metformin has been researched along with Gestational Weight Gain in 12 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Gestational Weight Gain: Increase in body weight of the mother during the course of her PREGNANCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 9.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 9.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| "Metformin has been used in pregnancy since the 1970s." | 9.22 | Metformin for pregnancy and beyond: the pros and cons. ( Dunne, FP; Newman, C, 2022) |
| "gov for randomized controlled trials (RCTs) that compared metformin to insulin in pregnancy." | 9.22 | The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials. ( Ge, J; Guo, Q; He, K; Jing, Z; Li, C; Li, J, 2022) |
| "Metformin counteracts excessive weight gain and leptin resistance in pregnant women with polycystic ovary syndrome." | 8.12 | Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study. ( Bixo, M; Dehlin, E; Løvvik, TS; Molin, J; Vanky, E, 2022) |
| " The aims of this study were to evaluate the potential effect of metformin in GWG in overweight or obese women with GDM, to report our experience and to assess metformin's safety in this population." | 7.91 | Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study. ( Belo, S; Bettencourt-Silva, R; Carvalho, D; Ferreira, MJ; Montenegro, N; Namora, G; Neves, JS; Oliveira, AI; Queirós, J; Souteiro, P, 2019) |
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 5.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 5.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| "Metformin has been used in pregnancy since the 1970s." | 5.22 | Metformin for pregnancy and beyond: the pros and cons. ( Dunne, FP; Newman, C, 2022) |
| "gov for randomized controlled trials (RCTs) that compared metformin to insulin in pregnancy." | 5.22 | The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials. ( Ge, J; Guo, Q; He, K; Jing, Z; Li, C; Li, J, 2022) |
| " Metformin is an effective oral antihyperglycaemic agent that is considered to be effective during pregnancy." | 5.01 | Metformin reduces maternal weight gain in obese pregnant women: A systematic review and meta-analysis of two randomized controlled trials. ( Benedetti Panici, P; Boccherini, C; Brunelli, R; D'Ambrosio, V; Di Mascio, D; Giancotti, A; Marchetti, C; Piccioni, MG; Vena, F, 2019) |
| "Metformin counteracts excessive weight gain and leptin resistance in pregnant women with polycystic ovary syndrome." | 4.12 | Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study. ( Bixo, M; Dehlin, E; Løvvik, TS; Molin, J; Vanky, E, 2022) |
| " The aims of this study were to evaluate the potential effect of metformin in GWG in overweight or obese women with GDM, to report our experience and to assess metformin's safety in this population." | 3.91 | Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study. ( Belo, S; Bettencourt-Silva, R; Carvalho, D; Ferreira, MJ; Montenegro, N; Namora, G; Neves, JS; Oliveira, AI; Queirós, J; Souteiro, P, 2019) |
| "Pregnancies affected by gestational diabetes mellitus (GDM) are associated with an increased risk of adverse maternal and foetal outcomes." | 3.11 | A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol. ( Alvarez-Iglesias, A; Browne, M; Devane, D; Dunne, F; Gillespie, P; Newman, C; O'Donnell, M; Smyth, A, 2022) |
| "Metformin treatment was associated with a better postprandial glycemic control than insulin for some meals, a lower risk of hypoglycemic episodes, less maternal weight gain, and a low rate of failure as an isolated treatment." | 3.01 | Metformin for gestational diabetes study: metformin vs insulin in gestational diabetes: glycemic control and obstetrical and perinatal outcomes: randomized prospective trial. ( González-Mesa, E; González-Romero, S; Molina-Vega, M; Olveira, G; Picón-César, MJ; Roldan-López, R; Romero-Narbona, F; Sola-Moyano, AP; Suárez-Arana, M; Tinahones, FJ, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 7 (58.33) | 2.80 |
| Authors | Studies |
|---|---|
| Newman, C | 2 |
| Dunne, FP | 1 |
| Molin, J | 1 |
| Vanky, E | 1 |
| Løvvik, TS | 1 |
| Dehlin, E | 1 |
| Bixo, M | 1 |
| Fu, J | 1 |
| Tomlinson, G | 1 |
| Feig, DS | 1 |
| Dunne, F | 1 |
| Devane, D | 1 |
| Smyth, A | 1 |
| Alvarez-Iglesias, A | 1 |
| Gillespie, P | 1 |
| Browne, M | 1 |
| O'Donnell, M | 1 |
| Zehra, SA | 1 |
| Shah, HH | 1 |
| Bettencourt-Silva, R | 1 |
| Neves, JS | 1 |
| Ferreira, MJ | 1 |
| Souteiro, P | 1 |
| Belo, S | 1 |
| Oliveira, AI | 1 |
| Carvalho, D | 1 |
| Namora, G | 1 |
| Montenegro, N | 1 |
| Queirós, J | 1 |
| Picón-César, MJ | 1 |
| Molina-Vega, M | 1 |
| Suárez-Arana, M | 1 |
| González-Mesa, E | 1 |
| Sola-Moyano, AP | 1 |
| Roldan-López, R | 1 |
| Romero-Narbona, F | 1 |
| Olveira, G | 1 |
| Tinahones, FJ | 1 |
| González-Romero, S | 1 |
| He, K | 1 |
| Guo, Q | 1 |
| Ge, J | 1 |
| Li, J | 1 |
| Li, C | 1 |
| Jing, Z | 1 |
| Aiken, CEM | 1 |
| Hone, L | 1 |
| Murphy, HR | 1 |
| Meek, CL | 1 |
| Dodd, JM | 1 |
| Louise, J | 1 |
| Deussen, AR | 1 |
| Grivell, RM | 1 |
| Dekker, G | 1 |
| McPhee, AJ | 1 |
| Hague, W | 1 |
| Bashir, M | 1 |
| Dabbous, Z | 1 |
| Baagar, K | 1 |
| Elkhatib, F | 1 |
| Ibrahim, A | 1 |
| Brich, SA | 1 |
| Abdel-Rahman, ME | 1 |
| Konje, JC | 1 |
| Abou-Samra, AB | 1 |
| D'Ambrosio, V | 1 |
| Brunelli, R | 1 |
| Vena, F | 1 |
| Di Mascio, D | 1 |
| Marchetti, C | 1 |
| Boccherini, C | 1 |
| Piccioni, MG | 1 |
| Benedetti Panici, P | 1 |
| Giancotti, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Placebo Controlled Trial of the Effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE)[NCT02980276] | Phase 3 | 535 participants (Actual) | Interventional | 2017-06-06 | Completed | ||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Gestational Weight Gain
| Article | Year |
|---|---|
Metformin for pregnancy and beyond: the pros and cons.
Topics: Administration, Oral; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Gestational W | 2022 |
The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials.
Topics: Birth Weight; Diabetes Mellitus, Type 2; Diabetes, Gestational; Drug Therapy, Combination; Female; G | 2022 |
Metformin reduces maternal weight gain in obese pregnant women: A systematic review and meta-analysis of two randomized controlled trials.
Topics: Female; Gestational Weight Gain; Humans; Hypoglycemic Agents; Metformin; Obesity; Pregnancy; Pregnan | 2019 |
4 trials available for metformin and Gestational Weight Gain
5 other studies available for metformin and Gestational Weight Gain
| Article | Year |
|---|---|
Gestational weight gain, appetite regulating hormones, and metformin treatment in polycystic ovary syndrome: A longitudinal, placebo-controlled study.
Topics: Appetite; Body Mass Index; Cohort Studies; Female; Gestational Weight Gain; Ghrelin; Humans; Leptin; | 2022 |
Gestational weight gain, appetite-regulating hormones and metformin treatment in polycystic ovary syndrome: The importance of exclusion criteria.
Topics: Appetite; Female; Gestational Weight Gain; Hormones; Humans; Hypoglycemic Agents; Metformin; Polycys | 2023 |
Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Gestational Weight Gain; Humans; Hypoglycemic A | 2019 |
Improving outcomes in gestational diabetes: does gestational weight gain matter?
Topics: Adult; Body Mass Index; Delivery, Obstetric; Diabetes, Gestational; Female; Fetal Macrosomia; Gestat | 2019 |
Type 2 diabetes mellitus in pregnancy: The impact of maternal weight and early glycaemic control on outcomes.
Topics: Adult; Case-Control Studies; Cesarean Section; Diabetes Mellitus, Type 2; Female; Fetal Macrosomia; | 2019 |