metformin has been researched along with Experimental Radiation Injuries in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the therapeutic effect of metformin on pathological pain in mice with radiation dermatitis and explore the underlying mechanism." | 8.31 | [Metformin alleviates pathologic pain in mice with radiation dermatitis by inhibiting p38MAPK/NF-κB signaling pathway]. ( An, Q; Cao, J; Han, F; Liu, H, 2023) |
| "Metformin was orally administered to irradiated mice." | 5.48 | Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3. ( Byeon, HJ; Cho, J; Choi, WH; Han, SY; Kang, JW; Kim, CS; Kim, JM; Kim, JY; Lee, EJ; Lee, WJ; Lee, YS; Oh, SH; Yoo, BR; Yoo, H, 2018) |
| "To observe the therapeutic effect of metformin on pathological pain in mice with radiation dermatitis and explore the underlying mechanism." | 4.31 | [Metformin alleviates pathologic pain in mice with radiation dermatitis by inhibiting p38MAPK/NF-κB signaling pathway]. ( An, Q; Cao, J; Han, F; Liu, H, 2023) |
| "Metformin treatment efficiently limited RT-induced senescence and SASP expression levels, thereby limiting vascular dysfunctions, namely increased vascular permeability associated with increased extravasation of circulating immune and tumor cells early after irradiation (acute effects)." | 1.62 | Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells. ( Barr, S; Hansel, C; Hess, J; Jendrossek, V; Klein, D; Lauber, K; Schemann, AV; Unger, K; Zitzelsberger, H, 2021) |
| "Metformin was orally administered to irradiated mice." | 1.48 | Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3. ( Byeon, HJ; Cho, J; Choi, WH; Han, SY; Kang, JW; Kim, CS; Kim, JM; Kim, JY; Lee, EJ; Lee, WJ; Lee, YS; Oh, SH; Yoo, BR; Yoo, H, 2018) |
| "Metformin (250 mg/kg) was effective in protecting splenic cells from a 7 Gy dose in vivo (protection factor = 1." | 1.40 | Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. ( Grdina, DJ; Miller, RC; Murley, JS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, J | 1 |
| Liu, H | 1 |
| An, Q | 1 |
| Han, F | 1 |
| Souza-Neto, FP | 1 |
| Marinello, PC | 1 |
| Melo, GP | 1 |
| Ramalho, LZN | 1 |
| Cela, EM | 1 |
| Campo, VE | 1 |
| González-Maglio, DH | 1 |
| Cecchini, R | 1 |
| Cecchini, AL | 1 |
| Hansel, C | 1 |
| Barr, S | 1 |
| Schemann, AV | 1 |
| Lauber, K | 1 |
| Hess, J | 1 |
| Unger, K | 1 |
| Zitzelsberger, H | 1 |
| Jendrossek, V | 1 |
| Klein, D | 1 |
| Hofer, M | 1 |
| Hoferová, Z | 1 |
| Depeš, D | 1 |
| Falk, M | 1 |
| Kim, JM | 1 |
| Yoo, H | 1 |
| Kim, JY | 1 |
| Oh, SH | 1 |
| Kang, JW | 1 |
| Yoo, BR | 1 |
| Han, SY | 1 |
| Kim, CS | 1 |
| Choi, WH | 1 |
| Lee, EJ | 1 |
| Byeon, HJ | 1 |
| Lee, WJ | 1 |
| Lee, YS | 1 |
| Cho, J | 1 |
| Karam, HM | 1 |
| Radwan, RR | 1 |
| Miller, RC | 1 |
| Murley, JS | 1 |
| Grdina, DJ | 1 |
1 review available for metformin and Experimental Radiation Injuries
| Article | Year |
|---|---|
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Dinoprostone; Drug Administration Schedule; Drug Comb | 2017 |
6 other studies available for metformin and Experimental Radiation Injuries
| Article | Year |
|---|---|
[Metformin alleviates pathologic pain in mice with radiation dermatitis by inhibiting p38MAPK/NF-κB signaling pathway].
Topics: Animals; Gabapentin; Interleukin-6; Male; MAP Kinase Signaling System; Metformin; Mice; Mice, Inbred | 2023 |
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
Topics: Aldehydes; Animals; Carcinogenesis; DNA Damage; Female; Humans; Melanoma; Metformin; Mice; Oxidative | 2020 |
Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells.
Topics: Animals; Bronchi; Cellular Senescence; Epithelial Cells; Metformin; Mice; Radiation Injuries, Experi | 2021 |
Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3.
Topics: Animals; Cells, Cultured; Class Ia Phosphatidylinositol 3-Kinase; Down-Regulation; Fibroblasts; Fibr | 2018 |
Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug.
Topics: Animals; Catalase; Endothelium, Vascular; Gamma Rays; Heart; Inflammation; Male; Metformin; Myocardi | 2019 |
Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Topics: Acetylcysteine; Acute Radiation Syndrome; Amifostine; Animals; Captopril; Cell Line, Transformed; Ce | 2014 |