| "While this class of drugs holds great promise for cases of refractory hyperinsulinemia and laminitis that do not respond to diet or metformin therapy, hypertriglyceridemia is a potential side effect." | 4.31 | Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors. ( Gustafson, KM; Kellon, EM, 2023) |
| "To investigate the role of apolipoprotein A5 (apoA5) in the pathogenesis of obesity-related hypertriglyceridemia and the related therapeutic effects of metformin." | 3.85 | [Metformin reduces plasma triglycerides in ob/ob obese mice via inhibiting the hepatic apoA5 expression]. ( Chen, L; Dai, W; Huang, X; Li, R, 2017) |
| " This study is to investigate the role of apoA5 in obesity-associated hypertriglyceridemia and metformin-related hypotriglyceridemic actions." | 3.83 | Metformin ameliorates obesity-associated hypertriglyceridemia in mice partly through the apolipoprotein A5 pathway. ( Chen, LZ; Huang, XS; Li, R; Zhao, SP; Zhao, W, 2016) |
| "Obesity is known to be the most common cause of simple steatosis in the preadolescent and adolescent population with a consequent serious health risk." | 2.47 | [Fatty liver and its clinical management in obese adolescents]. ( Álvarez Ferre, J; González Jiménez, E; Schmidt Río-Valle, J, 2011) |
| "Metformin effectiveness has been shown for the reduction of diabetes related complications and mortality, mainly in the cardiovascular field." | 2.42 | [Metabolic syndrome: to observe or to act?]. ( Picard, S; Slama, G, 2003) |
| "For now, the goals and methods of treating hypertension and dyslipidemia are the same in people with the metabolic syndrome as in the general population." | 2.41 | A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia. ( Hoogwerf, BJ; Nambi, V; Sprecher, DL, 2002) |
| "Metformin alone reduced hyperinsulinemia and circulating c-reactive protein, but exacerbated nephropathy." | 1.72 | Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice. ( Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC, 2022) |
| "Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype." | 1.51 | Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019) |
| "Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0." | 1.48 | Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia. ( Haluzik, M; Kazdova, L; Malinska, H; Markova, I; Škop, V; Svoboda, P; Trnovska, J, 2018) |
| "A significant decrement of hyperinsulinemia, triglyceridemia, serum IL6 and oxidised LDL were observed at the end of the study." | 1.43 | Metformin preconditioned adipose derived mesenchymal stem cells is a better option for the reversal of diabetes upon transplantation. ( Bhonde, RR; Shree, N, 2016) |
| "Metformin treatment increases serum cartonectin levels in these women and in omental AT explants." | 1.39 | Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. ( Adya, R; Amar, O; Chen, J; Hu, J; Lehnert, H; Mattu, HS; Patel, V; Ramanjaneya, M; Randeva, HS; Tan, BK, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dare, A | 1 |
| Channa, ML | 1 |
| Nadar, A | 1 |
| Reifsnyder, PC | 1 |
| Flurkey, K | 1 |
| Doty, R | 1 |
| Calcutt, NA | 1 |
| Koza, RA | 1 |
| Harrison, DE | 1 |
| Kellon, EM | 1 |
| Gustafson, KM | 1 |
| Malinska, H | 1 |
| Škop, V | 1 |
| Trnovska, J | 1 |
| Markova, I | 1 |
| Svoboda, P | 1 |
| Kazdova, L | 1 |
| Haluzik, M | 1 |
| Huang, X | 1 |
| Li, R | 2 |
| Chen, L | 1 |
| Dai, W | 1 |
| Tsuchiya, S | 1 |
| Sawada, S | 1 |
| Takeda, K | 1 |
| Takahashi, K | 1 |
| Nakajima, T | 1 |
| Kohata, M | 1 |
| Kurosawa, S | 1 |
| Satake, C | 1 |
| Imai, J | 1 |
| Kikuchi, K | 1 |
| Aiba, S | 1 |
| Katagiri, H | 1 |
| Sato, D | 1 |
| Morino, K | 1 |
| Ogaku, S | 1 |
| Tsuji, A | 1 |
| Nishimura, K | 1 |
| Sekine, O | 1 |
| Ugi, S | 1 |
| Maegawa, H | 1 |
| Mathuram Thiyagarajan, U | 1 |
| Ponnuswamy, A | 1 |
| Chung, A | 1 |
| Tan, BK | 1 |
| Chen, J | 1 |
| Hu, J | 1 |
| Amar, O | 1 |
| Mattu, HS | 1 |
| Adya, R | 1 |
| Patel, V | 1 |
| Ramanjaneya, M | 1 |
| Lehnert, H | 1 |
| Randeva, HS | 1 |
| Chen, LZ | 1 |
| Zhao, W | 1 |
| Zhao, SP | 1 |
| Huang, XS | 1 |
| Shree, N | 1 |
| Bhonde, RR | 1 |
| Wan, Q | 1 |
| Wang, F | 2 |
| Guan, Q | 1 |
| Liu, Y | 1 |
| Wang, C | 1 |
| Feng, L | 1 |
| Gao, G | 1 |
| Gao, L | 1 |
| Zhao, J | 1 |
| González Jiménez, E | 1 |
| Schmidt Río-Valle, J | 1 |
| Álvarez Ferre, J | 1 |
| Serrano Rios, M | 1 |
| Ascaso Gimilio, JF | 1 |
| Blázquez Fernández, E | 1 |
| Cabezas Cerraro, J | 1 |
| Carmena Rodríguez, R | 1 |
| Escobar Jiménez, F | 1 |
| Fernández-Real, JM | 1 |
| Gabriel Sánchez, R | 1 |
| Gomis de Barberá, R | 1 |
| Grande Aragón, C | 1 |
| Herrera Pomba, JL | 1 |
| Pallardo Sánchez, LF | 1 |
| Potau Vilalta, N | 1 |
| Ricart Engel, W | 1 |
| Rovira Loscos, A | 1 |
| Zorzano Olarte, A | 1 |
| Nambi, V | 1 |
| Hoogwerf, BJ | 1 |
| Sprecher, DL | 1 |
| Slama, G | 1 |
| Picard, S | 1 |
| Després, JP | 1 |
| Sahhar, NN | 1 |
| Ahmad, AT | 1 |
| Ammari, FL | 1 |
| Ajlouni, KM | 1 |
| Ratner, R | 1 |
| Goldberg, R | 1 |
| Haffner, S | 1 |
| Marcovina, S | 1 |
| Orchard, T | 1 |
| Fowler, S | 1 |
| Temprosa, M | 1 |
| Tessari, P | 1 |
| Tiengo, A | 1 |
| Pernet, A | 1 |
| Franceschini, G | 1 |
| Paoletti, R | 1 |
| Reaven, GM | 1 |
| Weintraub, MS | 1 |
| Charach, G | 1 |
| Grosskopf, I | 1 |
| Tanser, P | 1 |
| Archer, S | 1 |
| Feldman, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Emirates Heart Health Project: A Stepped-wedge Cluster Randomized-controlled Trial of a Family-based Health Coach Guided Dietary and Exercise Intervention for Reducing Weight and Cardiovascular Risk in Overweight and Obese Adult Nationals of the Unite[NCT04688684] | 80 participants (Anticipated) | Interventional | 2022-06-01 | Not yet recruiting | |||
| Physical Activity and Sedentary Behavior Change; Impact on Lifestyle Intervention Effects for Diabetes Translation[NCT02467881] | 308 participants (Actual) | Interventional | 2015-09-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metformin and Hypertriglyceridemia
| Article | Year |
|---|---|
[Fatty liver and its clinical management in obese adolescents].
Topics: Adiponectin; Adolescent; Apoptosis; Biomarkers; Chemokines; Disease Progression; Fatty Liver; Fibros | 2011 |
A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.
Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hyperinsulinism; Hypertension; Hypertrigly | 2002 |
[Metabolic syndrome: to observe or to act?].
Topics: Body Constitution; Humans; Hypertension; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistan | 2003 |
Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes.
Topics: Abdomen; Adipose Tissue; Arteriosclerosis; Blood Glucose; Body Constitution; Cardiovascular Diseases | 2003 |
[Therapeutic approach to a multi-metabolic syndrome].
Topics: Acarbose; Combined Modality Therapy; Diet Therapy; Enzyme Inhibitors; Exercise; Glucose Intolerance; | 1995 |
Drugs controlling triglyceride metabolism.
Topics: Anticholesteremic Agents; Arteriosclerosis; Fatty Acids, Omega-3; Humans; Hypertriglyceridemia; Metf | 1993 |
4 trials available for metformin and Hypertriglyceridemia
| Article | Year |
|---|---|
Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: A randomized cross-over pilot study.
Topics: Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; | 2019 |
Regression to normoglycaemia by fenofibrate in pre-diabetic subjects complicated with hypertriglyceridaemia: a prospective randomized controlled trial.
Topics: Adolescent; Adult; Aged; Blood Glucose; Female; Fenofibrate; Humans; Hypertriglyceridemia; Hypoglyce | 2010 |
Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Female; Glucose Intolerance; Humans; Hypertension; Hyper | 2005 |
Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Female; Glucose Intolerance; Humans; Hypertension; Hyper | 2005 |
Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Female; Glucose Intolerance; Humans; Hypertension; Hyper | 2005 |
Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Female; Glucose Intolerance; Humans; Hypertension; Hyper | 2005 |
Effects of fibric acid derivatives and metformin on postprandial lipemia.
Topics: Bezafibrate; Chylomicrons; Gemfibrozil; Glucose Tolerance Test; Humans; Hypertriglyceridemia; Hypogl | 1998 |
15 other studies available for metformin and Hypertriglyceridemia
| Article | Year |
|---|---|
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combina | 2021 |
Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Liver; Hyperglycemia; Hyp | 2022 |
Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors.
Topics: Animals; Canagliflozin; Diabetes Mellitus, Type 2; Glucose; Glucosides; Horse Diseases; Horses; Hype | 2023 |
Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia.
Topics: Animals; Deoxyglucose; Diet; Glutathione; Glyoxal; Hypertriglyceridemia; Hypoglycemic Agents; Lactoy | 2018 |
[Metformin reduces plasma triglycerides in ob/ob obese mice via inhibiting the hepatic apoA5 expression].
Topics: Animals; Apolipoprotein A-V; Hypertriglyceridemia; Hypolipidemic Agents; Liver; Metformin; Mice; Mic | 2017 |
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B | 2019 |
An enigmatic triad of acute pancreatitis, diabetic ketoacidosis and hypertriglyceridaemia: who is the culprit?
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Fluid Therapy; Humans; Hydroxymethylglutary | 2019 |
Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome.
Topics: Adipokines; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Carotid | 2013 |
Metformin ameliorates obesity-associated hypertriglyceridemia in mice partly through the apolipoprotein A5 pathway.
Topics: Animals; Apolipoprotein A-V; Body Weight; Hep G2 Cells; Humans; Hypertriglyceridemia; Male; Metformi | 2016 |
Metformin preconditioned adipose derived mesenchymal stem cells is a better option for the reversal of diabetes upon transplantation.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Type 2; Diet, Hig | 2016 |
[Insulin resistance and its involvement in multiple risk factors associated with type 2 diabetes mellitus].
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 2; Europe; Female; Humans; Hypercholesterolemia; Hyperli | 2002 |
Dysregulation of growth hormone in acquired generalized lipodystrophy.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administrati | 2004 |
Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver.
Topics: Animals; Diet, Atherogenic; Drug Evaluation, Preclinical; Hypertriglyceridemia; Hypoglycemic Agents; | 2008 |
Effect of metformin on various aspects of glucose, insulin and lipid metabolism in patients with non-insulin-dependent diabetes mellitus with varying degrees of hyperglycemia.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperglycemia; Hypertri | 1995 |
Case 2. Recurrence of myocardial infarction.
Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Drug Therapy, Combination; | 2000 |