metformin has been researched along with Hyperlactatemia in 11 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hyperlactatemia: Increase in blood LACTATE concentration often associated with SEPTIC SHOCK; LUNG INJURY; SEPSIS; and DRUG TOXICITY. When hyperlactatemia is associated with low body pH (acidosis) it is LACTIC ACIDOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA)." | 9.41 | Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review. ( Fuster, DG; Moser, M; Mueller, L; Prazak, J; Schefold, JC; Zuercher, P, 2023) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 7.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 7.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA)." | 5.41 | Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review. ( Fuster, DG; Moser, M; Mueller, L; Prazak, J; Schefold, JC; Zuercher, P, 2023) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 3.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 3.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "Although metformin-associated lactic acidosis is well described, there is less information on metformin overdose and whether it is of similar severity." | 3.81 | Hyperlactataemia and clinical severity of acute metformin overdose. ( Isbister, GK; McNamara, K, 2015) |
| "Metformin is a biguanaide antidiabetic drug used worldwide, and its effectiveness and benefits have already been established." | 1.43 | Investigation of Risk Factors Affecting Lactate Levels in Japanese Patients Treated with Metformin. ( Hiraoka, S; Nishihara, M; Tsuji, H; Yokoyama, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Mueller, L | 1 |
| Moser, M | 1 |
| Prazak, J | 1 |
| Fuster, DG | 1 |
| Schefold, JC | 1 |
| Zuercher, P | 1 |
| Gosmanova, EO | 1 |
| Shahzad, SR | 1 |
| Sumida, K | 1 |
| Kovesdy, CP | 1 |
| Gosmanov, AR | 1 |
| Koren, S | 1 |
| Zilberman-Itskovich, S | 1 |
| Koren, R | 1 |
| Doenyas-Barak, K | 1 |
| Golik, A | 1 |
| Naccarato, M | 1 |
| Yoong, D | 1 |
| Fong, IW | 1 |
| Cattaneo, D | 1 |
| Resnati, C | 1 |
| Rizzardini, G | 1 |
| Gervasoni, C | 1 |
| Taub, ES | 1 |
| Hoffman, RS | 1 |
| Manini, AF | 1 |
| Lalau, JD | 1 |
| Azzoug, ML | 1 |
| Kajbaf, F | 1 |
| Briet, C | 1 |
| Desailloud, R | 1 |
| McNamara, K | 1 |
| Isbister, GK | 1 |
| Yokoyama, S | 1 |
| Tsuji, H | 1 |
| Hiraoka, S | 1 |
| Nishihara, M | 1 |
| Lee, EY | 1 |
| Hwang, S | 1 |
| Lee, YH | 1 |
| Lee, SH | 1 |
| Lee, YM | 1 |
| Kang, HP | 1 |
| Han, E | 1 |
| Lee, W | 1 |
| Lee, BW | 1 |
| Kang, ES | 1 |
| Cha, BS | 1 |
| Lee, HC | 1 |
| van den Nouland, DP | 1 |
| Brouwers, MC | 1 |
| Stassen, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Hyperlactatemia
| Article | Year |
|---|---|
Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review.
Topics: Acidosis, Lactic; Creatinine; Humans; Hyperlactatemia; Hypoglycemic Agents; Intensive Care Units; La | 2023 |
10 other studies available for metformin and Hyperlactatemia
| Article | Year |
|---|---|
Metformin is associated with increase in lactate level in elderly patients with type 2 diabetes and CKD stage 3: A case-control study.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neph | 2020 |
Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward.
Topics: Acidosis, Lactic; Contraindications, Drug; Diabetes Mellitus; Hospitalization; Humans; Hyperlactatem | 2017 |
Dolutegravir and metformin: a case of hyperlactatemia.
Topics: Aged; Drug Interactions; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; HIV Infe | 2017 |
Dolutegravir and metformin: a clinically relevant or just a pharmacokinetic interaction?
Topics: Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Hyperlactatemia; Metformin; Oxazines; Pipera | 2018 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Hypersensitivi | 2014 |
Hyperlactataemia and clinical severity of acute metformin overdose.
Topics: Acidosis, Lactic; Acute Disease; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Hyperlactat | 2015 |
Investigation of Risk Factors Affecting Lactate Levels in Japanese Patients Treated with Metformin.
Topics: Adult; Aged; Asian People; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Type 2; Female; Glyca | 2016 |
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; H | 2017 |
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.
Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospit | 2017 |