metformin has been researched along with Hepatic Encephalopathy in 3 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients." | 7.78 | Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. ( Ampuero, J; Bautista, JD; Camacho, I; del Campo, JA; Díaz-Herrero, Mdel M; Figueruela, B; Maraver, M; Nuñez, D; Ranchal, I; Rojas, Á; Romero-Gómez, M, 2012) |
| "metformin was associated with a significant inhibition of glutaminase activity levels in the small intestine of porto-caval shunted rats (0." | 5.48 | Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy. ( Ampuero, J; Gallego-Durán, R; García-Valdecasas, M; Gil-GÓmez, A; Gómez-Sotelo, AI; Muñoz-Hernández, R; Ranchal, I; Rojas, Á; Romero Gómez, M, 2018) |
| "To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients." | 3.78 | Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. ( Ampuero, J; Bautista, JD; Camacho, I; del Campo, JA; Díaz-Herrero, Mdel M; Figueruela, B; Maraver, M; Nuñez, D; Ranchal, I; Rojas, Á; Romero-Gómez, M, 2012) |
| "metformin was associated with a significant inhibition of glutaminase activity levels in the small intestine of porto-caval shunted rats (0." | 1.48 | Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy. ( Ampuero, J; Gallego-Durán, R; García-Valdecasas, M; Gil-GÓmez, A; Gómez-Sotelo, AI; Muñoz-Hernández, R; Ranchal, I; Rojas, Á; Romero Gómez, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mohamed, EK | 1 |
| Hafez, DM | 1 |
| Gil-GÓmez, A | 1 |
| Gómez-Sotelo, AI | 1 |
| Ranchal, I | 2 |
| Rojas, Á | 2 |
| García-Valdecasas, M | 1 |
| Muñoz-Hernández, R | 1 |
| Gallego-Durán, R | 1 |
| Ampuero, J | 2 |
| Romero Gómez, M | 1 |
| Nuñez, D | 1 |
| Díaz-Herrero, Mdel M | 1 |
| Maraver, M | 1 |
| del Campo, JA | 1 |
| Camacho, I | 1 |
| Figueruela, B | 1 |
| Bautista, JD | 1 |
| Romero-Gómez, M | 1 |
3 other studies available for metformin and Hepatic Encephalopathy
| Article | Year |
|---|---|
Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats.
Topics: Animals; Apoptosis; Caspase 3; Gallic Acid; Hepatic Encephalopathy; Inflammation; Metformin; NF-kapp | 2023 |
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy.
Topics: Ammonia; Animals; Caco-2 Cells; Child, Preschool; Glutaminase; Glutamine; Hepatic Encephalopathy; Hu | 2018 |
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.
Topics: Age Factors; Ammonia; Diabetes Complications; Enzyme Inhibitors; Female; Glutaminase; Hepatic Enceph | 2012 |