metformin has been researched along with Genetic Predisposition in 40 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss-inducing interventions (lifestyle and metformin) versus placebo." | 9.16 | Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. ( Delahanty, LM; Florez, JC; Franks, PW; Jablonski, KA; Kahn, SE; Knowler, WC; McCaffery, JM; Pan, Q; Shuldiner, A; Watson, KE, 2012) |
| "We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss-inducing interventions (lifestyle and metformin) versus placebo." | 5.16 | Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. ( Delahanty, LM; Florez, JC; Franks, PW; Jablonski, KA; Kahn, SE; Knowler, WC; McCaffery, JM; Pan, Q; Shuldiner, A; Watson, KE, 2012) |
| "To investigate the association between family history and clinical symptoms of polycystic ovary syndrome (PCOS) that were thought to be inherited, by treating women with PCOS with contraceptive pills and metformin, and assessing outcomes." | 5.14 | The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome. ( Chen, X; Chi, H; Hu, Z; Li, M; Qiao, J; Wang, Y, 2010) |
| "The metabolic parameters and functional state of hypothalamic systems in mice with the Yellow mutation in the Agouti locus and with obesity of the melanocortin type and the effect of metformin (MF) treatment (9 days, 200 mg/kg/day) were studied." | 3.85 | Metabolic parameters and functional state of hypothalamic signaling systems in A ( Derkach, KV; Mikhrina, AL; Romanova, IV; Shpakov, AO; Zakharova, IO; Zorina, II, 2017) |
| " SNPs predictive of adverse reaction to warfarin indicated that the SAIF individual is not at risk for bleeding if treated with typical doses of warfarin." | 3.78 | Sequencing and analysis of a South Asian-Indian personal genome. ( Burhans, R; Butte, AJ; Chen, R; Davuluri, RV; Gupta, R; Kim, HL; Miller, W; Rajesh, C; Ratan, A; Santhosh, S; Schuster, SC; Seshagiri, S; Thomas, G, 2012) |
| "Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes (P < 0." | 2.73 | Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. ( Altshuler, D; Dabelea, D; Florez, JC; Franks, PW; Hamman, RF; Jablonski, KA; Kahn, SE; Knowler, WC; Nathan, DM, 2007) |
| "At 26 wk, edema was recorded in 48 of the patients (14%) treated with ragaglitazar, and Cox regression analyses identified the common Pro12Ala variant of the PPARG gene as biologically the most important risk factor (hazard ratio 4." | 2.72 | The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients. ( Anant, M; Ekstrøm, CT; Hansen, L; Reinhardt, RR; Tabanera Y Palacios, R; Wassermann, K, 2006) |
| "Diabetes mellitus and prostate cancer are 2 of the most important public health concerns, especially in the elderly population." | 2.50 | Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms. ( Hara, N; Hejazi, J; Marotta, F; Rastmanesh, R, 2014) |
| "Metformin has proven to be effective in the management of the metabolic disturbances, anovulation and hirsutism and is now a widely accepted therapy." | 2.43 | [Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences]. ( Madsbad, S; Nilas, L; Nørgaard, K; Svendsen, PF, 2005) |
| "Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146." | 1.72 | Association of gene polymorphisms with body weight changes in prediabetic patients. ( Ahmetov, II; Egorova, ES; Khasanova, KB; Kiseleva, TA; Medvedeva, MS; Pickering, C; Valeeva, EV; Valeeva, FV, 2022) |
| "Metformin users were older, more likely non-Caucasian, and had higher body mass index, Gleason score, and number of positive cores." | 1.62 | Association between metformin medication, genetic variation and prostate cancer risk. ( Finelli, A; Fleshner, NE; Freedland, SJ; Hamilton, RJ; Jayalath, VH; Kulkarni, GS; Lee, MJ; Lu, L; van der Kwast, TH; Xu, W, 2021) |
| "Participants were all prostate cancer-free men aged 40 to 79 years residing in Stockholm County, Sweden, between January 1, 2006, and December 31, 2015." | 1.51 | Association Between Antidiabetic Medications and Prostate-Specific Antigen Levels and Biopsy Results. ( Adolfsson, J; Aly, M; Beckmann, K; Binti Abd Jalal, N; Crawley, D; Eklund, M; Garmo, H; Lantz, A; Nordström, T; Olsson, H; Van Hemelrijck, M, 2019) |
| "Forty-three patients (47%) experienced gastrointestinal adverse effects in the first 6 months of metformin treatment." | 1.43 | Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes. ( Bego, T; Causevic, A; Dujic, T; Malenica, M; Pearson, ER; Semiz, S; Velija-Asimi, Z, 2016) |
| "Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood." | 1.42 | Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. ( Armasu, SM; Breitenstein, MK; Pathak, J; Ryu, E; Simon, G; Wang, L; Weinshilboum, RM, 2015) |
| "Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable." | 1.40 | Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis. ( Ahlqvist, E; Colhoun, HM; Deshmukh, H; Donnelly, L; Groop, L; Li, M; McCarthy, MI; Morris, AD; Palmer, CN; Pearson, ER; Sham, PC; Spencer, CC; Van Zuydam, N; Yang, J; Zhou, K, 2014) |
| "In the families of cancer-free DM2 women, DM2 was found to be significantly more frequent (30." | 1.38 | Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin. ( Berstein, LM; Boyarkina, MP; Teslenko, SY, 2012) |
| "Obesity is a common problem and its health consequences depend on the phenotype of obesity." | 1.38 | Menopausal obesity and metabolic syndrome - PolSenior study. ( Milewicz, A, 2012) |
| "Wildtype C." | 1.37 | Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans. ( LaRue, BL; Padilla, PA, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 30 (75.00) | 24.3611 |
| 2020's | 6 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valeeva, FV | 1 |
| Medvedeva, MS | 1 |
| Khasanova, KB | 1 |
| Valeeva, EV | 1 |
| Kiseleva, TA | 1 |
| Egorova, ES | 1 |
| Pickering, C | 1 |
| Ahmetov, II | 1 |
| Alfaqih, MA | 1 |
| Aljanabi, M | 1 |
| Ababneh, E | 1 |
| Khanfar, M | 1 |
| Alqudah, M | 1 |
| Sater, M | 1 |
| Merino, J | 1 |
| Jablonski, KA | 6 |
| Mercader, JM | 1 |
| Kahn, SE | 6 |
| Chen, L | 5 |
| Harden, M | 2 |
| Delahanty, LM | 2 |
| Araneta, MRG | 1 |
| Walford, GA | 2 |
| Jacobs, SBR | 1 |
| Ibebuogu, UN | 1 |
| Franks, PW | 5 |
| Knowler, WC | 6 |
| Florez, JC | 7 |
| Beckmann, K | 1 |
| Crawley, D | 1 |
| Nordström, T | 1 |
| Aly, M | 1 |
| Olsson, H | 1 |
| Lantz, A | 1 |
| Binti Abd Jalal, N | 1 |
| Garmo, H | 1 |
| Adolfsson, J | 1 |
| Eklund, M | 1 |
| Van Hemelrijck, M | 1 |
| Lee, MJ | 1 |
| Jayalath, VH | 1 |
| Xu, W | 1 |
| Lu, L | 1 |
| Freedland, SJ | 1 |
| Fleshner, NE | 1 |
| Kulkarni, GS | 1 |
| Finelli, A | 1 |
| van der Kwast, TH | 1 |
| Hamilton, RJ | 1 |
| Tsai, HY | 1 |
| Wu, SC | 1 |
| Li, JC | 1 |
| Chen, YM | 1 |
| Chan, CC | 1 |
| Chen, CH | 2 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 2 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 5 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 3 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 1 |
| Ren, Y | 1 |
| Li, J | 7 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 2 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 4 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 3 |
| Li, W | 2 |
| Wu, W | 1 |
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| Xu, Z | 1 |
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| Luo, X | 1 |
| Ning, Q | 1 |
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| Rathore, MG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004992] | Phase 3 | 3,234 participants (Actual) | Interventional | 1996-07-31 | Completed | ||
| Genetics of Diabetes Audit and Research in Tayside Scotland (DOLORisk Dundee)[NCT02783469] | 1,915 participants (Actual) | Observational | 2004-10-31 | Completed | |||
| Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans[NCT01762046] | Phase 1 | 1,000 participants (Anticipated) | Interventional | 2008-01-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metformin and Genetic Predisposition
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms.
Topics: Carcinogenesis; Diabetes Mellitus, Type 2; Diet Therapy; Genetic Predisposition to Disease; Humans; | 2014 |
Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus.
Topics: Adipose Tissue; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug Discovery; Fatty Liver; Genetic Pr | 2010 |
[Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences].
Topics: Contraceptives, Oral; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Humans; | 2005 |
12 trials available for metformin and Genetic Predisposition
| Article | Year |
|---|---|
Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors.
Topics: Adult; Cardiovascular Diseases; Coronary Artery Disease; Diabetes Mellitus, Type 2; Exercise; Exerci | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.
Topics: Adult; Aged; Alleles; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genetic Predispo | 2015 |
Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.
Topics: Acute Disease; Causality; Combined Modality Therapy; Comorbidity; Double-Blind Method; Female; Genet | 2015 |
The Relationships of Obesity-Related Genetic Variants With Metabolic Profiles and Response to Metformin in Clozapine-Treated Patients With Schizophrenia.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aldose-Ketose Isomerases; Alleles; Antipsychotic Agents | 2015 |
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genetic Variation; Huma | 2016 |
The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Topics: Chromans; Combined Modality Therapy; Diabetes Mellitus, Type 2; Exercise Therapy; Female; Gene Frequ | 2009 |
The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Area Under Curve; Blood Glucose; Contraceptives, Oral; Female; Follow-Up Studies; | 2010 |
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Weight; Brain-Derived Neurotrophic Factor; Cell | 2012 |
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
Topics: Alleles; Blood Glucose; Cohort Studies; Delta-5 Fatty Acid Desaturase; Diabetes Mellitus, Type 2; Et | 2012 |
The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.
Topics: Diabetes Mellitus, Type 2; DNA; Edema; Female; Genetic Predisposition to Disease; Genotype; Glyburid | 2006 |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
Topics: Alleles; ATP-Binding Cassette Transporters; Diabetes Mellitus, Type 2; Disease Progression; Female; | 2007 |
25 other studies available for metformin and Genetic Predisposition
| Article | Year |
|---|---|
Association of gene polymorphisms with body weight changes in prediabetic patients.
Topics: Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genotype; Humans; Metformin; M | 2022 |
Leptin and the rs2167270 Polymorphism Are Associated with Glycemic Control in Type Two Diabetes Mellitus Patients on Metformin Therapy.
Topics: Case-Control Studies; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genotype; Glycem | 2023 |
Association Between Antidiabetic Medications and Prostate-Specific Antigen Levels and Biopsy Results.
Topics: Adult; Aged; Biopsy; Case-Control Studies; Cohort Studies; Diabetes Mellitus; Educational Status; Ge | 2019 |
Association between metformin medication, genetic variation and prostate cancer risk.
Topics: Aged; Biopsy; Case-Control Studies; DNA, Neoplasm; Genetic Predisposition to Disease; Genome-Wide As | 2021 |
Loss of the
Topics: Amino Acids, Branched-Chain; Animals; Animals, Genetically Modified; Apoptosis; Brain; Casein Kinase | 2020 |
Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus.
Topics: Administration, Oral; Aged; Alleles; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genetic Predi | 2018 |
Metabolic parameters and functional state of hypothalamic signaling systems in A
Topics: Animals; Genetic Predisposition to Disease; Hypothalamus; Metformin; Mice; Obesity; Proto-Oncogene P | 2017 |
Searching for the roots of brain cancer.
Topics: Animals; Brain Neoplasms; Cell Phone; Chickenpox; Chickenpox Vaccine; Developed Countries; Diabetes | 2018 |
Effects of SLC22A2 (rs201919874) and SLC47A2 (rs138244461) genetic variants on Metformin Pharmacokinetics in Pakistani T2DM patients.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predispositi | 2019 |
No significant association of type 2 diabetes-related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Glycated Hemoglobin; Hum | 2019 |
Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
Topics: Blood Glucose; Body Mass Index; Data Interpretation, Statistical; Diabetes Mellitus, Type 2; Female; | 2014 |
Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.
Topics: Biological Specimen Banks; Diabetes Mellitus; Electronic Health Records; Genetic Predisposition to D | 2015 |
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; | 2015 |
Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes.
Topics: Aged; Alleles; Amino Acid Substitution; Bosnia and Herzegovina; Cohort Studies; Diabetes Mellitus, T | 2016 |
Metformin: treating the cause of Fanconi anemia?
Topics: Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Grou | 2016 |
Phenotype and Tissue Expression as a Function of Genetic Risk in Polycystic Ovary Syndrome.
Topics: Biomarkers; Case-Control Studies; Female; Follicle Stimulating Hormone; Gene Expression; Gene Expres | 2017 |
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Dise | 2017 |
Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin.
Topics: Breast Neoplasms; Estrogens; Estrogens, Catechol; Female; Gas Chromatography-Mass Spectrometry; Gene | 2010 |
New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Genetic Predisposition to Diseas | 2010 |
Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin.
Topics: Aged; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Stu | 2012 |
Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans.
Topics: Adenylate Kinase; Animals; Caenorhabditis elegans; Dietary Carbohydrates; Environment; Escherichia c | 2011 |
Gerosuppressant metformin: less is more.
Topics: Adenylate Kinase; Aging; Animals; Breast Neoplasms; Cellular Senescence; Disease Progression; Enzyme | 2011 |
Menopausal obesity and metabolic syndrome - PolSenior study.
Topics: Age of Onset; Aged; Aged, 80 and over; Anthropometry; Cardiovascular Diseases; Cohort Studies; Diabe | 2012 |
[Molecular and genetic aspects of heart failure in diabetic patients].
Topics: Biotransformation; Cardiotonic Agents; Cardiovascular Agents; Diabetes Complications; Drug Delivery | 2012 |
Sequencing and analysis of a South Asian-Indian personal genome.
Topics: Anticoagulants; Asian People; Chromosome Mapping; Diabetes Mellitus; DNA Copy Number Variations; Fem | 2012 |