metformin has been researched along with Equine Diseases in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin may be an effective therapeutic option for insulin-resistant (I-R) horses/ponies because, in humans, it reportedly enhances insulin sensitivity (SI) of peripheral tissues without stimulating insulin secretion." | 9.16 | The effect of oral metformin on insulin sensitivity in insulin-resistant ponies. ( Boston, RC; Harris, PA; Noble, GK; Raidal, SL; Sillence, MN; Tinworth, KD, 2012) |
| " However, obese mares exhibited a significantly longer duration of the oestrous cycle, significant increases in circulating concentrations of leptin and insulin, and decreased insulin sensitivity and concentrations of thyroxine compared with feed-restricted mares throughout the experiment." | 7.73 | Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity. ( Fitzgerald, BP; Kennedy, EL; Murphy, BA; Reedy, SE; Sessions, DR; Vick, MM, 2006) |
| " Further studies are required to define appropriate selection of subjects warranting therapy, dosing schedule and pharmacokinetics." | 5.35 | The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance. ( Durham, AE; Newton, JE; Rendle, DI, 2008) |
| "Metformin may be an effective therapeutic option for insulin-resistant (I-R) horses/ponies because, in humans, it reportedly enhances insulin sensitivity (SI) of peripheral tissues without stimulating insulin secretion." | 5.16 | The effect of oral metformin on insulin sensitivity in insulin-resistant ponies. ( Boston, RC; Harris, PA; Noble, GK; Raidal, SL; Sillence, MN; Tinworth, KD, 2012) |
| "While this class of drugs holds great promise for cases of refractory hyperinsulinemia and laminitis that do not respond to diet or metformin therapy, hypertriglyceridemia is a potential side effect." | 4.31 | Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors. ( Gustafson, KM; Kellon, EM, 2023) |
| "Metformin reportedly enhances insulin sensitivity of peripheral tissues without stimulating insulin secretion, but bioavailability in horses is low." | 3.76 | Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies. ( Edwards, S; Hackett, LP; Harris, PA; Noble, GK; Sillence, MN; Tinworth, KD, 2010) |
| " Within 5 hours after administration of a combination of glyburide and metformin, which is used to treat diabetes mellitus in humans, the glucose concentration was within reference limits." | 3.73 | Diabetes mellitus in a domesticated Spanish mustang. ( Johnson, PJ; Kreeger, JM; Messer, NT; Scotty, NC; Wiedmeyer, C, 2005) |
| " However, obese mares exhibited a significantly longer duration of the oestrous cycle, significant increases in circulating concentrations of leptin and insulin, and decreased insulin sensitivity and concentrations of thyroxine compared with feed-restricted mares throughout the experiment." | 3.73 | Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity. ( Fitzgerald, BP; Kennedy, EL; Murphy, BA; Reedy, SE; Sessions, DR; Vick, MM, 2006) |
| "Rolipram was the most potent inhibitor of cytokine production (IC50 0." | 1.42 | Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays. ( Bailey, SR; Bauquier, JR; Tudor, E, 2015) |
| " Further studies are required to define appropriate selection of subjects warranting therapy, dosing schedule and pharmacokinetics." | 1.35 | The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance. ( Durham, AE; Newton, JE; Rendle, DI, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kellon, EM | 1 |
| Gustafson, KM | 1 |
| Bauquier, JR | 1 |
| Tudor, E | 1 |
| Bailey, SR | 1 |
| Durham, AE | 3 |
| Hughes, KJ | 1 |
| Cottle, HJ | 1 |
| Rendle, DI | 2 |
| Boston, RC | 2 |
| Tinworth, KD | 2 |
| Edwards, S | 1 |
| Noble, GK | 2 |
| Harris, PA | 2 |
| Sillence, MN | 2 |
| Hackett, LP | 1 |
| Raidal, SL | 1 |
| Johnson, PJ | 1 |
| Scotty, NC | 1 |
| Wiedmeyer, C | 1 |
| Messer, NT | 1 |
| Kreeger, JM | 1 |
| Vick, MM | 1 |
| Sessions, DR | 1 |
| Murphy, BA | 1 |
| Kennedy, EL | 1 |
| Reedy, SE | 1 |
| Fitzgerald, BP | 1 |
| Newton, JE | 1 |
1 trial available for metformin and Equine Diseases
| Article | Year |
|---|---|
The effect of oral metformin on insulin sensitivity in insulin-resistant ponies.
Topics: Administration, Oral; Animals; Blood Glucose; Cross-Over Studies; Female; Horse Diseases; Horses; Hy | 2012 |
8 other studies available for metformin and Equine Diseases
| Article | Year |
|---|---|
Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors.
Topics: Animals; Canagliflozin; Diabetes Mellitus, Type 2; Glucose; Glucosides; Horse Diseases; Horses; Hype | 2023 |
Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays.
Topics: Animals; Anti-Inflammatory Agents; Azithromycin; Endotoxemia; Horse Diseases; Horses; In Vitro Techn | 2015 |
Type 2 diabetes mellitus with pancreatic beta cell dysfunction in 3 horses confirmed with minimal model analysis.
Topics: Animal Feed; Animals; Diabetes Mellitus, Type 2; Diet; Diet Therapy; Female; Glucose Tolerance Test; | 2009 |
Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies.
Topics: Administration, Oral; Animals; Area Under Curve; Drug Administration Schedule; Half-Life; Horse Dise | 2010 |
Metformin in equine metabolic syndrome: an enigma or a dead duck?
Topics: Animals; Female; Horse Diseases; Hypoglycemic Agents; Insulin Resistance; Metformin | 2012 |
Diabetes mellitus in a domesticated Spanish mustang.
Topics: Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus; Female; Glyburide; Horse Diseases; Hors | 2005 |
Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity.
Topics: Animals; Breeding; Dose-Response Relationship, Drug; Estrous Cycle; Female; Food Deprivation; Horse | 2006 |
The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.
Topics: Animals; Area Under Curve; Blood Glucose; Dose-Response Relationship, Drug; Drug Administration Sche | 2008 |