Page last updated: 2024-10-30

metformin and Glioma

metformin has been researched along with Glioma in 17 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"This work aims to study the roles and mechanisms of metformin in glioma cells stemness and epithelial-mesenchymal transition."7.88Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. ( Bao, Q; Chen, H; Jiang, W; Jin, P; Wei, W; Yuan, X, 2018)
"The present study reports for the first time a dual antiglioma effect of the well-known antidiabetic drug metformin."7.74Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. ( Harhaji, L; Isakovic, A; Markovic, Z; Micic, D; Starcevic, V; Stevanovic, D; Sumarac-Dumanovic, M; Trajkovic, V, 2007)
"Malignant gliomas are among the deadliest primary brain tumors."6.50Glioma stem cells: markers, hallmarks and therapeutic targeting by metformin. ( Kraljik, N; Najbauer, J; Németh, P, 2014)
"Taken together, we propose that pre-treatment of glioma cells with metformin sensitize tumor cells to CAP, which may serve as a potential therapeutic strategy for glioma."5.62Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos. ( Ahmad, N; Meng, X; Sun, M; Yang, F; Yang, J; Yu, H; Zhao, R; Zhou, Y; Zhu, C; Zhuang, J, 2021)
"This work aims to study the roles and mechanisms of metformin in glioma cells stemness and epithelial-mesenchymal transition."3.88Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. ( Bao, Q; Chen, H; Jiang, W; Jin, P; Wei, W; Yuan, X, 2018)
"The present study reports for the first time a dual antiglioma effect of the well-known antidiabetic drug metformin."3.74Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. ( Harhaji, L; Isakovic, A; Markovic, Z; Micic, D; Starcevic, V; Stevanovic, D; Sumarac-Dumanovic, M; Trajkovic, V, 2007)
"Metformin has in-vitro anti-cancer activity, through AMPK activation and mTOR inhibition."3.01A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma. ( Amit, U; Anikster, Y; Champ, CE; Cohen, ZR; Furman, O; Genssin, H; Hemi, R; Jan, E; Kanety, H; Lawrence, YR; Mardor, Y; Pechthold, RG; Plotkin, L; Porper, K; Shimoni-Sebag, A; Shpatz, Y; Symon, Z; Talianski, A; Zach, L, 2021)
"Malignant gliomas are among the deadliest primary brain tumors."2.50Glioma stem cells: markers, hallmarks and therapeutic targeting by metformin. ( Kraljik, N; Najbauer, J; Németh, P, 2014)
"Taken together, we propose that pre-treatment of glioma cells with metformin sensitize tumor cells to CAP, which may serve as a potential therapeutic strategy for glioma."1.62Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos. ( Ahmad, N; Meng, X; Sun, M; Yang, F; Yang, J; Yu, H; Zhao, R; Zhou, Y; Zhu, C; Zhuang, J, 2021)
"Radiation is a current standard treatment of glioma."1.56Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation. ( Dong, H; Feng, B; Gao, C; Gao, X; Mao, W; Sun, C; Wang, J; Wang, Y; Yang, Y; Zhang, B; Zhang, H; Zhang, J; Zhang, L, 2020)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.76)29.6817
2010's11 (64.71)24.3611
2020's4 (23.53)2.80

Authors

AuthorsStudies
Gao, X1
Yang, Y2
Wang, J5
Zhang, L3
Sun, C1
Wang, Y3
Zhang, J4
Dong, H1
Zhang, H2
Gao, C2
Zhang, B1
Feng, B1
Mao, W1
Nguépy Keubo, FR1
Mboua, PC1
Djifack Tadongfack, T1
Fokouong Tchoffo, E1
Tasson Tatang, C1
Ide Zeuna, J1
Noupoue, EM1
Tsoplifack, CB1
Folefack, GO1
Kettani, M1
Bandelier, P1
Huo, J1
Li, H4
Yu, D1
Arulsamy, N1
AlAbbad, S1
Sardot, T1
Lekashvili, O1
Decato, D1
Lelj, F1
Alexander Ross, JB1
Rosenberg, E1
Nazir, H1
Muthuswamy, N1
Louis, C1
Jose, S1
Prakash, J1
Buan, MEM1
Flox, C1
Chavan, S1
Shi, X1
Kauranen, P1
Kallio, T1
Maia, G1
Tammeveski, K1
Lymperopoulos, N1
Carcadea, E1
Veziroglu, E1
Iranzo, A1
M Kannan, A1
Arunamata, A1
Tacy, TA1
Kache, S1
Mainwaring, RD1
Ma, M1
Maeda, K1
Punn, R1
Noguchi, S1
Hahn, S3
Iwasa, Y3
Ling, J2
Voccio, JP2
Kim, Y3
Song, J3
Bascuñán, J2
Chu, Y1
Tomita, M1
Cazorla, M1
Herrera, E1
Palomeque, E1
Saud, N1
Hoplock, LB1
Lobchuk, MM1
Lemoine, J1
Li, X10
Henson, MA1
Unsihuay, D1
Qiu, J1
Swaroop, S1
Nagornov, KO1
Kozhinov, AN1
Tsybin, YO1
Kuang, S1
Laskin, J1
Zin, NNINM1
Mohamad, MN1
Roslan, K1
Abdul Wafi, S1
Abdul Moin, NI1
Alias, A1
Zakaria, Y1
Abu-Bakar, N1
Naveed, A1
Jilani, K1
Siddique, AB1
Akbar, M1
Riaz, M1
Mushtaq, Z1
Sikandar, M1
Ilyas, S1
Bibi, I1
Asghar, A1
Rasool, G1
Irfan, M1
Li, XY1
Zhao, S1
Fan, XH1
Chen, KP1
Hua, W1
Liu, ZM1
Xue, XD1
Zhou, B1
Zhang, S2
Xing, YL1
Chen, MA1
Sun, Y1
Neradilek, MB1
Wu, XT1
Zhang, D2
Huang, W1
Cui, Y1
Yang, QQ1
Li, HW1
Zhao, XQ1
Hossein Rashidi, B1
Tarafdari, A1
Ghazimirsaeed, ST1
Shahrokh Tehraninezhad, E1
Keikha, F1
Eslami, B1
Ghazimirsaeed, SM1
Jafarabadi, M1
Silvani, Y1
Lovita, AND1
Maharani, A1
Wiyasa, IWA1
Sujuti, H1
Ratnawati, R1
Raras, TYM1
Lemin, AS1
Rahman, MM1
Pangarah, CA1
Kiyu, A1
Zeng, C2
Du, H1
Lin, D1
Jalan, D1
Rubagumya, F1
Hopman, WM1
Vanderpuye, V1
Lopes, G1
Seruga, B1
Booth, CM1
Berry, S1
Hammad, N1
Sajo, EA1
Okunade, KS1
Olorunfemi, G1
Rabiu, KA1
Anorlu, RI1
Xu, C2
Xiang, Y1
Xu, X1
Zhou, L2
Dong, X1
Tang, S1
Gao, XC1
Wei, CH1
Zhang, RG1
Cai, Q1
He, Y1
Tong, F1
Dong, JH1
Wu, G1
Dong, XR1
Tang, X1
Tao, F1
Xiang, W1
Zhao, Y2
Jin, L1
Tao, H1
Lei, Y1
Gan, H1
Huang, Y1
Chen, Y3
Chen, L3
Shan, A1
Zhao, H2
Wu, M2
Ma, Q1
Zhang, E1
Li, Y5
Xue, F1
Deng, L1
Liu, L2
Yan, Z2
Meng, J1
Chen, G2
Anastassiadou, M1
Bernasconi, G1
Brancato, A1
Carrasco Cabrera, L1
Greco, L1
Jarrah, S1
Kazocina, A1
Leuschner, R1
Magrans, JO1
Miron, I1
Nave, S1
Pedersen, R1
Reich, H1
Rojas, A1
Sacchi, A1
Santos, M1
Theobald, A1
Vagenende, B1
Verani, A1
Du, L1
Liu, X1
Ren, Y1
Li, J7
Li, P1
Jiao, Q1
Meng, P1
Wang, F2
Wang, YS1
Wang, C3
Zhou, X2
Wang, W1
Wang, S2
Hou, J1
Zhang, A1
Lv, B1
Pang, D1
Lu, K1
Ahmad, NH1
Wang, L1
Zhu, J2
Zhuang, T1
Tu, J1
Zhao, Z1
Qu, Y1
Yao, H1
Wang, X5
Lee, DF1
Shen, J3
Wen, L1
Huang, G2
Xie, X1
Zhao, Q1
Hu, W1
Zhang, Y4
Wu, X1
Lu, J2
Li, M1
Li, W2
Wu, W1
Du, F1
Ji, H1
Yang, X2
Xu, Z1
Wan, L1
Wen, Q1
Cho, CH1
Zou, C1
Xiao, Z1
Liao, J1
Su, X1
Bi, Z1
Su, Q1
Huang, H1
Wei, Y2
Gao, Y2
Na, KJ1
Choi, H1
Oh, HR1
Kim, YH1
Lee, SB1
Jung, YJ1
Koh, J1
Park, S1
Lee, HJ1
Jeon, YK1
Chung, DH1
Paeng, JC1
Park, IK1
Kang, CH1
Cheon, GJ1
Kang, KW1
Lee, DS1
Kim, YT1
Pajuelo-Lozano, N1
Alcalá, S1
Sainz, B1
Perona, R1
Sanchez-Perez, I1
Logotheti, S1
Marquardt, S1
Gupta, SK1
Richter, C1
Edelhäuser, BAH1
Engelmann, D1
Brenmoehl, J1
Söhnchen, C1
Murr, N1
Alpers, M1
Singh, KP1
Wolkenhauer, O1
Heckl, D1
Spitschak, A1
Pützer, BM1
Liao, Y1
Cheng, J1
Kong, X1
Li, S1
Zhang, M4
Yang, T2
Dong, Y1
Xu, Y1
Yuan, Z1
Cao, J1
Zheng, Y1
Luo, Z1
Mei, Z1
Yao, Y1
Liu, Z2
Liang, C1
Yang, H1
Song, Y1
Yu, K1
Zhu, C2
Huang, Z1
Qian, J1
Ge, J1
Hu, J2
Wang, H2
Liu, Y4
Mi, Y1
Kong, H1
Xi, D1
Yan, W1
Luo, X1
Ning, Q1
Chang, X2
Zhang, T2
Wang, Q2
Rathore, MG1
Reddy, K1
Chen, H2
Shin, SH1
Ma, WY1
Bode, AM1
Dong, Z1
Mu, W1
Liu, C3
Gao, F1
Qi, Y1
Lu, H1
Zhang, X4
Cai, X1
Ji, RY1
Hou, Y3
Tian, J2
Shi, Y1
Ying, S1
Tan, M1
Feng, G1
Kuang, Y1
Chen, D1
Wu, D3
Zhu, ZQ1
Tang, HX1
Shi, ZE1
Kang, J1
Liu, Q1
Qi, J2
Mu, J1
Cong, Z1
Chen, S2
Fu, D1
Li, Z2
Celestrin, CP1
Rocha, GZ1
Stein, AM1
Guadagnini, D1
Tadelle, RM1
Saad, MJA1
Oliveira, AG1
Bianconi, V1
Bronzo, P1
Banach, M1
Sahebkar, A1
Mannarino, MR1
Pirro, M1
Patsourakos, NG1
Kouvari, M1
Kotidis, A1
Kalantzi, KI1
Tsoumani, ME1
Anastasiadis, F1
Andronikos, P1
Aslanidou, T1
Efraimidis, P1
Georgiopoulos, A1
Gerakiou, K1
Grigoriadou-Skouta, E1
Grigoropoulos, P1
Hatzopoulos, D1
Kartalis, A1
Lyras, A1
Markatos, G1
Mikrogeorgiou, A1
Myroforou, I1
Orkopoulos, A1
Pavlidis, P1
Petras, C1
Riga, M1
Skouloudi, M1
Smyrnioudis, N1
Thomaidis, K1
Tsikouri, GE1
Tsikouris, EI1
Zisimos, K1
Vavoulis, P1
Vitali, MG1
Vitsas, G1
Vogiatzidis, C1
Chantanis, S1
Fousas, S1
Panagiotakos, DB1
Tselepis, AD1
Jungen, C1
Alken, FA1
Eickholt, C1
Scherschel, K1
Kuklik, P1
Klatt, N1
Schwarzl, J1
Moser, J1
Jularic, M1
Akbulak, RO1
Schaeffer, B1
Willems, S1
Meyer, C1
Nowak, JK1
Szczepanik, M1
Trypuć, M1
Pogorzelski, A1
Bobkowski, W1
Grytczuk, M1
Minarowska, A1
Wójciak, R1
Walkowiak, J1
Lu, Y1
Xi, J1
Li, C1
Chen, W2
Hu, X1
Zhang, F1
Wei, H1
Wang, Z1
Gurzu, S1
Jung, I1
Sugimura, H2
Stefan-van Staden, RI1
Yamada, H1
Natsume, H1
Iwashita, Y1
Szodorai, R1
Szederjesi, J1
Yari, D1
Ehsanbakhsh, Z1
Validad, MH1
Langroudi, FH1
Esfandiari, H1
Prager, A1
Hassanpour, K1
Kurup, SP1
Mets-Halgrimson, R1
Yoon, H1
Zeid, JL1
Mets, MB1
Rahmani, B1
Araujo-Castillo, RV1
Culquichicón, C1
Solis Condor, R1
Efendi, F1
Sebayang, SK1
Astutik, E1
Hadisuyatmana, S1
Has, EMM1
Kuswanto, H1
Foroutan, T1
Ahmadi, F1
Moayer, F1
Khalvati, S1
Zhang, Q2
Lyu, Y1
Huang, J1
Yu, N1
Wen, Z1
Hou, H1
Zhao, T1
Gupta, A1
Khosla, N1
Govindasamy, V1
Saini, A1
Annapurna, K1
Dhakate, SR1
Akkaya, Ö1
Chandgude, AL1
Dömling, A1
Harnett, J1
Oakes, K1
Carè, J1
Leach, M1
Brown, D1
Cramer, H1
Pinder, TA1
Steel, A1
Anheyer, D1
Cantu, J1
Valle, J1
Flores, K1
Gonzalez, D1
Valdes, C1
Lopez, J1
Padilla, V1
Alcoutlabi, M1
Parsons, J1
Núñez, K1
Hamed, M1
Fort, D1
Bruce, D1
Thevenot, P1
Cohen, A1
Weber, P1
Menezes, AMB1
Gonçalves, H1
Perez-Padilla, R1
Jarvis, D1
de Oliveira, PD1
Wehrmeister, FC1
Mir, S1
Wong, J1
Ryan, CM1
Bellingham, G1
Singh, M2
Waseem, R1
Eckert, DJ1
Chung, F1
Hegde, H1
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Glurich, I1
Christie, P1
Acharya, A1
English, KL1
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Goetchius, E1
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Ryder, JW1
Ploutz-Snyder, R1
Guilliams, M1
Scott, JM1
Ploutz-Snyder, LL1
Martens, C1
Goplen, FK1
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Gjestad, R1
Nordfalk, KF1
Nordahl, SHG1
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Marumo, K1
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Caffaro, MM1
Patel, PR2
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Saleh, AA1
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El-Magd, MA1
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Schijven, MP1
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Schreuder, HWR1
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Picada, JN1
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Vasques, GJ1
Pereira, MADS1
Reginatto, FH1
Ferraz, ABF1
Vasilenko, EA1
Gorshkova, EN1
Astrakhantseva, IV1
Drutskaya, MS1
Tillib, SV1
Nedospasov, SA1
Mokhonov, VV1
Nam, YW1
Cui, M1
Orfali, R1
Viegas, A1
Nguyen, M1
Mohammed, EHM1
Zoghebi, KA1
Rahighi, S1
Parang, K1
Patterson, KC1
Kahanovitch, U1
Gonçalves, CM1
Hablitz, JJ1
Staruschenko, A1
Mulkey, DK1
Olsen, ML1
Gu, L1
Cao, X1
Mukhtar, A1
Wu, K1
Zhang, YY1
Zhu, Y1
Lu, DZ1
Dong, W1
Bi, WJ1
Feng, XJ1
Wen, LM1
Sun, H1
Qi, MC1
Chang, CC1
Dinh, TK1
Lee, YA1
Wang, FN1
Sung, YC1
Yu, PL1
Chiu, SC1
Shih, YC1
Wu, CY1
Huang, YD1
Lu, TT1
Wan, D1
Sakizadeh, J1
Cline, JP1
Snyder, MA1
Kiely, CJ1
McIntosh, S1
Jiang, X1
Cao, JW1
Zhao, CK1
Yang, R1
Zhang, QY1
Chen, KJ2
Liu, H1
He, Z1
Chen, B1
Wu, J1
Du, X1
Moore, J1
Blank, BR1
Eksterowicz, J1
Sutimantanapi, D1
Yuen, N1
Metzger, T1
Chan, B1
Huang, T1
Chen, X1
Duong, F1
Kong, W1
Chang, JH1
Sun, J1
Zavorotinskaya, T1
Ye, Q1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Metformin and Neo-adjuvant Temozolomide and Hypofractionated Accelerated Limited-margin Radiotherapy Followed by Adjuvant Temozolomide in Patients With Glioblastoma Multiforme (M-HARTT STUDY)[NCT02780024]Phase 250 participants (Anticipated)Interventional2015-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for metformin and Glioma

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Glioma stem cells: markers, hallmarks and therapeutic targeting by metformin.
    Pathology oncology research : POR, 2014, Volume: 20, Issue:4

    Topics: Biomarkers, Tumor; Glioma; Humans; Hypoglycemic Agents; Metformin; Neoplastic Stem Cells; Prognosis

2014

Trials

2 trials available for metformin and Glioma

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma.
    Journal of neuro-oncology, 2021, Volume: 153, Issue:3

    Topics: Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Ketones; Metformin; Middle Aged; Neoplas

2021

Other Studies

14 other studies available for metformin and Glioma

ArticleYear
Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 129

    Topics: Brain Neoplasms; Cell Line, Tumor; Electron Transport Complex I; Enzyme Inhibitors; Glioma; Humans;

2020
Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos.
    Neoplasma, 2021, Volume: 68, Issue:1

    Topics: Apoptosis; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Hydrog

2021
Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102

    Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Shape; Cell Survival; Central Nervous S

2018
Use of metformin and survival of patients with high-grade glioma.
    International journal of cancer, 2019, 01-15, Volume: 144, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Disease-Free Survival; Female; Germany; Glioma; Hum

2019
Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma.
    International journal of molecular sciences, 2018, Aug-31, Volume: 19, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prol

2018
Searching for the roots of brain cancer.
    Nature, 2018, Volume: 561, Issue:7724

    Topics: Animals; Brain Neoplasms; Cell Phone; Chickenpox; Chickenpox Vaccine; Developed Countries; Diabetes

2018
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6.
    Experimental oncology, 2018, Volume: 40, Issue:3

    Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dichloroacetic Acid; Female;

2018
Connecting the dots between metformin and high-grade glioma.
    International journal of cancer, 2019, 04-01, Volume: 144, Issue:7

    Topics: Brain Neoplasms; Glioma; Humans; Metformin

2019
Reply to Lu: Connecting the dots between metformin and high-grade glioma.
    International journal of cancer, 2019, 04-01, Volume: 144, Issue:7

    Topics: Brain Neoplasms; Glioma; Humans; Metformin

2019
Metformin inhibits glioma cell U251 invasion by downregulation of fibulin-3.
    Neuroreport, 2013, Jul-10, Volume: 24, Issue:10

    Topics: Actins; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Sur

2013
ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Aniline Compounds; Apoptosis; Blotting, Wes

2013
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
    Biochemical pharmacology, 2009, Jun-01, Volume: 77, Issue:11

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Antioxidants; Apop

2009
Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.
    Stem cells translational medicine, 2012, Volume: 1, Issue:11

    Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Differentiation;

2012
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.
    Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apop

2007