Page last updated: 2024-10-30

metformin and Diathesis

metformin has been researched along with Diathesis in 20 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"Stroke is a leading cause of mortality and disability worldwide."5.46Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. ( Guo, JM; Liu, AJ; Niu, XC; Shu, H; Su, DF; Wang, L; Xu, JJ; Zhang, L; Zhang, Y; Zhu, DQ, 2017)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."5.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment."4.12Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice. ( Huang, J; Li, Z; Ru, G; Sun, J; Sun, L, 2022)
" We evaluated the role of oxidative stress (OS), during early metabolic syndrome (MetS), on amyloidogenic processes in a MetS rat model induced by sucrose."4.02Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation. ( Baires-López, A; Camacho-Castillo, L; Campos-Peña, V; Carvajal, K; Phillips-Farfán, BV; Rosas-Mendoza, G; Toral-Ríos, D, 2021)
"Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM)."2.72Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC. ( Wang, H; Xiao, H; Zhang, Y, 2021)
"The relationship between metformin and prostate cancer (PCa) remains controversial."2.61The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis. ( Cui, R; He, K; Hu, H; Wang, H; Ye, S; Yi, L, 2019)
" Qualitative synthesis also suggests an apparently dose-response relationship and increased benefit when administered alone."2.58Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review. ( Estrugo Devesa, A; Jané-Salas, E; López-López, J; Saka Herrán, C, 2018)
"Metformin use was associated with an increased odds of AD (adjusted odds ratio [AOR] 1."1.62Association of metformin use with Alzheimer's disease in patients with newly diagnosed type 2 diabetes: a population-based nested case-control study. ( Cho, SY; Choi, DW; Ha, J; Kim, E; Kim, H; Kim, KJ; Kim, KY; Koh, Y; Nam, CM, 2021)
"Stroke is a leading cause of mortality and disability worldwide."1.46Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. ( Guo, JM; Liu, AJ; Niu, XC; Shu, H; Su, DF; Wang, L; Xu, JJ; Zhang, L; Zhang, Y; Zhu, DQ, 2017)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."1.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
" Adverse effect rates were 64% with placebo, 63."1.43Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus. ( Ampudia-Blasco, FJ; Ariño, B; Giljanovic Kis, S; Naderali, E; Pérez, A; Pfarr, E; Romera, I, 2016)
"Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II."1.40Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes. ( Bengtsson, E; Björkbacka, H; Dunér, P; Edsfeldt, A; Gonçalves, I; Grufman, H; Melander, O; Mollet, IG; Nilsson, J; Nilsson, M; Nitulescu, M; Orho-Melander, M; Persson, A, 2014)
"His parents both had a diagnosis of type 2 diabetes."1.39Diabetes mellitus with Laron syndrome: case report. ( Agladıoglu, SY; Aycan, Z; Bas, VN; Cetınkaya, S; Kendırcı, HN; Onder, A; Savas Erdeve, S, 2013)
"Type 2 diabetes mellitus is a major risk factor for melioidosis, which is caused by Burkholderia pseudomallei."1.39Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection. ( Ato, M; Bancroft, GJ; Kewcharoenwong, C; Lertmemongkolchai, G; Rinchai, D; Suwannasaen, D; Utispan, K, 2013)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (45.00)24.3611
2020's11 (55.00)2.80

Authors

AuthorsStudies
Camacho-Castillo, L1
Phillips-Farfán, BV1
Rosas-Mendoza, G1
Baires-López, A1
Toral-Ríos, D1
Campos-Peña, V1
Carvajal, K1
Ha, J1
Choi, DW1
Kim, KJ1
Cho, SY1
Kim, H1
Kim, KY1
Koh, Y1
Nam, CM1
Kim, E1
Huang, J1
Ru, G1
Sun, J1
Sun, L1
Li, Z1
Gao, J1
Yuan, J1
Wang, Q1
Lei, T1
Shen, X1
Cui, B1
Zhang, F1
Ding, W1
Lu, Z1
Zhao, X1
Jiang, Y1
Zhao, Y1
Xi, H1
Liu, C1
Qu, F1
Feng, X2
Li, B1
Po, SS1
Zhang, B1
Bai, F1
Li, J1
Qin, F1
Liu, N1
Sun, C1
Xiao, Y1
Tu, T1
Zhou, S1
Liu, Q1
Navarro-Pando, JM1
Bullón, P1
Cordero, MD1
Alcocer-Gómez, E1
Nesci, V1
Russo, E1
Arcidiacono, B1
Citraro, R1
Tallarico, M1
Constanti, A1
Brunetti, A1
De Sarro, G1
Leo, A1
Hasan, SS1
Kow, CS1
Bain, A1
Kavanagh, S1
Merchant, HA1
Hadi, MA1
Zhang, Y2
Wang, H2
Xiao, H1
Chen, W1
Ni, X1
Little, PJ1
Xu, S1
Tang, L1
Weng, J1
Saka Herrán, C1
Jané-Salas, E1
Estrugo Devesa, A1
López-López, J1
He, K1
Hu, H1
Ye, S1
Cui, R1
Yi, L1
Agladıoglu, SY1
Cetınkaya, S1
Savas Erdeve, S1
Onder, A1
Kendırcı, HN1
Bas, VN1
Aycan, Z1
Kewcharoenwong, C1
Rinchai, D1
Utispan, K1
Suwannasaen, D1
Bancroft, GJ1
Ato, M1
Lertmemongkolchai, G1
Tébar, MT1
de Luis, N1
Sánchez, I1
Aguilera, L1
Edsfeldt, A1
Gonçalves, I1
Grufman, H1
Nitulescu, M1
Dunér, P1
Bengtsson, E1
Mollet, IG1
Persson, A1
Nilsson, M1
Orho-Melander, M1
Melander, O1
Björkbacka, H1
Nilsson, J1
Ma, X1
Deng, J1
Cao, N1
Guo, Z1
Zheng, Y1
Geng, S1
Meng, M1
Lin, H1
Duan, Y1
Du, G1
Romera, I1
Ampudia-Blasco, FJ1
Pérez, A1
Ariño, B1
Pfarr, E1
Giljanovic Kis, S1
Naderali, E1
Guo, JM1
Zhang, L1
Niu, XC1
Shu, H1
Wang, L1
Su, DF1
Liu, AJ1
Zhu, DQ1
Xu, JJ1

Reviews

6 reviews available for metformin and Diathesis

ArticleYear
Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020, Volume: 39, Issue:7

    Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents; Antimalarials; Antiviral Agents; Basal Me

2020
Pharmacotherapeutic considerations for the management of diabetes mellitus among hospitalized COVID-19 patients.
    Expert opinion on pharmacotherapy, 2021, Volume: 22, Issue:2

    Topics: Adrenal Cortex Hormones; Blood Glucose; Comorbidity; COVID-19; Deprescriptions; Diabetes Mellitus, T

2021
Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC.
    International journal of molecular sciences, 2021, May-09, Volume: 22, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Disease Progression; Disease Susceptibility; DNA Damage; Hepatoc

2021
Metformin, Macrophage Dysfunction and Atherosclerosis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Atherosclerosis; Biomarkers; Cardiometabolic Risk Factors; Cell Plasticity; Diabetes Compli

2021
Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review.
    Oral oncology, 2018, Volume: 85

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Case-Control Studies; Cohort Studi

2018
The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis.
    Scientific reports, 2019, 02-18, Volume: 9, Issue:1

    Topics: Disease Susceptibility; Humans; Hypoglycemic Agents; Incidence; Male; Metformin; Prognosis; Proporti

2019

Other Studies

14 other studies available for metformin and Diathesis

ArticleYear
Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation.
    Scientific reports, 2021, 10-01, Volume: 11, Issue:1

    Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animal Feed; Animals; Antio

2021
Association of metformin use with Alzheimer's disease in patients with newly diagnosed type 2 diabetes: a population-based nested case-control study.
    Scientific reports, 2021, 12-15, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Comorbidity; Diabetes

2021
Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice.
    Molecular medicine (Cambridge, Mass.), 2022, 02-05, Volume: 28, Issue:1

    Topics: Animals; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Embryonic Development; Epig

2022
Metformin protects against PM
    Redox biology, 2020, Volume: 28

    Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Biopsy; Cell Line; Disease Models, Animal; Disea

2020
Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:14

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Atrial Fibrillation; Atrial Remodeli

2020
Is AMP-Activated Protein Kinase Associated to the Metabolic Changes in Primary Ovarian Insufficiency?
    Antioxidants & redox signaling, 2020, 11-20, Volume: 33, Issue:15

    Topics: AMP-Activated Protein Kinases; Biomarkers; Case-Control Studies; Disease Management; Disease Suscept

2020
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
    Molecular neurobiology, 2020, Volume: 57, Issue:11

    Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression;

2020
Diabetes mellitus with Laron syndrome: case report.
    Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:9-10

    Topics: Adult; Diabetes Mellitus, Type 2; Disease Susceptibility; Drug Monitoring; Humans; Hypoglycemic Agen

2013
Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection.
    Scientific reports, 2013, Nov-28, Volume: 3

    Topics: Burkholderia pseudomallei; Diabetes Mellitus, Type 2; Disease Susceptibility; Glyburide; Humans; Hyp

2013
[Metformin-associated lactic acidosis in the Intensive Care Unit].
    Revista espanola de anestesiologia y reanimacion, 2014, Volume: 61, Issue:8

    Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Bicarbonates; Combined Modality Therapy; Diabetes Mellitu

2014
Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.
    Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:9

    Topics: Aged; Antihypertensive Agents; Carotid Artery Diseases; Cytokines; Diabetes Mellitus, Type 2; Diseas

2014
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas

2016
Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2016, Volume: 63, Issue:10

    Topics: Aged; Benzhydryl Compounds; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Disease

2016
Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats.
    European journal of pharmacology, 2017, Mar-05, Volume: 798

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Arteries; Baroreflex; Brain Ischemia; Cytokines; D

2017