metformin has been researched along with Drug Overdose in 68 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subsequent publications have provided new information regarding metformin-associated lactic acidosis and its treatment." | 9.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "Metformin-associated lactic acidosis is rare despite its widespread use." | 7.96 | Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases. ( Berekatoglu, N; Günay, E; Kalkan, Z; Selim Ay, M; Yaman, M; Yuksel, E, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "The goals of this study are to describe clinical characteristics and risk factors for metabolic acidosis with hyperlactatemia in emergency department (ED) patients with acute metformin overdose." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Metformin overdose can cause severe hypoglycemia in the absence of other antidiabetic drugs." | 7.79 | Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. ( Al-Abri, SA; Hayashi, S; Olson, KR; Thoren, KL, 2013) |
| "In 56 cases of severe metformin-associated lactic acidosis, blood pH and lactate did not have prognostic value." | 7.79 | The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. ( Kajbaf, F; Lalau, JD, 2013) |
| "Metformin intoxication induces lactic acidosis, inhibits global oxygen consumption and causes mitochondrial dysfunction in liver and other tissues." | 7.78 | Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. ( Comi, GP; De Giuseppe, R; Fortunato, F; Gatti, S; Gattinoni, L; Monti, M; Protti, A; Vecchio, S, 2012) |
| " Metformin-associated lactic acidosis occurred in 9." | 7.76 | Can acute overdose of metformin lead to lactic acidosis? ( Bryant, SM; Buckley, P; Seo, B; Wills, BK, 2010) |
| "Metformin-associated lactic acidosis is a rare and serious complication of biguanide treatment." | 7.75 | Metformin-associated lactic acidosis: a prognostic and therapeutic study. ( Fourrier, F; Houdret, N; Nseir, S; Seidowsky, A, 2009) |
| "Metformin-associated lactic acidosis is a very rare but critical condition." | 7.75 | Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose. ( Lin, HD; Lin, KH; Lo, SH; Wang, LM; Yang, PW, 2009) |
| "We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril." | 7.74 | Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose. ( Bramham, K; Galea, M; Jelacin, N; White, I, 2007) |
| "In this report of a near-fatal metformin ingestion successfully treated with alkalinization and high-volume hemofiltration, we discuss the management of severe lactic acidosis and demonstrate that early aggressive intervention resulted in a positive outcome." | 7.73 | Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization. ( Harvey, B; Hickman, C; Hinson, G; Mayer, A; Ralph, T, 2005) |
| "Metformin is a common and generally well-tolerated medication in the treatment of diabetes but rarely has been implicated as the cause for metformin-associated lactate acidosis." | 5.48 | Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient. ( Baker, S; McCabe, DJ; Stellpflug, SJ, 2018) |
| "Subsequent publications have provided new information regarding metformin-associated lactic acidosis and its treatment." | 5.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "Metformin is a widely used antidiabetic agent that is generally considered safe." | 5.37 | Metformin-associated lactic acidosis in Chinese patients with type II diabetes. ( Chan, WM; Chung, HY; Fong, BM; Siu, TS; Tam, S; Tsai, NW; Tsui, SH; Yeung, CW, 2011) |
| "The second part of the review deals in detail with the diagnostics and treatment of toxic alcohols poisoning and management and indication of extracorporeal removal techniques in intoxication with other drugs, theophylline, valproic acid, metformin and metformin associated lactic acidosis, respectively." | 5.01 | Extracorporeal removal techniques in toxicology: part 2. ( Harazim, M; Horák, J; Matějovič, M; Raděj, J, 2019) |
| "The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain." | 4.90 | A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014) |
| "L-Carnitine combined with HDI may have helped with the calcium channel blocker (CCB) poisoning by decreasing insulin resistance, promoting intracellular glucose transport, facilitating the metabolism of free fatty acids, and increasing calcium channel sensitivity." | 4.89 | L-Carnitine for the treatment of a calcium channel blocker and metformin poisoning. ( Ajmo, I; Laliberté, M; Poirier, D; St-Onge, M, 2013) |
| "A 53-year-old man died following a reported ingestion of 80 g of his metformin tablets resulting in severe, refractory shock and metformin-associated lactic acidosis." | 4.31 | Toxicokinetics of metformin overdose treated with CVVHDF. ( Brooks, D; Dion, C; Lewis, B; Schwebach, C, 2023) |
| "Metformin-associated lactic acidosis is rare despite its widespread use." | 3.96 | Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases. ( Berekatoglu, N; Günay, E; Kalkan, Z; Selim Ay, M; Yaman, M; Yuksel, E, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "The goals of this study are to describe clinical characteristics and risk factors for metabolic acidosis with hyperlactatemia in emergency department (ED) patients with acute metformin overdose." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Massive metformin overdose can cause metabolic acidosis with hyperlactatemia." | 3.88 | 'Massive' metformin overdose. ( Chiew, AL; Dobos, NM; Isbister, GK; McArdle, K; Mostafa, AA; Newth, A; Roberts, MS; Wright, DFB, 2018) |
| "Overdosing of the oral antidiabetic metformin in impaired renal function is an important contributory cause to life-threatening lactic acidosis." | 3.83 | Development, implementation and outcome analysis of semi-automated alerts for metformin dose adjustment in hospitalized patients with renal impairment. ( Bucklar, G; Gött, C; Jödicke, A; Krattinger, R; Niedrig, D; Russmann, S, 2016) |
| "Metformin-associated lactic acidosis or lacticemia has been widely reported as an adverse drug effect in diabetic patients with other significant comorbidities and in acute overdose in adults." | 3.81 | Lacticemia After Acute Overdose of Metformin in an Adolescent Managed Without Intravenous Sodium Bicarbonate or Extracorporeal Therapy. ( Bebarta, VS; Pead, J; Varney, SM, 2015) |
| "Although metformin-associated lactic acidosis is well described, there is less information on metformin overdose and whether it is of similar severity." | 3.81 | Hyperlactataemia and clinical severity of acute metformin overdose. ( Isbister, GK; McNamara, K, 2015) |
| "In 56 cases of severe metformin-associated lactic acidosis, blood pH and lactate did not have prognostic value." | 3.79 | The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. ( Kajbaf, F; Lalau, JD, 2013) |
| "Metformin overdose can cause severe hypoglycemia in the absence of other antidiabetic drugs." | 3.79 | Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. ( Al-Abri, SA; Hayashi, S; Olson, KR; Thoren, KL, 2013) |
| "Metformin intoxication induces lactic acidosis, inhibits global oxygen consumption and causes mitochondrial dysfunction in liver and other tissues." | 3.78 | Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. ( Comi, GP; De Giuseppe, R; Fortunato, F; Gatti, S; Gattinoni, L; Monti, M; Protti, A; Vecchio, S, 2012) |
| "Lactic acidosis is a rare and often lethal complication of metformin therapy." | 3.77 | Prolonged hemodialysis for severe metformin intoxication. ( Juvvadi, R; McFarren, C; Rifkin, SI; Weinstein, SS, 2011) |
| " Metformin-associated lactic acidosis occurred in 9." | 3.76 | Can acute overdose of metformin lead to lactic acidosis? ( Bryant, SM; Buckley, P; Seo, B; Wills, BK, 2010) |
| "Metformin, widely used in the treatment of diabetes mellitus, is known to cause lactic acidosis in both therapeutic use and after an overdose." | 3.76 | Metformin overdose with a resultant serum pH of 6.59: survival without sequalae. ( Algren, DA; Dell'Aglio, DM; Morgan, BW; Perino, LJ; Todino, JD, 2010) |
| "To investigate the treatment of massive metformin overdose associated with lactic acidosis." | 3.75 | Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange. ( Erdur, B; Sari, I; Tura, P; Turkcuer, I; Yuksel, A; Yuksel, S, 2009) |
| "Metformin-associated lactic acidosis is a very rare but critical condition." | 3.75 | Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose. ( Lin, HD; Lin, KH; Lo, SH; Wang, LM; Yang, PW, 2009) |
| "Metformin-associated lactic acidosis is a rare and serious complication of biguanide treatment." | 3.75 | Metformin-associated lactic acidosis: a prognostic and therapeutic study. ( Fourrier, F; Houdret, N; Nseir, S; Seidowsky, A, 2009) |
| "We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril." | 3.74 | Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose. ( Bramham, K; Galea, M; Jelacin, N; White, I, 2007) |
| "A 39-year-old woman with type-2 diabetes mellitus presented with metabolic acidosis due to an attempted suicide with metformin." | 3.74 | [Fatal autointoxication with metformin]. ( Bijleveld, YA; de Pont, AC; Franssen, EJ; Hoekstra, JB; Jansen, ME; Kerver, ED, 2007) |
| "In this report of a near-fatal metformin ingestion successfully treated with alkalinization and high-volume hemofiltration, we discuss the management of severe lactic acidosis and demonstrate that early aggressive intervention resulted in a positive outcome." | 3.73 | Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization. ( Harvey, B; Hickman, C; Hinson, G; Mayer, A; Ralph, T, 2005) |
| "The major risk associated with metformin is lactic acidosis." | 3.72 | Toxic effects from metformin exposure. ( Quadrani, DA; Spiller, HA, 2004) |
| "Poisoning is a common problem in the United States." | 2.82 | The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022. ( Kraut, JA; Mullins, ME, 2022) |
| "Metformin is known to cause potentially fatal metabolic acidosis with an increased lactate level in both overdose and therapeutic use." | 2.45 | Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. ( Abramson, J; Dell'Aglio, DM; Kazzi, Z; Morgan, BW; Perino, LJ; Schwartz, MD, 2009) |
| "The prevalence of type 2 diabetes (T2D) continues to rise across the world." | 1.51 | Metformin overdose: A serious iatrogenic complication-Western France Poison Control Centre Data Analysis. ( Boels, D; Hadjadj, S; Hamel, JF; Stevens, A; Toure, A, 2019) |
| "Metformin is a common and generally well-tolerated medication in the treatment of diabetes but rarely has been implicated as the cause for metformin-associated lactate acidosis." | 1.48 | Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient. ( Baker, S; McCabe, DJ; Stellpflug, SJ, 2018) |
| "Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus." | 1.40 | Fatal metformin overdose: case report and postmortem biochemistry contribution. ( Bonsignore, A; Fraternali Orcioni, G; Palmiere, C; Pozzi, F; Ventura, F, 2014) |
| "Metformin has been used for many years as oral anti-hyperglycaemic agent in the treatment of type 2 diabetes mellitus either in Poland or in the world." | 1.39 | [Metformin poisoning--clinical features, diagnostics and treatment--case presentations]. ( Bak, M; Kołacinski, Z; Krakowiak, A; Krawczyk, K; Kuropatwa, J; Winnicka, R, 2013) |
| "Metformin is a widely used antidiabetic agent that is generally considered safe." | 1.37 | Metformin-associated lactic acidosis in Chinese patients with type II diabetes. ( Chan, WM; Chung, HY; Fong, BM; Siu, TS; Tam, S; Tsai, NW; Tsui, SH; Yeung, CW, 2011) |
| " In the children younger than six years, dosage ranged from 9 to 196 mg/kg, with a mean and median of 60+/-41." | 1.31 | Multicenter case series of pediatric metformin ingestion. ( Gorman, SE; Hofman, M; Klein-Schwartz, W; Krenzelok, EP; Spiller, HA; Stork, CM; Weber, JA; Winter, ML, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.41) | 18.2507 |
| 2000's | 17 (25.00) | 29.6817 |
| 2010's | 38 (55.88) | 24.3611 |
| 2020's | 10 (14.71) | 2.80 |
| Authors | Studies |
|---|---|
| Mullins, ME | 1 |
| Kraut, JA | 1 |
| Pollack, BE | 2 |
| Barbaro, RP | 2 |
| Selewski, DT | 2 |
| Carlton, EF | 2 |
| Trebach, J | 1 |
| Mohan, S | 1 |
| Gnirke, M | 1 |
| Su, MK | 1 |
| Gosselin, S | 1 |
| Hoffman, RS | 2 |
| Lewis, B | 1 |
| Brooks, D | 1 |
| Dion, C | 1 |
| Schwebach, C | 1 |
| Roberts, DM | 2 |
| Ghannoum, M | 1 |
| Hughes, BW | 1 |
| Gray, LA | 1 |
| Bradberry, SM | 1 |
| Sandilands, EA | 1 |
| Thanacoody, RH | 1 |
| Coulson, JM | 1 |
| Sohn, JT | 1 |
| Raděj, J | 1 |
| Horák, J | 1 |
| Harazim, M | 1 |
| Matějovič, M | 1 |
| Günay, E | 1 |
| Kalkan, Z | 1 |
| Selim Ay, M | 1 |
| Yuksel, E | 1 |
| Berekatoglu, N | 1 |
| Yaman, M | 1 |
| Goonoo, MS | 1 |
| Morris, R | 1 |
| Raithatha, A | 1 |
| Creagh, F | 1 |
| Liu, S | 1 |
| Xu, L | 1 |
| Ma, J | 1 |
| Huang, R | 1 |
| Lin, T | 1 |
| Li, Z | 2 |
| Liang, H | 1 |
| Li, S | 1 |
| Li, R | 1 |
| Zhang, L | 1 |
| Tao, Y | 1 |
| Chen, Y | 1 |
| Ye, Z | 1 |
| Zhang, B | 1 |
| Wang, W | 1 |
| Xiao, H | 1 |
| Liang, X | 1 |
| Shi, W | 1 |
| Chiew, AL | 2 |
| Wright, DFB | 2 |
| Dobos, NM | 1 |
| McArdle, K | 1 |
| Mostafa, AA | 1 |
| Newth, A | 1 |
| Roberts, MS | 2 |
| Isbister, GK | 3 |
| McCabe, DJ | 1 |
| Baker, S | 1 |
| Stellpflug, SJ | 1 |
| Stefani, M | 1 |
| Graham, GG | 1 |
| Krüger, HJ | 1 |
| De Wet, R | 1 |
| Blumberg, LH | 1 |
| Weyer, J | 1 |
| Lemke, FG | 1 |
| Taub, ES | 1 |
| Manini, AF | 1 |
| Stevens, A | 1 |
| Hamel, JF | 1 |
| Toure, A | 1 |
| Hadjadj, S | 1 |
| Boels, D | 1 |
| Al-Abri, SA | 1 |
| Hayashi, S | 1 |
| Thoren, KL | 1 |
| Olson, KR | 1 |
| Kajbaf, F | 1 |
| Lalau, JD | 1 |
| St-Onge, M | 1 |
| Ajmo, I | 1 |
| Poirier, D | 1 |
| Laliberté, M | 1 |
| Protti, A | 3 |
| Bonsignore, A | 1 |
| Pozzi, F | 1 |
| Fraternali Orcioni, G | 1 |
| Ventura, F | 1 |
| Palmiere, C | 1 |
| Krawczyk, K | 1 |
| Bak, M | 1 |
| Kuropatwa, J | 1 |
| Winnicka, R | 1 |
| Kołacinski, Z | 1 |
| Krakowiak, A | 1 |
| Adam, WR | 1 |
| O'Brien, RC | 1 |
| McNamara, K | 1 |
| Sharma, MP | 1 |
| Kar, SK | 1 |
| Díaz, R | 1 |
| Vega, J | 1 |
| Goecke, H | 1 |
| Graham, RE | 1 |
| Cartner, M | 1 |
| Winearls, J | 1 |
| Bebarta, VS | 1 |
| Pead, J | 1 |
| Varney, SM | 1 |
| Yamada, T | 1 |
| Shojima, N | 1 |
| Yamauchi, T | 1 |
| Kadowaki, T | 1 |
| Niedrig, D | 1 |
| Krattinger, R | 1 |
| Jödicke, A | 1 |
| Gött, C | 1 |
| Bucklar, G | 1 |
| Russmann, S | 1 |
| Sehra, S | 1 |
| Jaggi, S | 1 |
| Sehra, D | 1 |
| Aggarwal, R | 1 |
| Saraswat, V | 1 |
| Juneja, D | 1 |
| Ebrahim, I | 1 |
| Blockman, M | 1 |
| Turkcuer, I | 1 |
| Erdur, B | 1 |
| Sari, I | 1 |
| Yuksel, A | 1 |
| Tura, P | 1 |
| Yuksel, S | 1 |
| Chang, LC | 1 |
| Hung, SC | 1 |
| Yang, CS | 1 |
| Yang, PW | 1 |
| Lin, KH | 1 |
| Lo, SH | 1 |
| Wang, LM | 1 |
| Lin, HD | 1 |
| Seidowsky, A | 1 |
| Nseir, S | 1 |
| Houdret, N | 1 |
| Fourrier, F | 1 |
| McFadden, C | 1 |
| Dell'Aglio, DM | 2 |
| Perino, LJ | 2 |
| Kazzi, Z | 1 |
| Abramson, J | 1 |
| Schwartz, MD | 1 |
| Morgan, BW | 2 |
| French, LK | 1 |
| Horowitz, BZ | 1 |
| Hendrickson, RG | 1 |
| Kjelland, CB | 1 |
| Djogovic, D | 1 |
| Wills, BK | 1 |
| Bryant, SM | 1 |
| Buckley, P | 1 |
| Seo, B | 1 |
| Al-Makadma, YS | 1 |
| Riad, T | 1 |
| Rifkin, SI | 1 |
| McFarren, C | 1 |
| Juvvadi, R | 1 |
| Weinstein, SS | 1 |
| Yeung, CW | 1 |
| Chung, HY | 1 |
| Fong, BM | 1 |
| Tsai, NW | 1 |
| Chan, WM | 1 |
| Siu, TS | 1 |
| Tam, S | 1 |
| Tsui, SH | 1 |
| Miller, DK | 1 |
| Brinson, AJ | 1 |
| Catalano, G | 1 |
| Catalano, MC | 1 |
| Fortunato, F | 2 |
| Monti, M | 1 |
| Vecchio, S | 2 |
| Gatti, S | 1 |
| Comi, GP | 2 |
| De Giuseppe, R | 1 |
| Gattinoni, L | 2 |
| Lecchi, A | 1 |
| Artoni, A | 1 |
| Greppi, N | 1 |
| Fagiolari, G | 1 |
| Moggio, M | 1 |
| Mistraletti, G | 1 |
| Lanticina, B | 1 |
| Faraldi, L | 1 |
| Orban, JC | 1 |
| Fontaine, E | 1 |
| Ichai, C | 1 |
| Kopec, KT | 1 |
| Kowalski, MJ | 1 |
| Gjedde, S | 1 |
| Christiansen, A | 1 |
| Pedersen, SB | 1 |
| Rungby, J | 1 |
| Nisse, P | 1 |
| Mathieu-Nolf, M | 1 |
| Deveaux, M | 1 |
| Forceville, X | 1 |
| Combes, A | 1 |
| Spiller, HA | 2 |
| Quadrani, DA | 1 |
| Lacher, M | 1 |
| Hermanns-Clausen, M | 1 |
| Haeffner, K | 1 |
| Brandis, M | 1 |
| Pohl, M | 1 |
| Harvey, B | 1 |
| Hickman, C | 1 |
| Hinson, G | 1 |
| Ralph, T | 1 |
| Mayer, A | 1 |
| Soderstrom, J | 1 |
| Murray, L | 1 |
| Daly, FF | 1 |
| Little, M | 1 |
| Galea, M | 1 |
| Jelacin, N | 1 |
| Bramham, K | 1 |
| White, I | 1 |
| de Pont, AC | 1 |
| Kerver, ED | 1 |
| Jansen, ME | 1 |
| Bijleveld, YA | 1 |
| Franssen, EJ | 1 |
| Hoekstra, JB | 1 |
| Todino, JD | 1 |
| Algren, DA | 1 |
| Brady, WJ | 1 |
| Carter, CT | 1 |
| Heaney, D | 1 |
| Majid, A | 1 |
| Junor, B | 1 |
| Teale, KF | 1 |
| Devine, A | 1 |
| Stewart, H | 1 |
| Harper, NJ | 1 |
| Carlton, FB | 1 |
| Weber, JA | 1 |
| Winter, ML | 1 |
| Klein-Schwartz, W | 1 |
| Hofman, M | 1 |
| Gorman, SE | 1 |
| Stork, CM | 1 |
| Krenzelok, EP | 1 |
| Bates, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis[NCT00942123] | 10 participants (Actual) | Observational | 2009-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for metformin and Drug Overdose
| Article | Year |
|---|---|
The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022.
Topics: Acidosis; Curriculum; Drug Overdose; Humans; Metformin; Nephrologists; Poisoning | 2022 |
Expanding the evidence for managing metformin poisoning to support decision-making.
Topics: Acidosis; Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Poisoning; Renal | 2023 |
Extracorporeal removal techniques in toxicology: part 2.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; Theophyllin | 2019 |
L-Carnitine for the treatment of a calcium channel blocker and metformin poisoning.
Topics: Aged; Antidotes; Antihypertensive Agents; Calcium Channel Blockers; Carnitine; Combined Modality The | 2013 |
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat | 2014 |
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.
Topics: Acidosis, Lactic; Acute Disease; Adult; Drug Overdose; Female; Humans; Hydrogen-Ion Concentration; H | 2009 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
Metformin-associated lactic acidosis (MALA): case files of the Einstein Medical Center medical toxicology fellowship.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Humans; Hypoglycemic Agents; Male; Metformin; Renal Dialysis | 2013 |
Recent advances in the pharmacologic management of diabetes mellitus.
Topics: Acarbose; Administration, Oral; Carbamates; Chromans; Diabetes Mellitus; Drug Overdose; Emergencies; | 2000 |
Sulphonylureas and metformin overdose: clinical features and management.
Topics: Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds | 2001 |
58 other studies available for metformin and Drug Overdose
| Article | Year |
|---|---|
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis.
Topics: Acidosis, Lactic; Adolescent; Child; Continuous Renal Replacement Therapy; Drug Overdose; Humans; Ib | 2022 |
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis.
Topics: Acidosis, Lactic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycem | 2023 |
Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning.
Topics: Drug Overdose; Humans; Lactic Acid; Metformin; Renal Dialysis; Retrospective Studies | 2023 |
Toxicokinetics of metformin overdose treated with CVVHDF.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Drug Overdose; Hemodiafiltration; Humans; Hy | 2023 |
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Poisons; Retro | 2023 |
The elimination half-life of metformin during metformin overdose.
Topics: Acidosis, Lactic; Drug Overdose; Half-Life; Hemodiafiltration; Humans; Hypoglycemic Agents; Metformi | 2023 |
Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Metformin; Renal Dialysis; Suicide, Attempte | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
High-volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin-associated toxicity.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Hemodiafiltration; Hemoperfusion; Humans; Hypoglycem | 2018 |
'Massive' metformin overdose.
Topics: Acidosis; Drug Overdose; Female; Hemodiafiltration; Humans; Hypoglycemic Agents; Metformin; Middle A | 2018 |
Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient.
Topics: Acidosis, Lactic; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; You | 2018 |
Complex decisions in the use of extracorporeal treatments in acute metformin overdose: which modality, when and how to measure the effect.
Topics: Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Metform | 2018 |
Comment on ''Massive' metformin overdose' by Chiew et al.
Topics: Drug Overdose; Humans; Hypoglycemic Agents; Metformin | 2018 |
Response to 'Comment on ''Massive' metformin overdose' by Chiew et al.'
Topics: Drug Overdose; Humans; Hypoglycemic Agents; Metformin | 2018 |
Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned.
Topics: Acidosis; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diagnosis, Differential; Dr | 2019 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Metformin overdose: A serious iatrogenic complication-Western France Poison Control Centre Data Analysis.
Topics: Acidosis, Lactic; Adolescent; Adult; Age Factors; Aged; Data Analysis; Databases, Factual; Diabetes | 2019 |
Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Hypo | 2013 |
The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Drug Monitoring; Drug Overdose; Female; Humans; Hy | 2013 |
One other explanation for hypoglycemia during metformin overdose.
Topics: Drug Overdose; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin | 2013 |
Fatal metformin overdose: case report and postmortem biochemistry contribution.
Topics: Acidosis, Lactic; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Drug Overdo | 2014 |
[Metformin poisoning--clinical features, diagnostics and treatment--case presentations].
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Drug Overdose; Fatal Outcome; Female; Humans; Hypoglycemic A | 2013 |
Hyperlactataemia and clinical severity of acute metformin overdose.
Topics: Acidosis, Lactic; Acute Disease; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Hyperlactat | 2015 |
Surreptitious metformin abuse in anorexia nervosa presenting as periodic hypoglycaemia.
Topics: Anorexia Nervosa; Coma; Drug Overdose; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; | 2015 |
[Non-fatal hyperkalemia in lactic acidosis due to metformin overdose. Report of one case].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Overdose; Humans; Hyperkalemia; Hypoglycemic | 2015 |
A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.
Topics: Acidosis; Adult; Drug Overdose; Fluid Therapy; Gliclazide; Humans; Male; Metformin; Methylene Blue; | 2015 |
Lacticemia After Acute Overdose of Metformin in an Adolescent Managed Without Intravenous Sodium Bicarbonate or Extracorporeal Therapy.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Renal D | 2015 |
Lactic acidosis due to attempted suicide with metformin overdose: A case report.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Humans; Hypoglycemic Agents; Male | 2016 |
Development, implementation and outcome analysis of semi-automated alerts for metformin dose adjustment in hospitalized patients with renal impairment.
Topics: Acidosis, Lactic; Aged; Algorithms; Automation; Dose-Response Relationship, Drug; Drug Overdose; Fem | 2016 |
Management of Sitagliptin and Metformin Combination Toxic Overdose.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Metformin; Sitagliptin Phosphate; Suicide, A | 2016 |
Metabolic acidosis in a patient with metformin overdose.
Topics: Acidosis; Blood Gas Analysis; Cardiotonic Agents; Drug Overdose; Fatal Outcome; Female; Heart Arrest | 2017 |
Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Plasma Excha | 2009 |
The case. A suicidal woman with delayed high anion gap metabolic acidosis.
Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Overdose; Female; Humans; Metformin; Middle Aged; Pyridine | 2009 |
Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Female; Humans; Hypoglycemic Agen | 2009 |
Metformin-associated lactic acidosis: a prognostic and therapeutic study.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Buffers; Cohort Studies; | 2009 |
Why check metformin levels?
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Predictive Value of Tests; | 2009 |
Acute metformin overdose.
Topics: Drug Overdose; Humans; Lactates; Metformin; Prognosis | 2010 |
Can acute overdose of metformin lead to lactic acidosis?
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Drug Overdose; Female; Humans; Hypogly | 2010 |
Successful management of high-dose metformin intoxication. Role of vasopressin in the management of severe lactic acidosis.
Topics: Acidosis, Lactic; Adrenergic alpha-Agonists; Anti-Inflammatory Agents; Antidiuretic Agents; Drug Ove | 2010 |
Prolonged hemodialysis for severe metformin intoxication.
Topics: Acidosis, Lactic; Acute Kidney Injury; Drug Overdose; Humans; Hypoglycemic Agents; Male; Metformin; | 2011 |
Metformin-associated lactic acidosis in Chinese patients with type II diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Amylases; Asian People; China; Creatinine; Diabete | 2011 |
Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose.
Topics: Acidosis, Lactic; Drug Overdose; Glyburide; Hearing Loss, Sensorineural; Humans; Hypoglycemia; Hypog | 2011 |
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs.
Topics: Acidosis, Lactic; Animals; Drug Overdose; Hypoglycemic Agents; Infusions, Intravenous; Metformin; Ox | 2012 |
Metformin overdose causes platelet mitochondrial dysfunction in humans.
Topics: Acidosis, Lactic; Blood Platelets; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; | 2012 |
Metformin overdose: time to move on.
Topics: Blood Platelets; Drug Overdose; Female; Humans; Male; Metformin; Mitochondria | 2012 |
Survival following a metformin overdose of 63 g: a case report.
Topics: Administration, Oral; Aged; Denmark; Dialysis; Drug Overdose; Humans; Male; Metformin; Suicide, Atte | 2003 |
A fatal case of metformin poisoning.
Topics: Adult; Drug Overdose; Fatal Outcome; Humans; Male; Metformin | 2003 |
Toxic effects from metformin exposure.
Topics: Acidosis, Lactic; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Child; Drug Over | 2004 |
Severe metformin intoxication with lactic acidosis in an adolescent.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Drug Overdose; Female; Humans; Metformin; Renal D | 2005 |
Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Fluid Therapy; Hemofiltration; Humans; Hypoglyc | 2005 |
Toxicology case of the month: oral hypoglycaemic overdose.
Topics: Adolescent; Drug Overdose; Emergency Service, Hospital; Female; Glipizide; Humans; Hypoglycemia; Hyp | 2006 |
Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.
Topics: Acidosis, Lactic; Antihypertensive Agents; Compartment Syndromes; Drug Overdose; Hemofiltration; Hum | 2007 |
[Fatal autointoxication with metformin].
Topics: Acidosis; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Fatal Outcome; Female; Humans; Hypoglycem | 2007 |
Metformin overdose with a resultant serum pH of 6.59: survival without sequalae.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Hypoglycemic Agents; Hypotension; Metformin; | 2010 |
Metformin overdose.
Topics: Adult; Drug Overdose; Emergencies; Humans; Hypoglycemic Agents; Male; Metformin; Suicide, Attempted | 1997 |
Bicarbonate haemodialysis as a treatment of metformin overdose.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Buffers; Drug Overdose; Humans; Hypoglycemic Agents; Lactic A | 1997 |
The management of metformin overdose.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Fatal Outcome; Female; Humans; Hy | 1998 |
Multicenter case series of pediatric metformin ingestion.
Topics: Acidosis, Lactic; Adolescent; Blood Glucose; Child; Child, Preschool; Drug Overdose; Female; Humans; | 2000 |