metformin has been researched along with Granulocytic Leukemia in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metformin resulted in significant downregulation of OXPHOS; however, increase in glycolysis was observed in NB4 and KG1A cells." | 1.62 | Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling. ( Borutinskaitė, V; Navakauskienė, R; Skliutė, G; Valiulienė, G; Vitkevičienė, A, 2021) |
| "Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia." | 1.46 | Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I. ( Chen, K; Feng, T; Ling, S; Liu, J; Liu, P; Shan, Q; Song, P; Xiang, P; Xie, H; Xu, X; Zhang, X; Zheng, S; Zhou, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valiulienė, G | 1 |
| Vitkevičienė, A | 1 |
| Skliutė, G | 1 |
| Borutinskaitė, V | 1 |
| Navakauskienė, R | 1 |
| Ling, S | 1 |
| Shan, Q | 1 |
| Liu, P | 1 |
| Feng, T | 1 |
| Zhang, X | 1 |
| Xiang, P | 1 |
| Chen, K | 1 |
| Xie, H | 1 |
| Song, P | 1 |
| Zhou, L | 1 |
| Liu, J | 1 |
| Zheng, S | 1 |
| Xu, X | 1 |
2 other studies available for metformin and Granulocytic Leukemia
| Article | Year |
|---|---|
Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Leukemia, Myeloi | 2021 |
Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line; Chemical and Dru | 2017 |