metformin has been researched along with Hashimoto Disease in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Hashimoto Disease: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin was found to improve insulin sensitivity in hepatitis C patients, as well as to reduce elevated thyrotropin levels in patients with hypothyroidism." | 9.22 | The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study. ( Krysiak, R; Okopien, B; Szkrobka, W, 2016) |
| " Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism." | 8.12 | Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " The present study compared the impact of low-grade systemic inflammation and insulin resistance on levothyroxine action in subjects with this disorder." | 8.12 | Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " In both study arms, metformin reduced plasma glucose levels and improved insulin sensitivity but this effect was stronger in subjects receiving vitamin D." | 7.96 | The impact of combination therapy with metformin and exogenous vitamin D on hypothalamic-pituitary-thyroid axis activity in women with autoimmune thyroiditis and high-normal thyrotropin levels. ( Kowalcze, K; Krysiak, R; Okopień, B, 2020) |
| " Metformin was found to improve insulin sensitivity in hepatitis C patients, as well as to reduce elevated thyrotropin levels in patients with hypothyroidism." | 5.22 | The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study. ( Krysiak, R; Okopien, B; Szkrobka, W, 2016) |
| " Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism." | 4.12 | Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " The present study compared the impact of low-grade systemic inflammation and insulin resistance on levothyroxine action in subjects with this disorder." | 4.12 | Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " The diagnosis leaned toward latent autoimmune diabetes in adults, and the therapeutic approach involved cessation of preprandial insulin therapy, regulation, and subsequent discontinuation of basal insulin and introduction of metformin." | 4.12 | Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto's thyroiditis: a case report. ( Fousteris, E; Lygnos, D; Xenou, M; Zoupas, I, 2022) |
| " In both study arms, metformin reduced plasma glucose levels and improved insulin sensitivity but this effect was stronger in subjects receiving vitamin D." | 3.96 | The impact of combination therapy with metformin and exogenous vitamin D on hypothalamic-pituitary-thyroid axis activity in women with autoimmune thyroiditis and high-normal thyrotropin levels. ( Kowalcze, K; Krysiak, R; Okopień, B, 2020) |
| "The objective of the study was to describe the clinical and biochemical findings of four patients with chronic hypothyroidism, previously euthyroid on fixed doses of L-T4 for several years, in whom the metformin was initiated." | 3.73 | Thyrotropin suppression by metformin. ( Filmore-Nassar, A; Glass, AR; Vigersky, RA, 2006) |
| "Metformin was found to reduce serum thyrotropin levels in patients with hypothyroidism." | 1.42 | Different Effects of Metformin on the Hypothalamic-Pituitary-Thyroid Axis in Bromocriptine- and Cabergoline-treated Patients with Hashimoto's Thyroiditis and Glucose Metabolism Abnormalities. ( Krysiak, R; Okopien, B; Okrzesik, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 6 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Krysiak, R | 5 |
| Kowalcze, K | 3 |
| Okopień, B | 5 |
| Xenou, M | 1 |
| Zoupas, I | 1 |
| Lygnos, D | 1 |
| Fousteris, E | 1 |
| Jia, X | 1 |
| Zhai, T | 1 |
| Zhang, JA | 1 |
| Zhao, L | 1 |
| Wu, Q | 1 |
| Wang, X | 1 |
| Wang, S | 1 |
| Shi, X | 1 |
| Shan, Z | 1 |
| Teng, W | 1 |
| Okrzesik, J | 1 |
| Szkrobka, W | 1 |
| Vigersky, RA | 1 |
| Filmore-Nassar, A | 1 |
| Glass, AR | 1 |
1 review available for metformin and Hashimoto Disease
| Article | Year |
|---|---|
Metformin reduces autoimmune antibody levels in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
Topics: Autoantibodies; Hashimoto Disease; Humans; Hypothyroidism; Metformin; Observational Studies as Topic | 2020 |
1 trial available for metformin and Hashimoto Disease
| Article | Year |
|---|---|
The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Hashimoto Disease; Humans; H | 2016 |
7 other studies available for metformin and Hashimoto Disease
| Article | Year |
|---|---|
Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism.
Topics: Autoimmunity; C-Reactive Protein; Female; Glucose; Hashimoto Disease; Humans; Hypothyroidism; Inosit | 2022 |
Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin.
Topics: Atorvastatin; C-Reactive Protein; Female; Hashimoto Disease; Humans; Hydroxymethylglutaryl-CoA Reduc | 2022 |
Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto's thyroiditis: a case report.
Topics: Adult; Autoantibodies; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Hashimoto Disease; Humans; | 2022 |
The impact of combination therapy with metformin and exogenous vitamin D on hypothalamic-pituitary-thyroid axis activity in women with autoimmune thyroiditis and high-normal thyrotropin levels.
Topics: Adult; Blood Glucose; Case-Control Studies; Drug Synergism; Drug Therapy, Combination; Female; Hashi | 2020 |
Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway.
Topics: Adult; Aged; Animals; Deoxyglucose; Female; Glucose Transporter Type 1; Glycolysis; Hashimoto Diseas | 2021 |
Different Effects of Metformin on the Hypothalamic-Pituitary-Thyroid Axis in Bromocriptine- and Cabergoline-treated Patients with Hashimoto's Thyroiditis and Glucose Metabolism Abnormalities.
Topics: Adult; Bromocriptine; Cabergoline; Ergolines; Female; Glucose Metabolism Disorders; Hashimoto Diseas | 2015 |
Thyrotropin suppression by metformin.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Interactions; Female; Goiter; Graves D | 2006 |