metformin has been researched along with HbS Disease in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin was recently found to increase fetal hemoglobin, which is protective in sickle cell disease (SCD)." | 5.51 | Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus. ( Badawy, SM; Payne, AB, 2019) |
| "Metformin was recently found to increase fetal hemoglobin, which is protective in sickle cell disease (SCD)." | 1.51 | Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus. ( Badawy, SM; Payne, AB, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Badawy, SM | 1 |
| Payne, AB | 1 |
| Boulassel, MR | 1 |
| El-Hussain, AI | 1 |
| Hassan, MM | 1 |
| Toumi, ML | 1 |
| Merzoug, S | 1 |
| Al-Qarni, Z | 1 |
| Khan, H | 1 |
| Gaifer, Z | 1 |
| Al-Farsi, K | 1 |
| Al-Khabori, M | 1 |
| Al Huneini, M | 1 |
| Al-Kindi, S | 1 |
| Zhang, Y | 1 |
| Paikari, A | 1 |
| Sumazin, P | 1 |
| Ginter Summarell, CC | 1 |
| Crosby, JR | 1 |
| Boerwinkle, E | 1 |
| Weiss, MJ | 1 |
| Sheehan, VA | 1 |
| Han, J | 1 |
| Saraf, SL | 1 |
| Molokie, RE | 1 |
| Gordeuk, VR | 1 |
4 other studies available for metformin and HbS Disease
| Article | Year |
|---|---|
Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus.
Topics: Adult; Anemia, Sickle Cell; Comorbidity; Diabetes Complications; Diabetes Mellitus; Female; Humans; | 2019 |
Stability of fetal hemoglobin levels in patients receiving metformin therapy.
Topics: Anemia, Sickle Cell; Female; Fetal Hemoglobin; Follow-Up Studies; Humans; Male; Metformin; Protein S | 2018 |
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
Topics: Anemia, Sickle Cell; Biomarkers; Cell Differentiation; Cells, Cultured; Child; Child, Preschool; Ery | 2018 |
Use of metformin in patients with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Drug Evaluation; Drug Therapy, Combination; Female; | 2019 |