metformin has been researched along with Fra(X) Syndrome in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin is a drug used in individuals with type 2 diabetes, obesity or impaired glucose tolerance and it has a strong safety profile in children and adults." | 7.88 | Metformin as targeted treatment in fragile X syndrome. ( Dy, ABC; Eldeeb, M; Hagerman, R; Salcedo-Arellano, MJ; Tartaglia, N; Tassone, F, 2018) |
| "The metformin treatment was well tolerated, with no significant related AE." | 7.01 | The safety and efficacy of metformin in fragile X syndrome: An open-label study. ( Çaku, A; Corbin, F; Galarneau, L; Lacroix, A; Lepage, JF; Proteau-Lemieux, M, 2021) |
| "Metformin is a drug commonly used in individuals with type 2 diabetes, obesity, and impaired glucose tolerance." | 5.51 | Metformin treatment in young children with fragile X syndrome. ( Afzal, S; Biag, HMB; Hagerman, RJ; Manzano-Nunez, R; Potter, LA; Rajaratnam, A; Rivera, SM; Rosvall, A; Salcedo-Arellano, MJ; Schneider, A; Tassone, F; Wilkins, V, 2019) |
| " Metformin is a drug used in individuals with type 2 diabetes, obesity or impaired glucose tolerance and it has a strong safety profile in children and adults." | 3.88 | Metformin as targeted treatment in fragile X syndrome. ( Dy, ABC; Eldeeb, M; Hagerman, R; Salcedo-Arellano, MJ; Tartaglia, N; Tassone, F, 2018) |
| "The metformin treatment was well tolerated, with no significant related AE." | 3.01 | The safety and efficacy of metformin in fragile X syndrome: An open-label study. ( Çaku, A; Corbin, F; Galarneau, L; Lacroix, A; Lepage, JF; Proteau-Lemieux, M, 2021) |
| "The histories of targeted treatment trials in fragile X syndrome (FXS) are reviewed in animal studies and human trials." | 1.91 | Targeted Treatments for Fragile X Syndrome. ( Clark, C; Hagerman, R; Johnson, D, 2023) |
| "Metformin is a drug commonly used in individuals with type 2 diabetes, obesity, and impaired glucose tolerance." | 1.51 | Metformin treatment in young children with fragile X syndrome. ( Afzal, S; Biag, HMB; Hagerman, RJ; Manzano-Nunez, R; Potter, LA; Rajaratnam, A; Rivera, SM; Rosvall, A; Salcedo-Arellano, MJ; Schneider, A; Tassone, F; Wilkins, V, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, D | 1 |
| Clark, C | 1 |
| Hagerman, R | 2 |
| Biag, HMB | 1 |
| Potter, LA | 1 |
| Wilkins, V | 1 |
| Afzal, S | 1 |
| Rosvall, A | 1 |
| Salcedo-Arellano, MJ | 2 |
| Rajaratnam, A | 1 |
| Manzano-Nunez, R | 1 |
| Schneider, A | 2 |
| Tassone, F | 3 |
| Rivera, SM | 1 |
| Hagerman, RJ | 2 |
| Utami, KH | 1 |
| Yusof, NABM | 1 |
| Kwa, JE | 1 |
| Peteri, UK | 1 |
| Castrén, ML | 1 |
| Pouladi, MA | 1 |
| Proteau-Lemieux, M | 1 |
| Lacroix, A | 1 |
| Galarneau, L | 1 |
| Corbin, F | 1 |
| Lepage, JF | 1 |
| Çaku, A | 1 |
| Dy, ABC | 1 |
| Eldeeb, M | 1 |
| Tartaglia, N | 1 |
| Gantois, I | 2 |
| Khoutorsky, A | 2 |
| Popic, J | 2 |
| Aguilar-Valles, A | 1 |
| Freemantle, E | 1 |
| Cao, R | 1 |
| Sharma, V | 1 |
| Pooters, T | 1 |
| Nagpal, A | 1 |
| Skalecka, A | 1 |
| Truong, VT | 1 |
| Wiebe, S | 1 |
| Groves, IA | 1 |
| Jafarnejad, SM | 1 |
| Chapat, C | 1 |
| McCullagh, EA | 1 |
| Gamache, K | 1 |
| Nader, K | 1 |
| Lacaille, JC | 1 |
| Gkogkas, CG | 1 |
| Sonenberg, N | 2 |
| Wood, H | 1 |
| Protic, D | 1 |
| Aydin, EY | 1 |
| Tan, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome (FXS)[NCT03862950] | Phase 2 | 120 participants (Anticipated) | Interventional | 2019-05-24 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Fra(X) Syndrome
| Article | Year |
|---|---|
Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X | 2019 |
1 trial available for metformin and Fra(X) Syndrome
| Article | Year |
|---|---|
The safety and efficacy of metformin in fragile X syndrome: An open-label study.
Topics: Adolescent; Adult; Evoked Potentials, Motor; Female; Fragile X Syndrome; Humans; Hypoglycemic Agents | 2021 |
7 other studies available for metformin and Fra(X) Syndrome
| Article | Year |
|---|---|
Targeted Treatments for Fragile X Syndrome.
Topics: Adult; Animals; Cannabidiol; Fragile X Syndrome; Humans; Male; Metformin | 2023 |
Metformin treatment in young children with fragile X syndrome.
Topics: Child; Child, Preschool; Fragile X Syndrome; Humans; Hypoglycemic Agents; Male; Metformin; Neurodeve | 2019 |
Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment.
Topics: Cell Line; Cell Proliferation; Fragile X Syndrome; Gene Expression Profiling; Humans; Metformin; Mit | 2020 |
Metformin as targeted treatment in fragile X syndrome.
Topics: Adult; Animals; Child; Child, Preschool; Diabetes Mellitus, Type 2; Female; Fragile X Syndrome; Gluc | 2018 |
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Fragile X Mental | 2017 |
Neurodevelopmental disorders: Metformin - a therapeutic option for fragile X syndrome?
Topics: Animals; Disease Models, Animal; Fragile X Syndrome; Metformin; Mice; Neurodevelopmental Disorders | 2017 |
Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin-two cases.
Topics: Adult; Cognition; Fragile X Syndrome; Humans; Intelligence Tests; Male; Metformin | 2019 |