metformin has been researched along with Hyperplasia in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the adjuvant efficacy of metformin treatment to achieve pathological complete response (CR) in patients with endometrial complex hyperplasia (CH) and complex atypical hyperplasia (CAH), and secondarily, to evaluate their pregnancy outcomes after following assisted reproductive technology (ART)." | 9.51 | A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes. ( Kong, WY; Liu, ZA; Wu, X; Yan, L; Zhang, N; Zhao, XB, 2022) |
| "We demonstrated that the potential protection of the combined use of linagliptin and metformin on VSMC remodeling through AMPK/Nox4 signal pathway, resulting in the improvement of neointima hyperplasia in diabetic rats." | 7.91 | Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats. ( Li, XX; Tai, GJ; Xu, M; Zhang, WX, 2019) |
| "To investigate the adjuvant efficacy of metformin treatment to achieve pathological complete response (CR) in patients with endometrial complex hyperplasia (CH) and complex atypical hyperplasia (CAH), and secondarily, to evaluate their pregnancy outcomes after following assisted reproductive technology (ART)." | 5.51 | A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes. ( Kong, WY; Liu, ZA; Wu, X; Yan, L; Zhang, N; Zhao, XB, 2022) |
| "Metformin has been widely used for the treatment of type 2 diabetes." | 5.46 | Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. ( Kyohara, M; Okuyama, T; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y; Yamazaki, S, 2017) |
| "We demonstrated that the potential protection of the combined use of linagliptin and metformin on VSMC remodeling through AMPK/Nox4 signal pathway, resulting in the improvement of neointima hyperplasia in diabetic rats." | 3.91 | Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats. ( Li, XX; Tai, GJ; Xu, M; Zhang, WX, 2019) |
| "Metformin has been widely used for the treatment of type 2 diabetes." | 1.46 | Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. ( Kyohara, M; Okuyama, T; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y; Yamazaki, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, WY | 1 |
| Liu, ZA | 1 |
| Zhang, N | 1 |
| Wu, X | 1 |
| Zhao, XB | 1 |
| Yan, L | 1 |
| Wang, Y | 1 |
| Fu, M | 1 |
| Xiao, W | 1 |
| Zhao, Y | 1 |
| Yuan, P | 1 |
| Zhang, X | 1 |
| Wu, W | 1 |
| Kaplan, SA | 1 |
| Tajima, K | 1 |
| Shirakawa, J | 1 |
| Okuyama, T | 1 |
| Kyohara, M | 1 |
| Yamazaki, S | 1 |
| Togashi, Y | 1 |
| Terauchi, Y | 1 |
| Zhang, WX | 1 |
| Tai, GJ | 1 |
| Li, XX | 1 |
| Xu, M | 1 |
| Houssaini, A | 1 |
| Abid, S | 1 |
| Derumeaux, G | 1 |
| Wan, F | 1 |
| Parpaleix, A | 1 |
| Rideau, D | 1 |
| Marcos, E | 1 |
| Kebe, K | 1 |
| Czibik, G | 1 |
| Sawaki, D | 1 |
| Treins, C | 1 |
| Dubois-Randé, JL | 1 |
| Li, Z | 1 |
| Amsellem, V | 1 |
| Lipskaia, L | 1 |
| Pende, M | 1 |
| Adnot, S | 1 |
| Sachidanandam, K | 1 |
| Hutchinson, JR | 1 |
| Elgebaly, MM | 1 |
| Mezzetti, EM | 1 |
| Dorrance, AM | 1 |
| Motamed, K | 1 |
| Ergul, A | 1 |
| Campagnoli, C | 1 |
| Abbà, C | 1 |
| Ambroggio, S | 1 |
| Brucato, T | 1 |
| Pasanisi, P | 1 |
| Chomette, G | 1 |
| Sterne, J | 1 |
| Auriol, M | 1 |
| Tranbaloc, P | 1 |
| Junien, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Hyperplasia
| Article | Year |
|---|---|
Life-style and metformin for the prevention of endometrial pathology in postmenopausal women.
Topics: Anticarcinogenic Agents; Carcinoma, Endometrioid; Endometrial Neoplasms; Endometrium; Evidence-Based | 2013 |
1 trial available for metformin and Hyperplasia
| Article | Year |
|---|---|
A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes.
Topics: Endometrial Hyperplasia; Female; Humans; Hyperplasia; Infertility, Female; Metformin; Polycystic Ova | 2022 |
7 other studies available for metformin and Hyperplasia
| Article | Year |
|---|---|
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
Topics: Animals; Antioxidants; Hyperplasia; Metformin; Reactive Oxygen Species; Stents; Thrombosis | 2023 |
Re: The Preventive Effect of Metformin on Progression of Benign Prostatic Hyperplasia: A Nationwide Population-Based Cohort Study in Korea.
Topics: Cohort Studies; Humans; Hyperplasia; Male; Metformin; Prostatic Hyperplasia; Republic of Korea | 2020 |
Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.
Topics: Alanine Transaminase; Animals; Blood Glucose; Blotting, Western; Cell Line; Cell Proliferation; Chol | 2017 |
Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats.
Topics: AMP-Activated Protein Kinases; Animals; Aorta, Thoracic; Carotid Arteries; Constriction, Pathologic; | 2019 |
Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Gene Deletion; Hyperplasia; Hypertens | 2016 |
Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelin-1; H | 2009 |
[Endocrine pancreatic regeneration in diabetic mouse DBM. An ultrastructural and histoenzymological study (author's transl)].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Hyperplasia; Insulin; Islets of Lan | 1981 |