Page last updated: 2024-10-30

metformin and Diabetic Foot

metformin has been researched along with Diabetic Foot in 8 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Diabetic Foot: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

Research Excerpts

ExcerptRelevanceReference
"Metformin treatment reduces cell proliferation and reduces wound healing in an animal model and affects clinical outcomes in diabetic foot ulcer patients."7.83Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. ( Castañeda-Delgado, JE; Cervantes-Villagrana, AR; Enciso-Moreno, JA; Fernandez-Ruiz, JC; Hernandez-Correa, AC; Nava-Ramirez, HS; Ochoa-Gonzalez, F, 2016)
"Metformin treatment reduces cell proliferation and reduces wound healing in an animal model and affects clinical outcomes in diabetic foot ulcer patients."3.83Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. ( Castañeda-Delgado, JE; Cervantes-Villagrana, AR; Enciso-Moreno, JA; Fernandez-Ruiz, JC; Hernandez-Correa, AC; Nava-Ramirez, HS; Ochoa-Gonzalez, F, 2016)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Mkrtumyan, AM1
Zvenigorodskaya, LA1
Shinkin, MV1
Rodríguez-Carlos, A1
Trujillo, V1
Gonzalez-Curiel, I1
Marin-Luevano, S1
Torres-Juarez, F1
Santos-Mena, A1
Rivas-Santiago, C1
Enciso-Moreno, JA2
Zaga-Clavellina, V1
Rivas-Santiago, B1
Aguiar, P1
Amaral, C1
Rodrigues, A1
de Souza, AH1
Lin, JT1
Chen, HM1
Chiu, CH1
Liang, YJ1
Ochoa-Gonzalez, F1
Cervantes-Villagrana, AR1
Fernandez-Ruiz, JC1
Nava-Ramirez, HS1
Hernandez-Correa, AC1
Castañeda-Delgado, JE1
Stiefelhagen, P1
Heikkinen, M1
Salmenperä, M1
Lepäntalo, A1
Lepäntalo, M1
Turner, RC1
Holman, RR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of Glucose Lowering Therapies Including Dipeptidyl Peptidase-4 Inhibitor on Circulating Endothelial Progenitor Cells (EPCs) and Its Mobilising Factor Stromal Derived Factor-1α (SDF-1α) in Patients With Type 2 Diabetes[NCT02694575]241 participants (Actual)Observational2015-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for metformin and Diabetic Foot

ArticleYear
AMP-activated protein kinase activators in diabetic ulcers: from animal studies to Phase II drugs under investigation.
    Expert opinion on investigational drugs, 2014, Volume: 23, Issue:9

    Topics: AMP-Activated Protein Kinases; Animals; Clinical Trials, Phase II as Topic; Diabetic Foot; Drug Desi

2014
Diabetes care for patients with peripheral arterial disease.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2007, Volume: 33, Issue:5

    Topics: Anesthesia; Blood Pressure; Contrast Media; Diabetic Angiopathies; Diabetic Foot; Glycated Hemoglobi

2007
Lessons from UK prospective diabetes study.
    Diabetes research and clinical practice, 1995, Volume: 28 Suppl

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Foot; Diabeti

1995

Trials

1 trial available for metformin and Diabetic Foot

ArticleYear
Lessons from UK prospective diabetes study.
    Diabetes research and clinical practice, 1995, Volume: 28 Suppl

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Foot; Diabeti

1995

Other Studies

5 other studies available for metformin and Diabetic Foot

ArticleYear
[The study of microcirculation and tissue metabolism as early diagnostic criteria for the risk of diabetic foot development].
    Terapevticheskii arkhiv, 2022, Oct-12, Volume: 94, Issue:8

    Topics: Diabetes Mellitus; Diabetic Foot; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Laser-Doppler Fl

2022
Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin.
    Archives of medical research, 2020, Volume: 51, Issue:4

    Topics: Adult; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Foot; Down-Regulation; Female; Humans; M

2020
A diabetic foot ulcer treated with hydrogel and hyperbaric oxygen therapy: a case study.
    Journal of wound care, 2017, 11-02, Volume: 26, Issue:11

    Topics: Aged; Amputation, Surgical; Diabetes Mellitus, Type 2; Diabetic Foot; Humans; Hydrogels; Hyperbaric

2017
Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Adult; Aged; Animals; Cell Cycle Checkpoints; Cell Line; Diabetes Mellitus, Experimental; Diabetes M

2016
[Nothing here follows protocol F. Elderly diabetic patients are not "DMP qualified"].
    MMW Fortschritte der Medizin, 2005, Feb-03, Volume: 147, Issue:5

    Topics: Aged; Blood Glucose; Comorbidity; Contraindications; Diabetes Mellitus, Type 2; Diabetic Foot; Diabe

2005
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