metformin has been researched along with Glomerulonephritis, Lupus in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation." | 4.12 | Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway. ( An, N; Chen, XC; Huang, LF; Huang, XR; Li, HY; Liu, HF; Liu, ZJ; Lu, X; Pan, QJ; Su, HY; Wu, D; Wu, HL; Yang, C; Zhu, SP, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, XC | 1 |
| Wu, D | 1 |
| Wu, HL | 1 |
| Li, HY | 1 |
| Yang, C | 1 |
| Su, HY | 1 |
| Liu, ZJ | 1 |
| Huang, XR | 1 |
| Lu, X | 1 |
| Huang, LF | 1 |
| Zhu, SP | 1 |
| Pan, QJ | 1 |
| An, N | 1 |
| Liu, HF | 1 |
| Cornaby, C | 1 |
| Elshikha, AS | 1 |
| Teng, X | 1 |
| Choi, SC | 1 |
| Scindia, Y | 1 |
| Davidson, A | 1 |
| Morel, L | 1 |
| Peng, X | 1 |
| Yang, T | 1 |
| Liu, G | 1 |
| Liu, H | 1 |
| Peng, Y | 1 |
| He, L | 1 |
| Wang, H | 1 |
| Li, T | 1 |
| Chen, S | 1 |
| Gu, Y | 1 |
| Ye, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomised, Double-blind Placebo Controlled Trial on the Efficacy and Safety of add-on Metformin to Conventional Immunosuppressants in Systemic Lupus Erythematosus[NCT02741960] | Phase 4 | 180 participants (Actual) | Interventional | 2016-05-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metformin and Glomerulonephritis, Lupus
| Article | Year |
|---|---|
Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Case-Control Stud | 2015 |
3 other studies available for metformin and Glomerulonephritis, Lupus
| Article | Year |
|---|---|
Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway.
Topics: AMP-Activated Protein Kinases; Animals; Humans; Inflammation; Kidney; Lipopolysaccharides; Lupus Ery | 2022 |
Efficacy of the Combination of Metformin and CTLA4Ig in the (NZB × NZW)F1 Mouse Model of Lupus Nephritis.
Topics: Abatacept; Animals; Antigens, CD; Autoantibodies; CD4-Positive T-Lymphocytes; CTLA-4 Antigen; Diseas | 2020 |
Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.
Topics: Alkaloids; AMP-Activated Protein Kinase Kinases; Animals; Anti-Inflammatory Agents; Benzodioxoles; C | 2018 |