Page last updated: 2024-10-30

metformin and HbS Disease

metformin has been researched along with HbS Disease in 4 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"Metformin was recently found to increase fetal hemoglobin, which is protective in sickle cell disease (SCD)."5.51Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus. ( Badawy, SM; Payne, AB, 2019)
"Metformin was recently found to increase fetal hemoglobin, which is protective in sickle cell disease (SCD)."1.51Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus. ( Badawy, SM; Payne, AB, 2019)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Badawy, SM1
Payne, AB1
Boulassel, MR1
El-Hussain, AI1
Hassan, MM1
Toumi, ML1
Merzoug, S1
Al-Qarni, Z1
Khan, H1
Gaifer, Z1
Al-Farsi, K1
Al-Khabori, M1
Al Huneini, M1
Al-Kindi, S1
Zhang, Y1
Paikari, A1
Sumazin, P1
Ginter Summarell, CC1
Crosby, JR1
Boerwinkle, E1
Weiss, MJ1
Sheehan, VA1
Han, J1
Saraf, SL1
Molokie, RE1
Gordeuk, VR1

Other Studies

4 other studies available for metformin and HbS Disease

ArticleYear
Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus.
    Blood advances, 2019, 11-12, Volume: 3, Issue:21

    Topics: Adult; Anemia, Sickle Cell; Comorbidity; Diabetes Complications; Diabetes Mellitus; Female; Humans;

2019
Stability of fetal hemoglobin levels in patients receiving metformin therapy.
    Haematologica, 2018, Volume: 103, Issue:10

    Topics: Anemia, Sickle Cell; Female; Fetal Hemoglobin; Follow-Up Studies; Humans; Male; Metformin; Protein S

2018
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
    Blood, 2018, 07-19, Volume: 132, Issue:3

    Topics: Anemia, Sickle Cell; Biomarkers; Cell Differentiation; Cells, Cultured; Child; Child, Preschool; Ery

2018
Use of metformin in patients with sickle cell disease.
    American journal of hematology, 2019, Volume: 94, Issue:1

    Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Drug Evaluation; Drug Therapy, Combination; Female;

2019