metformin has been researched along with Diathesis in 20 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stroke is a leading cause of mortality and disability worldwide." | 5.46 | Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. ( Guo, JM; Liu, AJ; Niu, XC; Shu, H; Su, DF; Wang, L; Xu, JJ; Zhang, L; Zhang, Y; Zhu, DQ, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment." | 4.12 | Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice. ( Huang, J; Li, Z; Ru, G; Sun, J; Sun, L, 2022) |
| " We evaluated the role of oxidative stress (OS), during early metabolic syndrome (MetS), on amyloidogenic processes in a MetS rat model induced by sucrose." | 4.02 | Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation. ( Baires-López, A; Camacho-Castillo, L; Campos-Peña, V; Carvajal, K; Phillips-Farfán, BV; Rosas-Mendoza, G; Toral-Ríos, D, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM)." | 2.72 | Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC. ( Wang, H; Xiao, H; Zhang, Y, 2021) |
| "The relationship between metformin and prostate cancer (PCa) remains controversial." | 2.61 | The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis. ( Cui, R; He, K; Hu, H; Wang, H; Ye, S; Yi, L, 2019) |
| " Qualitative synthesis also suggests an apparently dose-response relationship and increased benefit when administered alone." | 2.58 | Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review. ( Estrugo Devesa, A; Jané-Salas, E; López-López, J; Saka Herrán, C, 2018) |
| "Metformin use was associated with an increased odds of AD (adjusted odds ratio [AOR] 1." | 1.62 | Association of metformin use with Alzheimer's disease in patients with newly diagnosed type 2 diabetes: a population-based nested case-control study. ( Cho, SY; Choi, DW; Ha, J; Kim, E; Kim, H; Kim, KJ; Kim, KY; Koh, Y; Nam, CM, 2021) |
| "Stroke is a leading cause of mortality and disability worldwide." | 1.46 | Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. ( Guo, JM; Liu, AJ; Niu, XC; Shu, H; Su, DF; Wang, L; Xu, JJ; Zhang, L; Zhang, Y; Zhu, DQ, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| " Adverse effect rates were 64% with placebo, 63." | 1.43 | Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus. ( Ampudia-Blasco, FJ; Ariño, B; Giljanovic Kis, S; Naderali, E; Pérez, A; Pfarr, E; Romera, I, 2016) |
| "Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II." | 1.40 | Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes. ( Bengtsson, E; Björkbacka, H; Dunér, P; Edsfeldt, A; Gonçalves, I; Grufman, H; Melander, O; Mollet, IG; Nilsson, J; Nilsson, M; Nitulescu, M; Orho-Melander, M; Persson, A, 2014) |
| "His parents both had a diagnosis of type 2 diabetes." | 1.39 | Diabetes mellitus with Laron syndrome: case report. ( Agladıoglu, SY; Aycan, Z; Bas, VN; Cetınkaya, S; Kendırcı, HN; Onder, A; Savas Erdeve, S, 2013) |
| "Type 2 diabetes mellitus is a major risk factor for melioidosis, which is caused by Burkholderia pseudomallei." | 1.39 | Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection. ( Ato, M; Bancroft, GJ; Kewcharoenwong, C; Lertmemongkolchai, G; Rinchai, D; Suwannasaen, D; Utispan, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 11 (55.00) | 2.80 |
| Authors | Studies |
|---|---|
| Camacho-Castillo, L | 1 |
| Phillips-Farfán, BV | 1 |
| Rosas-Mendoza, G | 1 |
| Baires-López, A | 1 |
| Toral-Ríos, D | 1 |
| Campos-Peña, V | 1 |
| Carvajal, K | 1 |
| Ha, J | 1 |
| Choi, DW | 1 |
| Kim, KJ | 1 |
| Cho, SY | 1 |
| Kim, H | 1 |
| Kim, KY | 1 |
| Koh, Y | 1 |
| Nam, CM | 1 |
| Kim, E | 1 |
| Huang, J | 1 |
| Ru, G | 1 |
| Sun, J | 1 |
| Sun, L | 1 |
| Li, Z | 1 |
| Gao, J | 1 |
| Yuan, J | 1 |
| Wang, Q | 1 |
| Lei, T | 1 |
| Shen, X | 1 |
| Cui, B | 1 |
| Zhang, F | 1 |
| Ding, W | 1 |
| Lu, Z | 1 |
| Zhao, X | 1 |
| Jiang, Y | 1 |
| Zhao, Y | 1 |
| Xi, H | 1 |
| Liu, C | 1 |
| Qu, F | 1 |
| Feng, X | 2 |
| Li, B | 1 |
| Po, SS | 1 |
| Zhang, B | 1 |
| Bai, F | 1 |
| Li, J | 1 |
| Qin, F | 1 |
| Liu, N | 1 |
| Sun, C | 1 |
| Xiao, Y | 1 |
| Tu, T | 1 |
| Zhou, S | 1 |
| Liu, Q | 1 |
| Navarro-Pando, JM | 1 |
| Bullón, P | 1 |
| Cordero, MD | 1 |
| Alcocer-Gómez, E | 1 |
| Nesci, V | 1 |
| Russo, E | 1 |
| Arcidiacono, B | 1 |
| Citraro, R | 1 |
| Tallarico, M | 1 |
| Constanti, A | 1 |
| Brunetti, A | 1 |
| De Sarro, G | 1 |
| Leo, A | 1 |
| Hasan, SS | 1 |
| Kow, CS | 1 |
| Bain, A | 1 |
| Kavanagh, S | 1 |
| Merchant, HA | 1 |
| Hadi, MA | 1 |
| Zhang, Y | 2 |
| Wang, H | 2 |
| Xiao, H | 1 |
| Chen, W | 1 |
| Ni, X | 1 |
| Little, PJ | 1 |
| Xu, S | 1 |
| Tang, L | 1 |
| Weng, J | 1 |
| Saka Herrán, C | 1 |
| Jané-Salas, E | 1 |
| Estrugo Devesa, A | 1 |
| López-López, J | 1 |
| He, K | 1 |
| Hu, H | 1 |
| Ye, S | 1 |
| Cui, R | 1 |
| Yi, L | 1 |
| Agladıoglu, SY | 1 |
| Cetınkaya, S | 1 |
| Savas Erdeve, S | 1 |
| Onder, A | 1 |
| Kendırcı, HN | 1 |
| Bas, VN | 1 |
| Aycan, Z | 1 |
| Kewcharoenwong, C | 1 |
| Rinchai, D | 1 |
| Utispan, K | 1 |
| Suwannasaen, D | 1 |
| Bancroft, GJ | 1 |
| Ato, M | 1 |
| Lertmemongkolchai, G | 1 |
| Tébar, MT | 1 |
| de Luis, N | 1 |
| Sánchez, I | 1 |
| Aguilera, L | 1 |
| Edsfeldt, A | 1 |
| Gonçalves, I | 1 |
| Grufman, H | 1 |
| Nitulescu, M | 1 |
| Dunér, P | 1 |
| Bengtsson, E | 1 |
| Mollet, IG | 1 |
| Persson, A | 1 |
| Nilsson, M | 1 |
| Orho-Melander, M | 1 |
| Melander, O | 1 |
| Björkbacka, H | 1 |
| Nilsson, J | 1 |
| Ma, X | 1 |
| Deng, J | 1 |
| Cao, N | 1 |
| Guo, Z | 1 |
| Zheng, Y | 1 |
| Geng, S | 1 |
| Meng, M | 1 |
| Lin, H | 1 |
| Duan, Y | 1 |
| Du, G | 1 |
| Romera, I | 1 |
| Ampudia-Blasco, FJ | 1 |
| Pérez, A | 1 |
| Ariño, B | 1 |
| Pfarr, E | 1 |
| Giljanovic Kis, S | 1 |
| Naderali, E | 1 |
| Guo, JM | 1 |
| Zhang, L | 1 |
| Niu, XC | 1 |
| Shu, H | 1 |
| Wang, L | 1 |
| Su, DF | 1 |
| Liu, AJ | 1 |
| Zhu, DQ | 1 |
| Xu, JJ | 1 |
6 reviews available for metformin and Diathesis
| Article | Year |
|---|---|
Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening.
Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents; Antimalarials; Antiviral Agents; Basal Me | 2020 |
Pharmacotherapeutic considerations for the management of diabetes mellitus among hospitalized COVID-19 patients.
Topics: Adrenal Cortex Hormones; Blood Glucose; Comorbidity; COVID-19; Deprescriptions; Diabetes Mellitus, T | 2021 |
Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC.
Topics: Animals; Carcinoma, Hepatocellular; Disease Progression; Disease Susceptibility; DNA Damage; Hepatoc | 2021 |
Metformin, Macrophage Dysfunction and Atherosclerosis.
Topics: Animals; Atherosclerosis; Biomarkers; Cardiometabolic Risk Factors; Cell Plasticity; Diabetes Compli | 2021 |
Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Case-Control Studies; Cohort Studi | 2018 |
The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis.
Topics: Disease Susceptibility; Humans; Hypoglycemic Agents; Incidence; Male; Metformin; Prognosis; Proporti | 2019 |
14 other studies available for metformin and Diathesis
| Article | Year |
|---|---|
Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animal Feed; Animals; Antio | 2021 |
Association of metformin use with Alzheimer's disease in patients with newly diagnosed type 2 diabetes: a population-based nested case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Comorbidity; Diabetes | 2021 |
Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Embryonic Development; Epig | 2022 |
Metformin protects against PM
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Biopsy; Cell Line; Disease Models, Animal; Disea | 2020 |
Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Atrial Fibrillation; Atrial Remodeli | 2020 |
Is AMP-Activated Protein Kinase Associated to the Metabolic Changes in Primary Ovarian Insufficiency?
Topics: AMP-Activated Protein Kinases; Biomarkers; Case-Control Studies; Disease Management; Disease Suscept | 2020 |
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression; | 2020 |
Diabetes mellitus with Laron syndrome: case report.
Topics: Adult; Diabetes Mellitus, Type 2; Disease Susceptibility; Drug Monitoring; Humans; Hypoglycemic Agen | 2013 |
Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection.
Topics: Burkholderia pseudomallei; Diabetes Mellitus, Type 2; Disease Susceptibility; Glyburide; Humans; Hyp | 2013 |
[Metformin-associated lactic acidosis in the Intensive Care Unit].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Bicarbonates; Combined Modality Therapy; Diabetes Mellitu | 2014 |
Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.
Topics: Aged; Antihypertensive Agents; Carotid Artery Diseases; Cytokines; Diabetes Mellitus, Type 2; Diseas | 2014 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus.
Topics: Aged; Benzhydryl Compounds; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Disease | 2016 |
Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Arteries; Baroreflex; Brain Ischemia; Cytokines; D | 2017 |