metformin has been researched along with Hypergonadotropic Hypogonadism in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this series of males with metabolic syndrome, treatment with metformin associated with healthy dietary modifications and a mild physical activity increment resulted in significant improvement of insulin sensitivity and increase in total and free testosterone levels, regardless of the presence of hypogonadism." | 9.14 | Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome. ( Caldas, AD; Casulari, LA; Domingues Casulari Motta, L; Lofrano-Porto, A, 2010) |
| "The aim of this retrospective observational study was to evaluate whether adding liraglutide to lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means of improving weight and glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism and erectile dysfunction (ED) in a 'real-life setting'." | 7.81 | Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. ( Carbone, MD; De Pergola, G; Giagulli, VA; Guastamacchia, E; Licchelli, B; Ramunni, MI; Sabbà, C; Triggiani, V, 2015) |
| "Metformin was found to reduce elevated, but not normal, thyrotropin and prolactin levels." | 7.01 | Plasma gonadotropin levels in metformin-treated men with prediabetes: a non-randomized, uncontrolled pilot study. ( Bednarska-Czerwińska, A; Krysiak, R; Okopień, B; Szkróbka, W, 2021) |
| "Men with type 2 diabetes are often characterized by abnormal plasma testosterone levels." | 5.43 | The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride. ( Gilowski, W; Krysiak, R; Okopień, B, 2016) |
| "In this series of males with metabolic syndrome, treatment with metformin associated with healthy dietary modifications and a mild physical activity increment resulted in significant improvement of insulin sensitivity and increase in total and free testosterone levels, regardless of the presence of hypogonadism." | 5.14 | Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome. ( Caldas, AD; Casulari, LA; Domingues Casulari Motta, L; Lofrano-Porto, A, 2010) |
| "The study included 28 men with late-onset hypogonadism (defined according to the criteria of the European Male Aging Study group) receiving testosterone undecanoate (120 mg in three equal doses), 12 of whom had been treated with oral metformin (1." | 4.02 | Hypothalamic-pituitary-gonadal axis and sexual functioning in metformin-treated men after discontinuation of testosterone replacement therapy: A pilot study. ( Kowalcze, K; Krysiak, R; Okopień, B, 2021) |
| "The aim of this retrospective observational study was to evaluate whether adding liraglutide to lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means of improving weight and glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism and erectile dysfunction (ED) in a 'real-life setting'." | 3.81 | Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. ( Carbone, MD; De Pergola, G; Giagulli, VA; Guastamacchia, E; Licchelli, B; Ramunni, MI; Sabbà, C; Triggiani, V, 2015) |
| "Metformin was found to reduce elevated, but not normal, thyrotropin and prolactin levels." | 3.01 | Plasma gonadotropin levels in metformin-treated men with prediabetes: a non-randomized, uncontrolled pilot study. ( Bednarska-Czerwińska, A; Krysiak, R; Okopień, B; Szkróbka, W, 2021) |
| "Because of concomitant type 2 diabetes, all men were treated with metformin (2550-3000 mg daily)." | 1.56 | The Impact of Testosterone on Metformin Action on Hypothalamic-Pituitary-Thyroid Axis Activity in Men: A Pilot Study. ( Krysiak, R; Okopień, B; Szkróbka, W, 2020) |
| "Men with type 2 diabetes are often characterized by abnormal plasma testosterone levels." | 1.43 | The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride. ( Gilowski, W; Krysiak, R; Okopień, B, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krysiak, R | 4 |
| Kowalcze, K | 1 |
| Okopień, B | 4 |
| Pelusi, C | 1 |
| Fanelli, F | 1 |
| Baccini, M | 1 |
| Triggiani, V | 2 |
| Bartolomeo, N | 1 |
| Carbone, MD | 2 |
| De Pergola, G | 2 |
| Di Dalmazi, G | 1 |
| Pagotto, U | 1 |
| Pasquali, R | 1 |
| Giagulli, VA | 2 |
| Szkróbka, W | 2 |
| Bednarska-Czerwińska, A | 1 |
| Ramunni, MI | 1 |
| Licchelli, B | 1 |
| Sabbà, C | 1 |
| Guastamacchia, E | 1 |
| Gilowski, W | 1 |
| Casulari, LA | 1 |
| Caldas, AD | 1 |
| Domingues Casulari Motta, L | 1 |
| Lofrano-Porto, A | 1 |
| Ahsan, T | 1 |
| Banu, Z | 1 |
3 trials available for metformin and Hypergonadotropic Hypogonadism
| Article | Year |
|---|---|
Effect of clomiphene citrate treatment on the Sertoli cells of dysmetabolic obese men with low testosterone levels.
Topics: Adult; Anti-Mullerian Hormone; Clomiphene; Cross-Over Studies; Diabetes Mellitus, Type 2; Dihydrotes | 2020 |
Plasma gonadotropin levels in metformin-treated men with prediabetes: a non-randomized, uncontrolled pilot study.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Gonadotropins; Humans; Hypoglycemic Agents; Hypogon | 2021 |
Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome.
Topics: Adult; Body Mass Index; Diet, Reducing; Humans; Hypoglycemic Agents; Hypogonadism; Life Style; Longi | 2010 |
5 other studies available for metformin and Hypergonadotropic Hypogonadism
| Article | Year |
|---|---|
Hypothalamic-pituitary-gonadal axis and sexual functioning in metformin-treated men after discontinuation of testosterone replacement therapy: A pilot study.
Topics: Adult; Aged; Blood Glucose; Gonadal Hormones; Gonadotropins; Hormone Replacement Therapy; Humans; Hy | 2021 |
The Impact of Testosterone on Metformin Action on Hypothalamic-Pituitary-Thyroid Axis Activity in Men: A Pilot Study.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Hypogonad | 2020 |
Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Erectile Dysfunctio | 2015 |
The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; H | 2016 |
Male partial hypogonadotrophic hypogonadism with gynaecomastia and metabolic syndrome.
Topics: Follow-Up Studies; Genital Diseases, Male; Gonadotropins; Gynecomastia; Humans; Hypogonadism; Male; | 2012 |