metformin has been researched along with Disease Models, Animal in 647 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pioglitazone treatment (n = 10) reduced hepatic fat as assessed by magnetic resonance spectroscopy, despite a significant increase in body weight (Δ = 3." | 9.15 | Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. ( Bajaj, M; Chan, L; Gonzalez, EV; Gutierrez, A; Jogi, M; Krishnamurthy, R; Muthupillai, R; Samson, SL; Sathyanarayana, P, 2011) |
| "Metformin is the most common anti-diabetic drug and a promising therapy for disorders beyond diabetes, including Rett syndrome (RTT), a rare neurologic disease characterized by severe intellectual disability." | 8.31 | Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome. ( Cosentino, L; De Filippis, B; Di Crescenzo, L; Di Domenico, F; Lanzillotta, C; Perluigi, M; Pietraforte, D; Prestia, F; Quattrini, MC; Urbinati, C; Vacca, RA; Valenti, D, 2023) |
| "The high-fat diet-induced mouse model of obesity and insulin resistance of both sexes was developed in a randomized block experiment and bulk RNA-Seq of the ileum tissue was the method of choice for comparative transcriptional profiling after metformin intervention for ten weeks." | 8.31 | Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance. ( Ansone, L; Birzniece, L; Brīvība, M; Elbere, I; Jagare, L; Kalniņa, I; Kloviņš, J; Silamiķele, L; Silamiķelis, I, 2023) |
| "To explore the therapeutic potential and the underlying mechanism of metformin, an adenosine monophosphate-activated kinase (AMPK) activator, in ocular melanoma." | 8.12 | Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma. ( Chai, P; Fan, X; Ge, S; Jia, R; Jia, S; Ruan, J; Shi, W; Wang, S; Xu, X; Yu, J; Zhou, Y; Zhuang, A; Zuo, S, 2022) |
| "The study suggests that the prolonged effect of metformin-induced euglycemia promoted the microglial activation, reduced neuronal cell death, and improved the overall survival following stroke, without any change in infarct size." | 8.12 | The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke. ( Kimball, SR; Kumari, R; Simpson, IA; Willing, L, 2022) |
| " Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well." | 8.02 | Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021) |
| "To explore the novel linkage between a Western diet combining high saturated fat, sugar, and salt (HFSS) and neurological dysfunctions during aging as well as Metformin intervention, we assessed cerebral cortex abnormalities associated with sensory and motor dysfunctions and cellular and molecular insights in brains using HFSS-fed mice during aging." | 8.02 | A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin. ( Bazan, NG; Duong, QA; Hong, S; Lu, Y; Nagayach, A; Peng, H; Pham, NB; Vuong, CA, 2021) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 8.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| "Resveratrol (RSV) and metformin (MET) play a role in the treatment of diabetes; however, the mechanisms through which they mediate insulin resistance by regulating long non‑coding RNAs (lncRNAs) remain unknown." | 8.02 | Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance. ( Hou, X; Ma, H; Shu, L; Song, G; Wang, C, 2021) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 8.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| "These findings highlight a novel pathogenic mechanism of sepsis-related cognitive impairment through activation of inflammatory factors, and these are blocked by metformin to attenuate sepsis-induced neuronal injury and cognitive impairment." | 8.02 | Metformin attenuates sepsis-induced neuronal injury and cognitive impairment. ( Guo, C; Qin, Z; Xiao, X; Zhou, C, 2021) |
| "Metformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, and results in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK." | 8.02 | Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase. ( Boyle, JJ; Carling, D; Cave, L; Haskard, DO; Hyde, G; Mason, JC; Moestrup, SK; Seneviratne, A, 2021) |
| "The present study aimed to investigate the possible effects of metformin on the olanzapine-induced insulin resistance in rats." | 8.02 | Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats. ( Guo, C; Li, H; Liu, J, 2021) |
| "Our findings suggest that in CLP induced sepsis model, metformin can improve the function of blood and cardiac cells through alleviating inflammation, improvement of anti-inflammation properties, and enhancement of blood profile, and all these effects are more pronounced after 24 h in comparison with 12 h after induction of sepsis." | 8.02 | Short-term Effects of Metformin on Cardiac and Peripheral Blood Cells Following Cecal Ligation and Puncture-induced Sepsis. ( Abdollahi, M; Baeeri, M; Didari, T; Gholami, M; Haghi-Aminjan, H; Hassan, FI; Hassani, S; Mojtahedzadeh, M; Navaei-Nigjeh, M; Nejad, SM; Rahimifard, M, 2021) |
| " Metformin has potential effects on improving asthma airway inflammation." | 8.02 | Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma. ( Chen, M; Guo, Y; Hong, L; Jiang, S; Liu, S; Shi, J; Wang, Q; Yuan, X, 2021) |
| "To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury." | 8.02 | Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. ( Bozdag, Z; Bozdayi, MA; Demir, M; Ince, O; Kalyoncu, S; Taysi, S; Tuncer, M; Ulusal, H; Yilmaz, B, 2021) |
| "Epidemiological evidence suggests that the antidiabetic drug metformin (MET) can also inhibit abdominal aortic aneurysm (AAA) formation." | 8.02 | Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway. ( Fan, Y; He, J; Hu, X; Li, N; Liu, C; Zhao, X, 2021) |
| "Evidence for the effectiveness of metformin in the treatment of acne is limited." | 8.02 | Effects of metformin on experimentally induced acne on rabbit ear. ( Bishnoi, A; De, D; Dutta, P; Handa, S; Kamboj, P; Nahar Saikia, U; Pal, A, 2021) |
| "The present study was conducted to investigate the therapeutic effects of a potent polyphenol, fisetin, on the letrozole-induced rat model of polycystic ovary syndrome (PCOS)." | 8.02 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021) |
| " Because previous data suggest the procognitive potential of the antidiabetic drug metformin, this study aimed to assess the effects of chronic clozapine and metformin oral administration (alone and in combination) on locomotor and exploratory activities and cognitive function in a reward-based test in control and a schizophrenia-like animal model (Wisket rats)." | 8.02 | Interaction of clozapine with metformin in a schizophrenia rat model. ( Adlan, LG; Benyhe, S; Büki, A; Heni, HE; Horvath, G; Kekesi, G; Kis, G; Szűcs, E, 2021) |
| "The metformin treatment counteracted the development of depression-like behaviors in mice suffering SDS when administered alone and enhanced the anti-depressant effect of fluoxetine when combined with fluoxetine." | 7.96 | Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. ( Chen, X; Dai, X; Fang, W; Hong, L; Huang, W; Ye, Q; Zhang, J, 2020) |
| "Chronic metformin presented anti-inflammatory and antioxidant effects and, independently of alterations in glycaemia, it improved cardiac autonomic parameters that are impaired in hypertension, being related to end-organ damage and mortality." | 7.96 | Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction. ( Birocale, AM; Bissoli, NS; de Abreu, GR; de Figueiredo, SG; de Sousa, GJ; Gouvêa, SA; Oliveira, PWC, 2020) |
| "In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression." | 7.96 | Metformin limits osteoarthritis development and progression through activation of AMPK signalling. ( Chen, D; Feng, S; Huang, J; Li, J; Liu, WX; Liu-Bryan, R; Lu, K; Ning, G; Oh, CD; Pan, H; Wang, T; Xiao, G; Xing, C; Yi, D; Zhang, B; Zhao, L, 2020) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 7.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| "Metformin injections elevated von Frey thresholds (reduced mechanical allodynia) in complex regional pain syndrome mice versus saline-treated fracture mice between days 25 and 56 (difference of mean area under the curve, 42." | 7.96 | Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. ( Buvanendran, A; Das, V; Kroin, JS; McCarthy, RJ; Moric, M, 2020) |
| " The drug metformin has been shown to activate neural stem cells, promote differentiation, and lead to functional motor recovery in a neonatal stroke model." | 7.91 | Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. ( Adams, KV; Morshead, CM; Ruddy, RM, 2019) |
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 7.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| "Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension and preeclampsia." | 7.91 | Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. ( Cao, G; Cao, X; Li, L; Wang, F; Yi, W, 2019) |
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 7.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| " We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bone formation sclerostin (SOST) and Dickkopf-related protein 1 (DKK1), and increased osteoprotegerin (OPG) secretion and the ratio of OPG/Receptor Activator for Nuclear Factor-κB Ligand (RANKL)." | 7.91 | Metformin protects bone mass in ultra-high-molecular-weight polyethylene particle-induced osteolysis by regulating osteocyte secretion. ( Cao, X; Lu, Z; Tian, X; Wei, D; Yan, Z; Ye, Z; Zhai, D; Zhu, Q; Zhu, S; Zhu, Z, 2019) |
| " Metformin is commonly used to treat insulin resistance-glucose intolerance, and flutamide, an androgen receptor (AR) antagonist, is used to target hyperandrogenemia and dyslipidemia." | 7.91 | Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. ( Diane, A; Ghosh, M; Kupreeva, M; Lehner, R; Proctor, S; Vine, D; Watts, R, 2019) |
| "The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function." | 7.91 | Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. ( Baumann, A; Bergheim, I; Brandt, A; Camarinha-Silva, A; Hernández-Arriaga, A; Jin, CJ; Kehm, R; Nier, A; Sánchez, V, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 7.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| " The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast cancer models." | 7.91 | Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation. ( Feng, J; Han, SX; Jiang, YN; Li, GY; Liu, JL; Liu, PJ; Lu, SY; Shen, YW; Sun, X; Wang, B; Wang, JC; Wang, MD; Zhou, C, 2019) |
| "In conclusion, our study revealed new therapeutic potential of metformin to attenuate calcineurin inhibitor-induced renal fibrosis, which was closely related to the suppression of MEK/ERK1/2 pathway." | 7.91 | Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats. ( Huang, YX; Li, Y; Liang, S; Lin, CX; Liu, SY; Su, YF; Tao, J; Zhang, LS; Zhao, ZK; Zheng, JM, 2019) |
| "The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis." | 7.88 | Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model. ( Karasik, D; Khajuria, DK; Patil, ON; Razdan, R, 2018) |
| "This study compared the antiproliferative effects of metformin and progesterone, via examination of the Bcl-2/Bax-caspase apoptotic pathway in estrogen-induced endometrial hyperplasia (EH) in 40 rats." | 7.88 | Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins. ( Akgun, H; Dolanbay, M; Eraslan Sahin, M; Ozcelik, B; Saatci, C; Sahin, E, 2018) |
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 7.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| "These data suggest that metformin protects against bleomycin-induced pulmonary fibrosis through activation of AMPK and amelioration of TGF-β signaling pathways." | 7.88 | Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms. ( Arava, S; Arya, DS; Bhatia, J; Gamad, N; Malik, S; Suchal, K; Tomar, A; Vasisht, S, 2018) |
| " Ursolic acid, metformin, gliclazide and their combinations when administered daily for 30 days significantly improved insulin sensitivity apart from behavioral and biochemical alterations in stressed mice." | 7.88 | Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations. ( Ahuja, S; Akhtar, A; Kumar, A; Mourya, A; Sah, SP, 2018) |
| "To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis." | 7.85 | Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis. ( Araújo Júnior, RF; Araújo, AA; Araújo, LS; Brito, GAC; Guedes, PMM; Hiyari, S; Leitão, RFC; Medeiros, CACX; Pereira, ASBF; Pirih, FQ, 2017) |
| "To compare the therapeutic potential of TP-113, a unique molecular entity linking DHA with metformin, for alleviating insulin resistance in obese diabetic mice through the PDX/IL-6 pathway." | 7.85 | Treatment with a novel agent combining docosahexaenoate and metformin increases protectin DX and IL-6 production in skeletal muscle and reduces insulin resistance in obese diabetic db/db mice. ( Barbier, O; Lachance, D; Marette, A; Mitchell, PL; Nachbar, R; St-Pierre, P; Trottier, J, 2017) |
| "In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models." | 7.85 | Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. ( André, N; Baglioni, M; Bondarenko, M; Carré, M; Laluce, NC; Menacho Márquez, M; Rico, M; Rozados, V; Scharovsky, OG, 2017) |
| "To investigate whether metformin can improve the cardiac function through improving the mitochondrial function in model of heart failure after myocardial infarction." | 7.85 | Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. ( Sun, D; Yang, F, 2017) |
| "To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS)." | 7.83 | Effect of colchicine on polycystic ovary syndrome: an experimental study. ( Aksoy, AN; Dokuyucu, R; Gozukara, IO; Kucur, SK; Kurt, RK; Ozcan, O; Ozgur, T; Pınar, N, 2016) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 7.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| " In this study, we investigated its effects on renal fibrosis in a mouse model of unilateral ureteral obstruction (UUO) in vivo and in angiotensin II (Ang II)-treated renal fibroblast NRK-49F cells in vitro." | 7.83 | Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. ( Gan, X; Lu, L; Miao, N; Shen, Y; Xu, D; Xu, J; Xue, H; Zhang, W; Zhou, L, 2016) |
| "Long-term metformin treatment reduces the risk of stroke." | 7.83 | Pre-stroke Metformin Treatment is Neuroprotective Involving AMPK Reduction. ( Chen, Y; Chen, Z; Deng, T; Hou, WW; Hu, WW; Shen, Z; Wu, XL; Yuan, Y; Zhang, LS; Zhang, XN; Zheng, YR, 2016) |
| "Metformin promoted revascularization in the presence of tissue ischemia through an AMPK/eNOS-related mechanism." | 7.81 | Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model. ( Komori, K; Murohara, T; Ouchi, N; Shibata, R; Sugimoto, M; Takahashi, N, 2015) |
| "FDA-approved ritonavir and metformin effectively target multiple myeloma cell metabolism to elicit cytotoxicity in multiple myeloma." | 7.81 | Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin. ( Adekola, KU; Bajpai, R; Dalva-Aydemir, S; Kandela, I; Koblinski, JE; Martinez, M; Raje, NS; Rosen, ST; Shanmugam, M; Singhal, S; Wei, C, 2015) |
| "To examine, in an animal study, whether EA combined with metformin (EA-metformin) results in a better glucose-lowering effect and greater insulin sensitivity than metformin alone in steroid-induced insulin-resistant rats." | 7.81 | Electroacupuncture plus metformin lowers glucose levels and facilitates insulin sensitivity by activating MAPK in steroid-induced insulin-resistant rats. ( Chang, SL; Lee, YC; Liao, HY; Lin, JG; Sun, MF, 2015) |
| "To evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction." | 7.81 | Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance. ( Alexandre, EC; Antunes, E; Calixto, MC; Calmasini, FB; Silva, FH, 2015) |
| " Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)." | 7.81 | Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015) |
| "To investigate the expression of silent information regulator 1 (SIRT1) in rats with polycystic ovary syndrome (PCOS) and its alteration after exenatide treatment." | 7.81 | Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. ( Ge, SQ; Tao, X; Zhang, B; Zhang, EH; Zhang, X, 2015) |
| "Metformin decreases polycystic ovary syndrome (PCOS) symptoms, induces ovulation, and may improve developmental competence of in vitro oocyte maturation." | 7.81 | Does metformin improve in vitro maturation and ultrastructure of oocytes retrieved from estradiol valerate polycystic ovary syndrome-induced rats. ( Mesbah, F; Mirkhani, H; Moslem, M; Vojdani, Z, 2015) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 7.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| " Many of these compounds, including olanzapine, cause metabolic side-effects such as impaired glucose tolerance and insulin resistance." | 7.80 | Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine. ( Asiri, Y; Barr, AM; Boyda, HN; Honer, WG; Lo, R; Pang, CC; Procyshyn, RM; Wang, CK; Wu, C, 2014) |
| "In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet." | 7.80 | Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014) |
| " To better understand the pathophysiology of obesity-associated NAFLD, the present study examined the involvement of liver and adipose tissues in metformin actions on reducing hepatic steatosis and inflammation during obesity." | 7.80 | Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity. ( An, X; Botchlett, R; Chen, L; Guo, T; Guo, X; Hu, X; Huo, Y; Li, H; Li, Q; Pei, Y; Qi, T; Woo, SL; Wu, C; Xiao, X; Xu, H; Xu, Y; Zhao, J; Zhao, Y; Zheng, J, 2014) |
| "These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease." | 7.80 | Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014) |
| "Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed." | 7.80 | Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats. ( Gao, Y; Luo, L; Pan, T; Wang, C, 2014) |
| "To study the effect of Mudan Granule (MD) on the glucose metabolism and beta cell function in monosodium glutamate (MSG) induced obese mice with insulin resistance (IR)." | 7.80 | [Effect of Mudan Granule on islets beta cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study]. ( Hou, SC; Liu, Q; Liu, SN; Shen, ZF; Sun, SJ, 2014) |
| "In an experimental model of obesity and hyperglycemia in Drosophila melanogaster we studied the effect of diet modification and administration of metformin on systemic infection with Rhizopus, a common cause of mucormycosis in diabetic patients." | 7.80 | Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. ( Albert, N; Do, KA; Farmakiotis, D; Kim-Anh, D; Kontoyiannis, DP; Shirazi, F; Yan, Y, 2014) |
| "Using ApoE−/− C57BL/6J mice, we found that metformin attenuates atherosclerosis and vascular senescence in mice fed a high‐fat diet and prevents the upregulation of angiotensin II type 1 receptor by a high‐fat diet in the aortas of mice." | 7.80 | Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. ( Alexander, RW; Fei, B; Forouzandeh, F; Hilenski, L; Patrushev, N; Salazar, G; Xiong, S, 2014) |
| "Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells." | 7.79 | Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner. ( Abbe, P; Allegra, M; Bahadoran, P; Ballotti, R; Bertolotto, C; Cerezo, M; Giacchero, D; Lehraiki, A; Ohanna, M; Rocchi, S; Rouaud, F; Tartare-Deckert, S; Tichet, M, 2013) |
| "Increased angiotensin II (AngII) levels cause hypertension, which is a major risk factor for erectile dysfunction (ED)." | 7.79 | Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. ( Labazi, H; Tostes, R; Webb, RC; Wynne, BM, 2013) |
| "Metformin treatment in the context of metabolic syndrome and myocardial ischemia dramatically upregulates the insulin signaling pathway in chronically ischemic myocardium, which is at the crossroads of known metabolic and survival benefits of metformin." | 7.79 | Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome. ( Chu, LM; Elmadhun, NY; Lassaletta, AD; Sellke, FW, 2013) |
| "This is the first study to show that metformin can improve immunosuppressant-induced hyperglycemia, when administered concurrently, and reduces exocrine apoptosis (reducing the impact on potential islet progenitor cells)." | 7.79 | Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. ( Bennett, RG; Clure, CC; Hamel, FG; Larsen, JL; Shivaswamy, V, 2013) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 7.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "To investigate the therapeutic effects of metformin, a commonly used antidiabetic drug, in preventing endotoxin-induced uveitis (EIU) in rats." | 7.78 | Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. ( Ansari, NH; Kalariya, NM; Ramana, KV; Shoeb, M; Srivastava, SK, 2012) |
| "Metformin inhibits the growth of most tumor cells, but BRAF-mutant melanoma cells are resistant to metformin in vitro, and metformin accelerates their growth in vivo." | 7.78 | Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. ( Hayward, R; Marais, R; Martin, MJ; Viros, A, 2012) |
| " We hypothesised that intervention with metformin would diminish the HF-feeding-evoked cognitive deficit by improving insulin sensitivity." | 7.78 | A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. ( Balfour, DJ; McNeilly, AD; Stewart, CA; Sutherland, C; Williamson, R, 2012) |
| "To investigate the potential preventive effects of metformin on non-alcoholic fatty liver disease (NAFLD) and roles of phospholipase A2/lysophosphatidylcholine pathway in hepatocyte lipoapoptosis in a rat NAFLD model induced by high-fat diet." | 7.77 | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. ( Fu, JF; Huang, Y; Liu, LR; Shi, HB, 2011) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 7.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway." | 7.76 | Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. ( Feng, W; Fu, Y; Lu, Z; Ma, X; Shen, Q; Xiao, H; Xu, M; Zhang, Y; Zhu, Y, 2010) |
| "Clinical studies have reported that the widely used antihyperglycemic drug metformin significantly reduces cardiac risk factors and improves clinical outcomes in patients with heart failure." | 7.75 | Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. ( Anaya-Cisneros, M; Calvert, JW; Gundewar, S; Jha, S; Ji, SY; Lefer, DJ; Nunez, D; Ramachandran, A; Tian, R; Toedt-Pingel, I, 2009) |
| "The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen." | 7.75 | Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. ( Erdemoglu, E; Giray, SG; Güney, M; Mungan, T; Take, G, 2009) |
| "Metformin, even at a dose mimicking accumulation, does not aggravate the mortality rate in this model of sepsis." | 7.73 | Effect of metformin on survival rate in experimental sepsis. ( Bouffandeau, B; Gras, V; Lalau, JD; Montravers, PH, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 7.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "Metformin was administrated through daily intraperitoneal injection from postnatal day 35 for 4 weeks." | 7.11 | Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice. ( Chang, MY; Chou, LF; Hsu, SH; Hung, CC; Ong, ACM; Tian, YC; Tsai, CY; Yang, CW; Yang, HY, 2022) |
| "Metformin is a pleiotropic drug, modulating different targets such as AMPK, insulin signalling and many others." | 6.82 | Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder. ( Casterá, F; Gómez-Escribano, AP; Herrero, MJ; Millán, JM; Peiró, C; Tortajada-Pérez, J; Trujillo-Del Río, C; Vázquez-Manrique, RP, 2022) |
| "Metformin is a drug in the family of biguanide compounds that is widely used in the treatment of type 2 diabetes (T2D)." | 6.72 | Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease. ( Sánchez, MP; Sanz, P; Serratosa, JM, 2021) |
| "Metformin is a first-line therapy for type 2 diabetes." | 6.61 | Metformin: Mechanisms in Human Obesity and Weight Loss. ( Soukas, AA; Yerevanian, A, 2019) |
| "Metformin has been the first-line drug for the treatment of type II diabetes mellitus for decades, being presently the most widely prescribed antihyperglycemic drug." | 6.61 | Metformin and Breast Cancer: Molecular Targets. ( Azevedo, A; Faria, J; Martel, F; Negalha, G, 2019) |
| "Epilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1% of global population making it a serious health concern." | 6.61 | Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk. ( H S, N; K L, K; Paudel, YN, 2019) |
| "Hyperglycemia is a known exacerbating factor in ischemic stroke." | 6.47 | [Effectiveness of metformin in prevention of development of hyperglycemia and neuronal damage caused by ischemic stress]. ( Fujita-Hamabe, W; Harada, S; Tokuyama, S, 2011) |
| "Obesity and insulin resistance have been associated with breast cancer risk, and breast cancer outcomes." | 6.47 | Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin. ( Goodwin, PJ; Stambolic, V, 2011) |
| "However, the mechanisms and treatments for depression in AR remain underexplored." | 5.91 | Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage. ( Chen, S; Cong, J; Gao, Z; Guan, M; Liu, P; Lv, H; Wang, Y; Xie, Y; Xu, Y, 2023) |
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 5.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "In addition, the benefits of metformin treatment of depression have been documented in a range of rodent studies and human trials, but few studies have probed into the effect of metformin on and the related mechanism in depressed elderly mice, especially in those APOE4 carriers." | 5.72 | Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis. ( Chen, X; Dai, X; Lin, Y; Zhang, J, 2022) |
| "Metformin was found to have a neuroprotective effect on the retina in ENU induced rat model of RP." | 5.72 | Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa? ( Ahmed, AA; Eltony, SA; Mohaseb, HS; Sayed, MM, 2022) |
| "Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice." | 5.72 | Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022) |
| "The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo." | 5.72 | Epithelial-mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model. ( Almeida, CP; da Silva, VHSR; de Araújo Campos, MR; de Carvalho, BA; de Souza Silva, FH; Del Puerto, HL; Ferreira, E; Lima, BM; Ribeiro, TS; Rocha, SA; Veloso, ES, 2022) |
| "Dengue is a prevalent mosquito-borne viral infection in the tropical and sub-tropical regions." | 5.62 | In vitro and in vivo efficacy of Metformin against dengue. ( Alonso, S; Cheang, YZN; Koh, HQV; Ting, HRD, 2021) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 5.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "Ulcerative colitis is an inflammatory condition of the colon." | 5.62 | Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling. ( Liu, X; Sun, Z; Wang, H, 2021) |
| "Metformin has protective effects on diabetic nephropathy." | 5.62 | Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway. ( Cai, W; Fu, Y; Hong, L; Liu, T; Qiao, X; Wang, M; Yang, Y; Zheng, Z; Zhong, M, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 5.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Metformin has exhibited anti-inflammatory and neuroprotective properties in numerous studies." | 5.62 | Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation. ( Anand, S; Bhatia, A; Bojja, SL; Joshi, R; Medhi, B; Minz, RW, 2021) |
| "A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)." | 5.62 | Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021) |
| "Metformin was administered orally every day to rats with OA." | 5.62 | Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021) |
| "Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis." | 5.62 | Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis. ( Akar, ZA; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2021) |
| "Oxandrolone (OXA) is an androgen and anabolic steroid (AAS) that is used to reverse weight loss associated with some medical conditions." | 5.62 | Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α. ( Abed, AF; Alfaraj, M; Hall, FS; Hammad, AM; Ibrahim, YA; Jarrar, Y; Khdair, SI, 2021) |
| "Inflammation is the first stage of this progression, becoming an appealing target of early therapeutic intervention." | 5.62 | Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation. ( Fan, C; He, Y; Li, J; Liu, W; Luo, G; Qian, Y; Sun, Z; Wang, F, 2021) |
| "Metformin is a first-line drug for the treatment of diabetes, and has great potential for the treatment of other disorders." | 5.56 | Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR. ( Bai, X; Cai, D; Feng, X; Li, J; Liu, L; Liu, X; Pan, J; Qi, W; Shao, Y; Xiao, G; Zeng, C; Zhang, H, 2020) |
| "Low-grade inflammation is often higher in older adults and remains a key risk factor of aging-related morbidities and mortalities." | 5.56 | Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis. ( Ahmadi, S; Ding, J; Jain, S; Justice, J; Kitzman, D; Kritchevsky, SB; McClain, DA; Mishra, SP; Nagpal, R; Razazan, A; Wang, B; Wang, S; Yadav, H, 2020) |
| "Metformin treatment caused astrocytes to alter reactive genes in a PD animal model." | 5.56 | Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. ( Choi, JH; Choi, YK; Go, J; Kim, KS; Lee, CH; Lee, TG; Park, HY; Rhee, M; Ryu, YK; Seo, YJ, 2020) |
| "Letrozole (1 mg/kg) was administered orally for a period of 28 days to induce PCOS." | 5.56 | The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. ( Ekramzadeh, M; Golmakani, MT; Koohpeyma, F; Sherafatmanesh, S; Tanideh, N, 2020) |
| "Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered." | 5.56 | AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. ( Dayn, A; Dayn, Y; Hellberg, K; Luo, EC; Shaw, RJ; Shokhirev, MN; Van Nostrand, EL; Van Nostrand, JL; Yeo, GW; Yu, J, 2020) |
| "Tendinopathy is a debilitating tendon disorder that affects millions of Americans and costs billions of health care dollars every year." | 5.56 | Effect of Metformin on Development of Tendinopathy Due to Mechanical Overloading in an Animal Model. ( Hogan, MV; Li, F; Nie, D; Onishi, K; Wang, JH; Zhang, J, 2020) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 5.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Systemic inflammation was induced by injecting LPS (1." | 5.51 | Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice. ( Anoopkumar-Dukie, S; Arora, D; Basu Mallik, S; Grant, G; Hall, S; Kinra, M; Mudgal, J; Nampoothiri, M; Rao, CM, 2019) |
| "Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice." | 5.51 | Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. ( Bugáňová, M; Haluzík, M; Holubová, M; Kuneš, J; Kuzma, M; Maletínská, L; Pelantová, H; Šedivá, B; Tomášová, P; Železná, B, 2019) |
| "Treatment with metformin altered macrophage polarization, reduced liver size and reduced micronuclei formation in NAFLD/NASH-associated HCC larvae." | 5.51 | Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish. ( de Oliveira, S; Golenberg, N; Graves, AL; Houseright, RA; Huttenlocher, A; Korte, BG; Miskolci, V, 2019) |
| "Metformin treatment upregulated SIRT3 expression and mitigated loss of cell viability and decreased the generation of mitochondria-induced ROS in chondrocytes stimulated with IL-1β." | 5.51 | Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes. ( Liu, J; Wang, C; Yang, Y; Yao, Z; Zhang, C; Zhang, Y, 2019) |
| "Nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease, and there is currently no available treatment strategy." | 5.51 | Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease. ( Chen, W; Fan, J; Hao, Q; Jin, X; Ju, D; Liu, H; Luan, J; Mei, X; Tang, S; Wu, Z; Zai, W; Zhang, X, 2019) |
| "Metformin reduced salivary gland inflammation and restored the salivary flow rate." | 5.51 | Metformin improves salivary gland inflammation and hypofunction in murine Sjögren's syndrome. ( Cho, ML; Choi, J; Hwang, SH; Jung, KA; Kim, JW; Kim, SM; Kwok, SK; Lee, SY; Park, JS; Park, SH; Ryu, JG, 2019) |
| "Huntington disease is a neurodegenerative condition for which there is no cure to date." | 5.51 | Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease. ( Cañada-Martínez, AJ; García-Gimeno, MA; Millán, JM; Sanchis, A; Sanz, P; Sequedo, MD; Vázquez-Manrique, RP, 2019) |
| "Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population." | 5.51 | Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin. ( AbdelMaksoud, S; El-Bahy, AA; Handoussa, H; Khaled, N; Radwan, R, 2019) |
| "Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss." | 5.51 | Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis. ( Grandgirard, D; Le, ND; Leib, SL; Muri, L; Zemp, J, 2019) |
| "Metformin has been the most prescribed glucose-lowering medicine worldwide, and its potential for many other therapeutic applications is also being explored intensively." | 5.48 | Metformin attenuates folic-acid induced renal fibrosis in mice. ( Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y, 2018) |
| "The metformin treatment largely reversed the correlations with diabetes-related pathways." | 5.48 | Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice. ( Cheng, Y; Cui, Q; Fang, W; Guo, J; Guo, L; Hu, G; Li, J; Lin, Y; Man, Y; Sun, M; Wei, J; Zhou, Y, 2018) |
| "Metformin has been widely used for the treatment of type 2 diabetes." | 5.46 | Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. ( Kyohara, M; Okuyama, T; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y; Yamazaki, S, 2017) |
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 5.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| "Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed." | 5.46 | Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity. ( Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S, 2017) |
| "Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress." | 5.46 | Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis. ( Crocenzi, FA; Cumino, AC; Dávila, VA; Loos, JA; Petrigh, R; Rodrígues, CR; Zoppi, JA, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Metformin treatment decreased very long chain fatty acid levels and pro-inflammatory cytokine gene expressions in X-ALD patient-derived cells." | 5.43 | Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase. ( Felicella, MM; Giri, S; Olle, B; Singh, J; Suhail, H, 2016) |
| "Metformin is an attractive agent for chemoprevention because it is inexpensive, has a favorable safety profile, and is well tolerated over long time periods." | 5.43 | Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis. ( Chung, RT; DePeralta, DK; Fuchs, BC; Ghoshal, S; Lanuti, M; Lauwers, GY; Schmidt, B; Tanabe, KK; Wei, L, 2016) |
| "In addition, we observed that bladder cancer cell lines (RT4, UMUC-3, and J82) with homozygous deletion of either TSC1 or PTEN are more sensitive to metformin than those (TEU2, TCCSUP, and HT1376) with wild-type TSC1 and PTEN genes." | 5.43 | High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum. ( Avizonis, D; Blair, CA; Li, X; Liu, Z; McClelland, M; Pollak, M; Uchio, E; Wu, XR; Yokoyama, NN; Youssef, R; Zi, X, 2016) |
| "Metformin was treated daily for 14 weeks in a high-fat dieting C57BL/6J mice." | 5.43 | Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21. ( Byun, JK; Cho, ML; Choi, JY; Jeong, JH; Jhun, JY; Kim, EK; Kim, JK; Lee, SH; Lee, SY, 2016) |
| "Metformin is a widely used drug to treat patients with type II diabetes." | 5.43 | Metformin blocks progression of obesity-activated thyroid cancer in a mouse model. ( Cheng, SY; Enomoto, K; Kim, WG; Park, J; Willingham, M; Zhao, L, 2016) |
| "Metformin was also given as a standard control to one of the rat groups." | 5.43 | Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. ( Afsar, T; Ain, QU; Almajwal, A; Jahan, S; Mehboob, A; Munir, F; Razak, S; Shaheen, G; Ullah, H, 2016) |
| "Treatment with metformin of athymic nude mice bearing xenograft tumors reduced tumor proliferation." | 5.42 | Antidiabetic drug metformin inhibits esophageal adenocarcinoma cell proliferation in vitro and in vivo. ( Chiyo, T; Fujihara, S; Iwama, H; Kato, K; Kobara, H; Kobayashi, M; Masaki, T; Miyoshi, H; Mori, H; Morishita, A; Nishioka, T; Nishiyama, N; Okano, K; Suzuki, Y, 2015) |
| "Metformin is a well-known activator of AMP-activated protein kinase (AMPK)." | 5.40 | Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke. ( Hammond, MD; Li, J; Mancini, NS; McCullough, LD; Venna, VR, 2014) |
| "Obesity is a significant contributing factor to endometrial cancer risk." | 5.39 | Chemopreventive effects of metformin on obesity-associated endometrial proliferation. ( Broaddus, RR; Burzawa, JK; Celestino, J; Huang, M; Iglesias, D; Lu, KH; McCampbell, AS; Meyer, LA; Schmandt, R; Urbauer, DL; Yates, MS; Zhang, Q, 2013) |
| "Salt-sensitive hypertension is a characteristic of the metabolic syndrome." | 5.38 | Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. ( Araki, H; Araki, S; Chin-Kanasaki, M; Deji, N; Haneda, M; Isshiki, K; Kashiwagi, A; Koya, D; Kume, S; Maegawa, H; Nishiyama, A; Tanaka, Y; Uzu, T, 2012) |
| "Both bortezomib and metformin have been proposed as potential therapeutics in TSC." | 5.38 | Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). ( Auricchio, N; Kwiatkowski, DJ; Malinowska, I; Manning, BD; Shaw, R, 2012) |
| "Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes." | 5.38 | Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. ( Ando, H; Fujimura, A; Hayashi, K; Kaneko, S; Kato, K; Kimura, T; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Miyamoto, K; Nakanuma, Y; Ni, Y; Ota, T; Otoda, T; Takamura, T; Takeshita, Y; Uno, M; Zen, Y, 2012) |
| "Advanced HF (heart failure) is associated with altered substrate metabolism." | 5.37 | Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. ( Benada, O; Benes, J; Cervenka, L; Drahota, Z; Houstek, J; Kazdova, L; Kolar, M; Kopecky, J; Kovarova, N; Medrikova, D; Melenovsky, V; Petrak, J; Sedmera, D; Skaroupkova, P; Strnad, H; Vrbacky, M, 2011) |
| "Treatment with metformin significantly attenuated the progression of aortic atherosclerosis." | 5.35 | Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits. ( Cheng, X; Deng, HP; Feng, YB; Li, SN; Mao, XB; Wang, TH; Wang, X; Zeng, QT, 2009) |
| " Pioglitazone treatment (n = 10) reduced hepatic fat as assessed by magnetic resonance spectroscopy, despite a significant increase in body weight (Δ = 3." | 5.15 | Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. ( Bajaj, M; Chan, L; Gonzalez, EV; Gutierrez, A; Jogi, M; Krishnamurthy, R; Muthupillai, R; Samson, SL; Sathyanarayana, P, 2011) |
| ", pioglitazone and metformin) used for the treatment of insulin resistance in PCOS, on androgen production." | 4.93 | Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS. ( Indran, IR; Lee, BH; Yong, EL, 2016) |
| "Metformin is the most common anti-diabetic drug and a promising therapy for disorders beyond diabetes, including Rett syndrome (RTT), a rare neurologic disease characterized by severe intellectual disability." | 4.31 | Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome. ( Cosentino, L; De Filippis, B; Di Crescenzo, L; Di Domenico, F; Lanzillotta, C; Perluigi, M; Pietraforte, D; Prestia, F; Quattrini, MC; Urbinati, C; Vacca, RA; Valenti, D, 2023) |
| "Our previous study found that the intravesical perfusion of metformin has excellent inhibitory effects against bladder cancer (BC)." | 4.31 | Metformin-Loaded Chitosan Hydrogels Suppress Bladder Tumor Growth in an Orthotopic Mouse Model via Intravesical Administration. ( Chen, X; Deng, J; Hu, X; Li, D; Peng, M; Xiao, D; Xie, L; Xie, Y; Yang, X; Zhang, X, 2023) |
| "The high-fat diet-induced mouse model of obesity and insulin resistance of both sexes was developed in a randomized block experiment and bulk RNA-Seq of the ileum tissue was the method of choice for comparative transcriptional profiling after metformin intervention for ten weeks." | 4.31 | Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance. ( Ansone, L; Birzniece, L; Brīvība, M; Elbere, I; Jagare, L; Kalniņa, I; Kloviņš, J; Silamiķele, L; Silamiķelis, I, 2023) |
| "To explore the therapeutic potential and the underlying mechanism of metformin, an adenosine monophosphate-activated kinase (AMPK) activator, in ocular melanoma." | 4.12 | Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma. ( Chai, P; Fan, X; Ge, S; Jia, R; Jia, S; Ruan, J; Shi, W; Wang, S; Xu, X; Yu, J; Zhou, Y; Zhuang, A; Zuo, S, 2022) |
| "Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment." | 4.12 | Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice. ( Huang, J; Li, Z; Ru, G; Sun, J; Sun, L, 2022) |
| " In this model, we also examined the medication effects of metformin (Met) which is known to ameliorate several symptoms of autism spectrum disorder (ASD)." | 4.12 | Effect of metformin in autistic BTBR T + Itpr3tf/J mice administered a high-fat diet. ( Chen, Y; Deng, W; Ke, H; Li, F; Li, Z; Lv, P; Wang, S, 2022) |
| " One possible modulator of ENaC is AMP-activated protein kinase (AMPK), a key molecule that controls a wide variety of cellular signals; however, little is known about whether metformin, a clinically available AMPK activator, has a protective role against ENaC-associated chronic pulmonary phenotypes, such as emphysema and pulmonary dysfunction." | 4.12 | Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases. ( Eto, Y; Fujikawa, H; Hayashi, M; Kai, H; Kamei, S; Kawakami, T; Kishimoto, T; Maruta, K; Nakashima, R; Nasu, A; Nohara, H; Shuto, T; Suico, MA; Takahashi, N; Ueno-Shuto, K, 2022) |
| "The study suggests that the prolonged effect of metformin-induced euglycemia promoted the microglial activation, reduced neuronal cell death, and improved the overall survival following stroke, without any change in infarct size." | 4.12 | The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke. ( Kimball, SR; Kumari, R; Simpson, IA; Willing, L, 2022) |
| " The effect of HFD on maternal rats was alleviated by prenatal metformin, which also ameliorated inflammation and apoptosis in the fetal liver and intestines." | 4.02 | Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis. ( Hou, CY; Huang, LT; Huang, SW; Lin, IC; Ou, YC; Sheen, JM; Tain, YL; Tang, KS; Tiao, MM; Tsai, CC; Yu, HR, 2021) |
| " Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well." | 4.02 | Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021) |
| "To explore the novel linkage between a Western diet combining high saturated fat, sugar, and salt (HFSS) and neurological dysfunctions during aging as well as Metformin intervention, we assessed cerebral cortex abnormalities associated with sensory and motor dysfunctions and cellular and molecular insights in brains using HFSS-fed mice during aging." | 4.02 | A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin. ( Bazan, NG; Duong, QA; Hong, S; Lu, Y; Nagayach, A; Peng, H; Pham, NB; Vuong, CA, 2021) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 4.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| "Resveratrol (RSV) and metformin (MET) play a role in the treatment of diabetes; however, the mechanisms through which they mediate insulin resistance by regulating long non‑coding RNAs (lncRNAs) remain unknown." | 4.02 | Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance. ( Hou, X; Ma, H; Shu, L; Song, G; Wang, C, 2021) |
| " We evaluated the role of oxidative stress (OS), during early metabolic syndrome (MetS), on amyloidogenic processes in a MetS rat model induced by sucrose." | 4.02 | Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation. ( Baires-López, A; Camacho-Castillo, L; Campos-Peña, V; Carvajal, K; Phillips-Farfán, BV; Rosas-Mendoza, G; Toral-Ríos, D, 2021) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 4.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| "These findings highlight a novel pathogenic mechanism of sepsis-related cognitive impairment through activation of inflammatory factors, and these are blocked by metformin to attenuate sepsis-induced neuronal injury and cognitive impairment." | 4.02 | Metformin attenuates sepsis-induced neuronal injury and cognitive impairment. ( Guo, C; Qin, Z; Xiao, X; Zhou, C, 2021) |
| "Metformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, and results in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK." | 4.02 | Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase. ( Boyle, JJ; Carling, D; Cave, L; Haskard, DO; Hyde, G; Mason, JC; Moestrup, SK; Seneviratne, A, 2021) |
| "The present study aimed to investigate the possible effects of metformin on the olanzapine-induced insulin resistance in rats." | 4.02 | Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats. ( Guo, C; Li, H; Liu, J, 2021) |
| "Our findings suggest that in CLP induced sepsis model, metformin can improve the function of blood and cardiac cells through alleviating inflammation, improvement of anti-inflammation properties, and enhancement of blood profile, and all these effects are more pronounced after 24 h in comparison with 12 h after induction of sepsis." | 4.02 | Short-term Effects of Metformin on Cardiac and Peripheral Blood Cells Following Cecal Ligation and Puncture-induced Sepsis. ( Abdollahi, M; Baeeri, M; Didari, T; Gholami, M; Haghi-Aminjan, H; Hassan, FI; Hassani, S; Mojtahedzadeh, M; Navaei-Nigjeh, M; Nejad, SM; Rahimifard, M, 2021) |
| " Metformin has potential effects on improving asthma airway inflammation." | 4.02 | Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma. ( Chen, M; Guo, Y; Hong, L; Jiang, S; Liu, S; Shi, J; Wang, Q; Yuan, X, 2021) |
| "To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury." | 4.02 | Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. ( Bozdag, Z; Bozdayi, MA; Demir, M; Ince, O; Kalyoncu, S; Taysi, S; Tuncer, M; Ulusal, H; Yilmaz, B, 2021) |
| "Epidemiological evidence suggests that the antidiabetic drug metformin (MET) can also inhibit abdominal aortic aneurysm (AAA) formation." | 4.02 | Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway. ( Fan, Y; He, J; Hu, X; Li, N; Liu, C; Zhao, X, 2021) |
| "Evidence for the effectiveness of metformin in the treatment of acne is limited." | 4.02 | Effects of metformin on experimentally induced acne on rabbit ear. ( Bishnoi, A; De, D; Dutta, P; Handa, S; Kamboj, P; Nahar Saikia, U; Pal, A, 2021) |
| "The present study was conducted to investigate the therapeutic effects of a potent polyphenol, fisetin, on the letrozole-induced rat model of polycystic ovary syndrome (PCOS)." | 4.02 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021) |
| " Because previous data suggest the procognitive potential of the antidiabetic drug metformin, this study aimed to assess the effects of chronic clozapine and metformin oral administration (alone and in combination) on locomotor and exploratory activities and cognitive function in a reward-based test in control and a schizophrenia-like animal model (Wisket rats)." | 4.02 | Interaction of clozapine with metformin in a schizophrenia rat model. ( Adlan, LG; Benyhe, S; Büki, A; Heni, HE; Horvath, G; Kekesi, G; Kis, G; Szűcs, E, 2021) |
| "The metformin treatment counteracted the development of depression-like behaviors in mice suffering SDS when administered alone and enhanced the anti-depressant effect of fluoxetine when combined with fluoxetine." | 3.96 | Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. ( Chen, X; Dai, X; Fang, W; Hong, L; Huang, W; Ye, Q; Zhang, J, 2020) |
| "Chronic metformin presented anti-inflammatory and antioxidant effects and, independently of alterations in glycaemia, it improved cardiac autonomic parameters that are impaired in hypertension, being related to end-organ damage and mortality." | 3.96 | Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction. ( Birocale, AM; Bissoli, NS; de Abreu, GR; de Figueiredo, SG; de Sousa, GJ; Gouvêa, SA; Oliveira, PWC, 2020) |
| "In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression." | 3.96 | Metformin limits osteoarthritis development and progression through activation of AMPK signalling. ( Chen, D; Feng, S; Huang, J; Li, J; Liu, WX; Liu-Bryan, R; Lu, K; Ning, G; Oh, CD; Pan, H; Wang, T; Xiao, G; Xing, C; Yi, D; Zhang, B; Zhao, L, 2020) |
| "Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis in different models of experimental chronic kidney disease (CKD)." | 3.96 | Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease. ( Borges, CM; de Ávila, VF; Formigari, GP; Fujihara, CK; Lopes de Faria, JB; Malheiros, DMAC, 2020) |
| "Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age." | 3.96 | Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos. ( Adiga, SK; Agarwal, P; Kalthur, G; Kalthur, SG; Kumari, S; Mutalik, S; Nayak, G; Rao, A; Salian, SR; Shreya, AB; Suresh Poojary, P, 2020) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 3.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| "Metformin injections elevated von Frey thresholds (reduced mechanical allodynia) in complex regional pain syndrome mice versus saline-treated fracture mice between days 25 and 56 (difference of mean area under the curve, 42." | 3.96 | Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. ( Buvanendran, A; Das, V; Kroin, JS; McCarthy, RJ; Moric, M, 2020) |
| " Improvement of insulin sensitivity by both aerobic exercise and metformin ameliorated HFD-induced abnormalities." | 3.91 | Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. ( Dasari, S; Kabiraj, P; Klaus, KA; Lucchinetti, CF; McCarthy, CB; Nair, KS; Ruegsegger, GN; Vanderboom, PM, 2019) |
| " The drug metformin has been shown to activate neural stem cells, promote differentiation, and lead to functional motor recovery in a neonatal stroke model." | 3.91 | Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. ( Adams, KV; Morshead, CM; Ruddy, RM, 2019) |
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 3.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| "Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension and preeclampsia." | 3.91 | Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. ( Cao, G; Cao, X; Li, L; Wang, F; Yi, W, 2019) |
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 3.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| " We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bone formation sclerostin (SOST) and Dickkopf-related protein 1 (DKK1), and increased osteoprotegerin (OPG) secretion and the ratio of OPG/Receptor Activator for Nuclear Factor-κB Ligand (RANKL)." | 3.91 | Metformin protects bone mass in ultra-high-molecular-weight polyethylene particle-induced osteolysis by regulating osteocyte secretion. ( Cao, X; Lu, Z; Tian, X; Wei, D; Yan, Z; Ye, Z; Zhai, D; Zhu, Q; Zhu, S; Zhu, Z, 2019) |
| " Metformin is commonly used to treat insulin resistance-glucose intolerance, and flutamide, an androgen receptor (AR) antagonist, is used to target hyperandrogenemia and dyslipidemia." | 3.91 | Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. ( Diane, A; Ghosh, M; Kupreeva, M; Lehner, R; Proctor, S; Vine, D; Watts, R, 2019) |
| "This study showed that the combination of metformin and 2DG blocked the formation of renal cysts and improved the renal function in ADPKD miniature pigs." | 3.91 | The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease. ( Bai, XY; Cai, G; Chen, X; Li, Q; Li, Z; Lian, X; Lin, S; Song, K; Wu, X; Zhang, Y, 2019) |
| "The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function." | 3.91 | Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. ( Baumann, A; Bergheim, I; Brandt, A; Camarinha-Silva, A; Hernández-Arriaga, A; Jin, CJ; Kehm, R; Nier, A; Sánchez, V, 2019) |
| "Previous studies have shown that metformin (MET) prevents experimental pulmonary arterial hypertension (PAH) and that activation of autophagy is involved in the development of pulmonary vascular remodeling." | 3.91 | Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase. ( Li, H; Liu, Y; Sun, Z; Xu, Y; Yang, G; Zhang, J; Zhu, J, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 3.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| " The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast cancer models." | 3.91 | Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation. ( Feng, J; Han, SX; Jiang, YN; Li, GY; Liu, JL; Liu, PJ; Lu, SY; Shen, YW; Sun, X; Wang, B; Wang, JC; Wang, MD; Zhou, C, 2019) |
| "In conclusion, our study revealed new therapeutic potential of metformin to attenuate calcineurin inhibitor-induced renal fibrosis, which was closely related to the suppression of MEK/ERK1/2 pathway." | 3.91 | Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats. ( Huang, YX; Li, Y; Liang, S; Lin, CX; Liu, SY; Su, YF; Tao, J; Zhang, LS; Zhao, ZK; Zheng, JM, 2019) |
| "The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis." | 3.88 | Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model. ( Karasik, D; Khajuria, DK; Patil, ON; Razdan, R, 2018) |
| "This study compared the antiproliferative effects of metformin and progesterone, via examination of the Bcl-2/Bax-caspase apoptotic pathway in estrogen-induced endometrial hyperplasia (EH) in 40 rats." | 3.88 | Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins. ( Akgun, H; Dolanbay, M; Eraslan Sahin, M; Ozcelik, B; Saatci, C; Sahin, E, 2018) |
| "Metformin treatment significantly reduced cardiac fibrosis and alleviated arrhythmia in the diabetic rats." | 3.88 | Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats. ( Cao, Q; Du, H; Duan, N; Fu, X; Li, B; Li, X; Pan, Y; Wang, S, 2018) |
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 3.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| "These data suggest that metformin protects against bleomycin-induced pulmonary fibrosis through activation of AMPK and amelioration of TGF-β signaling pathways." | 3.88 | Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms. ( Arava, S; Arya, DS; Bhatia, J; Gamad, N; Malik, S; Suchal, K; Tomar, A; Vasisht, S, 2018) |
| "Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury." | 3.88 | Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. ( Afshari, K; Dehdashtian, A; Dehpour, AR; Ebrahimi, MA; Faghir-Ghanesefat, H; Haddadi, NS; Haj-Mirzaian, A; Iranmehr, A; Javidan, AN; Mohammadi, F; Rahimi, N; Tavangar, SM, 2018) |
| " Ursolic acid, metformin, gliclazide and their combinations when administered daily for 30 days significantly improved insulin sensitivity apart from behavioral and biochemical alterations in stressed mice." | 3.88 | Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations. ( Ahuja, S; Akhtar, A; Kumar, A; Mourya, A; Sah, SP, 2018) |
| "The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA." | 3.88 | Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018) |
| " We were able to show in vivo that reducing phospho-STAT3-miR-21 levels in C57/BL6 mice liver, by long-term treatment with metformin, protected mice from aging-dependent hepatic vesicular steatosis." | 3.88 | Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model. ( Belloni, L; Blandino, G; Di Cocco, S; Guerrieri, F; Levrero, M; Marra, F; Mori, F; Nunn, ADG; Pallocca, M; Pediconi, N; Piconese, S; Pulito, C; Sacconi, A; Salerno, D; Strano, S; Testoni, B; Vivoli, E, 2018) |
| "The objective of this study was to determine whether intravascular infusion of metformin at the time of reperfusion reduces myocardial IS in a porcine model of acute myocardial infarction." | 3.88 | Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine. ( Canty, JM; Palka, BA; Techiryan, G; Weil, BR, 2018) |
| "The present study aimed to investigate the effect of metformin on the induction of autophagy in the liver and adipose tissues of a mouse model of obesity." | 3.85 | Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice. ( Li, M; Sharma, A; Tan, X; Xiao, Y; Yin, C, 2017) |
| "Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC." | 3.85 | Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer. ( Cao, J; Chen, K; Cheng, L; Duan, W; Gao, L; Jiang, Z; Lei, M; Li, J; Ma, Q; Qian, W; Sun, L; Yan, B; Zhou, C, 2017) |
| "To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis." | 3.85 | Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis. ( Araújo Júnior, RF; Araújo, AA; Araújo, LS; Brito, GAC; Guedes, PMM; Hiyari, S; Leitão, RFC; Medeiros, CACX; Pereira, ASBF; Pirih, FQ, 2017) |
| "To compare the therapeutic potential of TP-113, a unique molecular entity linking DHA with metformin, for alleviating insulin resistance in obese diabetic mice through the PDX/IL-6 pathway." | 3.85 | Treatment with a novel agent combining docosahexaenoate and metformin increases protectin DX and IL-6 production in skeletal muscle and reduces insulin resistance in obese diabetic db/db mice. ( Barbier, O; Lachance, D; Marette, A; Mitchell, PL; Nachbar, R; St-Pierre, P; Trottier, J, 2017) |
| "To evaluate the impact of depression on NASH through the involvement of JNK1 and to assess the effect of sitagliptin and metformin on hepatic JNK1 expression in both NASH and NASH associated with depression." | 3.85 | Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress. ( Abd-Elaziz, LF; Aboul-Fotouh, S; El-Kharashi, OA; Magdy, YM; Nabih, ES; Shaker, SM, 2017) |
| "In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models." | 3.85 | Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. ( André, N; Baglioni, M; Bondarenko, M; Carré, M; Laluce, NC; Menacho Márquez, M; Rico, M; Rozados, V; Scharovsky, OG, 2017) |
| "To investigate whether metformin can improve the cardiac function through improving the mitochondrial function in model of heart failure after myocardial infarction." | 3.85 | Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. ( Sun, D; Yang, F, 2017) |
| "To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS)." | 3.83 | Effect of colchicine on polycystic ovary syndrome: an experimental study. ( Aksoy, AN; Dokuyucu, R; Gozukara, IO; Kucur, SK; Kurt, RK; Ozcan, O; Ozgur, T; Pınar, N, 2016) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 3.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| " In this study, we investigated its effects on renal fibrosis in a mouse model of unilateral ureteral obstruction (UUO) in vivo and in angiotensin II (Ang II)-treated renal fibroblast NRK-49F cells in vitro." | 3.83 | Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. ( Gan, X; Lu, L; Miao, N; Shen, Y; Xu, D; Xu, J; Xue, H; Zhang, W; Zhou, L, 2016) |
| "The guideline for the management of new-onset diabetes after transplantation recommends metformin (MET) as a first-line drug, and addition of a second-line drug is needed to better control of hyperglycemia." | 3.83 | Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus. ( Chung, BH; Jin, J; Jin, L; Lim, SW; Yang, CW, 2016) |
| "Long-term metformin treatment reduces the risk of stroke." | 3.83 | Pre-stroke Metformin Treatment is Neuroprotective Involving AMPK Reduction. ( Chen, Y; Chen, Z; Deng, T; Hou, WW; Hu, WW; Shen, Z; Wu, XL; Yuan, Y; Zhang, LS; Zhang, XN; Zheng, YR, 2016) |
| "Metformin promoted revascularization in the presence of tissue ischemia through an AMPK/eNOS-related mechanism." | 3.81 | Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model. ( Komori, K; Murohara, T; Ouchi, N; Shibata, R; Sugimoto, M; Takahashi, N, 2015) |
| "FDA-approved ritonavir and metformin effectively target multiple myeloma cell metabolism to elicit cytotoxicity in multiple myeloma." | 3.81 | Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin. ( Adekola, KU; Bajpai, R; Dalva-Aydemir, S; Kandela, I; Koblinski, JE; Martinez, M; Raje, NS; Rosen, ST; Shanmugam, M; Singhal, S; Wei, C, 2015) |
| " What is the main finding and its importance? We demonstrated, for the first time, that DPP-4 inhibitor, but not metformin, exerted similar efficacy in improving cardiac function and attenuating cardiac fibrosis compared with enalapril in rats with chronic MI." | 3.81 | Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Inthachai, T; Kumfu, S; Lekawanvijit, S; Pongkan, W, 2015) |
| " In this study, the effect of metformin on senescence and antisenescence mediators (SirT1-7, p53, and p16(INK4a)) mRNA expression in white blood cells (WBCs) following lipopolysaccharides (LPS)-induced inflammation in mice was examined." | 3.81 | Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin. ( Aljada, A, 2015) |
| "We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth." | 3.81 | Impact of diabetes type II and chronic inflammation on pancreatic cancer. ( Albert, AC; Amme, J; Bürtin, F; Partecke, LI; Radecke, T; Vollmar, B; Zechner, D, 2015) |
| "To examine, in an animal study, whether EA combined with metformin (EA-metformin) results in a better glucose-lowering effect and greater insulin sensitivity than metformin alone in steroid-induced insulin-resistant rats." | 3.81 | Electroacupuncture plus metformin lowers glucose levels and facilitates insulin sensitivity by activating MAPK in steroid-induced insulin-resistant rats. ( Chang, SL; Lee, YC; Liao, HY; Lin, JG; Sun, MF, 2015) |
| "To evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction." | 3.81 | Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance. ( Alexandre, EC; Antunes, E; Calixto, MC; Calmasini, FB; Silva, FH, 2015) |
| " Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)." | 3.81 | Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015) |
| "To investigate the expression of silent information regulator 1 (SIRT1) in rats with polycystic ovary syndrome (PCOS) and its alteration after exenatide treatment." | 3.81 | Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. ( Ge, SQ; Tao, X; Zhang, B; Zhang, EH; Zhang, X, 2015) |
| "Metformin decreases polycystic ovary syndrome (PCOS) symptoms, induces ovulation, and may improve developmental competence of in vitro oocyte maturation." | 3.81 | Does metformin improve in vitro maturation and ultrastructure of oocytes retrieved from estradiol valerate polycystic ovary syndrome-induced rats. ( Mesbah, F; Mirkhani, H; Moslem, M; Vojdani, Z, 2015) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 3.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| " Many of these compounds, including olanzapine, cause metabolic side-effects such as impaired glucose tolerance and insulin resistance." | 3.80 | Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine. ( Asiri, Y; Barr, AM; Boyda, HN; Honer, WG; Lo, R; Pang, CC; Procyshyn, RM; Wang, CK; Wu, C, 2014) |
| "In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet." | 3.80 | Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014) |
| " Whether the vascular benefits of antidiabetic drug metformin (AMPK activator) in diabetes mellitus and obesity is mediated by PPARδ remains unknown." | 3.80 | Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. ( Cheang, WS; Chen, ZY; Huang, Y; Lau, CW; Lee, SS; Tian, XY; Wang, N; Wong, WT; Yao, X, 2014) |
| " To better understand the pathophysiology of obesity-associated NAFLD, the present study examined the involvement of liver and adipose tissues in metformin actions on reducing hepatic steatosis and inflammation during obesity." | 3.80 | Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity. ( An, X; Botchlett, R; Chen, L; Guo, T; Guo, X; Hu, X; Huo, Y; Li, H; Li, Q; Pei, Y; Qi, T; Woo, SL; Wu, C; Xiao, X; Xu, H; Xu, Y; Zhao, J; Zhao, Y; Zheng, J, 2014) |
| "These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease." | 3.80 | Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014) |
| "Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed." | 3.80 | Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats. ( Gao, Y; Luo, L; Pan, T; Wang, C, 2014) |
| "To study the effect of Mudan Granule (MD) on the glucose metabolism and beta cell function in monosodium glutamate (MSG) induced obese mice with insulin resistance (IR)." | 3.80 | [Effect of Mudan Granule on islets beta cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study]. ( Hou, SC; Liu, Q; Liu, SN; Shen, ZF; Sun, SJ, 2014) |
| "In an experimental model of obesity and hyperglycemia in Drosophila melanogaster we studied the effect of diet modification and administration of metformin on systemic infection with Rhizopus, a common cause of mucormycosis in diabetic patients." | 3.80 | Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. ( Albert, N; Do, KA; Farmakiotis, D; Kim-Anh, D; Kontoyiannis, DP; Shirazi, F; Yan, Y, 2014) |
| "Using ApoE−/− C57BL/6J mice, we found that metformin attenuates atherosclerosis and vascular senescence in mice fed a high‐fat diet and prevents the upregulation of angiotensin II type 1 receptor by a high‐fat diet in the aortas of mice." | 3.80 | Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. ( Alexander, RW; Fei, B; Forouzandeh, F; Hilenski, L; Patrushev, N; Salazar, G; Xiong, S, 2014) |
| "Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells." | 3.79 | Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner. ( Abbe, P; Allegra, M; Bahadoran, P; Ballotti, R; Bertolotto, C; Cerezo, M; Giacchero, D; Lehraiki, A; Ohanna, M; Rocchi, S; Rouaud, F; Tartare-Deckert, S; Tichet, M, 2013) |
| " Metformin is a first-line drug for treatment of type 2 diabetes that improves peripheral insulin resistance." | 3.79 | TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats. ( Ito, R; Matsuda-Nagasumi, K; Mori, I; Negoro, N; Takeuchi, K; Tsujihata, Y, 2013) |
| "Increased angiotensin II (AngII) levels cause hypertension, which is a major risk factor for erectile dysfunction (ED)." | 3.79 | Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. ( Labazi, H; Tostes, R; Webb, RC; Wynne, BM, 2013) |
| "Metformin treatment in the context of metabolic syndrome and myocardial ischemia dramatically upregulates the insulin signaling pathway in chronically ischemic myocardium, which is at the crossroads of known metabolic and survival benefits of metformin." | 3.79 | Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome. ( Chu, LM; Elmadhun, NY; Lassaletta, AD; Sellke, FW, 2013) |
| "This is the first study to show that metformin can improve immunosuppressant-induced hyperglycemia, when administered concurrently, and reduces exocrine apoptosis (reducing the impact on potential islet progenitor cells)." | 3.79 | Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. ( Bennett, RG; Clure, CC; Hamel, FG; Larsen, JL; Shivaswamy, V, 2013) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 3.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "To investigate the therapeutic effects of metformin, a commonly used antidiabetic drug, in preventing endotoxin-induced uveitis (EIU) in rats." | 3.78 | Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. ( Ansari, NH; Kalariya, NM; Ramana, KV; Shoeb, M; Srivastava, SK, 2012) |
| "Metformin inhibits the growth of most tumor cells, but BRAF-mutant melanoma cells are resistant to metformin in vitro, and metformin accelerates their growth in vivo." | 3.78 | Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. ( Hayward, R; Marais, R; Martin, MJ; Viros, A, 2012) |
| " We hypothesised that intervention with metformin would diminish the HF-feeding-evoked cognitive deficit by improving insulin sensitivity." | 3.78 | A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. ( Balfour, DJ; McNeilly, AD; Stewart, CA; Sutherland, C; Williamson, R, 2012) |
| " Metformin treatment improved the insulin sensitivity, and normalized the in vitro bladder hypercontractility and cystometric dysfunction in obese mice." | 3.78 | Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. ( Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A, 2012) |
| "The administration of a HFD induces insulin resistance in the liver sinusoidal endothelium, which is mediated, at least in part, through iNOS upregulation and can be prevented by the administration of metformin." | 3.77 | Insulin resistance and liver microcirculation in a rat model of early NAFLD. ( Abraldes, JG; Bosch, J; García-Pagán, JC; La Mura, V; Pasarín, M; Rodríguez-Vilarrupla, A, 2011) |
| "To investigate the potential preventive effects of metformin on non-alcoholic fatty liver disease (NAFLD) and roles of phospholipase A2/lysophosphatidylcholine pathway in hepatocyte lipoapoptosis in a rat NAFLD model induced by high-fat diet." | 3.77 | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. ( Fu, JF; Huang, Y; Liu, LR; Shi, HB, 2011) |
| " Metformin mediates a phenotypic shift away from lipid accretion through AMPK-NAMPT-SIRT1 mediated changes in clock components, supporting chronotherapeutic treatment approaches for obesity." | 3.77 | Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice. ( Caton, PW; Holness, MJ; Kieswich, J; Sugden, MC; Yaqoob, MM, 2011) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 3.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway." | 3.76 | Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. ( Feng, W; Fu, Y; Lu, Z; Ma, X; Shen, Q; Xiao, H; Xu, M; Zhang, Y; Zhu, Y, 2010) |
| "Clinical studies have reported that the widely used antihyperglycemic drug metformin significantly reduces cardiac risk factors and improves clinical outcomes in patients with heart failure." | 3.75 | Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. ( Anaya-Cisneros, M; Calvert, JW; Gundewar, S; Jha, S; Ji, SY; Lefer, DJ; Nunez, D; Ramachandran, A; Tian, R; Toedt-Pingel, I, 2009) |
| "The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen." | 3.75 | Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. ( Erdemoglu, E; Giray, SG; Güney, M; Mungan, T; Take, G, 2009) |
| " We followed the spontaneous evolution of liver steatosis and tested the therapeutic usefulness of metformin and fenofibrate in a model of steatosis, the Zucker diabetic fatty (ZDF) rat." | 3.75 | Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. ( Abdallah, P; Basset, A; Beylot, M; del Carmine, P; Forcheron, F; Haffar, G, 2009) |
| "To make available experimental model for the metabolic syndrome (MS) and verify effects of chronic oral treatment with metformin upon blood pressure (BP), body weight (BW), glucose metabolism, epididimal fat content (EF)." | 3.75 | [Metformin effects upon blood pressure and glucose metabolism of monossodium glutamate induced-obese spontaneously hypertensive rats]. ( Cesaretti, ML; Ferreira, CB; Ginoza, M; Kohlmann, O, 2009) |
| " These mice also have enhanced inflammatory responses to ozone, a common air pollutant that exacerbates asthma." | 3.74 | No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice. ( Shore, SA; Williams, ES; Zhu, M, 2008) |
| "Prominent weight gain (mostly subcutaneous fat area) was observed in the pioglitazone-treated OLETF (O-P) rats versus significant weight loss was observed in the metformin-treated OLETF (O-M) rats." | 3.74 | The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats. ( Ahn, CW; Cha, BS; Choi, SH; Kim, DJ; Kim, SK; Lee, HC; Lee, YJ; Lim, SK; Zhao, ZS, 2007) |
| "Metformin, even at a dose mimicking accumulation, does not aggravate the mortality rate in this model of sepsis." | 3.73 | Effect of metformin on survival rate in experimental sepsis. ( Bouffandeau, B; Gras, V; Lalau, JD; Montravers, PH, 2006) |
| "To investigate the therapeutic effects of insulin-sensitizing drugs, rosiglitazone and metformin, on nonalcoholic fatty liver disease (NAFLD)." | 3.73 | [Therapeutic effects of insulin-sensitizing drugs on nonalcoholic fatty liver disease: experiment with rats]. ( Chen, WK; Wang, T; Zhang, DM; Zhang, GY; Zhong, HJ, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 3.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "Metformin was administrated through daily intraperitoneal injection from postnatal day 35 for 4 weeks." | 3.11 | Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice. ( Chang, MY; Chou, LF; Hsu, SH; Hung, CC; Ong, ACM; Tian, YC; Tsai, CY; Yang, CW; Yang, HY, 2022) |
| "Metformin is a pleiotropic drug, modulating different targets such as AMPK, insulin signalling and many others." | 2.82 | Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder. ( Casterá, F; Gómez-Escribano, AP; Herrero, MJ; Millán, JM; Peiró, C; Tortajada-Pérez, J; Trujillo-Del Río, C; Vázquez-Manrique, RP, 2022) |
| "Metformin is a drug in the family of biguanide compounds that is widely used in the treatment of type 2 diabetes (T2D)." | 2.72 | Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease. ( Sánchez, MP; Sanz, P; Serratosa, JM, 2021) |
| "Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2 diabetes mellitus with obesity." | 2.66 | Metformin: the updated protective property in kidney disease. ( Chen, X; Guo, F; Liao, S; Liu, HF; Lu, X; Pan, Q; Yang, C; Zhao, C, 2020) |
| "Breast cancer is the most ubiquitous type of neoplasms among women worldwide." | 2.66 | Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. ( Manoharan, R; Natarajan, SR; Ponnusamy, L; Thangaraj, K, 2020) |
| "Mycophenolic acid was detected in all cats." | 2.61 | ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019) |
| "It is thought that it exerts its anti-cancer effect through the inhibition of the mammalian target of rapamycin (mTOR) signalling pathway." | 2.61 | The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth. ( Amin, S; Lux, A; O'Callaghan, F, 2019) |
| "Metformin is a first-line therapy for type 2 diabetes." | 2.61 | Metformin: Mechanisms in Human Obesity and Weight Loss. ( Soukas, AA; Yerevanian, A, 2019) |
| "Metformin has been the first-line drug for the treatment of type II diabetes mellitus for decades, being presently the most widely prescribed antihyperglycemic drug." | 2.61 | Metformin and Breast Cancer: Molecular Targets. ( Azevedo, A; Faria, J; Martel, F; Negalha, G, 2019) |
| "Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS)." | 2.61 | A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice. ( Craig, A; Issberner, J; Parvez, F, 2019) |
| "Epilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1% of global population making it a serious health concern." | 2.61 | Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk. ( H S, N; K L, K; Paudel, YN, 2019) |
| "Metformin has been shown to exert beneficial effects on the kidney in various clinical trials and experimental studies performed in divergent rodent models representing different types of renal diseases going from AKI to CKD." | 2.58 | Metformin: A Candidate Drug for Renal Diseases. ( Corremans, R; D'Haese, PC; Neven, E; Verhulst, A; Vervaet, BA, 2018) |
| "Metformin has the potential effect of inducing hippocampal neurogenesis, and additional studies of this drug are warranted in patients with mood or cognitive disorders." | 2.49 | A "glucose eater" drug as a therapeutic agent in psychiatry. ( Howland, RH, 2013) |
| "Colorectal cancer is the third leading cause of cancer death in Japan and the United States and is strongly associated with obesity, especially visceral obesity." | 2.49 | Colon epithelial proliferation and carcinogenesis in diet-induced obesity. ( Endo, H; Hosono, K; Nakajima, A; Takahashi, H, 2013) |
| "Hyperglycemia is a known exacerbating factor in ischemic stroke." | 2.47 | [Effectiveness of metformin in prevention of development of hyperglycemia and neuronal damage caused by ischemic stress]. ( Fujita-Hamabe, W; Harada, S; Tokuyama, S, 2011) |
| "Obesity and insulin resistance have been associated with breast cancer risk, and breast cancer outcomes." | 2.47 | Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin. ( Goodwin, PJ; Stambolic, V, 2011) |
| "Obesity is not necessary to observe insulin resistance in humans since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART (highly-active antiretroviral therapy) - associated lipodystrophy." | 2.43 | The fatty liver and insulin resistance. ( Westerbacka, J; Yki-Järvinen, H, 2005) |
| "Metformin therapy was found to eliminate fatty liver disease in this model." | 2.42 | Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach. ( Barkin, JS; Hookman, P, 2003) |
| "Metformin is a hypoglycaemic agent widely used in the management of type 2 diabetes." | 2.42 | Antiatherogenic properties of metformin: the experimental evidence. ( Mamputu, JC; Renier, G; Wiernsperger, NF, 2003) |
| "Metformin was administrated through drinking water for four months, and we observed tau spreading in the brain of tau-seeded PS19 mice." | 1.91 | Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. ( Chen, Y; Fan, Z; Li, K; Li, Z; Liu, Z; Pu, J; Shen, T; Tian, J; Yan, Y; Yuan, Y; Zhang, B; Zhang, X; Zhao, S, 2023) |
| " Long-term use of metformin, an AMPK activator, was previously reported to be neuroprotective, as it promotes behavioral improvement and angiogenesis following an acute ischemic injury of the brain." | 1.91 | Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice. ( Cai, B; Xie, W; Zeng, Y; Zheng, Y, 2023) |
| "Metformin was administered via drinking water to mice with a unilateral ureteric obstruction (UUO) model of renal fibrosis." | 1.91 | Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney. ( Gleich, K; Harley, G; Katerelos, M; Lee, M; Mount, PF; Power, DA, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide." | 1.91 | Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS ( Andia, ME; Arrese, M; Aspichueta, P; Botnar, RM; Buqué, X; Eykyn, TR; Kumar, S; Lavin, B; Phinikaridou, A; Sing-Long, C; Xavier, A, 2023) |
| "CA6 and CA12 (p." | 1.91 | Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment. ( Nieoczym, D; Pieróg, M; Samorek-Pieróg, M; Socała, K; Wlaź, P; Wyska, E, 2023) |
| "However, the mechanisms and treatments for depression in AR remain underexplored." | 1.91 | Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage. ( Chen, S; Cong, J; Gao, Z; Guan, M; Liu, P; Lv, H; Wang, Y; Xie, Y; Xu, Y, 2023) |
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 1.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "In addition, the benefits of metformin treatment of depression have been documented in a range of rodent studies and human trials, but few studies have probed into the effect of metformin on and the related mechanism in depressed elderly mice, especially in those APOE4 carriers." | 1.72 | Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis. ( Chen, X; Dai, X; Lin, Y; Zhang, J, 2022) |
| "Metformin was found to have a neuroprotective effect on the retina in ENU induced rat model of RP." | 1.72 | Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa? ( Ahmed, AA; Eltony, SA; Mohaseb, HS; Sayed, MM, 2022) |
| "Metformin, a first-line treatment for diabetes, has shown promising results in the treatment for other diseases and is known to interact with the mitochondria." | 1.72 | Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit. ( Becker, LB; Chillale, RK; Choudhary, RC; Frankfurt, M; Haque, S; Kim, J; Kim, N; Miyara, SJ; Molmenti, EP; Shoaib, M; Yin, T; Zanos, S, 2022) |
| "Metformin treatments did not change IR and Akt expressions but increased pIR and pAkt expressions." | 1.72 | Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease. ( Kazkayasi, I; Nemutlu, E; Telli, G; Uma, S, 2022) |
| "Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice." | 1.72 | Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022) |
| "Metformin was able to inhibit depressive-like behavior and increase signaling pathway proteins, transcription factors and autophagosome-forming proteins, thus inducing autophagy in both the hippocampus and the substantia nigra." | 1.72 | Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus. ( da Silva, RS; de Melo, MG; de Paiva, IHR; do Nascimento, MIX; Duarte-Silva, EP; Mendonça, IP; Peixoto, CA, 2022) |
| "The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo." | 1.72 | Epithelial-mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model. ( Almeida, CP; da Silva, VHSR; de Araújo Campos, MR; de Carvalho, BA; de Souza Silva, FH; Del Puerto, HL; Ferreira, E; Lima, BM; Ribeiro, TS; Rocha, SA; Veloso, ES, 2022) |
| "Dengue is a prevalent mosquito-borne viral infection in the tropical and sub-tropical regions." | 1.62 | In vitro and in vivo efficacy of Metformin against dengue. ( Alonso, S; Cheang, YZN; Koh, HQV; Ting, HRD, 2021) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 1.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "The anti-diabetic nephropathy properties were systematically analyzed in the diabetic db/db mice treated with Met, BBR or with combination of Met and BBR." | 1.62 | Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation. ( Sun, G; Sun, X; Zhang, B; Zhang, C; Zhang, X, 2021) |
| "Ulcerative colitis is an inflammatory condition of the colon." | 1.62 | Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling. ( Liu, X; Sun, Z; Wang, H, 2021) |
| "Fibrosis was significantly less in treated mice atria." | 1.62 | Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021) |
| "Metformin treatment altered the metabolomics profiles of diabetic rats and lowered their blood sugar levels." | 1.62 | The effects of high-fat diet and metformin on urinary metabolites in diabetes and prediabetes rat models. ( Gam, LH; Greimel, P; Ibrahim, B; Ismail, MN; Lee, YF; Murugaiyah, V; Sim, XY; Teh, YH, 2021) |
| "Metformin has protective effects on diabetic nephropathy." | 1.62 | Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway. ( Cai, W; Fu, Y; Hong, L; Liu, T; Qiao, X; Wang, M; Yang, Y; Zheng, Z; Zhong, M, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 1.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility." | 1.62 | The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet. ( Almaghrawi, W; Henkel, R; Leisegang, K, 2021) |
| "Metformin has exhibited anti-inflammatory and neuroprotective properties in numerous studies." | 1.62 | Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation. ( Anand, S; Bhatia, A; Bojja, SL; Joshi, R; Medhi, B; Minz, RW, 2021) |
| "Metformin is an AMP kinase (AMPK) activator, the widest used antidiabetic drug." | 1.62 | Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats. ( Ammar, HI; Ashour, H; Dhingra, S; Fadel, M; Kamar, SS; Rashed, LA; Shamseldeen, AM; Shoukry, HS; Srivastava, A, 2021) |
| "Metformin was administrated in the drinking water for 2 months." | 1.62 | Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice. ( Chen, Y; Fan, Z; Li, K; Li, Z; Liu, Z; Shen, T; Tian, J; Yan, Y; Zhang, B; Zhao, S; Zhu, Y, 2021) |
| "A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)." | 1.62 | Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021) |
| "0." | 1.62 | Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes. ( Chen, X; Chen, Y; Gu, H; Li, M; Lin, S; Song, C; Xiao, T; Xu, S, 2021) |
| "Treatment with metformin suppressed the activation of Smad3 and compensated the diminished autophagy in 9-wk pBOO rat bladders." | 1.62 | Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction. ( Chen, L; Cui, J; Gao, Z; Jiang, X; Li, Y; Liu, Y; Lv, L; Shi, B; Wang, S; Xia, Y; Zhang, L; Zhang, X; Zhou, N, 2021) |
| "Metformin was administered orally every day to rats with OA." | 1.62 | Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021) |
| "Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis." | 1.62 | Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis. ( Akar, ZA; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2021) |
| "Metformin has been shown to expand the endogenous neural stem cell (NSC) pool and promote neurogenesis under physiological conditions and in response to neonatal brain injury, suggesting a potential role in neurorepair." | 1.62 | Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation. ( Derkach, D; Heidari, M; Kehtari, T; Lakshman, N; Morshead, CM; Renaud, M, 2021) |
| " This study is designed to explore the therapeutic potential of metformin and montelukast, in combination with Lactobacillus, for modulation of intestinal flora and suppression of oxidative stress in testicular and liver damage in diabetic male rats." | 1.62 | The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress. ( El-Baz, AM; El-Sokkary, MMA; Hassan, HM; Khodir, AE; Shata, A, 2021) |
| "Metformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional treatment regimens." | 1.62 | Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects. ( Kemnade, JO; Newton, JM; Sandulache, VC; Sikora, AG; Skinner, HD; Veeramachaneni, R; Yu, W, 2021) |
| "Oxandrolone (OXA) is an androgen and anabolic steroid (AAS) that is used to reverse weight loss associated with some medical conditions." | 1.62 | Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α. ( Abed, AF; Alfaraj, M; Hall, FS; Hammad, AM; Ibrahim, YA; Jarrar, Y; Khdair, SI, 2021) |
| "Metformin is a biguanide antihyperglycemic drug used worldwide for the treatment of type 2 diabetes." | 1.62 | Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice. ( Araújo, SMR; Braga, CF; Duarte-Silva, E; França, MR; Lós, DB; Oliveira, WH; Peixoto, CA; Rocha, SWS; Rodrigues, GB, 2021) |
| "Inflammation is the first stage of this progression, becoming an appealing target of early therapeutic intervention." | 1.62 | Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation. ( Fan, C; He, Y; Li, J; Liu, W; Luo, G; Qian, Y; Sun, Z; Wang, F, 2021) |
| "Metformin treatment reduced liver injury caused by bile acid, and it suppressed ER stress, inflammation, chemokine expression, and neutrophil infiltration." | 1.56 | Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress. ( Cho, DH; Han, JH; Kim, S; Lee, CH; Lee, H; Nam, DH; Woo, CH, 2020) |
| "Metformin is a first-line drug for the treatment of diabetes, and has great potential for the treatment of other disorders." | 1.56 | Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR. ( Bai, X; Cai, D; Feng, X; Li, J; Liu, L; Liu, X; Pan, J; Qi, W; Shao, Y; Xiao, G; Zeng, C; Zhang, H, 2020) |
| "Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion." | 1.56 | Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model ( Cengiz, H; Ekin, M; Güraslan, H; Karakaş, S; Kaya, C; Sakiz, D; Süzen Çaypinar, S; Yaşar, L, 2020) |
| "Unhealthy dietary habits contribute to the increasing incidence of metabolic syndrome and type 2 diabetes (T2D), which is accompanied by oxidative stress, compromised nitric oxide (NO) bioavailability and increased cardiovascular risk." | 1.56 | Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease. ( Andersson, DC; Carlström, M; Cordero-Herrera, I; Guimarães, DD; Han, H; Lundberg, JO; McCann Haworth, S; Moretti, C; Uribe Gonzalez, AE; Weitzberg, E; Zhuge, Z, 2020) |
| "Low-grade inflammation is often higher in older adults and remains a key risk factor of aging-related morbidities and mortalities." | 1.56 | Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis. ( Ahmadi, S; Ding, J; Jain, S; Justice, J; Kitzman, D; Kritchevsky, SB; McClain, DA; Mishra, SP; Nagpal, R; Razazan, A; Wang, B; Wang, S; Yadav, H, 2020) |
| "Metformin has a protective effect on DA neurons against rotenone-induced neurotoxicity through inhibiting neuroinflammation and ER stress in PD mouse model." | 1.56 | Protective effect of metformin against rotenone-induced parkinsonism in mice. ( Chen, AD; Jing, YH; Wang, DX; Wang, QJ; Xin, YY; Yin, J, 2020) |
| "Metformin (Met) has a protective effect on the heart." | 1.56 | Metformin ameliorates cardiac conduction delay by regulating microRNA-1 in mice. ( Fang, R; Li, C; Li, R; Li, X; Li, Y; Liang, H; Liu, Y; Lv, L; Shabanova, A; Shan, H; Yang, R; Zhang, L; Zheng, N; Zhou, Y, 2020) |
| "Metformin treatment caused astrocytes to alter reactive genes in a PD animal model." | 1.56 | Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. ( Choi, JH; Choi, YK; Go, J; Kim, KS; Lee, CH; Lee, TG; Park, HY; Rhee, M; Ryu, YK; Seo, YJ, 2020) |
| "Dapagliflozin treatment results' significantly surpassed improvement of metformin treatment nearly in all parameters." | 1.56 | Dapagliflozin, a sodium glucose cotransporter 2 inhibitors, protects cardiovascular function in type-2 diabetic murine model. ( El-Domiaty, H; El-Nabi, SH; Fayez Ewida, S; Hanna, G; Saleh, S; Shabaan, A, 2020) |
| "Metformin treatment led to an upregulation of clock regulatory genes such as melanopsin (Opn4) and aralkylamine N-acetyltransferase (Aanat)." | 1.56 | Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. ( Alex, A; Bhatwadekar, AD; Di, R; Luo, Q; Mathew, D, 2020) |
| "The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline." | 1.56 | Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease. ( Kluša, V; Langrate, IK; Muceniece, R; Narbute, K; Pilipenko, V; Pupure, J, 2020) |
| "Metformin is an activator of AMP-activated protein kinase (AMPK)." | 1.56 | Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway. ( Ferdowsi, A; Rahimi, S; Siahposht-Khachaki, A, 2020) |
| "Metformin 200 mg/kg was given intravenously to the cardiac I/R group (n = 10/group), either during ischemia (D-MET) or at the onset of reperfusion (R-MET)." | 1.56 | Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats. ( Apaijai, N; Arunsak, B; Benjanuwattra, J; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Jaiwongkam, T; Kerdphoo, S; Wongsuchai, S, 2020) |
| "Metformin was orally administered for two weeks before induction of epilepsy." | 1.56 | Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats. ( Ali, MK; Alireza, MS; Babae, JF; Hashemi, P; Nikbakht, F; Vazifehkhah, S, 2020) |
| "Metformin is an old antidiabetic drug with anti-inflammatory and neuroprotective effects." | 1.56 | The possible role of progranulin on anti-inflammatory effects of metformin in temporal lobe epilepsy. ( Khanizadeh, AM; Mojarad, TB; Nikbakht, F; Vazifehkhah, S, 2020) |
| "Letrozole (1 mg/kg) was administered orally for a period of 28 days to induce PCOS." | 1.56 | The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. ( Ekramzadeh, M; Golmakani, MT; Koohpeyma, F; Sherafatmanesh, S; Tanideh, N, 2020) |
| "Metformin is a primary treatment for type 2 diabetes mellitus that can pass through the blood-brain barrier." | 1.56 | Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. ( Chaisawang, P; Pannangrong, W; Prajit, R; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P, 2020) |
| "Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered." | 1.56 | AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. ( Dayn, A; Dayn, Y; Hellberg, K; Luo, EC; Shaw, RJ; Shokhirev, MN; Van Nostrand, EL; Van Nostrand, JL; Yeo, GW; Yu, J, 2020) |
| "Metformin is a well-tolerated drug for type 2 diabetes with multiple cellular targets." | 1.56 | Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a. ( Chen, J; Flygare, J; Glader, B; Kam, S; Kapur, S; Lin, S; Mercado, J; Narla, A; Perez, CA; Sakamoto, KM; Saxena, M; Serrano, M; Siva, K; Varetti, G; Wentworth, EP; Wilkes, MC, 2020) |
| "Metformin, a drug that has been used to treat type 2 diabetes, was found to have antineoplastic activity in different cancers." | 1.56 | Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer. ( Kong, Y; Li, Z; Liu, J; Liu, X; Mao, F; Wang, R; Zhang, Y; Zhang, Z, 2020) |
| "Tendinopathy is a debilitating tendon disorder that affects millions of Americans and costs billions of health care dollars every year." | 1.56 | Effect of Metformin on Development of Tendinopathy Due to Mechanical Overloading in an Animal Model. ( Hogan, MV; Li, F; Nie, D; Onishi, K; Wang, JH; Zhang, J, 2020) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 1.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Metformin was used as a positive control." | 1.51 | Human adipose tissue mesenchymal stem cells as a novel treatment modality for correcting obesity induced metabolic dysregulation. ( Bhonde, RR; Datta, I; Shree, N; Venkategowda, S; Venkatranganna, MV, 2019) |
| "Systemic inflammation was induced by injecting LPS (1." | 1.51 | Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice. ( Anoopkumar-Dukie, S; Arora, D; Basu Mallik, S; Grant, G; Hall, S; Kinra, M; Mudgal, J; Nampoothiri, M; Rao, CM, 2019) |
| "Metformin-treated mice exhibited suppressed intraperitoneal tumor growth and extended survival, and these effects were lost in mice with severe combined immunodeficiency." | 1.51 | Metformin Prevents Peritoneal Dissemination ( Eguchi, S; Hirayama, T; Kanetaka, K; Kobayashi, S; Matsuo, M; Nagata, Y; Nishida, M; Udono, H; Yoneda, A, 2019) |
| "HER2-positive breast tumors are found in 25-30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both chemotherapy and hormone therapy." | 1.51 | Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor. ( Alexandrov, VA; Baranenko, DA; Bespalov, VG; Filatova, LV; Osipov, MA; Panchenko, AV; Semenov, AL; Semiglazova, TY; Stukov, AN; Tyndyk, ML; Yurova, MN, 2019) |
| "Thus, to understand the cognitive impairments caused by this chemotherapeutic agent, a clinically relevant dose to cancer treatment was used in mice to establish the chemobrain models, and the spatial memory of these mice was assessed using multiple behavior tests." | 1.51 | Ameliorative effect of metformin on cyclophosphamide-induced memory impairment in mice. ( Alhowail, AH; Chigurupati, S; Mani, V; Sajid, S, 2019) |
| "Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice." | 1.51 | Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. ( Bugáňová, M; Haluzík, M; Holubová, M; Kuneš, J; Kuzma, M; Maletínská, L; Pelantová, H; Šedivá, B; Tomášová, P; Železná, B, 2019) |
| "Metformin was injected intraperitoneally after surgery." | 1.51 | Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis. ( Ansong, E; Lin, HL; Lin, Q; Shen, LE; Wu, XQ; Xu, XX; Zhang, SS, 2019) |
| "Metformin-treated mice have unaltered PEVK phosphorylation but increased phosphorylation of PKA sites in the N2B element, a change which has previously been shown to lower titin's stiffness." | 1.51 | Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance. ( Gotthardt, M; Granzier, HL; Liss, M; Methawasin, M; Slater, RE; Strom, JG; Sweitzer, N, 2019) |
| "Treatment with metformin altered macrophage polarization, reduced liver size and reduced micronuclei formation in NAFLD/NASH-associated HCC larvae." | 1.51 | Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish. ( de Oliveira, S; Golenberg, N; Graves, AL; Houseright, RA; Huttenlocher, A; Korte, BG; Miskolci, V, 2019) |
| "Metformin treatment upregulated SIRT3 expression and mitigated loss of cell viability and decreased the generation of mitochondria-induced ROS in chondrocytes stimulated with IL-1β." | 1.51 | Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes. ( Liu, J; Wang, C; Yang, Y; Yao, Z; Zhang, C; Zhang, Y, 2019) |
| "Nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease, and there is currently no available treatment strategy." | 1.51 | Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease. ( Chen, W; Fan, J; Hao, Q; Jin, X; Ju, D; Liu, H; Luan, J; Mei, X; Tang, S; Wu, Z; Zai, W; Zhang, X, 2019) |
| "Metformin pretreatment (a) reduced visceral hypersensitivity to colorectal distension, immobility time and enhanced sucrose consumption; (b) decreased urine lactulose/mannitol ratio and sucralose output; (c) inhibited the dilation of tight junction and prevented claudin-4 translocation; (d) inhibited mast cell activation and downregulated the expression of IL-6, IL-18, tryptase, PAR-2, and ERK activation; (e) inhibited claudin-4 phosphorylation at serine sites and interactions between clau-4 and ZO-1." | 1.51 | Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats. ( Fang, E; Li, S; Li, W; Li, Y; Liu, C; Yang, T; Yao, Q, 2019) |
| "LDH evoked persistent thermal hyperalgesia and mechanical allodynia on the ipsilateral paw, as indicated by the decreased PWL and 50% PWT." | 1.51 | AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. ( Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y, 2019) |
| "Metformin-treated mice revealed increased expression of lipogenic genes, i." | 1.51 | Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice. ( Brichmann, E; Kuhla, A; Meuth, L; Rühlmann, C; Thiele, R; Vollmar, B, 2019) |
| " After 6 weeks of metformin treatment, pharmacodynamic indexes were determined." | 1.51 | In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats. ( Chen, M; Gao, Y; Hu, J; Huang, W; Liu, M; Wu, B; Zhang, W, 2019) |
| "A rodent model of type 2 diabetes (30 mg/kg streptozotocin and high-fat feeding in male Sprague-Dawley rats) was used to assess 12 weeks of co-treatment with a sodium-glucose cotransporter 2 inhibitor (SGLT2i) and exercise (EX; treadmill running) on glycemic control and exercise capacity." | 1.51 | The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes. ( Beebe, DA; Braun, B; Esler, WP; Gorgoglione, MF; Hamilton, KL; Linden, MA; Miller, BF; Ross, TT, 2019) |
| "Metformin reduced salivary gland inflammation and restored the salivary flow rate." | 1.51 | Metformin improves salivary gland inflammation and hypofunction in murine Sjögren's syndrome. ( Cho, ML; Choi, J; Hwang, SH; Jung, KA; Kim, JW; Kim, SM; Kwok, SK; Lee, SY; Park, JS; Park, SH; Ryu, JG, 2019) |
| "Huntington disease is a neurodegenerative condition for which there is no cure to date." | 1.51 | Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease. ( Cañada-Martínez, AJ; García-Gimeno, MA; Millán, JM; Sanchis, A; Sanz, P; Sequedo, MD; Vázquez-Manrique, RP, 2019) |
| "Metformin was titrated to a mean maintenance dose of 1167 mg/day (range: 500-2000 mg)." | 1.51 | Treatment with metformin in twelve patients with Lafora disease. ( Avolio, C; Bisulli, F; Canafoglia, L; d'Orsi, G; Freri, E; Licchetta, L; Martino, T; Michelucci, R; Mostacci, B; Muccioli, L; Pondrelli, F; Riguzzi, P; Tinuper, P, 2019) |
| "Metformin was administered per os (p." | 1.51 | Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019) |
| "Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population." | 1.51 | Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin. ( AbdelMaksoud, S; El-Bahy, AA; Handoussa, H; Khaled, N; Radwan, R, 2019) |
| "Metformin (MET) has anti-inflammatory and anti-fibrotic effects, but its effect on the in vivo pathogenesis of scleroderma remains unknown." | 1.51 | Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation. ( Feng, M; Gao, C; Guo, H; Li, X; Liang, Z; Luo, J; Qin, K; Wang, Y; Zhang, S; Zhao, X, 2019) |
| "Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss." | 1.51 | Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis. ( Grandgirard, D; Le, ND; Leib, SL; Muri, L; Zemp, J, 2019) |
| "Metformin is a medication that is widely prescribed for the management of type 2 diabetes." | 1.48 | Metformin Inhibits the Development of L-DOPA-Induced Dyskinesia in a Murine Model of Parkinson's Disease. ( Choi, DH; Go, J; Hwang, JH; Kim, KS; Kim, YH; Lee, CH; Lee, TG; Noh, JR; Park, HY; Ryu, YK, 2018) |
| "Metformin treatment decreased the expression of IL-1β and IL-6 in epididymal fat, which was correlated with the abundance of various bacterial genera." | 1.48 | Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice. ( An, J; Kim, J; Kim, K; Kong, H; Lee, CK; Lee, H; Lee, S; Lee, Y; Song, Y, 2018) |
| "Metformin was administered orally to mice to test effects on immunohistochemical markers in xenografts." | 1.48 | Metformin Effects on Metabolic Coupling and Tumor Growth in Oral Cavity Squamous Cell Carcinoma Coinjection Xenografts. ( Curry, J; Domingo-Vidal, M; Lin, Z; Martinez-Outschoorn, U; Roche, M; Tassone, P; Tuluc, M; Whitaker-Menezes, D, 2018) |
| "Metformin has been the most prescribed glucose-lowering medicine worldwide, and its potential for many other therapeutic applications is also being explored intensively." | 1.48 | Metformin attenuates folic-acid induced renal fibrosis in mice. ( Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y, 2018) |
| "Metformin is a widely available drug that possesses the ability to activate AMPK." | 1.48 | Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain. ( Ge, A; Miao, B; Wang, S; Yan, M, 2018) |
| "The metformin treatment largely reversed the correlations with diabetes-related pathways." | 1.48 | Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice. ( Cheng, Y; Cui, Q; Fang, W; Guo, J; Guo, L; Hu, G; Li, J; Lin, Y; Man, Y; Sun, M; Wei, J; Zhou, Y, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Metformin is a commonly used drug for the treatment of diabetes." | 1.48 | Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways. ( Li, J; Mi, J; Wang, Y; Xu, W; Yan, H; Yan, Z; Zhao, W, 2018) |
| "Dapagliflozin or metformin treatment decreased insulin resistance, hypercholesterolemia, creatinine clearance and renal oxidative stress leading to improved renal function." | 1.48 | Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model. ( Chatsudthipong, V; Chattipakorn, N; Chueakula, N; Jaikumkao, K; Lungkaphin, A; Pongchaidecha, A; Thongnak, L; Wanchai, K, 2018) |
| "Metformin-treated rats did not develop hyperphosphatemia or hypocalcemia and this prevented the development of vascular calcification and inhibited the progression toward high bone turnover disease." | 1.48 | Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder. ( Brand, K; D'Haese, PC; De Broe, ME; De Maré, A; Gottwald-Hostalek, U; Kamel, S; Lalau, JD; Neven, E; Opdebeeck, B; Verhulst, A; Vervaet, B, 2018) |
| "HFD successfully induces gallstone (4 out of 4 of the HFD members)." | 1.48 | Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice. ( Dehghanian, A; Dorvash, MR; Firouzabadi, N; Khoshnood, MJ; Mosaddeghi, P; Saber, H, 2018) |
| "Sudden cardiac arrest (CA) often results in severe injury to the brain, and neuroprotection after CA has proved to be difficult to achieve." | 1.48 | Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation. ( Gu, Y; Hu, Y; Huang, K; Ji, Z; Liu, K; Pan, S; Zhu, J, 2018) |
| "Metformin and combined treatment groups reduced the body and ovary weights compared to the PCOS group." | 1.48 | Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. ( Ceylan, S; Eraldemır, C; Furat Rencber, S; Guzel, E; Kum, T; Kurnaz Ozbek, S; Sezer, Z, 2018) |
| "Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated." | 1.48 | Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. ( Damsky, WE; Nasiri, AR; Perry, CJ; Perry, RJ; Pollak, MN; Rabin-Court, A; Shulman, GI; Wang, Y; Zhang, XM, 2018) |
| "Metformin has a well described antifibrotic effect, and increases phosphorylation of ACC by AMPK, thereby increasing FAO." | 1.48 | Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin. ( Galic, S; Gleich, K; Katerelos, M; Kemp, BE; Lee, M; Mount, PF; Power, DA, 2018) |
| "Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear." | 1.48 | Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. ( Hughey, CC; Hunter, RW; Jessen, N; Lantier, L; Peggie, M; Sakamoto, K; Sicheri, F; Sundelin, EI; Wasserman, DH; Zeqiraj, E, 2018) |
| "Non‑alcoholic fatty liver disease (NAFLD), which affects approximately one‑third of the general population, has become a global health problem." | 1.48 | Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling. ( Gao, S; Huang, D; Huang, J; Tong, P; Wang, Y; Wu, X; Yue, Y; Zhao, J, 2018) |
| "Metformin has both hypoglycaemic effects and reno-protection ability." | 1.48 | Metabolic profiling of metformin treatment for low-level Pb-induced nephrotoxicity in rat urine. ( Chen, SM; Huang, YS; Lee, JA; Wang, SH, 2018) |
| "Metformin has a protective effect on noise-induced hearing loss in rats." | 1.48 | The protective effect of metformin against the noise-induced hearing loss. ( Erbek, HS; Erdem, ŞR; Gürgen, SG; Kesici, GG; Öcal, FCA; Öğüş, E; Özlüoğlu, LN, 2018) |
| "In the present study, type 2 diabetes was induced in male Goto‑Kakizaki (GK) rats fed with high‑fat diet (HFD)." | 1.48 | Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet. ( Fang, H; Hu, J; Li, M, 2018) |
| "Mast cells are major effectors of allergy and asthma, and can be activated by the alarmin IL-33, which is linked to allergic disease." | 1.48 | Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis. ( Baldwin, EA; Barnstein, BO; Caslin, HL; Haque, T; Pondicherry, N; Ryan, JJ; Taruselli, MT, 2018) |
| "Metformin has been widely used for the treatment of type 2 diabetes." | 1.46 | Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. ( Kyohara, M; Okuyama, T; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y; Yamazaki, S, 2017) |
| "Metformin (MET) is an anti-diabetic drug used to prevent hepatic glucose release and increase tissue insulin sensitivity." | 1.46 | Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster. ( Constante, SAR; de Rezende, AAA; Nepomuceno, JC; Oliveira, VC; Orsolin, PC; Spanó, MA, 2017) |
| "Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies." | 1.46 | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. ( Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC, 2017) |
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 1.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| "Metformin treatment led to maintained good glycemic control and improved neuropathy and pancreatic lesions in female SDT fatty rats." | 1.46 | Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model. ( Fatchiyah, F; Miyajima, K; Murai, Y; Ohta, T; Shinohara, M; Tadaki, H; Yamada, T, 2017) |
| "Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed." | 1.46 | Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity. ( Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S, 2017) |
| "Metformin restrained esophageal cancer cell proliferation partly by suppressing the PI3K/AKT/mTOR pathway." | 1.46 | Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells ( An, R; Jiang, YQ; Tang, JC; Yang, J, 2017) |
| " Chitosan cross-linked alginate provides improvement of swelling and mucoadhesive properties and might be used to design sustained release dosage forms." | 1.46 | The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation. ( Kasacka, I; Lewandowska, A; Sosnowska, K; Szekalska, M; Winnicka, K; Zakrzeska, A, 2017) |
| "Atherosclerosis is known to be the primary underlying factor responsible for the development of cardiovascular diseases." | 1.46 | Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis. ( An, Y; Fang, W; Ma, A; Wang, D; Zhu, H, 2017) |
| "Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress." | 1.46 | Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis. ( Crocenzi, FA; Cumino, AC; Dávila, VA; Loos, JA; Petrigh, R; Rodrígues, CR; Zoppi, JA, 2017) |
| "Metformin was shown to interact with Hh signaling by inhibiting the effector protein glioma-associated oncogene homolog 1 (GLI1) in PCa cells both in vitro and in vivo." | 1.46 | The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells. ( Gonnissen, A; Haustermans, K; Isebaert, S; McKee, CM; Muschel, RJ, 2017) |
| "Metformin has inhibitory effect on passive cutaneous anaphylaxis." | 1.43 | Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. ( Huang, DW; Huang, DY; Lin, KC; Lin, WW; Tzeng, SJ, 2016) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Metformin treatment decreased very long chain fatty acid levels and pro-inflammatory cytokine gene expressions in X-ALD patient-derived cells." | 1.43 | Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase. ( Felicella, MM; Giri, S; Olle, B; Singh, J; Suhail, H, 2016) |
| "Metformin is an attractive agent for chemoprevention because it is inexpensive, has a favorable safety profile, and is well tolerated over long time periods." | 1.43 | Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis. ( Chung, RT; DePeralta, DK; Fuchs, BC; Ghoshal, S; Lanuti, M; Lauwers, GY; Schmidt, B; Tanabe, KK; Wei, L, 2016) |
| "In addition, we observed that bladder cancer cell lines (RT4, UMUC-3, and J82) with homozygous deletion of either TSC1 or PTEN are more sensitive to metformin than those (TEU2, TCCSUP, and HT1376) with wild-type TSC1 and PTEN genes." | 1.43 | High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum. ( Avizonis, D; Blair, CA; Li, X; Liu, Z; McClelland, M; Pollak, M; Uchio, E; Wu, XR; Yokoyama, NN; Youssef, R; Zi, X, 2016) |
| "Pretreatment with metformin in I/R animals reduced levels of pro-BDNF compared with the I/R group (p < 0." | 1.43 | Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway. ( Ashabi, G; Ghadernezhad, N; Khalaj, L; Mirmasoumi, M; Pazoki-Toroudi, H, 2016) |
| "Metformin (MET) was administered to activate AMPK." | 1.43 | Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery. ( Han, D; Ke, R; Li, M; Li, S; Liu, L; Song, Y; Xie, X; Yang, L; Zhang, Y; Zhu, Y, 2016) |
| "Metformin was treated daily for 14 weeks in a high-fat dieting C57BL/6J mice." | 1.43 | Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21. ( Byun, JK; Cho, ML; Choi, JY; Jeong, JH; Jhun, JY; Kim, EK; Kim, JK; Lee, SH; Lee, SY, 2016) |
| "Metformin is a widely used drug to treat patients with type II diabetes." | 1.43 | Metformin blocks progression of obesity-activated thyroid cancer in a mouse model. ( Cheng, SY; Enomoto, K; Kim, WG; Park, J; Willingham, M; Zhao, L, 2016) |
| " Long-term administration of metformin improved health and life span in mice." | 1.43 | Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics. ( Anders, NM; Duan, W; Gu, H; Jiang, M; Jin, J; Peng, Q; Ren, T; Rudek, MA; Tao, M, 2016) |
| "Metformin is a biguanide antidiabetic medication and its pharmacological action is mediated through the activation of AMP-activated protein kinase (AMPK), which regulates not only energy homeostasis but also stress responses, including ROS." | 1.43 | Metformin attenuates lung fibrosis development via NOX4 suppression. ( Araya, J; Fujita, Y; Hara, H; Hashimoto, M; Ito, S; Kadota, T; Kaneko, Y; Kobayashi, K; Kohrogi, H; Kojima, J; Kurita, Y; Kuwano, K; Minagawa, S; Morikawa, T; Nakayama, K; Numata, T; Odaka, M; Saito, N; Sato, N; Takasaka, N; Tsubouchi, K; Utsumi, H; Wakui, H; Yanagisawa, H; Yoshida, M, 2016) |
| "Metformin treatment suppressed EC cell growth in a time-dependent manner in vitro; this effect was cancelled by cotreatment with an AMPK inhibitor, compound C." | 1.43 | Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway. ( Cai, B; Cheng, J; Hong, L; Hu, Y; Huang, J; Huang, T; Li, Z; Luo, C; Wen, T; Yuan, H; Zhang, X; Zhang, Y; Zhu, Y; Zhuang, W; Zou, J, 2016) |
| "Pancreatic cancer is one of the hardest-to-treat types of neoplastic diseases." | 1.43 | Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer. ( Bezawork-Geleta, A; Boukalova, S; Cerny, J; Dong, L; Drahota, Z; Ezrova, Z; Neuzil, J; Pecinova, A; Stursa, J; Werner, L, 2016) |
| "A significant decrement of hyperinsulinemia, triglyceridemia, serum IL6 and oxidised LDL were observed at the end of the study." | 1.43 | Metformin preconditioned adipose derived mesenchymal stem cells is a better option for the reversal of diabetes upon transplantation. ( Bhonde, RR; Shree, N, 2016) |
| "Metformin was also given as a standard control to one of the rat groups." | 1.43 | Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. ( Afsar, T; Ain, QU; Almajwal, A; Jahan, S; Mehboob, A; Munir, F; Razak, S; Shaheen, G; Ullah, H, 2016) |
| "Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression." | 1.42 | Metformin treatment alters memory function in a mouse model of Alzheimer's disease. ( DiTacchio, KA; Dziewczapolski, G; Heinemann, SF, 2015) |
| "Metformin promotes irisin release from murine skeletal muscle into blood, independently of AMPK pathway activation." | 1.42 | Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation. ( Deng, YP; Huang, F; Jiang, GJ; Li, DJ; Lu, WJ; Shen, FM, 2015) |
| "Three differently-differentiated gastric cancer cell lines, MKN-28, SGC-7901 and BGC-823, along with one noncancerous gastric cell line GES-1 were used." | 1.42 | AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. ( Gong, H; Guo, S; Han, G; Liu, K; Wang, Y, 2015) |
| "Bariatric surgery rapidly improves Type 2 diabetes mellitus (T2DM)." | 1.42 | Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. ( Abegg, K; Boza, C; Corteville, C; Docherty, NG; le Roux, CW; Lutz, TA; Muñoz, R, 2015) |
| "Metformin was administered by gavage or in the diet, at a human equivalent dose, in standard mammary cancer models: (i) methylnitrosourea (MNU)-induced estrogen receptor-positive (ER(+)) mammary cancers in rats, and (ii) MMTV-Neu/p53KO ER(-) (estrogen receptor-negative) mammary cancers in mice." | 1.42 | Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models. ( Bennett, C; Bernard, PS; Bode, AM; Green, JE; Grubbs, CJ; Juliana, MM; Lubet, RA; McGovern, R; Moeinpour, F; Reid, JM; Steele, VE; Stijleman, IJ; Thompson, MD, 2015) |
| "Metformin pretreatment protected against APAP toxicity with decreased liver damage, and inhibited APAP-induced prolonged hepatic JNK phosphorylation in WT mice." | 1.42 | Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. ( Choi, DH; Choi, HS; Hwang, JH; Kim, DK; Kim, KS; Kim, YH; Lee, CH; Noh, JR; Tadi, S; Yim, YH, 2015) |
| "Treatment with metformin of athymic nude mice bearing xenograft tumors reduced tumor proliferation." | 1.42 | Antidiabetic drug metformin inhibits esophageal adenocarcinoma cell proliferation in vitro and in vivo. ( Chiyo, T; Fujihara, S; Iwama, H; Kato, K; Kobara, H; Kobayashi, M; Masaki, T; Miyoshi, H; Mori, H; Morishita, A; Nishioka, T; Nishiyama, N; Okano, K; Suzuki, Y, 2015) |
| "Increasing prevalence of type 2 diabetes in women of childbearing age has led to a higher incidence of diabetes-associated birth defects." | 1.42 | Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy. ( Fu, M; Quon, MJ; Wang, C; Wang, F; Wu, Y; Yang, P, 2015) |
| "Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage." | 1.42 | Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes. ( Abdelkader, D; Chen, Y; Hassan, W; Liu, J; Sun, H; Wang, X, 2015) |
| "Metformin treatment in RD and HED mice resulted in a significant reduction in tumor burden in the peritoneum, liver, kidney, spleen and bowel accompanied by decreased levels of growth factors (IGF-1, insulin and leptin), inflammatory cytokines (MCP-1, IL-6) and VEGF in plasma and ascitic fluid, akin to the CR diet mice." | 1.42 | Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction. ( Al-Wahab, Z; Ali-Fehmi, R; Chhina, J; Giri, S; Hijaz, M; Mert, I; Morris, RT; Munkarah, AR; Rattan, R; Tebbe, C, 2015) |
| "Inhibition of prostate cancer progression in HiMyc mice by RAPA was associated with a significant reduction in mTORC1 signaling that was further potentiated by the combination of MET and RAPA." | 1.42 | Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice. ( Blando, J; DiGiovanni, J; Saha, A; Tremmel, L, 2015) |
| "Metformin treatment prevented acute stress-induced necroinflammatory reaction, reduced alanine aminotransferase and aspartate aminotransferase serum activity, and diminished lipoperoxidation." | 1.42 | Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. ( Burian, M; Cahova, M; Cervinkova, Z; Dankova, H; Drahota, Z; Gladkova, C; Kazdova, L; Krizova, J; Kucera, O; Oliyarnyk, O; Palenickova, E; Papackova, Z; Sticova, E; Stopka, P, 2015) |
| "Treatment with metformin inhibited the expression of interleukin (IL)-17, p-STAT3, and p-mTOR." | 1.42 | Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance. ( Cho, ML; Kim, EK; Kim, JK; Lee, SH; Lee, SY; Shin, DY; Yang, EJ, 2015) |
| "The prognosis of pancreatic cancer remains dismal, with little advance in chemotherapy because of its high frequency of chemoresistance." | 1.42 | Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling. ( Chai, X; Chu, H; Gou, S; Meng, Y; Shi, P; Yang, X, 2015) |
| "Metformin treatment was similarly evaluated and found not to have adverse effects on pancreas." | 1.40 | Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin. ( Cunningham, C; Dey, M; Forest, T; Frederick, C; Holder, D; Prahalada, S; Smith, A; Yao, X, 2014) |
| "Metformin was not cytotoxic or radioprotective in cultured auditory hair cells." | 1.40 | Safety and otoprotection of metformin in radiation-induced sensorineural hearing loss in the guinea pig. ( Daniel, SJ; Devic, S; Mujica-Mota, MA; Salehi, P, 2014) |
| "Metformin is a well-known activator of AMP-activated protein kinase (AMPK)." | 1.40 | Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke. ( Hammond, MD; Li, J; Mancini, NS; McCullough, LD; Venna, VR, 2014) |
| "Hyperglycemia is the main feature for the diagnosis of this disease." | 1.40 | Persistent impaired glucose metabolism in a zebrafish hyperglycemia model. ( Antonioli, R; Bogo, MR; Bonan, CD; Capiotti, KM; Da Silva, RS; Kist, LW, 2014) |
| "Oral metformin treatment via drinking water significantly delayed tumor growth in both tumor development model and established tumor models." | 1.40 | Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo. ( Cho, SW; Han, SK; Kim, YA; Oh, BC; Park, DJ; Park, YJ; Sun, HJ; Yi, KH, 2014) |
| "In conclusion, hyperinsulinemia and metformin infusion constrict resistance arterial vessels in vivo." | 1.40 | Immediate direct peripheral vasoconstriction in response to hyperinsulinemia and metformin in the anesthetized pig. ( Edge, D; Markos, F; Noble, MI; Ruane-O'Hora, T; Shortt, CM, 2014) |
| "Metformin suppress adipocyte-induced cell proliferation and adipocyte-secreted adipokines in vitro." | 1.40 | Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. ( Carlock, C; Chen, J; Chen, JS; Choi, HH; Chou, PC; Ensor, J; Esteva, FJ; Fraser Symmans, W; Fuentes-Mattei, E; Gully, C; Hortobagyi, GN; Lee, MH; Luo, Y; McKeehan, WL; Phan, L; Pusztai, L; Qi, Y; Shin, JH; Velazquez-Torres, G; Wu, Y; Yeung, SC; Zhang, F; Zhang, Y; Zhao, R, 2014) |
| "The roles of SHP in cardiac hypertrophy were tested in primary cultured cardiomyocytes and in animal models." | 1.40 | Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling. ( Ahn, Y; Cho, YK; Choe, N; Choi, HC; Choi, HS; Eom, GH; Joung, H; Kim, DK; Kim, HS; Kim, Y; Kim, YH; Kim, YS; Kook, H; Kwon, DH; Lee, CH; Lee, IK; Min, HK; Nam, KI; Nam, YS; Park, DH; Suk, K, 2014) |
| "Metformin treatments would have positive effects on growth patterns, adiposity and metabolic features of young females from ethnicities with thrifty genotype or developing leptin resistance, but a negative effect by advancing the attainment of puberty." | 1.40 | Advanced onset of puberty after metformin therapy in swine with thrifty genotype. ( Astiz, I; Astiz, S; Barbero, A; Garcia-Real, I; Gonzalez-Bulnes, A; Perez-Solana, ML, 2014) |
| "Metformin pretreatment at doses of 200 and 300 mg/kg significantly increased skin flap survival rate." | 1.40 | Metformin improves skin flap survival through nitric oxide system. ( Abbasi, A; Dehpour, AR; Ejtemaei-Mehr, S; Moghaddas, P; Rahimi Balaei, M; Rahimpour, S; Taleb, S, 2014) |
| "Metformin (200 mg/kg) was administrated for up to 14 days." | 1.40 | Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. ( Chen, X; Gu, X; Li, Y; Liu, Y; Tang, G; Wang, Y; Yang, GY; Zhang, Z, 2014) |
| "Obesity is a significant contributing factor to endometrial cancer risk." | 1.39 | Chemopreventive effects of metformin on obesity-associated endometrial proliferation. ( Broaddus, RR; Burzawa, JK; Celestino, J; Huang, M; Iglesias, D; Lu, KH; McCampbell, AS; Meyer, LA; Schmandt, R; Urbauer, DL; Yates, MS; Zhang, Q, 2013) |
| "Myocardial fibrosis is a key process in diabetic cardiomyopathy." | 1.39 | Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms. ( Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J, 2013) |
| "Metformin treatment did not affect body weight, fasting blood glucose and arterial blood pressure." | 1.39 | Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice. ( Eskens, BJ; van Haare, J; van Teeffelen, JW; Vink, H; Zuurbier, CJ, 2013) |
| "Metformin treatment appeared to attenuate mTORC1 signalling in Tsc1(+/-) kidney tissues but not in renal tumours." | 1.39 | Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. ( Gallacher, J; Kalogerou, M; Sampson, JR; Shen, MH; Yang, J, 2013) |
| "Nonalcoholic fatty liver disease (NAFLD), one of chronic liver diseases, seems to be rising as the obesity epidemic continues." | 1.38 | Synthesis and biological evaluation of 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione derivatives for the treatment of obesity-related nonalcoholic fatty liver disease. ( Chen, J; Chen, L; Huang, L; Lai, H; Liang, X; Liu, J; Ma, L; Pei, H; Peng, A; Ran, Y; Sang, Y; Wei, Y; Xiang, M; Xie, C, 2012) |
| "Metformin treatment improved these alterations." | 1.38 | Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012) |
| "Salt-sensitive hypertension is a characteristic of the metabolic syndrome." | 1.38 | Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. ( Araki, H; Araki, S; Chin-Kanasaki, M; Deji, N; Haneda, M; Isshiki, K; Kashiwagi, A; Koya, D; Kume, S; Maegawa, H; Nishiyama, A; Tanaka, Y; Uzu, T, 2012) |
| "Both bortezomib and metformin have been proposed as potential therapeutics in TSC." | 1.38 | Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). ( Auricchio, N; Kwiatkowski, DJ; Malinowska, I; Manning, BD; Shaw, R, 2012) |
| "Diabetes increases the risk of Alzheimer's disease (AD)." | 1.38 | Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. ( Deng, J; Li, J; Sheng, W; Zuo, Z, 2012) |
| "Pretreatment with metformin preserves alveolar capillary permeability and, thus, decreases the severity of ventilator-induced lung injury in this model." | 1.38 | Metformin attenuates ventilator-induced lung injury. ( Armaganidis, A; Kardara, M; Kopterides, P; Kotanidou, A; Magkou, C; Maniatis, NA; Panoutsou, S; Roussos, C; Siempos, II; Tsaknis, G, 2012) |
| "Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance." | 1.38 | Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin. ( Korbut, R; Madej, J; Okoń, K; Olszanecki, R; Stachowicz, A; Suski, M, 2012) |
| "Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes." | 1.38 | Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. ( Ando, H; Fujimura, A; Hayashi, K; Kaneko, S; Kato, K; Kimura, T; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Miyamoto, K; Nakanuma, Y; Ni, Y; Ota, T; Otoda, T; Takamura, T; Takeshita, Y; Uno, M; Zen, Y, 2012) |
| "Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves both fluid secretion and abnormal proliferation of cyst-lining epithelial cells." | 1.37 | Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. ( Caplan, MJ; Hallows, KR; Karihaloo, A; King, JD; Li, H; Nishio, S; Seo-Mayer, P; Somlo, S; Takiar, V; Zhang, L, 2011) |
| "Advanced HF (heart failure) is associated with altered substrate metabolism." | 1.37 | Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. ( Benada, O; Benes, J; Cervenka, L; Drahota, Z; Houstek, J; Kazdova, L; Kolar, M; Kopecky, J; Kovarova, N; Medrikova, D; Melenovsky, V; Petrak, J; Sedmera, D; Skaroupkova, P; Strnad, H; Vrbacky, M, 2011) |
| "Metformin was administered i." | 1.37 | The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II. ( Bairamov, A; Galagudza, M; Grineva, E; Kravchuk, E; Vlasov, T, 2011) |
| "Treatment with metformin did not stimulate expression of the cycle blocker p21, indicating that p21 was dispensable for the observed cell cycle arrest." | 1.37 | In vitro and in vivo anti-melanoma action of metformin. ( Harhaji-Trajkovic, L; Janjetovic, K; Micic, D; Misirkic-Marjanovic, M; Stevanovic, D; Sumarac-Dumanovic, M; Trajkovic, V; Vucicevic, L; Zogovic, N, 2011) |
| "Metformin is an anti-type II diabetes drug that has anti-inflammatory and anti-oxidant properties, can bring about mitochondrial biogenesis and has been shown to attenuate pathology in mouse models of Huntington's disease and multiple sclerosis." | 1.37 | Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice. ( Kaneb, HM; Rahmani-Kondori, N; Sharp, PS; Wells, DJ, 2011) |
| "Metformin was administered intravenously at a dose of 50mg/kg to control and U-ARF rats." | 1.36 | Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances. ( Choi, YH; Lee, I; Lee, MG, 2010) |
| "Metformin treatment decreased glucose concentration, glycated haemoglobin % and improved glucose tolerance." | 1.36 | Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model. ( Isajevs, S; Kalvinsh, I; Lauberte, L; Rostoka, E; Sharipova, J; Sjakste, N; Sjakste, T; Sokolovska, J; Sugoka, O; Svirina, D, 2010) |
| "Treatment with rosiglitazone enhanced glucose utilization and diminished MFAO, thus reversing the metabolic phenotype of the diabetic heart." | 1.35 | In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy. ( Finck, BN; Gropler, RJ; Herrero, P; Schechtman, KB; Sharp, T; Shoghi, KI; Welch, MJ, 2009) |
| "Treatment with metformin significantly attenuated the progression of aortic atherosclerosis." | 1.35 | Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits. ( Cheng, X; Deng, HP; Feng, YB; Li, SN; Mao, XB; Wang, TH; Wang, X; Zeng, QT, 2009) |
| "Metformin was administered i." | 1.35 | Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels. ( Choi, YH; Lee, I; Lee, MG, 2008) |
| "Metformin treatment significantly prolonged the survival time of male HD mice at the 2mg/ml dose (20." | 1.34 | Metformin therapy in a transgenic mouse model of Huntington's disease. ( Buescher, JL; Carrier, RL; Funk, JA; Hoyt, KR; Ma, TC; Nash, AJ; Oatis, B, 2007) |
| "Metformin treatment, known to reduce insulin resistance, got sleep apnea scores back to their basic levels, reinforcing the idea that insulin resistance is a major factor in the occurrence of apneas in this rat model." | 1.33 | Effect of high-fat diet and metformin treatment on ventilation and sleep apnea in non-obese rats. ( Delanaud, S; Dewasmes, G; Geloen, A; Gros, F; Loos, N; Petitjean, M; Ramadan, W; Vardon, G, 2006) |
| "Metformin treatment significantly blunted the ethanol effect by >60%." | 1.33 | Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. ( Arteel, GE; Beier, JI; Bergheim, I; Davis, MA; Duveau, I; Guo, L; Lambert, JC; Luyendyk, JP; Roth, RA, 2006) |
| " Eight-week-old male C57BL/Ks (db/db) mice were sorted into control and exercise groups and dosed daily for 4 weeks with vehicle, metformin (150 mg/kg/d), or acarbose (40 mg/kg/d)." | 1.31 | Exercise adds to metformin and acarbose efficacy in db/db mice. ( Reed, MJ; Tang, T, 2001) |
| "Treatment with metformin led to decreased diabetes-induced TxCAD in the larger vessels." | 1.31 | Reversal of diabetes-induced rat graft transplant coronary artery disease by metformin. ( Cantin, B; Dai, X; Gwathmey, JK; Panchal, SN; Reaven, GM; Valantine, HA; Wen, P; Zhu, D, 2002) |
| "Metformin treatment prevented the increase in plasma insulin levels in the FT rats (FT, 32 +/- 4 microU; F, 51 +/- 7 microU-ml; P < ." | 1.29 | Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats. ( Bhanot, S; McNeill, JH; Verma, S, 1994) |
| "Metformin was selected as the test compound, because it has been shown to decrease aortic and liver lipid accumulation in cholesterol fed rabbits, while only slightly affecting plasma cholesterol levels." | 1.26 | Turnover and aortic uptake of very low density lipoproteins (VLDL) from hypercholesteremic rabbits as a model for testing antiatherosclerotic compounds. ( Catapano, A; Ghiselli, GC; Rodriguez, J; Sirtori, CR, 1976) |
| " Metformin, administered at 200 mg/kg per os, ineffective dosage in normal mice, showed a strong hypoglycemic effect in younger mice (11--18 weeks) with a plasma IRI decrease and no blood lactate and liver glycogen alteration." | 1.26 | DBM mice as a pharmacological model of maturity onset diabetes. Studies with metformin. ( Brohon, J; Guillaume, M; Junien, JL; Sterne, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.31) | 18.7374 |
| 1990's | 4 (0.62) | 18.2507 |
| 2000's | 35 (5.41) | 29.6817 |
| 2010's | 404 (62.44) | 24.3611 |
| 2020's | 202 (31.22) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, S | 2 |
| Pandey, G | 1 |
| Rahuja, N | 1 |
| Srivastava, AK | 2 |
| Saxena, AK | 1 |
| Xiong, Y | 1 |
| Guo, J | 6 |
| Candelore, MR | 1 |
| Liang, R | 1 |
| Miller, C | 1 |
| Dallas-Yang, Q | 1 |
| Jiang, G | 2 |
| McCann, PE | 1 |
| Qureshi, SA | 1 |
| Tong, X | 1 |
| Xu, SS | 1 |
| Shang, J | 1 |
| Vincent, SH | 1 |
| Tota, LM | 1 |
| Wright, MJ | 1 |
| Yang, X | 12 |
| Zhang, BB | 1 |
| Tata, JR | 1 |
| Parmee, ER | 1 |
| Ma, L | 3 |
| Xie, C | 1 |
| Ran, Y | 1 |
| Liang, X | 1 |
| Huang, L | 2 |
| Pei, H | 1 |
| Chen, J | 5 |
| Liu, J | 9 |
| Sang, Y | 1 |
| Lai, H | 1 |
| Peng, A | 1 |
| Xiang, M | 1 |
| Wei, Y | 3 |
| Chen, L | 9 |
| Venier, O | 1 |
| Pascal, C | 1 |
| Braun, A | 1 |
| Namane, C | 1 |
| Mougenot, P | 1 |
| Crespin, O | 1 |
| Pacquet, F | 1 |
| Mougenot, C | 1 |
| Monseau, C | 1 |
| Onofri, B | 1 |
| Dadji-Faïhun, R | 1 |
| Leger, C | 1 |
| Ben-Hassine, M | 1 |
| Van-Pham, T | 1 |
| Ragot, JL | 1 |
| Philippo, C | 1 |
| Farjot, G | 1 |
| Noah, L | 1 |
| Maniani, K | 1 |
| Boutarfa, A | 1 |
| Nicolaï, E | 1 |
| Guillot, E | 1 |
| Pruniaux, MP | 1 |
| Güssregen, S | 1 |
| Engel, C | 1 |
| Coutant, AL | 1 |
| de Miguel, B | 1 |
| Castro, A | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 2 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 7 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Huang, SW | 1 |
| Ou, YC | 1 |
| Tang, KS | 1 |
| Yu, HR | 1 |
| Huang, LT | 1 |
| Tain, YL | 1 |
| Lin, IC | 1 |
| Sheen, JM | 1 |
| Hou, CY | 1 |
| Tsai, CC | 1 |
| Tiao, MM | 1 |
| Tokuda, K | 1 |
| Yamanaka, Y | 1 |
| Mano, Y | 1 |
| Tsukamoto, M | 1 |
| Tajima, T | 1 |
| Suzuki, H | 1 |
| Kawasaki, M | 1 |
| Uchida, S | 1 |
| Nakamura, E | 1 |
| Wang, KY | 1 |
| Sakai, A | 1 |
| Hong, S | 1 |
| Nagayach, A | 1 |
| Lu, Y | 2 |
| Peng, H | 1 |
| Duong, QA | 1 |
| Pham, NB | 1 |
| Vuong, CA | 1 |
| Bazan, NG | 1 |
| Oliveira, AL | 2 |
| de Oliveira, MG | 1 |
| Medeiros, ML | 2 |
| Mónica, FZ | 2 |
| Antunes, E | 4 |
| Cobb, LP | 1 |
| Siamakpour-Reihani, S | 1 |
| Zhang, D | 4 |
| Qin, X | 1 |
| Owzar, K | 1 |
| Zhou, C | 6 |
| Conrads, TP | 1 |
| Maxwell, GL | 1 |
| Darcy, KM | 1 |
| Bateman, NW | 1 |
| Litzi, T | 1 |
| Bae-Jump, V | 2 |
| Secord, AA | 1 |
| Said, ES | 1 |
| Elsayed, AM | 1 |
| Rashed, LA | 2 |
| Nadwa, EH | 1 |
| Alsuhaibani, NA | 1 |
| Alfuraih, BS | 1 |
| Mahmoud, RH | 1 |
| Vandanmagsar, B | 1 |
| Yu, Y | 1 |
| Simmler, C | 1 |
| Dang, TN | 1 |
| Kuhn, P | 1 |
| Poulev, A | 1 |
| Ribnicky, DM | 1 |
| Pauli, GF | 1 |
| Floyd, ZE | 1 |
| Abdi, M | 1 |
| Pasbakhsh, P | 2 |
| Shabani, M | 2 |
| Nekoonam, S | 2 |
| Sadeghi, A | 1 |
| Fathi, F | 1 |
| Abouzaripour, M | 1 |
| Mohamed, W | 1 |
| Zibara, K | 1 |
| Kashani, IR | 2 |
| Zendedel, A | 1 |
| Shu, L | 1 |
| Hou, X | 2 |
| Song, G | 1 |
| Wang, C | 12 |
| Ma, H | 2 |
| Camacho-Castillo, L | 1 |
| Phillips-Farfán, BV | 1 |
| Rosas-Mendoza, G | 1 |
| Baires-López, A | 1 |
| Toral-Ríos, D | 1 |
| Campos-Peña, V | 1 |
| Carvajal, K | 1 |
| Sritawan, N | 2 |
| Suwannakot, K | 1 |
| Naewla, S | 1 |
| Chaisawang, P | 2 |
| Aranarochana, A | 1 |
| Sirichoat, A | 2 |
| Pannangrong, W | 2 |
| Wigmore, P | 2 |
| Welbat, JU | 2 |
| Cheang, YZN | 1 |
| Ting, HRD | 1 |
| Koh, HQV | 1 |
| Alonso, S | 1 |
| Taghipour, F | 1 |
| Oladpour, O | 1 |
| Rezayati, MT | 1 |
| Khorramdelazad, H | 1 |
| Nemati, M | 1 |
| Taghipour, Z | 1 |
| Masoumi, J | 1 |
| Hassan, ZM | 1 |
| Jafarzadeh, A | 1 |
| Wang, Z | 8 |
| Xue, M | 1 |
| Mi, L | 1 |
| Zhao, M | 3 |
| Ma, C | 1 |
| Wu, J | 4 |
| Han, X | 4 |
| Tombulturk, FK | 1 |
| Todurga-Seven, ZG | 1 |
| Huseyinbas, O | 1 |
| Ozyazgan, S | 2 |
| Ulutin, T | 1 |
| Kanigur-Sultuybek, G | 1 |
| Zhang, B | 10 |
| Zhang, X | 21 |
| Zhang, C | 6 |
| Sun, G | 1 |
| Sun, X | 5 |
| Augusto, PSA | 2 |
| Matsui, TC | 1 |
| Braga, AV | 2 |
| Rodrigues, FF | 2 |
| Morais, MI | 2 |
| Dutra, MMGB | 2 |
| Batista, CRA | 2 |
| Melo, ISF | 2 |
| Costa, SOAM | 2 |
| Bertollo, CM | 1 |
| Coelho, MM | 2 |
| Machado, RR | 2 |
| Zhang, W | 6 |
| Zhao, L | 3 |
| Zhang, J | 17 |
| Li, P | 4 |
| Lv, Z | 1 |
| Binyamin, O | 1 |
| Frid, K | 1 |
| Keller, G | 1 |
| Saada, A | 1 |
| Gabizon, R | 1 |
| Qin, Z | 2 |
| Xiao, X | 3 |
| Guo, C | 2 |
| Chen, Q | 2 |
| Xie, D | 2 |
| Yao, Q | 2 |
| Yang, L | 3 |
| Chang, MY | 2 |
| Tsai, CY | 1 |
| Chou, LF | 1 |
| Hsu, SH | 1 |
| Yang, HY | 1 |
| Hung, CC | 2 |
| Tian, YC | 2 |
| Ong, ACM | 1 |
| Yang, CW | 4 |
| Sanati, M | 1 |
| Aminyavari, S | 1 |
| Afshari, AR | 1 |
| Sahebkar, A | 2 |
| Bakhtyukov, AA | 1 |
| Derkach, KV | 1 |
| Sorokoumov, VN | 1 |
| Stepochkina, AM | 1 |
| Romanova, IV | 1 |
| Morina, IY | 1 |
| Zakharova, IO | 1 |
| Bayunova, LV | 1 |
| Shpakov, AO | 1 |
| Hao, Q | 2 |
| Huang, Z | 2 |
| Li, Q | 5 |
| Liu, D | 3 |
| Wang, P | 1 |
| Wang, K | 1 |
| Li, J | 35 |
| Cao, W | 1 |
| Deng, W | 3 |
| Wu, K | 2 |
| Su, R | 1 |
| Liu, Z | 13 |
| Vadgama, J | 1 |
| Wu, Y | 6 |
| Takahara, M | 1 |
| Takaki, A | 1 |
| Hiraoka, S | 1 |
| Takei, K | 1 |
| Yasutomi, E | 1 |
| Igawa, S | 1 |
| Yamamoto, S | 1 |
| Oka, S | 1 |
| Ohmori, M | 1 |
| Yamasaki, Y | 1 |
| Inokuchi, T | 1 |
| Kinugasa, H | 1 |
| Harada, K | 1 |
| Udono, H | 4 |
| Okada, H | 1 |
| Zhuang, A | 1 |
| Chai, P | 1 |
| Wang, S | 12 |
| Zuo, S | 1 |
| Yu, J | 3 |
| Jia, S | 1 |
| Ge, S | 2 |
| Jia, R | 1 |
| Zhou, Y | 5 |
| Shi, W | 1 |
| Xu, X | 7 |
| Ruan, J | 1 |
| Fan, X | 1 |
| Lin, Y | 2 |
| Dai, X | 3 |
| Chen, X | 14 |
| Czika, A | 1 |
| Yang, Y | 5 |
| Yang, JP | 1 |
| Adu-Gyamfi, EA | 1 |
| Ullah, A | 1 |
| Ruan, LL | 1 |
| Chen, XM | 2 |
| Wang, YX | 1 |
| Wang, MJ | 1 |
| Ding, YB | 1 |
| Huang, J | 5 |
| Ru, G | 1 |
| Sun, J | 3 |
| Sun, L | 3 |
| Li, Z | 19 |
| Elnahas, EM | 1 |
| Abuelezz, SA | 1 |
| Mohamad, MI | 1 |
| Nabil, MM | 1 |
| Abdelraouf, SM | 1 |
| Bahaa, N | 1 |
| Hassan, GAM | 1 |
| Aboul-Fotouh, S | 2 |
| Jia, RB | 1 |
| Luo, D | 2 |
| Li, ZR | 1 |
| Lin, L | 2 |
| Zheng, Q | 1 |
| Olivier, S | 2 |
| Diounou, H | 2 |
| Pochard, C | 2 |
| Frechin, L | 1 |
| Durieu, E | 1 |
| Foretz, M | 3 |
| Neunlist, M | 2 |
| Rolli-Derkinderen, M | 2 |
| Viollet, B | 4 |
| Li, F | 4 |
| Ke, H | 1 |
| Lv, P | 1 |
| Chen, Y | 19 |
| Eltony, SA | 1 |
| Mohaseb, HS | 1 |
| Ahmed, AA | 1 |
| Sayed, MM | 1 |
| Chen, F | 2 |
| Zhang, Y | 21 |
| Shi, B | 2 |
| Song, J | 6 |
| Chaudhari, K | 1 |
| Yang, SH | 1 |
| Zhang, GJ | 1 |
| Taylor, HS | 1 |
| Li, D | 7 |
| Huang, Y | 5 |
| Trujillo-Del Río, C | 1 |
| Tortajada-Pérez, J | 1 |
| Gómez-Escribano, AP | 1 |
| Casterá, F | 1 |
| Peiró, C | 1 |
| Millán, JM | 2 |
| Herrero, MJ | 1 |
| Vázquez-Manrique, RP | 2 |
| Sabzali, M | 1 |
| Eidi, A | 1 |
| Khaksari, M | 1 |
| Khastar, H | 1 |
| Shoaib, M | 1 |
| Choudhary, RC | 1 |
| Chillale, RK | 1 |
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| Miyara, SJ | 1 |
| Haque, S | 1 |
| Yin, T | 1 |
| Frankfurt, M | 1 |
| Molmenti, EP | 1 |
| Zanos, S | 1 |
| Kim, J | 3 |
| Becker, LB | 1 |
| Kazkayasi, I | 1 |
| Telli, G | 1 |
| Nemutlu, E | 1 |
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| Rieusset, J | 1 |
| Thibault, H | 1 |
| Paillard, M | 1 |
| El Leithy, AA | 1 |
| Al-Karmalawy, AA | 1 |
| Youssif, OM | 1 |
| Ebrahim, YA | 1 |
| Khalifa, AS | 1 |
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| Tian, J | 7 |
| Xie, W | 4 |
| Zeng, Y | 3 |
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| Cai, B | 4 |
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| Quattrini, MC | 3 |
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| Prestia, F | 3 |
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| Di Domenico, F | 3 |
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| De Filippis, B | 3 |
| Wu, H | 1 |
| Wang, X | 18 |
| Fang, X | 1 |
| Lian, F | 1 |
| Li, M | 9 |
| Liao, J | 2 |
| Dai, D | 1 |
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| Botnar, RM | 1 |
| Andia, ME | 1 |
| Mehdar, KM | 1 |
| Alsareii, SAM | 1 |
| Rashid, R | 1 |
| Tripathi, R | 1 |
| Singh, A | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin as a Novel Treatment for Vitiligo by Targeting CD8+ T Cell Metabolism[NCT05607316] | Phase 2 | 30 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients[NCT05298670] | Phase 2 | 80 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | ||
| Preeclampsia Intervention 4 - A Triple Blind Phase III Randomised Controlled Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia[NCT06033131] | Phase 3 | 294 participants (Anticipated) | Interventional | 2024-01-22 | Not yet recruiting | ||
| Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.[NCT05262257] | Early Phase 1 | 120 participants (Anticipated) | Interventional | 2022-04-01 | Not yet recruiting | ||
| A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome (FXS)[NCT03862950] | Phase 2 | 120 participants (Anticipated) | Interventional | 2019-05-24 | Recruiting | ||
| Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813] | 200 participants (Anticipated) | Observational | 2019-09-10 | Not yet recruiting | |||
| Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis[NCT04750135] | Phase 2 | 40 participants (Anticipated) | Interventional | 2021-02-07 | Not yet recruiting | ||
| "Randomized, Double-blind, Placebo-controlled Study to Assess the Effect of Metformin, an Activator of AMPK, on Cognitive Measures of Progression in Huntington's Disease Patients"[NCT04826692] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-12-10 | Recruiting | ||
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Feasibility Study of Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease.[NCT02903511] | Phase 2 | 56 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513] | 414 participants (Anticipated) | Interventional | 2022-03-24 | Not yet recruiting | |||
| Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854] | Phase 2 | 68 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| Metformin Pharmacology in Human Cancers[NCT03477162] | Early Phase 1 | 18 participants (Actual) | Interventional | 2018-05-15 | Terminated (stopped due to Enrollment was closed as efforts had become more challenging, and the lab indicated that they were able to obtain their primary objective with the number that had already been enrolled.) | ||
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population[NCT05317806] | Phase 4 | 15 participants (Anticipated) | Interventional | 2022-10-10 | Active, not recruiting | ||
| Effect of Exenatide Treatment on Hepatic Fat Content and Plasma Adipocytokine Levels in Patients With Type 2 Diabetes Mellitus[NCT01432405] | Phase 4 | 24 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Phase II Trial, Open Label, Clinical Activity of Metformin in Combination With High-dose of Dexamethasone (HDdexa) in Patients With Relapsed/Refractory Multiple Myeloma[NCT02967276] | Phase 2 | 28 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia[NCT05326984] | 20 participants (Anticipated) | Interventional | 2021-02-09 | Recruiting | |||
| Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.[NCT04626089] | Phase 2 | 0 participants (Actual) | Interventional | 2021-02-28 | Withdrawn (stopped due to Administrative decision of the company) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Estimated glomerular filtration rate (eGFR) will be calculated from serum creatinine measurements at baseline and after 3, 6, 9 and 12 months. Change from baseline at 12 months is reported. (NCT02903511)
Timeframe: 12 months
| Intervention | mL/min/1.73 m^2 (Mean) |
|---|---|
| Metformin | -0.41 |
| Placebo | -3.35 |
Total kidney volume will be measured by MRI (magnetic resonance imaging) at baseline and at 12 months. Percentage change from baseline in height-adjusted total kidney volume is reported. (NCT02903511)
Timeframe: 12 months
| Intervention | percent change (Mean) |
|---|---|
| Metformin | 3.45 |
| Placebo | 3.15 |
Serious adverse events occurring from the time of signing informed consent until the end of the study will be monitored in both treatment arms (NCT02903511)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Metformin | 2 |
| Placebo | 0 |
Percentage of participants who at the end of 12 months are still prescribed the full randomized dose of metformin or placebo, and the percentage of participants who are prescribed at least 50% of the randomized dose (NCT02903511)
Timeframe: 12 months
| Intervention | percentage of participants (Number) | |
|---|---|---|
| Full Dose | 50% Dose | |
| Metformin | 50 | 82 |
| Placebo | 100 | 100 |
To determine the concentration of metformin in adipose tissue. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 70 |
To determine the concentration of metformin in plasma. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/mL (Median) |
|---|---|
| Metformin | 450 |
To determine the concentration of metformin in tumor-adjacent normal tissue. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 749 |
To determine the concentration of metformin in whole blood. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/mL (Median) |
|---|---|
| Metformin | 514 |
To determine the intra-tumor concentrations of metformin, with a standard deviation ≤25% of the mean, in patients with solid tumors of thoracic origin administered metformin extended release. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 1290 |
The effect of exenatide and pioglitazone on liver fat content after one year of treatment in patients with type 2 diabetes. (NCT01432405)
Timeframe: one year
| Intervention | percent of liver fat (Mean) |
|---|---|
| Pioglitazone and Exenatide | 4.7 |
| Pioglitazone | 6.5 |
the effect of the intervention on plasma adiponectin levels. (NCT01432405)
Timeframe: one year
| Intervention | microgram per ml (Mean) |
|---|---|
| Pioglitazone and Exenatide | 23.2 |
| Pioglitazone | 15.8 |
37 reviews available for metformin and Disease Models, Animal
| Article | Year |
|---|---|
Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis.
Topics: Animals; Disease Models, Animal; Hypoglycemic Agents; Locomotion; Metformin; Rats; Recovery of Funct | 2021 |
Mechanistic insight into the role of metformin in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Hippoca | 2022 |
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Humans; Huntington Disease; Metformin; Neurodegene | 2022 |
Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Diabetes Mellitus, Type 2; Disease Models, | 2023 |
Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P | 2019 |
Metformin effect on gut microbiota: insights for HIV-related inflammation.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus; Disease Models, Animal; Dysbiosis; Gastrointes | 2020 |
Metformin: the updated protective property in kidney disease.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Disease Models, Anima | 2020 |
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Aspirin; Biological Products; Breast | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.
Topics: Animals; Central Nervous System; Diabetes Mellitus, Type 2; Disease Models, Animal; Epilepsy; Humans | 2021 |
GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes.
Topics: Animals; Blood Glucose; Brain; Cognition; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucago | 2018 |
Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; DNA, Mitochondrial; Drug Evaluation, Preclinical; | 2018 |
The Role of Microbiota in Retinal Disease.
Topics: Animals; Conjunctiva; Cornea; Diabetic Retinopathy; Disease Models, Animal; Gastrointestinal Microbi | 2018 |
The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth.
Topics: Animals; Blood Glucose; Cardiovascular Diseases; Cell Line, Tumor; Clinical Trials as Topic; Cogniti | 2019 |
Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X | 2019 |
Metformin: A Candidate Drug for Renal Diseases.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Clinical Trials as To | 2018 |
Metformin: Mechanisms in Human Obesity and Weight Loss.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gastrointestinal Microbiome; Huma | 2019 |
Metformin and Breast Cancer: Molecular Targets.
Topics: AMP-Activated Protein Kinases; Animals; Breast Neoplasms; Cell Line, Tumor; Diabetes Mellitus, Type | 2019 |
A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition; | 2019 |
Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Epilepsy; Hypoglycemic Agents; Metformin | 2019 |
Prevention and intervention trials for colorectal cancer.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; An | 2013 |
Repositioning metformin for cancer prevention and treatment.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hypogl | 2013 |
A "glucose eater" drug as a therapeutic agent in psychiatry.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Depressive Disorder, Major; Diabetes Mellitus, Typ | 2013 |
Colon epithelial proliferation and carcinogenesis in diet-induced obesity.
Topics: Aberrant Crypt Foci; Adiponectin; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell T | 2013 |
[Metformin as a key to alternative activation of microglia?].
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain; Cells, | 2014 |
Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis.
Topics: 3-O-Methylglucose; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Acids; Gluco | 2015 |
Hereditary cancer syndromes as model systems for chemopreventive agent development.
Topics: Adaptor Proteins, Signal Transducing; Adenomatous Polyposis Coli; Adenosine Triphosphatases; Animals | 2016 |
Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS.
Topics: Androgens; Animals; Death Domain Receptor Signaling Adaptor Proteins; Decanoic Acids; Disease Models | 2016 |
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome.
Topics: Androgens; Animals; Dehydroepiandrosterone; Disease Models, Animal; Embryo Loss; Female; Humans; Hyp | 2010 |
[Effectiveness of metformin in prevention of development of hyperglycemia and neuronal damage caused by ischemic stress].
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Brain; Brain Ischemia; Disease Models, | 2011 |
Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin.
Topics: Animals; Breast Neoplasms; Chemoprevention; Cohort Studies; Comorbidity; Disease Models, Animal; Fem | 2011 |
Metformin in cancer: translational challenges.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metfor | 2012 |
Metformin in cancer: translational challenges.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metfor | 2012 |
Metformin in cancer: translational challenges.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metfor | 2012 |
Metformin in cancer: translational challenges.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metfor | 2012 |
Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Heart; Heart Failur | 2012 |
Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.
Topics: Adult; Animals; Biochemical Phenomena; Biochemistry; Biopsy, Needle; Clinical Trials as Topic; Disea | 2003 |
Antiatherogenic properties of metformin: the experimental evidence.
Topics: Animals; Aortic Diseases; Arteries; Arteriosclerosis; Diabetes Mellitus, Type 2; Disease Models, Ani | 2003 |
Alpha-lipoic acid, an anti-obesity agent?
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Disease Models, Animal; Humans; Lipid M | 2004 |
The fatty liver and insulin resistance.
Topics: Adiponectin; Adipose Tissue; Alanine Transaminase; Animals; Antiretroviral Therapy, Highly Active; C | 2005 |
4 trials available for metformin and Disease Models, Animal
| Article | Year |
|---|---|
Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice.
Topics: Animals; Cysts; Disease Models, Animal; Female; Kidney; Lactic Acid; Male; Metformin; Mice; Mice, Tr | 2022 |
Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.
Topics: Aged; Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet, Atherogenic; Di | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.
Topics: Adult; Aged; Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, | 2011 |
607 other studies available for metformin and Disease Models, Animal
| Article | Year |
|---|---|
Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.
Topics: Animals; Binding Sites; Catalytic Domain; Computer Simulation; Diabetes Mellitus, Experimental; Dise | 2010 |
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.
Topics: Animals; Area Under Curve; beta-Alanine; Blood Glucose; CHO Cells; Cricetinae; Cricetulus; Diabetes | 2012 |
Synthesis and biological evaluation of 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione derivatives for the treatment of obesity-related nonalcoholic fatty liver disease.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Alanine Transaminase; Animals; Barbiturates; Body Weight; Cho | 2012 |
Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Diabetes Mellitus, Experimental; D | 2013 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis.
Topics: Administration, Oral; Animals; Apoptosis; Diet, High-Fat; Disease Models, Animal; Drinking Water; Dy | 2021 |
Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization.
Topics: Animals; Contracture; Disease Models, Animal; Fibrosis; Gene Expression; Immobilization; Immunohisto | 2021 |
A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin.
Topics: Aged; Aging; Animals; Diet, Carbohydrate Loading; Diet, High-Fat; Diet, Western; Disease Models, Ani | 2021 |
Metformin abrogates the voiding dysfunction induced by prolonged methylglyoxal intake.
Topics: Administration, Oral; Animals; Disease Models, Animal; Glycation End Products, Advanced; Humans; Mal | 2021 |
Obesity and altered angiogenic-related gene expression in endometrial cancer.
Topics: AMP-Activated Protein Kinases; Animals; Body Mass Index; Calcium-Binding Proteins; Cell Adhesion Mol | 2021 |
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Caspase 3; Cell Death; Cognitive Dysfuncti | 2021 |
Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Artemisia; Cell Line; Diet, High | 2021 |
Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Blotting, Western; Cuprizone; Disease Models, Animal; Male; Metformin; Mice; Mice, Inbred C | 2021 |
Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulati | 2021 |
Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animal Feed; Animals; Antio | 2021 |
Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Doublecortin P | 2021 |
In vitro and in vivo efficacy of Metformin against dengue.
Topics: AMP-Activated Protein Kinases; Animals; Antiviral Agents; Chlorocebus aethiops; Dengue; Dengue Virus | 2021 |
Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cimetidine; Disease Models, Animal; Female; | 2021 |
Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Autophagy; Autophagy-Related Protein 7; Disea | 2022 |
Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats.
Topics: Administration, Topical; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diseas | 2022 |
Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation.
Topics: Animals; Berberine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Drug Synerg | 2021 |
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Topics: Adenosine Triphosphate; Animals; Carrageenan; Diabetes Mellitus, Type 2; Disease Models, Animal; Ede | 2022 |
Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia.
Topics: Anesthesia; Animals; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2021 |
Comparing anti-aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease.
Topics: Adenylate Kinase; Animals; Antioxidants; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Electro | 2022 |
Metformin attenuates sepsis-induced neuronal injury and cognitive impairment.
Topics: Animals; Brain; Cecum; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal | 2021 |
The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis.
Topics: Adenylate Kinase; Allosteric Regulation; Animals; Area Under Curve; Blood Glucose; Body Weight; Diab | 2021 |
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea | 2022 |
Metformin ameliorates chronic colitis in a mouse model by regulating interferon-γ-producing lamina propria CD4
Topics: Adoptive Transfer; AMP-Activated Protein Kinases; Animals; CD4-Positive T-Lymphocytes; Colitis; Colo | 2022 |
Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma.
Topics: Animals; Autophagy; Cell Cycle Proteins; Disease Models, Animal; Eye; Histone Demethylases; Melanoma | 2022 |
Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis.
Topics: Aging; Animals; Apolipoprotein E3; Apolipoprotein E4; Behavior, Animal; Depression; Disease Models, | 2022 |
A decrease in cluster of differentiation 2 expression on natural killer cells is associated with polycystic ovary syndrome but not influenced by metformin in a mouse model†.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Killer Cel | 2022 |
Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Embryonic Development; Epig | 2022 |
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2022 |
Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis.
Topics: AMP-Activated Protein Kinases; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Metformin; | 2022 |
Effect of metformin in autistic BTBR T + Itpr3tf/J mice administered a high-fat diet.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Diet, High-Fat; Disease Models, Animal; Metfor | 2022 |
Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa?
Topics: Animals; Caspase 3; Disease Models, Animal; Humans; Male; Metformin; Rats; Rats, Wistar; Retina; Ret | 2022 |
Let-7 underlies metformin-induced inhibition of hepatic glucose production.
Topics: Animals; Disease Models, Animal; Glucose; Hepatocytes; Hyperglycemia; Hypoglycemic Agents; Liver; Me | 2022 |
Anti-inflammatory, Antioxidant, and Antiapoptotic Action of Metformin Attenuates Ethanol Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Models, Animal; Ethanol; Female; | 2022 |
Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit.
Topics: Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Heart Arrest; Humans; Metfo | 2022 |
Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Diabetes Mellitus, Type 2; Disease Mod | 2022 |
Effect of Metformin on T2D-Induced MAM Ca
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Heart Failure | 2022 |
Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model.
Topics: Animals; bcl-2-Associated X Protein; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; | 2022 |
Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Emphysema; Epithelial Sodium Channel | 2022 |
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; Metformin; Mice | 2022 |
Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter py | 2022 |
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Metformin; Mice; Polycystic | 2022 |
Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis.
Topics: Animals; Chondrocytes; Diabetes Mellitus, Type 2; Disease Models, Animal; Ferroptosis; Metformin; Mi | 2022 |
The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; H | 2022 |
Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study.
Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Type 2; Disease Models, Animal; Metformin; Mice; P | 2022 |
Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus.
Topics: Animals; Antidepressive Agents; Autophagy; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; | 2022 |
Epithelial-mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model.
Topics: Animals; Cadherins; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Epithelial-Mesenchymal | 2022 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome.
Topics: Animals; Brain; Cognition; Diabetes Mellitus; Disease Models, Animal; Female; Metformin; Mice; Rett | 2023 |
Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome.
Topics: Animals; Brain; Cognition; Diabetes Mellitus; Disease Models, Animal; Female; Metformin; Mice; Rett | 2023 |
Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome.
Topics: Animals; Brain; Cognition; Diabetes Mellitus; Disease Models, Animal; Female; Metformin; Mice; Rett | 2023 |
Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome.
Topics: Animals; Brain; Cognition; Diabetes Mellitus; Disease Models, Animal; Female; Metformin; Mice; Rett | 2023 |
Metformin modulates the gut microbiome in a mice model of high-fat diet-induced glycolipid metabolism disorder.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Glucose; Glycolipids; | 2022 |
Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation.
Topics: Adenoma; Animals; Disease Models, Animal; Lung Neoplasms; Metformin; Mice; Weight Gain | 2023 |
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney.
Topics: Animals; Disease Models, Animal; Fibrosis; Kidney; Kidney Diseases; Metformin; Mice; Mutation; Phosp | 2023 |
Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross-link between XBP-1/PPAR-1, regulatory proteins for lipogenesis/steroids.
Topics: Animals; Disease Models, Animal; Female; Humans; Letrozole; Lipogenesis; Metformin; Peroxisome Proli | 2023 |
Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS
Topics: Animals; Disease Models, Animal; Fatty Acids; Humans; Liver; Magnetic Resonance Spectroscopy; Metfor | 2023 |
Potential therapeutic effect of medium chain triglyceride oil in ameliorating diabetic liver injury in a streptozotocin-induced diabetic murine model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoglycemic Agents | 2023 |
Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats.
Topics: Androgens; Animals; Disease Models, Animal; Female; Follicular Cyst; Humans; Letrozole; Metformin; P | 2023 |
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment.
Topics: AMP-Activated Protein Kinases; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relat | 2023 |
Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion.
Topics: Animals; Brain Ischemia; Carotid Stenosis; Cognitive Dysfunction; Dementia, Vascular; Diabetes Melli | 2023 |
Exploration of Imaging Biomarkers for Metabolically-Targeted Osteosarcoma Therapy in a Murine Xenograft Model.
Topics: Animals; Biomarkers; Bone Neoplasms; Child; Disease Models, Animal; Fluorodeoxyglucose F18; Heterogr | 2023 |
Metformin Counteracts the Deleterious Effects of Methylglyoxal on Ovalbumin-Induced Airway Eosinophilic Inflammation and Remodeling.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Lung | 2023 |
Changes in the Subchondral Bone, Visfatin, and Cartilage Biomarkers after Pharmacological Treatment of Experimental Osteoarthritis with Metformin and Alendronate.
Topics: Alendronate; Animals; Biomarkers; Cartilage, Articular; Disease Models, Animal; Metformin; Mice; Nic | 2023 |
Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Heart Failure; Hypertension, | 2023 |
Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage.
Topics: AMP-Activated Protein Kinases; Animals; Depression; Disease Models, Animal; Metformin; Mice; Olfacto | 2023 |
Comparing the acute and chronic effects of metformin and antioxidant protective effects of N-acetyl cysteine on memory retrieval and oxidative stress in rats with Alzheimer's disease.
Topics: Acetylcysteine; Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Maze Learning; Met | 2023 |
Metformin-Loaded Chitosan Hydrogels Suppress Bladder Tumor Growth in an Orthotopic Mouse Model via Intravesical Administration.
Topics: Administration, Intravesical; Animals; Chitosan; Disease Models, Animal; Hydrogels; Metformin; Mice; | 2023 |
Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Female; Immune System; Immunoglobulins; Insulin; In | 2023 |
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.
Topics: Adipose Tissue; Animals; Disease Models, Animal; Feeding Behavior; Hypoglycemic Agents; Inflammation | 2019 |
Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease M | 2019 |
Metformin attenuates autoimmune disease of the neuromotor system in animal models of myasthenia gravis.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antibodies; B-Lymphocytes; Blood G | 2019 |
Human adipose tissue mesenchymal stem cells as a novel treatment modality for correcting obesity induced metabolic dysregulation.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Humans; Mesenchymal Stem Cell Trans | 2019 |
Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Cyclic AMP; | 2019 |
Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice.
Topics: Animals; Antioxidants; Brain; Cytokines; Disease Models, Animal; Down-Regulation; Glutathione; Infla | 2019 |
Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Gene E | 2019 |
Metformin Prevents Peritoneal Dissemination
Topics: Animals; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Humans; Immunomodulation; Immunopheno | 2019 |
Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Antidepressive Agents; Brain-Derived Neurotroph | 2020 |
Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats.
Topics: AMP-Activated Protein Kinases; Androgens; Animals; Blood Glucose; Disease Models, Animal; Exenatide; | 2019 |
Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain.
Topics: Administration, Intranasal; Administration, Oral; Animals; Astrocytes; Cells, Cultured; Cerebral Cor | 2019 |
Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Movement; Cognition Disorders; Disease Models, | 2019 |
Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.
Topics: Animals; Blood Glucose; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diet, High-Fat; Di | 2019 |
Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Breast Neoplasms, Male; Disease Models, Animal; Fe | 2019 |
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.
Topics: Animals; Blood-Testis Barrier; Disease Models, Animal; Fertility; Humans; Hypoglycemic Agents; Male; | 2019 |
Metabolic stress is a primary pathogenic event in transgenic
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Caenorhabditis ele | 2019 |
Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis.
Topics: AMP-Activated Protein Kinases; Animals; Cuprizone; Disease Models, Animal; Down-Regulation; Enzyme A | 2019 |
Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model.
Topics: AMP-Activated Protein Kinases; Animals; Areca; Arecoline; Carcinogenesis; Disease Models, Animal; Dy | 2019 |
Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Autonomic Nervous System; | 2020 |
Metformin prevents the pathological browning of subcutaneous white adipose tissue.
Topics: Acetyl-CoA Carboxylase; Adipocytes, Beige; Adipose Tissue, White; Adult; Aminoimidazole Carboxamide; | 2019 |
Metformin protects against PM
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Biopsy; Cell Line; Disease Models, Animal; Disea | 2020 |
Ameliorative effect of metformin on cyclophosphamide-induced memory impairment in mice.
Topics: Animals; Cognitive Dysfunction; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship | 2019 |
Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress.
Topics: Acute Disease; Animals; Bile Ducts; Cholestasis; Disease Models, Animal; Endoplasmic Reticulum Stres | 2020 |
Targeting liver stage malaria with metformin.
Topics: Animals; Antimalarials; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2019 |
Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis eleg | 2021 |
AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Gene | 2019 |
Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet.
Topics: Animals; Blood Pressure; Body Weight; Diet, High-Fat; Disease Models, Animal; Female; Matrix Metallo | 2019 |
Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Immunomodulation; Lupus Erythematosus, Systemic; M | 2020 |
In Alzheimer Research, Glucose Metabolism Moves to Center Stage.
Topics: Alzheimer Disease; Animals; Brain; Diet, Ketogenic; Disease Models, Animal; Exercise; Glucose; Healt | 2020 |
Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Auditory Cortex; Disease Mod | 2020 |
Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.
Topics: Adult; Animals; Apoptosis; Cell Survival; Cells, Cultured; Coloring Agents; Disease Models, Animal; | 2020 |
Statins Directly Regulate Pituitary Cell Function and Exert Antitumor Effects in Pituitary Tumors.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, A | 2020 |
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Biopsy; Cartilage, Articular; Cellular Senescenc | 2020 |
Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model
Topics: Animals; Anti-Mullerian Hormone; Disease Models, Animal; Female; Gynecologic Surgical Procedures; Me | 2020 |
Infliximab ameliorates tumor necrosis factor-alpha exacerbated renal insulin resistance induced in rats by regulating insulin signaling pathway.
Topics: Animals; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Humans; Hyperglycemia; Infli | 2020 |
Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Appendage; Atrial Fibrillation; Atrial Function, Left | 2020 |
Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease.
Topics: Administration, Oral; Animals; Cardiovascular Diseases; Diet, High-Fat; Disease Models, Animal; Enzy | 2020 |
AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Disease Models, Animal; Dysferlin; Humans; Lasers | 2020 |
Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model.
Topics: Animals; Disease Models, Animal; Echocardiography; Gene Expression Profiling; Gene Expression Regula | 2020 |
Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis.
Topics: Aging; Animals; Cognition; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Gastrointestinal Micro | 2020 |
Metformin limits osteoarthritis development and progression through activation of AMPK signalling.
Topics: AMP-Activated Protein Kinases; Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease | 2020 |
Protective effect of metformin against rotenone-induced parkinsonism in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Endoplasmic Reticulum Chape | 2020 |
Retinoprotection by BGP-15, a Hydroximic Acid Derivative, in a Type II Diabetic Rat Model Compared to Glibenclamide, Metformin, and Pioglitazone.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Models, Animal; Ele | 2020 |
Study of the effect of metformin on expression levels of TNF-α and IL-18 in animal models of polycystic ovary syndrome.
Topics: Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Down-Regulation; Estradiol; Estrous | 2021 |
Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats.
Topics: AMP-Activated Protein Kinases; Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, An | 2020 |
Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease.
Topics: Albuminuria; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Disease Progression; En | 2020 |
Effects of Metformin and Sitagliptin Monotherapy on Expression of Intestinal and Renal Sweet Taste Receptors and Glucose Transporters in a Rat Model of Type 2 Diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Glucose Tran | 2020 |
Agriophyllum oligosaccharides ameliorate hepatic injury in type 2 diabetic db/db mice targeting INS-R/IRS-2/PI3K/AKT/PPAR-γ/Glut4 signal pathway.
Topics: Animals; Biomarkers; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Type 2; Disease Models, A | 2020 |
Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos.
Topics: Adult; Animals; Blastocyst; Blood Glucose; Diabetes, Gestational; Disease Models, Animal; Embryonic | 2020 |
Metformin ameliorates animal models of dermatitis.
Topics: AMP-Activated Protein Kinases; Animals; Collagen; Dermatitis; Disease Models, Animal; Enzyme Activat | 2020 |
Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiotonic | 2020 |
Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system.
Topics: Animals; Anticonvulsants; Antioxidants; Autism Spectrum Disorder; Disease Models, Animal; Female; Hy | 2020 |
Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Atrial Fibrillation; Atrial Remodeli | 2020 |
Metformin ameliorates cardiac conduction delay by regulating microRNA-1 in mice.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Conduction System Disease; Connexin 43; | 2020 |
Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model.
Topics: Alzheimer Disease; Animals; Cytokines; Disease Models, Animal; Hippocampus; Inflammation; Liposomes; | 2020 |
Combined use of Diane-35 and metformin improves the ovulation in the PCOS rat model possibly via regulating glycolysis pathway.
Topics: Androgen Antagonists; Animals; Apoptosis; Body Weight; Cyproterone Acetate; Disease Models, Animal; | 2020 |
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.
Topics: Aging; Animals; Astrocytes; Corpus Striatum; Disease Models, Animal; Female; Male; Metformin; Mice, | 2020 |
Transcriptomic landscape profiling of metformin-treated healthy mice: Implication for potential hypertension risk when prophylactically used.
Topics: Animals; Blood Pressure; Computational Biology; Disease Models, Animal; Dose-Response Relationship, | 2020 |
Dapagliflozin, a sodium glucose cotransporter 2 inhibitors, protects cardiovascular function in type-2 diabetic murine model.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, | 2020 |
Efficacy of the Combination of Metformin and CTLA4Ig in the (NZB × NZW)F1 Mouse Model of Lupus Nephritis.
Topics: Abatacept; Animals; Antigens, CD; Autoantibodies; CD4-Positive T-Lymphocytes; CTLA-4 Antigen; Diseas | 2020 |
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes.
Topics: Animals; Cells, Cultured; Circadian Rhythm; Diabetes Mellitus, Experimental; Diabetic Retinopathy; D | 2020 |
Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Behavior, Animal; Brain; Cognition; Disease Models | 2020 |
Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Colitis; Dextran Sulfate; Disease M | 2021 |
Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Disea | 2020 |
Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats.
Topics: Administration, Intravenous; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Brain Ischemia; Dendr | 2020 |
Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Electroencephalo | 2020 |
Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Metformin; Mice; Mice, Inbred C57BL; T-Lymphocy | 2021 |
Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase.
Topics: Activating Transcription Factor 1; AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; A | 2021 |
The possible role of progranulin on anti-inflammatory effects of metformin in temporal lobe epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial | 2020 |
Loss of the
Topics: Amino Acids, Branched-Chain; Animals; Animals, Genetically Modified; Apoptosis; Brain; Casein Kinase | 2020 |
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; | 2020 |
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Line; Disease Models, Animal; Glyoxal; Humans; H | 2020 |
Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice†.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Metformin; Mice; Oocytes; Ovary; Po | 2020 |
The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats.
Topics: Animals; Biomarkers; Carum; Disease Models, Animal; Female; Hypoglycemic Agents; Iran; Letrozole; Me | 2020 |
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Doublecortin Protein; Hippocampus; | 2020 |
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial | 2021 |
Delayed metformin treatment improves functional recovery following traumatic brain injury via central AMPK-dependent brain tissue repair.
Topics: Adenylate Kinase; Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypoglycemic Ag | 2020 |
Combination of
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Diet, Carbohydrate Loading; Diet, High-Fat; Disea | 2020 |
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expr | 2020 |
Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.
Topics: 3' Untranslated Regions; Anemia, Diamond-Blackfan; Animals; Cells, Cultured; Colony-Forming Units As | 2020 |
The effects of high-fat diet and metformin on urinary metabolites in diabetes and prediabetes rat models.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2021 |
Metformin prevents brain injury after cardiopulmonary resuscitation by inhibiting the endoplasmic reticulum stress response and activating AMPK-mediated autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Brain Injuries; Cardiopulmonary Resuscitation; Di | 2021 |
Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.
Topics: Amino Acids, Branched-Chain; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disea | 2020 |
Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synerg | 2020 |
Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Disease Models, Animal; Drug Therapy, Com | 2021 |
PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat.
Topics: Alanine Transaminase; Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; A | 2020 |
Effect of Metformin on Development of Tendinopathy Due to Mechanical Overloading in an Animal Model.
Topics: Achilles Tendon; Animals; Disease Models, Animal; Female; HMGB1 Protein; Hypoglycemic Agents; Metfor | 2020 |
Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1.
Topics: Animals; Apoptosis; Brain; Cardiopulmonary Resuscitation; Cytoprotection; Disease Models, Animal; En | 2021 |
Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Disease Models, Animal; | 2021 |
Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway.
Topics: AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure | 2021 |
NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Disease Models, Animal | 2020 |
The effect of metformin in EML
Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Sur | 2021 |
Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Diseas | 2020 |
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N | 2021 |
Short-term Effects of Metformin on Cardiac and Peripheral Blood Cells Following Cecal Ligation and Puncture-induced Sepsis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Blood Cells; Cecum; Disease Models, Ani | 2021 |
Metformin attenuates lipopolysaccharide-induced epithelial cell senescence by activating autophagy.
Topics: Acute Lung Injury; Animals; Autophagy; Autophagy-Related Protein 5; Cell Line; Cellular Senescence; | 2021 |
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet.
Topics: Animals; Anti-Obesity Agents; Biomarkers; Disease Models, Animal; Fertility; Fertility Agents, Male; | 2021 |
Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Dr | 2021 |
Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; CD4 Lymphocyte | 2021 |
Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Experimental; Disease | 2021 |
Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Metformin; Nitrosative Stress; Ovarian Torsio | 2021 |
Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cell Movement; Cell Survival; Cells, Cultured | 2021 |
New Insight Into Metformin-Induced Cholesterol-Lowering Effect Crosstalk Between Glucose and Cholesterol Homeostasis via ChREBP (Carbohydrate-Responsive Element-Binding Protein)-Mediated PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Regulation.
Topics: Adolescent; Adult; Animals; Anticholesteremic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcri | 2021 |
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis.
Topics: AMP-Activated Protein Kinases; Animals; Bacteria; Colon; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2021 |
Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2021 |
Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Dilatation, Pa | 2021 |
Inhibition of Glucose Metabolism Abrogates the Effector Phase of Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita.
Topics: Animals; Autoantibodies; Deoxyglucose; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Gluc | 2021 |
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Eucommiaceae; Female; Flavonoids; Gona | 2021 |
Metformin alleviates cisplatin-induced ototoxicity by autophagy induction possibly via the AMPK/FOXO3a pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Autophagy; Cells, Cultured; Ci | 2021 |
The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Aspirin; Blood Glucose; Diabetes Mel | 2021 |
Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Carcinogenesis; Disease Models, Animal | 2021 |
Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Diseas | 2021 |
Multi-omics analyses reveal that HIV-1 alters CD4
Topics: Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Gene Expressi | 2021 |
Metformin ameliorates the severity of experimental Alport syndrome.
Topics: Animals; Collagen Type IV; Diabetic Nephropathies; Disease Models, Animal; Hypoglycemic Agents; Kidn | 2021 |
Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway.
Topics: Animals; Arthritis, Experimental; Celecoxib; Chondrocytes; Diabetes Mellitus, Type 2; Disease Models | 2021 |
Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Female; Gastrointestinal | 2021 |
Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bleomycin; Collagen; Disease Models, Animal; Female; Fib | 2021 |
Effects of metformin on experimentally induced acne on rabbit ear.
Topics: Acne Vulgaris; Animals; Disease Models, Animal; Metformin; Outcome Assessment, Health Care; Rabbits | 2021 |
Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury.
Topics: Animals; Apoptosis Regulatory Proteins; Disease Models, Animal; Energy Metabolism; Glycolysis; Hepat | 2021 |
Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines.
Topics: Animals; Biomarkers; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neopla | 2021 |
Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.
Topics: Animals; Brain; Brain Injuries; Cognitive Dysfunction; Cranial Irradiation; Disease Models, Animal; | 2021 |
Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis.
Topics: Adenoviridae; Adenoviridae Infections; Animals; Cells, Cultured; Disease Models, Animal; Energy Meta | 2021 |
Promise and complexity of lupus mouse models.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Congresses as Topic; Disease Models, Animal; Drug | 2021 |
The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress.
Topics: Acetates; Animals; Cyclopropanes; Cytochrome P-450 CYP1A2 Inducers; Diabetes Complications; Diabetes | 2021 |
Metformin reduces neuroinflammation and improves cognitive functions after traumatic brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cognition; Disease Models, Animal; Metformin; Mice; Mice, | 2021 |
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.
Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fa | 2021 |
Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 signalling pathway.
Topics: Animals; Blood Glucose; Cell Line; Cell Line, Tumor; Cytokines; Diabetes Mellitus, Experimental; Dia | 2021 |
Metformin-Inducible Small Heterodimer Partner Interacting Leucine Zipper Protein Ameliorates Intestinal Inflammation.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Epithelial Cells; Female; Gene Expression Regulat | 2021 |
Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity.
Topics: Animals; Aorta; Disease Models, Animal; Endothelium, Vascular; Hypoglycemic Agents; Male; Metformin; | 2021 |
Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Hypoglycem | 2021 |
Metformin inhibits polyphosphate-induced hyper-permeability and inflammation.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Anti-Inflammatory Agents; Capillary Permeability; Cel | 2021 |
Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α.
Topics: Anabolic Agents; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cytokines; Depression; Disease | 2021 |
Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2021 |
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Benzylamines; Cell Line, | 2021 |
Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Blood Glucose; Carboxymet | 2021 |
Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model.
Topics: Animals; Arachidonic Acid; Basal Metabolism; Biomarkers; Cardiotonic Agents; Disease Models, Animal; | 2021 |
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
Topics: Animals; Aquaporins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Di | 2021 |
Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and memory in a rat model of multiple sclerosis disease.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme | 2021 |
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Butadienes; Diet, Hig | 2021 |
Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation.
Topics: Animals; Burns; Disease Models, Animal; Humans; Inflammation; Macrophages; Male; Metformin; Mice; Os | 2021 |
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Autophagy; Autophagy-Related Proteins; Butanes; Cell Extracts; | 2021 |
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
Topics: Animals; Antibodies; Antimetabolites; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Anim | 2021 |
Interaction of clozapine with metformin in a schizophrenia rat model.
Topics: Animals; Behavior, Animal; Body Weight; Clozapine; Disease Models, Animal; Drug Interactions; Feedin | 2021 |
Metformin suppresses interleukin-22 induced hepatocellular carcinoma by upregulating Hippo signaling pathway.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Hippo Signaling Pathway; Interleukin-22; | 2021 |
Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers.
Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cells, Cultured; Disease Models, Animal; Energy M | 2017 |
Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome.
Topics: Animals; Chorionic Gonadotropin; Disease Models, Animal; Embryo Implantation; Estradiol; Estrous Cyc | 2017 |
The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model.
Topics: Acylation; Animals; Diet, High-Fat; Disease Models, Animal; Epigenesis, Genetic; Histone Code; Histo | 2017 |
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Fragile X Mental | 2017 |
Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.
Topics: Alanine Transaminase; Animals; Blood Glucose; Blotting, Western; Cell Line; Cell Proliferation; Chol | 2017 |
Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet.
Topics: Animals; Atherosclerosis; Atorvastatin; Biomarkers; Biopsy; Cholesterol; Diet, High-Fat; Disease Mod | 2017 |
Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.
Topics: Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; Drug Synergism; Drug Therapy | 2017 |
Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Autophagy; Body Weight; Diet, High-Fat; Dise | 2017 |
Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.
Topics: Animals; Carcinogenesis; Disease Models, Animal; DNA Damage; Doxorubicin; Drosophila melanogaster; F | 2017 |
Neurodevelopmental disorders: Metformin - a therapeutic option for fragile X syndrome?
Topics: Animals; Disease Models, Animal; Fragile X Syndrome; Metformin; Mice; Neurodevelopmental Disorders | 2017 |
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
Topics: Acidosis, Lactic; Adenine; Animals; Disease Models, Animal; Enzyme Inhibitors; Gluconeogenesis; Kidn | 2017 |
Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection.
Topics: Activating Transcription Factor 2; Animals; Brain; Cell Line, Tumor; Cell Survival; Cyclic AMP Respo | 2017 |
Modulatory effects of Caralluma fimbriata extract against high-fat diet induced abnormalities in carbohydrate metabolism in Wistar rats.
Topics: Adipose Tissue; alpha-Amylases; Animals; Apocynaceae; Carbohydrate Metabolism; Diabetes Mellitus; Di | 2017 |
Metformin HCl has curative effect on rebuilding of ventricular diastolic functions in high-fat-diet fed rats.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Liver; Male; Metformin; Myocardium; Non-alcoholic F | 2017 |
Metformin Attenuates Neurological Deficit after Intracerebral Hemorrhage by Inhibiting Apoptosis, Oxidative Stress and Neuroinflammation in Rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Infla | 2017 |
Metformin ameliorates the Phenotype Transition of Peritoneal Mesothelial Cells and Peritoneal Fibrosis via a modulation of Oxidative Stress.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cells, Cultured; Disease Models, Animal; Epithelial-M | 2017 |
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Catalase; Disease Models, Animal; Enzy | 2018 |
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.
Topics: Animals; Carcinogenesis; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Di | 2017 |
Polyphenols activate energy sensing network in insulin resistant models.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cell Differentiation; Cell Line; Cell Surviva | 2017 |
Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cell Proliferation; Cloaca; Cysts; Disease Models | 2017 |
Metformin Protects against Experimental Acrylamide Neuropathy in Rats.
Topics: Acrylamide; Administration, Oral; Animals; Brain Injuries; Caspase 3; Disease Models, Animal; Gene E | 2017 |
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Diseas | 2017 |
Metformin maintains mucosal integrity in experimental model of colitis by inhibiting oxidative stress and pro-inflammatory signaling.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Disease | 2017 |
Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats.
Topics: Animals; Ascorbic Acid; Biogenic Monoamines; Blood Glucose; Comorbidity; Corticosterone; Cytokines; | 2017 |
A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity.
Topics: Animals; Diet, High-Fat; Diet, Western; Disease Models, Animal; Hypoglycemic Agents; Metformin; Mice | 2017 |
Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Gingiva; Glutathione Peroxidase; Glutathione Pe | 2017 |
Metformin influences on respiratory system in obese mice induced by postnatal overnutrition.
Topics: Animals; Bronchoalveolar Lavage Fluid; Diet; Disease Models, Animal; Hypoglycemic Agents; Lung; Male | 2018 |
Metformin accelerates wound healing in type 2 diabetic db/db mice.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabete | 2017 |
Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal | 2017 |
Metformin Inhibits the Development of L-DOPA-Induced Dyskinesia in a Murine Model of Parkinson's Disease.
Topics: Amantadine; Animals; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Ma | 2018 |
Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Chitosan; Disease Models, Animal; Drug Implants; | 2018 |
Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Metformin; Pilocarp | 2018 |
Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice.
Topics: Age Factors; Animals; Bacteria; Blood Glucose; Body Weight; Diet, High-Fat; Disease Models, Animal; | 2018 |
Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins.
Topics: Animals; Apoptosis; Disease Models, Animal; Endometrial Hyperplasia; Estradiol; Female; Metformin; P | 2018 |
Metformin Effects on Metabolic Coupling and Tumor Growth in Oral Cavity Squamous Cell Carcinoma Coinjection Xenografts.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Caveolin 1; Cell Culture Techniques; Disease Models, A | 2018 |
Metformin Mediates Protection against
Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Disease Models, Animal; Female; Gene Expression P | 2018 |
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway.
Topics: Animals; Antihypertensive Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line | 2017 |
Metformin attenuates folic-acid induced renal fibrosis in mice.
Topics: Albuminuria; Animals; Cell Line; Chemokine CCL2; Collagen Type IV; Disease Models, Animal; Extracell | 2018 |
Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain.
Topics: AMP-Activated Protein Kinases; Animals; Astrocytes; Behavior, Animal; Biomarkers; Blood Glucose; Dis | 2018 |
Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, | 2017 |
Effects of metformin on prostatic tissue of rats with metabolic syndrome and benign prostatic hyperplasia.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Hypoglycemic Agents; Insulin Resistance; Insulin-Li | 2018 |
Alteration of renal excretion pathways in gentamicin-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Antiporters; ATP Binding Cassette Transporter, Subfamily G, Member 2; | 2018 |
Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Disease Models, Anim | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model.
Topics: Animals; Biomarkers; Cell Proliferation; Cytochrome P450 Family 17; Disease Models, Animal; Female; | 2018 |
Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats.
Topics: Animals; Chorionic Gonadotropin; Disease Models, Animal; Embryo Implantation; Female; Gene Expressio | 2018 |
Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Eva | 2018 |
Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; | 2018 |
Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model.
Topics: Animals; Benzhydryl Compounds; Diet, High-Fat; Disease Models, Animal; Glucosides; Humans; Insulin; | 2018 |
Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction.
Topics: AMP-Activated Protein Kinases; Animals; Burns; Disease Models, Animal; Energy Metabolism; Glucose; H | 2018 |
Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diabetes Mellitus; Disease | 2018 |
Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.
Topics: Age Factors; Animals; Disease Models, Animal; Female; Glucose; Glucose Tolerance Test; Insulin; Insu | 2018 |
Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.
Topics: Animals; Cholesterol; Diet; Disease Models, Animal; Eating; Female; Hypoglycemic Agents; Metformin; | 2018 |
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model.
Topics: Acyltransferases; Administration, Oral; Animals; Carcinogenesis; Carcinoma, Pancreatic Ductal; Chemo | 2018 |
New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats.
Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Male; M | 2018 |
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Extracellular Signal-Regulated MA | 2018 |
Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.
Topics: Adenine; Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Disease Models, Animal; Humans; | 2018 |
Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heart Failure; Hypertensio | 2018 |
Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms.
Topics: Animals; Biomarkers; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models | 2018 |
Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice.
Topics: Animals; Calcinosis; Cholagogues and Choleretics; Cholesterol; Diabetes Mellitus, Type 2; Diet, High | 2018 |
Metformin Preconditioning of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells Promotes Their Engraftment and Improves Post-Stroke Regeneration and Recovery.
Topics: Animals; Brain; Cell Differentiation; Disease Models, Animal; Humans; Induced Pluripotent Stem Cells | 2018 |
Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain Ischemia; CA1 Region, Hippocampa | 2018 |
Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Proliferation; Diet, High-Fat; Disease Models, Animal | 2018 |
Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; BRCA1 Protein; Cell Line, Tumor; Disea | 2018 |
Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Count; Dehydroepiandrosterone; Disease Model | 2018 |
Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy.
Topics: Animals; Central Nervous System Agents; Disease Models, Animal; Hyperalgesia; Inflammation; Locomoti | 2018 |
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagon | 2019 |
Metformin reverses established lung fibrosis in a bleomycin model.
Topics: Adenylate Kinase; Animals; Bleomycin; Disease Models, Animal; Enzyme Activation; Extracellular Matri | 2018 |
Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Humans; Inflam | 2018 |
Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.
Topics: Adenomatous Polyposis Coli Protein; Animals; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co | 2018 |
Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Female; Fetal Development; Gene Expression; Gene Ex | 2019 |
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Biopsy, Needle | 2018 |
Metformin protects bone mass in ultra-high-molecular-weight polyethylene particle-induced osteolysis by regulating osteocyte secretion.
Topics: Adaptor Proteins, Signal Transducing; Adenylate Kinase; Animals; Bone and Bones; Cell Differentiatio | 2019 |
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dihydro | 2018 |
Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycyt | 2018 |
Metformin, sitagliptin, and liraglutide modulate serum retinol-binding protein-4 level and adipocytokine production in type 2 diabetes mellitus rat model.
Topics: Adipokines; Animals; Blood Glucose; Body Mass Index; Diabetes Mellitus, Experimental; Diabetes Melli | 2018 |
Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations.
Topics: Acetylcholinesterase; Adiponectin; Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Co | 2018 |
Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Biomarkers; | 2018 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H | 2018 |
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Base Sequence; Chickens; Disease Model | 2018 |
Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model.
Topics: Androgen Antagonists; Animals; Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Blood G | 2019 |
Metformin relieves acute respiratory distress syndrome by reducing miR-138 expression.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Lipopolysaccharides; Lung | 2018 |
Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.
Topics: Animals; Astrocytes; Behavior, Animal; Caenorhabditis elegans; Calcium; Cell Respiration; Cerebral C | 2018 |
Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.
Topics: Aging; Animals; Cell Line, Tumor; Disease Models, Animal; Fatty Liver; Genome-Wide Association Study | 2018 |
Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling.
Topics: Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Aspartate Aminotransferases; Be | 2018 |
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Mo | 2018 |
Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Hypoglycemic Agents; Male; M | 2018 |
Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Disease Models, Animal; Heart Rupture, | 2018 |
Metabolic profiling of metformin treatment for low-level Pb-induced nephrotoxicity in rat urine.
Topics: Administration, Oral; Animals; Biological Factors; Disease Models, Animal; Environmental Pollutants; | 2018 |
Activation of the Glutathione Peroxidase by Metformin in the Bile-duct Ligation induced Liver Injury: In vivo Combined with Molecular Docking Studies.
Topics: Animals; Bile Ducts; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidas | 2018 |
Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model.
Topics: Analysis of Variance; Animals; Blood Glucose; Cholesterol; Disease Models, Animal; Estrone; Expector | 2018 |
Metformin Ameliorates Periapical Lesions through Suppression of Hypoxia-induced Apoptosis of Osteoblasts.
Topics: Animals; Apoptosis; Caspase 9; Cell Hypoxia; Cells, Cultured; Cytochromes c; Depression, Chemical; D | 2018 |
The protective effect of metformin against the noise-induced hearing loss.
Topics: Animals; Auditory Threshold; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearin | 2018 |
Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy.
Topics: Animals; Coronary Vessels; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Hypoglycemic | 2018 |
Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Drug Administration Schedule; Echocardiograp | 2018 |
Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.
Topics: Animals; Colitis; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic | 2019 |
Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet.
Topics: Animals; Atorvastatin; Biomarkers; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Experi | 2018 |
Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Hypoglycemic | 2019 |
Metformin can inhibit Helicobacter pylori growth.
Topics: Animals; Anti-Infective Agents; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; Fema | 2018 |
Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endometrium; Endoplasmic Reticulum S | 2019 |
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Drug Therapy, Combination; Kidney; MAP Kinase Signali | 2019 |
Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.
Topics: Animals; Desoxycorticosterone Acetate; Diastole; Disease Models, Animal; Heart Failure; Heart Ventri | 2019 |
Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish.
Topics: Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular; Cell Polarity; Diet, High-Fat; Di | 2019 |
Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes.
Topics: Animals; Cartilage, Articular; Cell Survival; Cells, Cultured; Chondrocytes; Disease Models, Animal; | 2019 |
Metformin reduces neuronal damage and promotes neuroblast proliferation and differentiation in a cerebral ischemia/reperfusion rat model.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Proliferation; Disease Models, Anima | 2019 |
Metformin Promotes the Protection of Mice Infected With
Topics: Animals; Disease Models, Animal; Female; Humans; Lymphocyte Activation; Malaria; Metformin; Mice; Mi | 2018 |
Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Cells, Cultured; Deoxyglucose; Disease Models, Ani | 2018 |
Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation.
Topics: Adenosine Triphosphate; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumo | 2019 |
Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease.
Topics: Animals; Cell-Penetrating Peptides; Chitosan; Diet, High-Fat; Disease Models, Animal; Gene Transfer | 2019 |
Re: Effects of Metformin on Prostatic Tissue of Rats with Metabolic Syndrome and Benign Prostatic Hyperplasia.
Topics: Animals; Disease Models, Animal; Humans; Male; Metabolic Syndrome; Metformin; Prostatic Hyperplasia; | 2019 |
Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.
Topics: Animals; Body Weight; Cell Death; Chemokine CCL2; Disease Models, Animal; Dogs; Ethylene Glycol; Hum | 2019 |
Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.
Topics: Animals; Disease Models, Animal; Hypoglycemic Agents; Intestinal Mucosa; Irritable Bowel Syndrome; M | 2019 |
Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Female; Hypoglycemic Agents | 2020 |
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.
Topics: Anhedonia; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Drug Therapy | 2019 |
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inter | 2019 |
Renal dysfunction in a mouse model of GDM is prevented by metformin through MAPKs.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Diet, High-Fat; Disease Models, Animal; Female; Gluco | 2019 |
Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice.
Topics: Adenylate Kinase; Animals; Apolipoproteins E; Cognitive Dysfunction; Disease Models, Animal; Fibrobl | 2019 |
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance.
Topics: Animals; Biological Products; Biopsy, Needle; Carbamates; Disease Models, Animal; Glucose Intoleranc | 2019 |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
Topics: Adenine; Animals; Antiporters; Cephalexin; Creatinine; Disease Models, Animal; Down-Regulation; Huma | 2019 |
In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Catecholamine Plasma Membrane Transport Proteins; Chin | 2019 |
Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Maze Learning; Memory; Metformin; Mice; Neuropro | 2019 |
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Disease Models, An | 2019 |
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Mod | 2019 |
Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine.
Topics: Animals; Biomarkers; Disease Models, Animal; Gastrointestinal Microbiome; Hypoglycemic Agents; Intes | 2019 |
Treatment with metformin prevents myocardial ischemia-reperfusion injury via STEAP4 signaling pathway.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Male; Membrane Proteins; Metformin; Myocardial | 2019 |
Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; AMP-Activated Protein Kinases; Animals; Atrial Fibrillation; Car | 2019 |
Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Dise | 2019 |
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction | 2019 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dis | 2019 |
Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Cell Movement; Cells, Cultured; Chondrocytes; Cyt | 2019 |
Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, A | 2019 |
Metformin improves salivary gland inflammation and hypofunction in murine Sjögren's syndrome.
Topics: Administration, Oral; Animals; B-Lymphocytes; Cell Differentiation; Cytokines; Disease Models, Anima | 2019 |
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease.
Topics: AMP-Activated Protein Kinases; Animals; Brain; Caenorhabditis elegans; Disease Models, Animal; Human | 2019 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Res | 2019 |
Treatment with metformin in twelve patients with Lafora disease.
Topics: Adolescent; Animals; Disease Models, Animal; Female; Humans; Lafora Disease; Male; Metformin; Mutati | 2019 |
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr | 2019 |
Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Biomarkers; Cytokines; Dehydroepiandrosterone; Diet, Hi | 2019 |
Therapy of empagliflozin plus metformin on T2DM mice shows no higher amelioration for glucose and lipid metabolism than empagliflozin monotherapy.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Dru | 2019 |
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.
Topics: AMP-Activated Protein Kinases; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, C | 2019 |
Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin.
Topics: Aged; Animals; Antioxidants; Aromatase Inhibitors; Blood Glucose; Body Weight; Chromatography, High | 2019 |
Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia.
Topics: Animals; Disease Models, Animal; Female; Lipopolysaccharides; Metformin; NF-kappa B; Oxidative Stres | 2019 |
Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats.
Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Fibrosis; Humans; Immunosuppressive Agent | 2019 |
Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation.
Topics: Animals; Bleomycin; Cell Differentiation; Collagen; Disease Models, Animal; Female; Fibrosis; Germin | 2019 |
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Ceftriaxone; Cytokines; Disease Models, Animal; Drug Ther | 2019 |
Pro-neurocognitive and anti-sarcopenic benefits of one-year metformin therapy in ovariectomized aged mice.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Drug Administra | 2019 |
Mitigation of Radiation-Induced Lung Pneumonitis and Fibrosis Using Metformin and Melatonin: A Histopathological Study.
Topics: Animals; Antioxidants; Disease Models, Animal; Melatonin; Metformin; Mice; Protective Agents; Radiat | 2019 |
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.
Topics: Administration, Oral; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Dose-R | 2012 |
A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2013 |
Chemopreventive effects of metformin on obesity-associated endometrial proliferation.
Topics: Analysis of Variance; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Endometrial Ne | 2013 |
[D-Leu-4]-OB3, an orally bioavailable leptin-related synthetic peptide insulin sensitizer: a study comparing the efficacies of [D-Leu-4]-OB3 and metformin on energy balance and glycemic regulation in insulin-deficient male Swiss Webster mice.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Disease Models, Animal; Energ | 2013 |
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Disease Models, Animal; Glucose; G | 2013 |
Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Enz | 2013 |
Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; Enzyme Induction; Male; Metformin; Nephrectomy; R | 2013 |
TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats.
Topics: Animals; Benzofurans; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; | 2013 |
Metformin impairs endothelialization after placement of newer generation drug eluting stents.
Topics: Angioplasty, Balloon; Animals; Disease Models, Animal; Drug-Eluting Stents; Endothelium, Vascular; E | 2013 |
Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive Agents; Arterial Pressure; | 2013 |
Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes, | 2014 |
Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Therapy, Combination; Fasting; Female; Glucos | 2014 |
Metformin inhibits skin tumor promotion in overweight and obese mice.
Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; | 2014 |
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Di | 2013 |
Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice.
Topics: Animals; Blood Glucose; Capillary Permeability; Diabetes Mellitus, Type 1; Disease Models, Animal; E | 2013 |
Paradoxic effects of metformin on endothelial cells and angiogenesis.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Antineoplastic Agen | 2014 |
Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2.
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Disease Models, Animal; Heart Failure, Systolic; Hype | 2014 |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Ex | 2014 |
Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Carrier Proteins; Cell Survival; Cells, Cultured | 2014 |
Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus; Diet, High-Fat; Disease Mod | 2014 |
Safety and otoprotection of metformin in radiation-induced sensorineural hearing loss in the guinea pig.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, A | 2014 |
Repurposing to fight cancer: the metformin-prostate cancer connection.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Diab | 2014 |
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Diseas | 2014 |
Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Glucose; Glucose Intol | 2014 |
Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke.
Topics: AMP-Activated Protein Kinases; Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonist | 2014 |
Persistent impaired glucose metabolism in a zebrafish hyperglycemia model.
Topics: Animals; Disease Models, Animal; Eye Proteins; Glucose; Glycosylation; Hyperglycemia; Hypoglycemic A | 2014 |
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextran Sulfat | 2014 |
Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats.
Topics: Adipose Tissue; Animals; Cholesterol; Diet, High-Fat; Disease Models, Animal; Down-Regulation; Hypog | 2014 |
Beneficial effects of pioglitazone and metformin in murine model of polycystic ovaries via improvement of chemerin gene up-regulation.
Topics: Adipokines; Animals; Chemokines; Disease Models, Animal; Drug Combinations; Drug Resistance; Female; | 2014 |
Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes.
Topics: Animals; Blood Glucose; Bone Remodeling; Dental Implants; Diabetes Mellitus, Type 2; Disease Models, | 2014 |
Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma; Carcinoma, Papillary; Cells | 2014 |
Immediate direct peripheral vasoconstriction in response to hyperinsulinemia and metformin in the anesthetized pig.
Topics: Anesthesia, General; Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Female; H | 2014 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbr | 2014 |
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.
Topics: Adipocytes; Adipokines; Aged; Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; C | 2014 |
Metformin mitigates apoptosis in ischemic myocardium.
Topics: Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Forkhead Transcription Factors; Hypo | 2014 |
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood | 2014 |
Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model.
Topics: Adenylate Kinase; Angiogenesis Inducing Agents; Animals; Blood Flow Velocity; Capillaries; Disease M | 2015 |
Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.
Topics: Animals; Atrial Natriuretic Factor; Binding Sites; Cardiomegaly; Disease Models, Animal; GATA6 Trans | 2014 |
Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.
Topics: AMP-Activated Protein Kinases; Animals; Benzophenanthridines; Berberine Alkaloids; Blood Glucose; Bo | 2014 |
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Th | 2015 |
Advanced onset of puberty after metformin therapy in swine with thrifty genotype.
Topics: Adiposity; Age Factors; Animals; Biomarkers; Blood Glucose; Diet, High-Fat; Disease Models, Animal; | 2014 |
Metformin improves skin flap survival through nitric oxide system.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Survival; Hypoglycemic Agen | 2014 |
[Effect of Mudan Granule on islets beta cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Insulin Resistance; Insulin-Secretin | 2014 |
Metformin treatment alters memory function in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Blood Glucose; Dis | 2015 |
Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis.
Topics: Animals; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Drosophila melanogaster; Feeding Beha | 2014 |
Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Infarction; Cells, Cultured; Cyto | 2014 |
GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.
Topics: Animals; Animals, Genetically Modified; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Diseas | 2015 |
Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Cells, Cultured; Diabetes Mellitu | 2015 |
Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Blotting, Western; Cholecalciferol; Colorecta | 2015 |
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; | 2015 |
AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease | 2015 |
Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Glucose; Cardiovascular A | 2014 |
Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats.
Topics: Age Factors; Animals; Behavior, Animal; Biomarkers; Blood Glucose; Caloric Restriction; Combined Mod | 2015 |
Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease | 2015 |
Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease.
Topics: Animals; Brain; Disease Models, Animal; Fluorescent Antibody Technique; Gliosis; Glucans; Hippocampu | 2016 |
MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Cluster Analysis; Diet; Disease Models, Animal; Gene Expression; Gene E | 2015 |
Normalization of CD4+ T cell metabolism reverses lupus.
Topics: Animals; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Lupus Erythematosus, Syst | 2015 |
Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models.
Topics: Alkylating Agents; Animals; Biomarkers, Tumor; Disease Models, Animal; Female; Humans; Hypoglycemic | 2015 |
Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.
Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Modulatory effects of adiponectin on the polarization of tumor-associated macrophages.
Topics: Adiponectin; Animals; CD8-Positive T-Lymphocytes; Chemokine CCL2; Disease Models, Animal; Disease Pr | 2015 |
Antidiabetic drug metformin inhibits esophageal adenocarcinoma cell proliferation in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferat | 2015 |
Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy.
Topics: Animals; Apoptosis; Caspases; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; End | 2015 |
Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.
Topics: Animals; Biomarkers; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diseas | 2015 |
Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction.
Topics: Adamantane; Angiotensin-Converting Enzyme Inhibitors; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Pe | 2015 |
Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.
Topics: Animals; Anti-Inflammatory Agents; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Disea | 2015 |
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2015 |
Impact of diabetes type II and chronic inflammation on pancreatic cancer.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Cell Death; Cell Line, Tumor; Cell | 2015 |
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Caloric Restriction; Cell Line, Tum | 2015 |
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Histamine; Hypoglycemic Agents; Male; Me | 2015 |
Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Hypoglycemic Agents; M | 2015 |
Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Pro | 2015 |
Metformin potentiates rapamycin and cisplatin in gastric cancer in mice.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Cycle; | 2015 |
Early treatment with metformin induces resistance against tumor growth in adult rats.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Heterogra | 2015 |
Electroacupuncture plus metformin lowers glucose levels and facilitates insulin sensitivity by activating MAPK in steroid-induced insulin-resistant rats.
Topics: Animals; Blood Glucose; Combined Modality Therapy; Dexamethasone; Diabetes Mellitus, Type 2; Disease | 2015 |
Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytoprotection; | 2015 |
Can Animal Models of PCOS Help Point the Way Towards Early and Effective Therapeutic Intervention in Women With the Syndrome?
Topics: Androgen Antagonists; Animals; Contraceptives, Oral, Hormonal; Disease Models, Animal; Disease Progr | 2015 |
Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance.
Topics: Animals; Disease Models, Animal; Erectile Dysfunction; Hypoglycemic Agents; Insulin Resistance; Male | 2015 |
Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis.
Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Disease Models, Animal; Erythropoietin; Galact | 2015 |
Effect of metformin and adriamycin on transplantable tumor model.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Disease Models, Animal; Doxorubicin; Hypoglycemic A | 2015 |
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Exenatide; Female; Gene Expression Regulati | 2015 |
Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance.
Topics: Animals; Cell Differentiation; Cell Line; Cytokines; Disease Models, Animal; Gene Expression; Humans | 2015 |
Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Humans; Hyperse | 2016 |
Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect.
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colorect | 2015 |
Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling.
Topics: AC133 Antigen; Animals; Antigens, CD; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Drug | 2015 |
Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats.
Topics: Animals; Blotting, Western; Caloric Restriction; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2015 |
Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat | 2016 |
Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Diet, High-Fat; Disease Models, Animal; | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Effect of colchicine on polycystic ovary syndrome: an experimental study.
Topics: Androstenedione; Animals; C-Reactive Protein; Colchicine; Disease Models, Animal; Dose-Response Rela | 2016 |
Does metformin improve in vitro maturation and ultrastructure of oocytes retrieved from estradiol valerate polycystic ovary syndrome-induced rats.
Topics: Animals; Blood Glucose; Body Weight; Contraceptive Agents; Cumulus Cells; Disease Models, Animal; Es | 2015 |
Metformin for cancer and aging prevention: is it a time to make the long story short?
Topics: Animals; Anticarcinogenic Agents; Cricetinae; Disease Models, Animal; Drug Administration Routes; Dr | 2015 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Aci | 2016 |
Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Asp | 2016 |
Chondrocyte-Specific Ablation of AMPKα1 Does Not Affect Bone Development or Pathogenesis of Osteoarthritis in Mice.
Topics: AMP-Activated Protein Kinases; Animals; Bone Development; Cartilage; Chondrocytes; Disease Models, A | 2016 |
Age-dependent effects in fathead minnows from the anti-diabetic drug metformin.
Topics: Age Factors; Animals; Cyprinidae; Diabetes Mellitus; Disease Models, Animal; Hypoglycemic Agents; Ma | 2016 |
Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal | 2016 |
Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts.
Topics: Angiotensin II; Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Gene Ex | 2016 |
Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase.
Topics: Adrenoleukodystrophy; AMP-Activated Protein Kinases; Animals; Animals, Newborn; ATP Binding Cassette | 2016 |
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Metformin; Mice; Mice, Transgenic; tau Pro | 2016 |
Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biophysics; Diet, High-Fat; Disease Models, Anima | 2016 |
Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis.
Topics: Animals; Biopsy, Needle; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplast | 2016 |
Effects of Exenatide on Metabolic Changes, Sexual Hormones, Inflammatory Cytokines, Adipokines, and Weight Change in a DHEA-Treated Rat Model.
Topics: Adipokines; Animals; Body Weight; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; Exenati | 2016 |
High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum.
Topics: Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent K | 2016 |
Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Exp | 2016 |
Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Brain Ischemia; Brain-Derived Neurotrophic | 2016 |
Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2016 |
Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Extracellular Mat | 2016 |
Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Cisplatin; Cognition Disorders; Disease Models, An | 2016 |
Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21.
Topics: 3T3-L1 Cells; Adipose Tissue; Adiposity; Animals; Body Weight; CD4-Positive T-Lymphocytes; Diet, Hig | 2016 |
Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibito | 2016 |
Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Hypoglycemic Agents; Metformin; Mice | 2016 |
Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hy | 2016 |
Metformin treatment status and abdominal aortic aneurysm disease progression.
Topics: Administration, Oral; Aged; Animals; Aortic Aneurysm, Abdominal; California; Data Mining; Databases, | 2016 |
Differential metformin dose-dependent effects on cognition in rats: role of Akt.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cogniti | 2016 |
Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate-activated protein kinase-autophagy for the balance between T helper 17 an
Topics: Adenylate Kinase; Animals; Autophagy; Cell Differentiation; Cell Proliferation; Disease Models, Anim | 2016 |
Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.
Topics: Adenocarcinoma, Follicular; Anaplasia; Animals; Antineoplastic Agents; Cell Proliferation; Diet, Hig | 2016 |
The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Flavonoids; Hypoglycemic Agents; M | 2016 |
A Rapid and Convenient Method for in Vivo Fluorescent Imaging of Protoscolices of Echinococcus multilocularis.
Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Carbocyanines; Disease Models, Animal; Echinoco | 2016 |
Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Huntingtin Protei | 2016 |
Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Drinki | 2016 |
Oral Metformin Ameliorates Bleomycin-Induced Skin Fibrosis.
Topics: Administration, Oral; Animals; Bleomycin; Disease Models, Animal; Female; Fibrosis; Humans; Metformi | 2016 |
Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice.
Topics: AMP-Activated Protein Kinases; Animals; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimen | 2016 |
Pre-stroke Metformin Treatment is Neuroprotective Involving AMPK Reduction.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Disease Models, Animal; Infarction, Middle Cerebr | 2016 |
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibrob | 2016 |
Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dise | 2016 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, | 2016 |
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Disease Models, An | 2016 |
Strategies and Challenges in Clinical Trials Targeting Human Aging.
Topics: Acarbose; Aging; Animals; Anti-Bacterial Agents; Biomedical Research; Clinical Trials as Topic; Cong | 2016 |
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect | 2016 |
Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model.
Topics: Acetylcholinesterase; Amino Acids; Animals; Biogenic Monoamines; Blood Glucose; Canagliflozin; Cereb | 2016 |
Metformin attenuates lung fibrosis development via NOX4 suppression.
Topics: AMP-Activated Protein Kinases; Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Cytoprotec | 2016 |
Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway.
Topics: Adult; Aged; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; Disease M | 2016 |
Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells.
Topics: Animals; Apoptosis; Biomarkers; Cell Cycle Checkpoints; Cell Line, Transformed; Cell Line, Tumor; Ce | 2016 |
Preventive effect of Caralluma fimbriata vs. Metformin against high-fat diet-induced alterations in lipid metabolism in Wistar rats.
Topics: Animals; Apocynaceae; Biomarkers; Diet, High-Fat; Disease Models, Animal; Hyperlipidemias; Hypolipid | 2016 |
Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Disease Model | 2016 |
Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease M | 2016 |
Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Dogs; Ethylene Glycol; Humans; Kidney Cal | 2016 |
Resveratrol Reverses Functional Chagas Heart Disease in Mice.
Topics: Animals; Antioxidants; Chagas Cardiomyopathy; Cyclic N-Oxides; Disease Models, Animal; Female; Male; | 2016 |
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; | 2017 |
Treatment with a novel agent combining docosahexaenoate and metformin increases protectin DX and IL-6 production in skeletal muscle and reduces insulin resistance in obese diabetic db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Docosahexaenoic Acids; Dr | 2017 |
Metformin preconditioned adipose derived mesenchymal stem cells is a better option for the reversal of diabetes upon transplantation.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Type 2; Diet, Hig | 2016 |
Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells
Topics: Animals; Antineoplastic Agents; Apoptosis; Carrier Proteins; Cell Cycle Checkpoints; Cell Line, Tumo | 2017 |
Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress.
Topics: Animals; Behavior, Animal; Biomarkers; Chronic Disease; Depression; Diet, High-Fat; Disease Models, | 2017 |
Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Biomarkers; Blood Glucose; Body Weights and Measures; C | 2016 |
Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Duodenum; Dysbiosis; Gastric Bypass; Gas | 2017 |
Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.
Topics: Animals; Antihypertensive Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell | 2017 |
Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Disease Models, Animal; Gene Expression Re | 2017 |
Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.
Topics: Animals; Anxiety; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders | 2017 |
Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Humans; Metformin; Mice; Mutant Prot | 2017 |
Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Down Syndrome; Fibroblasts; GTP Phosphohydr | 2017 |
Subchronic metformin pretreatment enhances novel object recognition memory task in forebrain ischemia: behavioural, molecular, and electrophysiological studies.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cognitive Dysfunction; Cyclic AMP Response E | 2017 |
The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation.
Topics: Alginates; Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Dela | 2017 |
mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dis | 2017 |
Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis.
Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Liv | 2017 |
4-Phenylbutyric acid and metformin decrease sensitivity to pentylenetetrazol-induced seizures in a malin knockout model of Lafora disease.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis.
Topics: Administration, Oral; Animals; Anthelmintics; Chemoprevention; Disease Models, Animal; Drug Synergis | 2017 |
The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease | 2017 |
The desert gerbil Psammomys obesus as a model for metformin-sensitive nutritional type 2 diabetes to protect hepatocellular metabolic damage: Impact of mitochondrial redox state.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gerbillinae; Hypoglycemic Agents; Insuli | 2017 |
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Dise | 2017 |
Metformin Suppresses Systemic Autoimmunity in
Topics: AMP-Activated Protein Kinases; Animals; Autoimmunity; B-Lymphocytes; Blotting, Western; Cell Differe | 2017 |
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Cell Respiration; Disease Models | 2017 |
Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug | 2008 |
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronch | 2008 |
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Cell Respiration | 2009 |
Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Disease Models, Animal; Fatty Liver; Lipid Pe | 2009 |
Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelin-1; H | 2009 |
db/+ Mice as an alternate model in antidiabetic drug discovery research.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Discovery; Gluco | 2009 |
Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.
Topics: Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2009 |
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.
Topics: Amyloid; Animals; Animals, Genetically Modified; Arginine; Diabetes Mellitus, Type 2; Disease Models | 2009 |
Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Injections, Intravenous; Kidney Function Tests | 2010 |
Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Central Nervous System; Chronic Disease; Cy | 2009 |
Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia.
Topics: Animals; Carrier Proteins; Cell Proliferation; Disease Models, Animal; Endometrial Hyperplasia; Endo | 2009 |
Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Eating | 2009 |
[Metformin effects upon blood pressure and glucose metabolism of monossodium glutamate induced-obese spontaneously hypertensive rats].
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Hypoglycemic Agents; Male; Metabolic | 2009 |
In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.
Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Disease Models, Animal; Echocardiography; | 2009 |
Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Hypoglycemic Agents; Immunohist | 2010 |
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose; Diabetes Mellitus; Disease Models, Ani | 2010 |
Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Atherosclerosis; Biomarkers; Blood Glucose; Blotting, West | 2009 |
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; L | 2010 |
Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway.
Topics: Active Transport, Cell Nucleus; Animals; Aorta, Thoracic; Cardiotonic Agents; Cells, Cultured; Colla | 2010 |
Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glucos | 2010 |
New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Genetic Predisposition to Diseas | 2010 |
Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats.
Topics: Animals; Blood Pressure; Clerodendrum; Disease Models, Animal; Dyslipidemias; Insulin Resistance; Li | 2010 |
Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats.
Topics: Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; H | 2011 |
Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control.
Topics: Animals; Blood Pressure; Diabetes Mellitus; Disease Models, Animal; Hypoglycemic Agents; Metformin; | 2011 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Cell Proliferation; Cystic Fibrosis Transmembrane | 2011 |
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose; Body Weight; Disease Models, Animal; D | 2011 |
Insulin resistance and liver microcirculation in a rat model of early NAFLD.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Diet, High-Fat; Disease Models, Animal; Endothelium; | 2011 |
Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Dehydroepiandrosterone; Disease | 2011 |
[Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes].
Topics: Animals; Apoptosis; Disease Models, Animal; Down-Regulation; Fatty Liver; Insulin Resistance; Lipid | 2011 |
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Benzopyrans; Dietary Fats; Disease Models, | 2011 |
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Natriuretic Factor; Blood Glucose; Cardiotonic Agents | 2011 |
Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats.
Topics: Animals; Antipsychotic Agents; Blood Glucose; Disease Models, Animal; Dyslipidemias; Glyburide; Huma | 2011 |
Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Blood Glucose; | 2011 |
The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Mode | 2011 |
In vitro and in vivo anti-melanoma action of metformin.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autophagy; bcl-2-Associate | 2011 |
Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice.
Topics: Aging; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Cell Count; Dis | 2011 |
Controlling release of metformin HCl through incorporation into stomach specific floating alginate beads.
Topics: Alginates; Animals; Calorimetry, Differential Scanning; Delayed-Action Preparations; Diabetes Mellit | 2011 |
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost | 2012 |
Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blo | 2012 |
The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats.
Topics: Administration, Oral; Agouti-Related Protein; AMP-Activated Protein Kinases; Animals; Blood Glucose; | 2012 |
Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
Topics: Animals; Body Weight; Boronic Acids; Bortezomib; Disease Models, Animal; Humans; Immunoblotting; Imm | 2012 |
Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Conditioning, Psychological; Diabetes Mellitus, T | 2012 |
Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function.
Topics: Animals; Disease Models, Animal; Endotoxins; Fatty Liver; Fructose; Gene Expression; Hypoglycemic Ag | 2012 |
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Aqueous Humor; Blotting, Western; Cyclooxygenase 2; C | 2012 |
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.
Topics: AMP-Activated Protein Kinases; Animals; Axitinib; Cell Line, Tumor; Cell Proliferation; Disease Mode | 2012 |
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Insulin Receptor Substrate Proteins; Met | 2012 |
An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.
Topics: Adenylate Kinase; Administration, Oral; Aging; Animals; CREB-Binding Protein; Disease Models, Animal | 2012 |
Metformin attenuates ventilator-induced lung injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; In Vitro Tech | 2012 |
A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Body Weight; Brain; Cognition Disorders; Conditioning, | 2012 |
Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin.
Topics: Animals; Apolipoproteins E; Disease Models, Animal; Fatty Liver; Hypoglycemic Agents; Metformin; Mic | 2012 |
Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis.
Topics: Animals; Cluster Analysis; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Gene Expr | 2012 |
Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Asthma; Base Sequence; Blotting, Western; Disease Models, An | 2012 |
Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Animals; Antioxidants; Apoptosis; Deoxyguanosine; Diabetes | 2012 |
Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Coronary Circulation; Disease Models, Animal; Energy Metabol | 2013 |
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Cal | 2012 |
Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes.
Topics: Adipose Tissue; Adult; Aged; Alleles; Animals; Calgranulin B; Diabetes Mellitus, Type 2; Diet; Disea | 2013 |
Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Di | 2013 |
Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Topics: Animals; Azacitidine; Blotting, Western; Catecholamine Plasma Membrane Transport Proteins; Decitabin | 2013 |
Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats.
Topics: Animals; Apoptosis; Biomarkers; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hyper | 2013 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Ho | 2003 |
Increased adipose tissue expression of Grb14 in several models of insulin resistance.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Adipose Tissue; Animals; Carrier Protei | 2004 |
Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 2005 |
Effect of high-fat diet and metformin treatment on ventilation and sleep apnea in non-obese rats.
Topics: Analysis of Variance; Animals; Body Mass Index; Carbon Dioxide; Diabetes Mellitus; Dietary Fats; Dis | 2006 |
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats.
Topics: 17-Hydroxysteroid Dehydrogenases; Adjuvants, Immunologic; Animals; Chromans; Dehydroepiandrosterone; | 2006 |
Effect of metformin on survival rate in experimental sepsis.
Topics: Animals; Blood Glucose; Death; Disease Models, Animal; Injections, Intraperitoneal; Lethal Dose 50; | 2006 |
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Line; Diabetes Mellitus, Type 2; Di | 2006 |
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.
Topics: Animals; Animals, Newborn; Biopsy, Needle; Cells, Cultured; Disease Models, Animal; Ethanol; Immunoh | 2006 |
Metformin and the fate of fat.
Topics: Animals; Disease Models, Animal; Fats; Humans; Hypoglycemic Agents; Insulin Resistance; Lipid Metabo | 2006 |
[Therapeutic effects of insulin-sensitizing drugs on nonalcoholic fatty liver disease: experiment with rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cholesterol; Dietary Fats; Disease Model | 2006 |
Metformin therapy in a transgenic mouse model of Huntington's disease.
Topics: Age Factors; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Blood Glucose; Disease Models | 2007 |
The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Metformin; Pioglita | 2007 |
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.
Topics: Animals; Chromones; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2008 |
Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels.
Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome | 2008 |
Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.
Topics: AMP-Activated Protein Kinases; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; | 2009 |
[An animal model for testing hypoglycemic and hypolipidemic drugs].
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Drugs, Chinese Herbal; Hyperlipide | 1994 |
Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Fructose; Hypertension; In | 1994 |
Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, | 1993 |
Nongenetic mouse models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Di | 1998 |
Exercise adds to metformin and acarbose efficacy in db/db mice.
Topics: Acarbose; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Ea | 2001 |
Reversal of diabetes-induced rat graft transplant coronary artery disease by metformin.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Coronary Disease; Diabetes Mellitus, Experimental; | 2002 |
Turnover and aortic uptake of very low density lipoproteins (VLDL) from hypercholesteremic rabbits as a model for testing antiatherosclerotic compounds.
Topics: Animals; Aorta; Apoproteins; Arteriosclerosis; Cholesterol; Disease Models, Animal; Hypercholesterol | 1976 |
DBM mice as a pharmacological model of maturity onset diabetes. Studies with metformin.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, A | 1979 |