metformin has been researched along with Hypertension, Portal in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Portal hypertension is the main determinant of clinical decompensation in patients with liver cirrhosis." | 3.01 | Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension. ( Aagaard, NK; George, J; Grønbaek, H; Jessen, N; Rittig, N; Sandahl, TD; Villadsen, GE, 2021) |
| "Metformin-treated CCl4-cirrhotic rats had lower PP and hepatic vascular resistance than vehicle-treated rats, without significant changes in MAP or PBF." | 1.42 | Metformin reduces hepatic resistance and portal pressure in cirrhotic rats. ( Bosch, J; Erice, E; García-Calderó, H; García-Pagán, JC; Gracia-Sancho, J; Lafoz, E; Sarin, SK; Tripathi, DM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rittig, N | 2 |
| Aagaard, NK | 2 |
| Villadsen, GE | 2 |
| Sandahl, TD | 2 |
| Jessen, N | 2 |
| Grønbaek, H | 2 |
| George, J | 2 |
| Palaniyappan, N | 1 |
| Fallowfield, JA | 1 |
| Tripathi, DM | 1 |
| Erice, E | 1 |
| Lafoz, E | 1 |
| García-Calderó, H | 1 |
| Sarin, SK | 1 |
| Bosch, J | 1 |
| Gracia-Sancho, J | 1 |
| García-Pagán, JC | 1 |
1 trial available for metformin and Hypertension, Portal
| Article | Year |
|---|---|
Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension.
Topics: Humans; Hypertension, Portal; Liver Cirrhosis; Metformin; Portal Pressure | 2021 |
3 other studies available for metformin and Hypertension, Portal
| Article | Year |
|---|---|
Editorial: metformin for portal hypertension-old dog, new tricks?
Topics: Humans; Hypertension, Portal; Metformin | 2021 |
Editorial: metformin for portal hypertension-old dog, new tricks? Authors' reply.
Topics: Humans; Hypertension, Portal; Liver Cirrhosis; Metformin | 2021 |
Metformin reduces hepatic resistance and portal pressure in cirrhotic rats.
Topics: Animals; Blood Pressure; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Metformin; Portal Vein; | 2015 |