metformin has been researched along with Genome Instability in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i." | 6.82 | Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. ( Chen, M; Chen, S; Gan, D; Lin, S; Shao, Z; Xiao, G; Zhong, Y; Zou, X, 2022) |
| "Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i." | 2.82 | Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. ( Chen, M; Chen, S; Gan, D; Lin, S; Shao, Z; Xiao, G; Zhong, Y; Zou, X, 2022) |
| "Metformin has certain genotoxicity on planarian in a dose- and time-related manner." | 1.72 | Genotoxicity Evaluation of Metformin in Freshwater Planarian ( Chen, D; Feng, M; Song, L; Xu, Z; Yin, D; Zhao, Z, 2022) |
| "Treatment with metformin ameliorated these biochemical markers." | 1.35 | Assessment of genomic instability in normal and diabetic rats treated with metformin. ( Alhaider, AA; Attia, SM; Helal, GK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S | 1 |
| Gan, D | 1 |
| Lin, S | 1 |
| Zhong, Y | 1 |
| Chen, M | 1 |
| Zou, X | 1 |
| Shao, Z | 1 |
| Xiao, G | 1 |
| Yin, D | 1 |
| Xu, Z | 1 |
| Feng, M | 1 |
| Zhao, Z | 1 |
| Chen, D | 1 |
| Song, L | 1 |
| Najafi, M | 1 |
| Cheki, M | 1 |
| Rezapoor, S | 1 |
| Geraily, G | 1 |
| Motevaseli, E | 1 |
| Carnovale, C | 1 |
| Clementi, E | 1 |
| Shirazi, A | 1 |
| Alonso-Villaverde, C | 1 |
| Menéndez, JA | 3 |
| Joven, J | 3 |
| Cuyàs, E | 2 |
| Fernández-Arroyo, S | 2 |
| Alarcón, T | 1 |
| Lupu, R | 1 |
| Attia, SM | 1 |
| Helal, GK | 1 |
| Alhaider, AA | 1 |
2 reviews available for metformin and Genome Instability
| Article | Year |
|---|---|
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.
Topics: Aging; Cellular Senescence; Genomic Instability; Humans; Metformin; Telomere | 2022 |
Metformin: Prevention of genomic instability and cancer: A review.
Topics: Genomic Instability; Humans; Hypoglycemic Agents; Metformin; Neoplasms | 2018 |
5 other studies available for metformin and Genome Instability
| Article | Year |
|---|---|
Genotoxicity Evaluation of Metformin in Freshwater Planarian
Topics: Animals; Comet Assay; DNA Damage; Fresh Water; Genomic Instability; Metformin; Planarians; Random Am | 2022 |
Metabolic stress in infected cells may represent a therapeutic target for human immunodeficiency virus infection.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Chloroquine; Genomic Instability; HIV Infections; HIV-1 | 2013 |
Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.
Topics: BRCA1 Protein; Breast; Cell Line; Cell Transformation, Neoplastic; Energy Metabolism; Epithelial Cel | 2016 |
Metformin targets histone acetylation in cancer-prone epithelial cells.
Topics: Acetyl Coenzyme A; Acetylation; BRCA1 Protein; Carcinogenesis; Epigenesis, Genetic; Epithelial Cells | 2016 |
Assessment of genomic instability in normal and diabetic rats treated with metformin.
Topics: Animals; Chromosome Aberrations; Diabetes Mellitus, Experimental; Drug Administration Schedule; Geno | 2009 |