metformin has been researched along with Erectile Dysfunction in 10 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among men with obesity and low testosterone concentrations, the combination of metformin plus testosterone, metformin only, and testosterone only, compared to placebo, reduced insulin resistance with no evidence of additive benefit." | 9.51 | Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial. ( Asenjo-Plaza, M; Barrios-Rodríguez, R; Fernández-García, JC; Guzmán-Guzmán, A; Jiménez-Moleón, JJ; Martínez-González, MÁ; Molina-Vega, M; Moreno-León, L; Ramos-Molina, B; Rius-Díaz, F; Tinahones, FJ; Valdés, S; Yubero-Serrano, EM, 2022) |
| "To evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction." | 7.81 | Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance. ( Alexandre, EC; Antunes, E; Calixto, MC; Calmasini, FB; Silva, FH, 2015) |
| "The aim of this retrospective observational study was to evaluate whether adding liraglutide to lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means of improving weight and glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism and erectile dysfunction (ED) in a 'real-life setting'." | 7.81 | Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. ( Carbone, MD; De Pergola, G; Giagulli, VA; Guastamacchia, E; Licchelli, B; Ramunni, MI; Sabbà, C; Triggiani, V, 2015) |
| "Increased angiotensin II (AngII) levels cause hypertension, which is a major risk factor for erectile dysfunction (ED)." | 7.79 | Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. ( Labazi, H; Tostes, R; Webb, RC; Wynne, BM, 2013) |
| "Among men with obesity and low testosterone concentrations, the combination of metformin plus testosterone, metformin only, and testosterone only, compared to placebo, reduced insulin resistance with no evidence of additive benefit." | 5.51 | Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial. ( Asenjo-Plaza, M; Barrios-Rodríguez, R; Fernández-García, JC; Guzmán-Guzmán, A; Jiménez-Moleón, JJ; Martínez-González, MÁ; Molina-Vega, M; Moreno-León, L; Ramos-Molina, B; Rius-Díaz, F; Tinahones, FJ; Valdés, S; Yubero-Serrano, EM, 2022) |
| "To evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction." | 3.81 | Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance. ( Alexandre, EC; Antunes, E; Calixto, MC; Calmasini, FB; Silva, FH, 2015) |
| "The aim of this retrospective observational study was to evaluate whether adding liraglutide to lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means of improving weight and glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism and erectile dysfunction (ED) in a 'real-life setting'." | 3.81 | Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. ( Carbone, MD; De Pergola, G; Giagulli, VA; Guastamacchia, E; Licchelli, B; Ramunni, MI; Sabbà, C; Triggiani, V, 2015) |
| "In subjects with erectile dysfunction responding poorly to sildenafil, metformin was reported to improve erections." | 3.80 | Metformin in vitro and in vivo increases adenosine signaling in rabbit corpora cavernosa. ( Cellai, I; Comeglio, P; Filippi, S; Maggi, M; Maneschi, E; Mannucci, E; Morelli, A; Rastrelli, G; Vignozzi, L, 2014) |
| "Increased angiotensin II (AngII) levels cause hypertension, which is a major risk factor for erectile dysfunction (ED)." | 3.79 | Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. ( Labazi, H; Tostes, R; Webb, RC; Wynne, BM, 2013) |
| "Combining 2 first-line treatments for erectile dysfunction (ED) or initiating other modalities in addition to a first-line therapy may produce beneficial outcomes." | 2.72 | Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis. ( Haidich, AB; Hatzichristodoulou, G; Hatzichristou, D; Mykoniatis, I; Ouranidis, A; Pyrgidis, N; Sokolakis, I; Sountoulides, P; van Renterghem, K, 2021) |
| "It is thought that it exerts its anti-cancer effect through the inhibition of the mammalian target of rapamycin (mTOR) signalling pathway." | 2.61 | The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth. ( Amin, S; Lux, A; O'Callaghan, F, 2019) |
| " Therefore, in this study we investigated whether a pharmacokinetic interaction occurs between DA-8159 and metformin, as both drugs are metabolized via hepatic CYP3A1/2 in rats." | 1.35 | Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2. ( Choi, YH; Chung, SJ; Lee, MG, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández-García, JC | 1 |
| Barrios-Rodríguez, R | 1 |
| Asenjo-Plaza, M | 1 |
| Ramos-Molina, B | 1 |
| Molina-Vega, M | 1 |
| Guzmán-Guzmán, A | 1 |
| Moreno-León, L | 1 |
| Yubero-Serrano, EM | 1 |
| Rius-Díaz, F | 1 |
| Valdés, S | 1 |
| Martínez-González, MÁ | 1 |
| Jiménez-Moleón, JJ | 1 |
| Tinahones, FJ | 1 |
| Mykoniatis, I | 1 |
| Pyrgidis, N | 1 |
| Sokolakis, I | 1 |
| Ouranidis, A | 1 |
| Sountoulides, P | 1 |
| Haidich, AB | 1 |
| van Renterghem, K | 1 |
| Hatzichristodoulou, G | 1 |
| Hatzichristou, D | 1 |
| Amin, S | 1 |
| Lux, A | 1 |
| O'Callaghan, F | 1 |
| Labazi, H | 1 |
| Wynne, BM | 1 |
| Tostes, R | 1 |
| Webb, RC | 1 |
| Vignozzi, L | 1 |
| Filippi, S | 1 |
| Comeglio, P | 1 |
| Cellai, I | 1 |
| Morelli, A | 1 |
| Rastrelli, G | 1 |
| Maneschi, E | 1 |
| Mannucci, E | 1 |
| Maggi, M | 1 |
| Stokes, VJ | 1 |
| Anderson, RA | 1 |
| George, JT | 1 |
| Silva, FH | 1 |
| Alexandre, EC | 1 |
| Calmasini, FB | 1 |
| Calixto, MC | 1 |
| Antunes, E | 1 |
| Giagulli, VA | 1 |
| Carbone, MD | 1 |
| Ramunni, MI | 1 |
| Licchelli, B | 1 |
| De Pergola, G | 1 |
| Sabbà, C | 1 |
| Guastamacchia, E | 1 |
| Triggiani, V | 1 |
| Schröder, H | 1 |
| Choi, YH | 1 |
| Chung, SJ | 1 |
| Lee, MG | 1 |
2 reviews available for metformin and Erectile Dysfunction
| Article | Year |
|---|---|
Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Combined Modal | 2021 |
The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth.
Topics: Animals; Blood Glucose; Cardiovascular Diseases; Cell Line, Tumor; Clinical Trials as Topic; Cogniti | 2019 |
1 trial available for metformin and Erectile Dysfunction
| Article | Year |
|---|---|
Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial.
Topics: Double-Blind Method; Erectile Dysfunction; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; | 2022 |
7 other studies available for metformin and Erectile Dysfunction
| Article | Year |
|---|---|
Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive Agents; Arterial Pressure; | 2013 |
Metformin in vitro and in vivo increases adenosine signaling in rabbit corpora cavernosa.
Topics: Adenosine; AMP Deaminase; Animals; Diet, High-Fat; Enzyme Inhibitors; Erectile Dysfunction; Hypoglyc | 2014 |
How does obesity affect fertility in men - and what are the treatment options?
Topics: Adiposity; Androgens; Aromatase Inhibitors; Body Mass Index; Clomiphene; Erectile Dysfunction; Estro | 2015 |
Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance.
Topics: Animals; Disease Models, Animal; Erectile Dysfunction; Hypoglycemic Agents; Insulin Resistance; Male | 2015 |
Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Erectile Dysfunctio | 2015 |
[Medications for type-2 diabetes and high blood pressure].
Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Diuretics; Erectile Dysfun | 2002 |
Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2.
Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP | 2008 |