metformin has been researched along with Endometriosis in 12 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models." | 8.12 | Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. ( Coskun, G; Efendic, F; Erdem, E; Hayretdag, C; Irkorucu, O; Keles, P; Kuras, S; Pence, HH; Polat, S; Saker, D; Sapmaz, E; Sapmaz, T; Sevgin, K; Tekayev, M; Topkaraoglu, S, 2022) |
| "Thirty-six female B6CBA/F1 mice were divided into 4 groups (Control-C, Surgery-induced Endometriosis and Metformin-EM (50 mg/kg/day orally administrated for 3 months), Endometriosis-E and Metformin-M)." | 8.12 | Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3- independent GPx1 expression in the heart of mice with endometriosis. ( Almeida, H; Felgueiras, R; Gouveia, AM; Neto, AC; Neves, D; Rodrigues, AR, 2022) |
| " Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved." | 7.81 | Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis. ( Li, C; Li, M; Wei, D; Xue, J; Zhang, H; Zhao, X, 2015) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 7.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "Metformin has been reported to inhibit the growth of ectopic lesions in endometriosis." | 5.72 | Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis. ( Huang, W; Huang, X; Li, Y; Liao, T; Long, Y; Luo, B; Ouyang, Y; Pei, T; Xiao, L; Zhu, H, 2022) |
| " Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models." | 4.12 | Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. ( Coskun, G; Efendic, F; Erdem, E; Hayretdag, C; Irkorucu, O; Keles, P; Kuras, S; Pence, HH; Polat, S; Saker, D; Sapmaz, E; Sapmaz, T; Sevgin, K; Tekayev, M; Topkaraoglu, S, 2022) |
| "Thirty-six female B6CBA/F1 mice were divided into 4 groups (Control-C, Surgery-induced Endometriosis and Metformin-EM (50 mg/kg/day orally administrated for 3 months), Endometriosis-E and Metformin-M)." | 4.12 | Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3- independent GPx1 expression in the heart of mice with endometriosis. ( Almeida, H; Felgueiras, R; Gouveia, AM; Neto, AC; Neves, D; Rodrigues, AR, 2022) |
| " Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved." | 3.81 | Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis. ( Li, C; Li, M; Wei, D; Xue, J; Zhang, H; Zhao, X, 2015) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 3.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "ESCs derived from ovarian endometriomas were cultured with various concentrations of metformin." | 3.74 | Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells. ( Harada, M; Hasegawa, A; Hirata, T; Hirota, Y; Koga, K; Morimoto, C; Nose, E; Osuga, Y; Tajima, T; Takemura, Y; Taketani, Y; Yano, T; Yoshino, O, 2007) |
| "Metformin has been reported to inhibit the growth of ectopic lesions in endometriosis." | 1.72 | Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis. ( Huang, W; Huang, X; Li, Y; Liao, T; Long, Y; Luo, B; Ouyang, Y; Pei, T; Xiao, L; Zhu, H, 2022) |
| "Endometriosis is a benign gynecological disease that is manifested by the presence and growth of endometrial cells and glands outside the uterine." | 1.62 | Metformin attenuates expression of angiogenic and inflammatory genes in human endometriotic stromal cells. ( Esfandiari, F; Khoei, HH; Moini, A; Saber, M; Shahhoseini, M; Yari, S, 2021) |
| "Metformin is known to suppress prostaglandin E2 (PGE2)-induced CYP19A1 messenger RNA (mRNA) expression in human endometriotic stromal cells (ESCs)." | 1.42 | Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells. ( Li, X; Qi, Y; Xu, JN; Xue, Q; Zeng, C; Zhou, Y; Zhou, YF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, X | 1 |
| Xiao, L | 1 |
| Long, Y | 1 |
| Pei, T | 1 |
| Luo, B | 1 |
| Liao, T | 1 |
| Li, Y | 1 |
| Zhu, H | 1 |
| Ouyang, Y | 1 |
| Huang, W | 1 |
| Sapmaz, T | 1 |
| Coskun, G | 1 |
| Saker, D | 1 |
| Pence, HH | 1 |
| Keles, P | 1 |
| Hayretdag, C | 1 |
| Kuras, S | 1 |
| Topkaraoglu, S | 1 |
| Erdem, E | 1 |
| Efendic, F | 1 |
| Sevgin, K | 1 |
| Tekayev, M | 1 |
| Polat, S | 1 |
| Sapmaz, E | 1 |
| Irkorucu, O | 1 |
| Felgueiras, R | 1 |
| Neto, AC | 1 |
| Rodrigues, AR | 1 |
| Gouveia, AM | 1 |
| Almeida, H | 1 |
| Neves, D | 1 |
| Jamali, N | 1 |
| Zal, F | 1 |
| Mostafavi-Pour, Z | 1 |
| Samare-Najaf, M | 1 |
| Poordast, T | 1 |
| Dehghanian, A | 1 |
| Yari, S | 1 |
| Khoei, HH | 1 |
| Saber, M | 1 |
| Esfandiari, F | 1 |
| Moini, A | 1 |
| Shahhoseini, M | 1 |
| Zhou, Y | 1 |
| Xu, JN | 1 |
| Zeng, C | 1 |
| Li, X | 1 |
| Zhou, YF | 1 |
| Qi, Y | 1 |
| Xue, Q | 1 |
| Zhang, H | 1 |
| Xue, J | 1 |
| Li, M | 1 |
| Zhao, X | 1 |
| Wei, D | 1 |
| Li, C | 1 |
| Zhang, L | 1 |
| Liao, Q | 1 |
| Yilmaz, B | 1 |
| Sucak, A | 1 |
| Kilic, S | 1 |
| Aksakal, O | 1 |
| Aksoy, Y | 1 |
| Lortlar, N | 1 |
| Sut, N | 1 |
| Gungor, T | 1 |
| Oner, G | 1 |
| Ozcelik, B | 1 |
| Ozgun, MT | 1 |
| Serin, IS | 1 |
| Ozturk, F | 1 |
| Basbug, M | 1 |
| Al-Inany, H | 1 |
| Takemura, Y | 1 |
| Osuga, Y | 1 |
| Yoshino, O | 1 |
| Hasegawa, A | 1 |
| Hirata, T | 1 |
| Hirota, Y | 1 |
| Nose, E | 1 |
| Morimoto, C | 1 |
| Harada, M | 1 |
| Koga, K | 1 |
| Tajima, T | 1 |
| Yano, T | 1 |
| Taketani, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin and Combination of Olive Oil Plus Nutritional Supplements on Inflammatory Markers IL-6 and IL-8 in PCOS.[NCT05952349] | Phase 2 | 88 participants (Anticipated) | Interventional | 2023-07-01 | Recruiting | ||
| Phase II Randomized Study of Neoadjuvant Metformin Plus Letrozole vs Placebo Plus Letrozole for ER-positive Postmenopausal Breast Cancer[NCT01589367] | Phase 2 | 208 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Endometriosis
| Article | Year |
|---|---|
Female infertility.
Topics: Clomiphene; Endometriosis; Fallopian Tubes; Female; Fertility Agents, Female; Fertilization in Vitro | 2006 |
11 other studies available for metformin and Endometriosis
| Article | Year |
|---|---|
Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis.
Topics: Adult; Animals; Biomarkers; Endometriosis; Endometrium; Female; Humans; Infertility, Female; Metform | 2022 |
Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat.
Topics: Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Endometriosis; Female; Humans; Inflamm | 2022 |
Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3- independent GPx1 expression in the heart of mice with endometriosis.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Endometriosis; Female; Humans; Metformin; Mice | 2022 |
Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Disease Models, Animal; Drug Therapy, Com | 2021 |
Metformin attenuates expression of angiogenic and inflammatory genes in human endometriotic stromal cells.
Topics: Cell Movement; Cell Proliferation; Cells, Cultured; Endometriosis; Endometrium; Epithelial Cells; Fe | 2021 |
Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells.
Topics: Adult; AMP-Activated Protein Kinases; Aromatase; Binding Sites; Case-Control Studies; Cells, Culture | 2015 |
Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis.
Topics: Adult; beta Catenin; Cell Communication; Endometriosis; Epithelial Cells; Female; Humans; Metformin; | 2015 |
Effects of testosterone and metformin on glucose metabolism in endometrium.
Topics: Adult; Cells, Cultured; Endometriosis; Endometrium; Epithelial Cells; Female; Follicular Phase; Gene | 2010 |
Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Hypoglycemic Agents; Immunohist | 2010 |
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; L | 2010 |
Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.
Topics: Adult; Antimetabolites; Aromatase; Biomarkers; Bromodeoxyuridine; Cell Separation; Cell Survival; Ce | 2007 |
Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.
Topics: Adult; Antimetabolites; Aromatase; Biomarkers; Bromodeoxyuridine; Cell Separation; Cell Survival; Ce | 2007 |
Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.
Topics: Adult; Antimetabolites; Aromatase; Biomarkers; Bromodeoxyuridine; Cell Separation; Cell Survival; Ce | 2007 |
Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.
Topics: Adult; Antimetabolites; Aromatase; Biomarkers; Bromodeoxyuridine; Cell Separation; Cell Survival; Ce | 2007 |