metformin has been researched along with Diabetes, Gestational in 362 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Diabetes, Gestational: Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 9.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| " The TSH level was not affected by metformin, whereas fT4 was significantly higher in the metformin group with less decrease throughout pregnancy compared to placebo, p<0." | 9.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| "The Pregnancy Outcomes: Effects of Metformin study is a multicentre, open-label, randomised, controlled trial." | 9.51 | Pregnancy Outcomes: Effects of Metformin (POEM) study: a protocol for a long-term, multicentre, open-label, randomised controlled trial in gestational diabetes mellitus. ( Erwich, JJHM; Hoogenberg, K; Kooy, A; Lutgers, HL; Prins, JR; van Dijk, PR; van Hoorn, EGM, 2022) |
| "In this study, we observed a high percentage of SGA births among women with type 2 diabetes and chronic hypertension and/or nephropathy who were treated with metformin." | 9.51 | Determinants of Small for Gestational Age in Women With Type 2 Diabetes in Pregnancy: Who Should Receive Metformin? ( Asztalos, E; Donovan, LE; Feig, DS; Murphy, KE; Sanchez, JJ; Shah, PS; Tomlinson, G; Zinman, B, 2022) |
| "Metformin is used worldwide in the treatment of type 2 diabetes and has been used in the treatment of diabetes in pregnancy since the 1970s." | 9.41 | Focus on Metformin: Its Role and Safety in Pregnancy and Beyond. ( Dunne, FP; Ero, A; Newman, C; Rabbitt, L, 2023) |
| "This document purpose is to create an evidence-based position statement on the role of metformin therapy in pregnancy complicated by obesity, gestational diabetes (GDM), type 2 diabetes mellitus (T2DM), polycystic ovary syndrome (PCOS) and in women undergoing assisted reproductive technology (ART)." | 9.41 | Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy. ( Bianchi, C; Burlina, S; Formoso, G; Manicardi, E; Resi, V; Sciacca, L; Sculli, MA, 2023) |
| " We evaluated whether liraglutide in combination with metformin (MET-LIRA) is more effective than metformin monotherapy (MET-P) in improving insulin action and reducing body weight in overweight prior GDM (pGDM) women." | 9.34 | Postpartum treatment with liraglutide in combination with metformin versus metformin monotherapy to improve metabolic status and reduce body weight in overweight/obese women with recent gestational diabetes: A double-blind, randomized, placebo-controlled ( Elkind-Hirsch, KE; Harris, R; Shaler, D, 2020) |
| "To compare the effects of metformin and insulin treatment on maternal serum lipids in patients with gestational diabetes (GDM), and to analyse the associations between individual lipids and birth weight (BW)." | 9.34 | Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes. ( Huhtala, MS; Rönnemaa, T; Tertti, K, 2020) |
| "This study aimed to evaluate the treatment efficacy of dapagliflozin and metformin, alone and in combination, on body weight and anthropometric, cardiovascular, and metabolic parameters in overweight women with a recent history of gestational diabetes mellitus." | 9.34 | A randomized trial of dapagliflozin and metformin, alone and combined, in overweight women after gestational diabetes mellitus. ( Elkind-Hirsch, KE; Harris, R; Seidemann, E, 2020) |
| " Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group." | 9.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "We aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR)." | 9.27 | Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study. ( Abusada, N; Candia, P; Cuellar, E; Manukian, B; Orellana, R; Sepúlveda-Martínez, A; Valdés, E, 2018) |
| "Metformin has been used in pregnancy since the 1970s." | 9.22 | Metformin for pregnancy and beyond: the pros and cons. ( Dunne, FP; Newman, C, 2022) |
| "gov for randomized controlled trials (RCTs) that compared metformin to insulin in pregnancy." | 9.22 | The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials. ( Ge, J; Guo, Q; He, K; Jing, Z; Li, C; Li, J, 2022) |
| "Less maternal weight gain was found in the metformin treated groups (9." | 9.20 | Metformin versus insulin treatment in gestational diabetes in pregnancy in a developing country: a randomized control trial. ( Ainuddin, J; Hasan, AA; Karim, N; Naqvi, SA, 2015) |
| "We sought to compare weight loss in the first 6 weeks postpartum among women with gestational diabetes mellitus (GDM) treated with metformin or placebo, a promising therapy to reduce later risk of progression to diabetes mellitus." | 9.20 | The effects of metformin on weight loss in women with gestational diabetes: a pilot randomized, placebo-controlled trial. ( Blackwell, SC; Hutchinson, M; Pedroza, C; Ramin, SM; Refuerzo, JS; Tyson, JE; Viteri, OA, 2015) |
| "To determine if metformin monotherapy or metformin in combination with insulin is equally effective as insulin monotherapy at glycemic control in diabetes mellitus in pregnancy among Ghanaians." | 9.20 | Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial. ( Adjepong-Yamoah, KK; Beyuo, T; Bugyei, KA; Marfoh, K; Obed, SA; Oppong, SA, 2015) |
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 9.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "To compare the efficacy of metformin with insulin in the management of pregnancy with diabetes." | 9.17 | Efficacy of metformin versus insulin in the management of pregnancy with diabetes. ( Malik, FP; Mazhar, SB; Waheed, S, 2013) |
| "Prospectively assess whether metformin/diet pre-conception and throughout pregnancy would safely reduce first trimester miscarriage and improve pregnancy outcomes in women with polycystic ovary syndrome (PCOS)." | 9.17 | Effects of metformin-diet intervention before and throughout pregnancy on obstetric and neonatal outcomes in patients with polycystic ovary syndrome. ( Glueck, CJ; Goldenberg, N; Khan, Z; Padda, J; Pranikoff, J; Wang, P, 2013) |
| "To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome." | 9.15 | The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. ( De Leo, V; Di Sabatino, A; Morgante, G; Musacchio, MC; Piomboni, P, 2011) |
| " 'Cases' were women with PCOS who conceived while taking Metformin and it whom it was continued throughout pregnancy." | 9.14 | Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. ( Nawaz, FH; Rizvi, J, 2010) |
| "Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt to reduce pregnancy complications." | 9.14 | Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. ( Almås, I; Berg, AH; Berg, KF; Bjerke, C; Bunford, G; Carlsen, SM; Danielson, A; Eikeland, T; Flo, K; Heimstad, R; Hjelle, S; Kleggetveit, O; Lahmami, G; Lund, A; Romundstad, P; Skogøy, K; Stridsklev, S; Vanky, E; von Brandis, P, 2010) |
| "Our first specific aim in an observational study of 431 nondiabetic women with polycystic ovary syndrome (PCOS), aged >or=20 years and with >or=11 months follow-up on metformin diet, was to prospectively assess relationships between pretreatment glucose and insulin resistance (IR) and the development of type 2 diabetes mellitus (T2DM) or gestational diabetes (GD)." | 9.13 | An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet. ( Glueck, CJ; Goldenberg, N; Sieve, L; Wang, P, 2008) |
| "One hundred forty-two nondiabetic women with polycystic ovary syndrome (PCOS) who had at least one live-birth (LB) pregnancy on metformin diet (172 pregnancies, 180 LBs)." | 9.13 | Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome. ( Aregawi, D; Glueck, CJ; Pranikoff, J; Wang, P, 2008) |
| "To review the current evidence for the use of metformin in pregnancy for women with type 2 diabetes." | 9.12 | Metformin in Pregnancy for Women with Type 2 Diabetes: a Review. ( Benham, JL; Donovan, LE; Yamamoto, JM, 2021) |
| " Metformin is known to decrease insulin resistance and is also associated with weight loss." | 9.12 | Postpartum Use of Weight Loss and Metformin for the Prevention of Type 2 Diabetes Mellitus: a Review of the Evidence. ( Ayala, NK; Werner, EF; Whelan, AR, 2021) |
| "To evaluate metformin's effects on pregnancy outcomes in women with polycystic ovary syndrome." | 9.12 | Gestational metformin administration in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized control studies. ( Cao, Q; Fu, J; Hu, Y; Huang, W; Huang, X; Wu, L; Zhang, J, 2021) |
| "The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicine reducing insulin resistance appears to be promising." | 9.12 | Metformin administration during pregnancy - current insight. ( Cypryk, K; Krekora, M; Skibinska, M; Zurawska-Klis, M, 2021) |
| "We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes." | 9.12 | Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2021) |
| "In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 +/- 4 years) with polycystic ovary syndrome (PCOS), we examined effects of metformin on maternal insulin, insulin resistance (IR), insulin secretion (IS), weight gain, development of gestational diabetes (GD), testosterone and plasminogen activator inhibitor activity." | 9.11 | Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg ( Glueck, CJ; Goldenberg, N; Loftspring, M; Sherman, A; Wang, P, 2004) |
| "We prospectively assessed growth and motor-social development during the first 18 months of life in 126 live births (122 pregnancies) to 109 women with polycystic ovary syndrome (PCOS) who conceived on and continued metformin (1." | 9.11 | Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. ( Glueck, CJ; Goldenberg, N; Loftspring, M; Pranikoff, J; Sieve, L; Wang, P, 2004) |
| "Investigation of a possible effect of metformin on androgen levels in pregnant women with polycystic ovary syndrome (PCOS)." | 9.11 | Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. ( Carlsen, SM; Fougner, KJ; Heimstad, R; Romundstad, P; Salvesen, KA; Vanky, E, 2004) |
| "Previous randomized and observational studies on the efficacy of metformin in pregnancy to reduce incident gestational diabetes mellitus (GDM) in women at high risk (obesity, polycystic ovary syndrome [PCOS], or pregestational insulin resistance) have been conflicting and several groups are planning further randomized controlled trials (RCTs) to answer this question conclusively." | 9.05 | Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials. ( Clark, J; Doi, SAR; Furuya-Kanamori, L; Islam, N; Musa, OAH; Thalib, L; Toft, E, 2020) |
| " Metformin is taken by many patients before pregnancy due to both previously diagnosed type 2 diabetes and in the treatment of prediabetes, obesity and polycystic ovary syndrome (PCOS) as part of therapy for insulin resistance." | 9.05 | Metformin therapy in pregnancy [Zastosowanie metforminy w ciąży]. ( Cichocka, E; Gumprecht, J; Kędzierski, L; Krupej-Kędzierska, J; Okopień, B, 2020) |
| "A systematic review and meta-analysis of clinical trials or observational studies of metformin intervention in preventing symptoms of GDM during pregnancy were performed." | 9.05 | The Effect of Metformin Therapy for Preventing Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Meta-Analysis. ( Liu, X; Zhang, W; Zhao, J, 2020) |
| "It seems to have no sense to prolong the use of metformin after a pregnancy diagnosis in women with PCOS." | 9.01 | Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions. ( Alvariñas, J; Bagnes, MFG; Di Girolamo, G; Gonzalez, CD, 2019) |
| "To perform meta-analyses of studies evaluating the risk of pre-eclampsia in high-risk insulin-resistant women taking metformin prior to, or during pregnancy." | 8.98 | Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. ( Alqudah, A; Graham, U; Lyons, TJ; McClements, L; McKinley, MC; McNally, R; Watson, CJ, 2018) |
| "Metformin has been reported to reduce the risk of pre-eclampsia." | 8.98 | Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. ( Abdi, A; Kalafat, E; Khalil, A; Sukur, YE; Thilaganathan, B, 2018) |
| "Metformin use in pregnancy is increasing worldwide as randomised controlled trial (RCT) evidence is emerging demonstrating its safety and efficacy." | 8.98 | Metformin in Pregnancy: Mechanisms and Clinical Applications. ( Balani, J; Hyer, S; Shehata, H, 2018) |
| "To assess the short- and long-term maternal and fetal impact of metformin in pregnancy compared with insulin." | 8.95 | Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. ( Aitken, E; Butalia, S; Donovan, L; Gutierrez, L; Lodha, A; Zakariasen, A, 2017) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 8.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS)." | 8.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| "Metformin is an effective oral anti-hyperglycemic agent that is widely used to manage diabetes mellitus type 2 in the general population and more recently, in pregnancy." | 8.89 | Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. ( Goulis, DG; Lautatzis, ME; Vrontakis, M, 2013) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 8.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "No adverse pregnancy outcomes with metformin use have been reported, except in one unmatched study." | 8.82 | Metformin therapy and diabetes in pregnancy. ( McIntyre, HD; Rowan, JA; Simmons, D; Walters, BN, 2004) |
| " Metformin appears to reduce these risks in mothers with polycystic ovary syndrome and their children; but may increase the risk of childhood-obesity in children form women without PCOS." | 8.12 | Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. ( Brusselaers, N; Crisosto, N; Cruz, G; Engstrand, L; Fornes, R; Nguyen, MH; Simin, J; van der Schaaf, M, 2022) |
| "To use the framework of the Health Belief Model (HBM) to explore factors associated with metformin use among adults with prediabetes." | 8.12 | Health Beliefs Associated With Metformin Use Among Insured Adults With Prediabetes. ( Herman, WH; Hurst, TE; Joiner, KL; McEwen, LN, 2022) |
| "To investigate effects of maternal diabetes and metformin treatment on metabolic newborn screening (NBS) results of infants born to mothers with hyperglycemia during pregnancy." | 8.02 | Effect of Maternal Metformin Treatment in Pregnancy on Neonatal Metabolism: Evidence From Newborn Metabolic Screening. ( Estrella, J; Hng, TM; McLean, M; Simmons, D; Wiley, V, 2021) |
| "Recent research has demonstrated the benefits of metformin treatment in gestational diabetes (GDM) on short-term pregnancy outcomes (including excessive fetal growth and pre-eclampsia), but its effects on fetal metabolism remain mostly unknown." | 8.02 | Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone. ( Huhtala, MS; Pellonperä, O; Rönnemaa, T; Tertti, K, 2021) |
| "Gestational metformin attenuated the adiposity in obese dams and increased the gestation length without correcting the offspring in utero growth restriction and catch-up growth caused by maternal obesity." | 8.02 | Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Ozanne, SE; Schoonejans, JM, 2021) |
| " This study will provide robust evidence regarding the efficacy and safety of metformin use in pregnancy, and may identify subgroups of patients who may benefit most from this treatment modality." | 7.96 | Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis. ( Burden, C; Carlsen, SM; Dodd, JM; Hague, W; Hilkka, I; Løvvik, T; Morin-Papunen, L; Mousa, A; Nicolaides, K; Norman, JE; Rönnemaa, T; Rowan, J; Shehata, H; Syngelaki, A; Teede, HJ; Tertti, K; Vanky, E, 2020) |
| " In our study, we explored the changes in metabolic health and cognitive function in mice of middle- and old- age after exposure to GDM, and whether metformin therapy during pregnancy provided long-term benefits." | 7.96 | Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes. ( Baker, PN; Chen, X; Han, TL; Qi, H; Wang, A; Yu, X; Zhang, H; Zhao, X; Zhao, Y; Zhou, X, 2020) |
| " The aims of this study were to evaluate the potential effect of metformin in GWG in overweight or obese women with GDM, to report our experience and to assess metformin's safety in this population." | 7.91 | Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study. ( Belo, S; Bettencourt-Silva, R; Carvalho, D; Ferreira, MJ; Montenegro, N; Namora, G; Neves, JS; Oliveira, AI; Queirós, J; Souteiro, P, 2019) |
| "We found no clear evidence of any adverse outcomes related to the use of metformin for the treatment of hyperglycemia in pregnancy." | 7.91 | Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register. ( Barzi, F; Boyle, J; Brown, A; Chitturi, S; Connors, C; Corpus, S; Cotter, M; Dowden, M; Inglis, C; Kirkham, R; Kirkwood, M; Lee, IL; Lindenmayer, G; Longmore, D; Maple-Brown, LJ; McIntyre, HD; Moore, E; O'Dea, K; Oats, J; Shaw, JE; Thomas, S; van Dokkum, P; Whitbread, C; Wicks, M; Zimmet, P, 2019) |
| "The initiation of metformin in early pregnancy in Gestational Diabetes mellitus (GDM) remains controversial." | 7.88 | How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India. ( Asha, HS; Dasgupta, R; Gupta, V; Mathews, JE; Paul, T; Ramachandran, R; Regi, A; Thomas, N; Visalakshi, P, 2018) |
| "To assess the effect of metformin in controlling Gestational Diabetes Mellitus (GDM) in women with Polycystic Ovarian Syndrome (PCOS)." | 7.81 | Metformin for preventing gestational diabetes in women with polycystic ovarian syndrome. ( Aftab, S; Ainuddin, JA; Kamran, A; Kazi, S, 2015) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 7.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women." | 7.77 | Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. ( Aboul Foutouh, I; Ashmawi, HS; Khattab, S; Mohsen, IA; Mohsen, MN; van der Veen, F; van Wely, M; Youssef, MA, 2011) |
| "The aim of the present study was to assess whether continuation of metformin therapy throughout pregnancy can reduce the development of gestational diabetes in women with polycystic ovarian syndrome (PCOS)." | 7.75 | Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome. ( Begum, A; Begum, MR; Begum, MS; Ferdous, J; Khan, F; Khanam, NN; Quadir, E, 2009) |
| "Women with GDM treated with metformin and with similar baseline risk factors for adverse pregnancy outcomes had less weight gain and improved neonatal outcomes compared with those treated with insulin." | 7.75 | Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. ( Balani, J; Hyer, SL; Rodin, DA; Shehata, H, 2009) |
| "The pharmacokinetic disposition of metformin in late pregnancy was studied together with the level of fetal exposure at birth." | 7.73 | Population pharmacokinetics of metformin in late pregnancy. ( Charles, B; Hague, W; Norris, R; Xiao, X, 2006) |
| "To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS)." | 7.73 | Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls." | 7.73 | Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy. ( Glezerman, M; Gur, D; Kovo, M; Levran, D; Rotmensch, S; Weissman, A, 2006) |
| "Before metformin therapy, after covariance adjustment for age, the two cohorts did not differ in height, weight, basal metabolic index, insulin, insulin resistance, or insulin secretion." | 7.71 | Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. ( Glueck, CJ; Kobayashi, S; Phillips, H; Sieve-Smith, L; Wang, P, 2002) |
| "Metformin has a molecular weight of 129 Daltons and therefore readily crosses the placenta." | 6.55 | Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. ( Conde-Agudelo, A; Erez, O; Grossman, LI; Hüttemann, M; Maymon, E; Pacora, P; Panaitescu, B; Romero, R; Yoon, BH, 2017) |
| "Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus." | 6.50 | Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and meta-analysis. ( Wang, A; Yu, H; Zhuo, Z, 2014) |
| "Metformin is an oral insulin-sensitizing anti-diabetic drug." | 6.50 | [Metformin in pregnancy]. ( Bijok, J; Bińkowska, M; Jakiel, G, 2014) |
| "Metformin is increasingly used to treat gestational diabetes (GDM) and pregnancies complicated by pregestational type 2 diabetes or polycystic ovary syndrome but data regarding long-term offspring outcome are lacking in both human studies and animal models." | 5.72 | Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Dearden, L; Fernandez-Twinn, DS; Ozanne, SE; Pantaleão, LC; Pellegrini Pisani, L; Schoonejans, JM; Tadross, JA, 2022) |
| "To compare body composition, visceral adiposity, adipocytokines, and low-grade inflammation markers in prepubertal offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM)." | 5.69 | Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years. ( Koskensalo, K; Loo, BM; Niinikoski, H; Nikkinen, H; Paavilainen, E; Parkkola, R; Rönnemaa, T; Tertti, K; Tossavainen, P; Vääräsmäki, M; Veijola, R, 2023) |
| "<6." | 5.56 | Metformin Should Not Be Used to Treat Prediabetes. ( Davidson, MB, 2020) |
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 5.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| " The TSH level was not affected by metformin, whereas fT4 was significantly higher in the metformin group with less decrease throughout pregnancy compared to placebo, p<0." | 5.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| "The Pregnancy Outcomes: Effects of Metformin study is a multicentre, open-label, randomised, controlled trial." | 5.51 | Pregnancy Outcomes: Effects of Metformin (POEM) study: a protocol for a long-term, multicentre, open-label, randomised controlled trial in gestational diabetes mellitus. ( Erwich, JJHM; Hoogenberg, K; Kooy, A; Lutgers, HL; Prins, JR; van Dijk, PR; van Hoorn, EGM, 2022) |
| "In this study, we observed a high percentage of SGA births among women with type 2 diabetes and chronic hypertension and/or nephropathy who were treated with metformin." | 5.51 | Determinants of Small for Gestational Age in Women With Type 2 Diabetes in Pregnancy: Who Should Receive Metformin? ( Asztalos, E; Donovan, LE; Feig, DS; Murphy, KE; Sanchez, JJ; Shah, PS; Tomlinson, G; Zinman, B, 2022) |
| "To evaluate the impact of preemptive metformin on the level of glycosylated hemoglobin (HbA1c) at 36 weeks of pregnancy in women with gestational diabetes mellitus controlled by diet change (GDMA1)." | 5.51 | Metformin in gestational diabetes mellitus: A double-blind placebo-controlled randomized trial. ( Hong, JGS; Omar, SZ; Saaid, R; Tan, PC; Tew, MP, 2022) |
| "The use of metformin in gestational diabetes is safe and effective, yet some women require additional insulin therapy to achieve glycaemic targets." | 5.43 | Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes. ( Fulcher, GR; Glastras, SJ; Hocking, S; McGrath, RT, 2016) |
| "Unlike insulin, metformin lowered neonatal birth weights (mean difference - 122." | 5.41 | Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials. ( Jiang, G; Li, H; Lin, X; Lv, B; Ni, J; Sheng, B, 2023) |
| "Metformin is used worldwide in the treatment of type 2 diabetes and has been used in the treatment of diabetes in pregnancy since the 1970s." | 5.41 | Focus on Metformin: Its Role and Safety in Pregnancy and Beyond. ( Dunne, FP; Ero, A; Newman, C; Rabbitt, L, 2023) |
| "This document purpose is to create an evidence-based position statement on the role of metformin therapy in pregnancy complicated by obesity, gestational diabetes (GDM), type 2 diabetes mellitus (T2DM), polycystic ovary syndrome (PCOS) and in women undergoing assisted reproductive technology (ART)." | 5.41 | Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy. ( Bianchi, C; Burlina, S; Formoso, G; Manicardi, E; Resi, V; Sciacca, L; Sculli, MA, 2023) |
| " Except one woman in the myoinositol group, all women provided glycaemia data throughout their pregnancy." | 5.41 | Efficacy of myoinositol in treatment of gestational diabetes mellitus in Asian Indian women: A pilot randomized clinical trial. ( Balani, S; Bhatla, N; Kachhawa, G; Kulshrestha, V; Kumari, R; Sharma, JB; Vanamail, P, 2021) |
| "Metformin is widely used in women with Type 2 diabetes of child-bearing age, many of whom become pregnant." | 5.36 | Metformin treatment for Type 2 diabetes in pregnancy? ( Simmons, D, 2010) |
| "Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin." | 5.35 | Metformin--a convenient alternative to insulin for Indian women with diabetes in pregnancy. ( Kamath, A; Meenakshi, D; Rai, L, 2009) |
| "Gestational diabetes mellitus is a condition similar to type 2 diabetes mellitus (T2DM) in that patients are unable to compensate for the degree of insulin resistance, and both conditions are often treated with metformin." | 5.34 | Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus. ( Ahmed, MS; Brown, Z; Caritis, S; Clark, S; Easterling, TR; Flood Nichols, SK; Haas, DM; Haneline, LS; Hebert, MF; Ma, X; Manuck, TA; Morris Brown, L; Quinney, SK; Ren, Z; Shen, DD; Shireman, LM; Shuster, DL; Thummel, KE; Tita, AT; Venkataramanan, R, 2020) |
| " We evaluated whether liraglutide in combination with metformin (MET-LIRA) is more effective than metformin monotherapy (MET-P) in improving insulin action and reducing body weight in overweight prior GDM (pGDM) women." | 5.34 | Postpartum treatment with liraglutide in combination with metformin versus metformin monotherapy to improve metabolic status and reduce body weight in overweight/obese women with recent gestational diabetes: A double-blind, randomized, placebo-controlled ( Elkind-Hirsch, KE; Harris, R; Shaler, D, 2020) |
| "Optimising health outcomes with Metformin to prevent diAbetes After pregnancy (OMAhA) is a multicentre placebo-controlled double-blind randomised feasibility trial, where we will randomly allocate 160 postnatal women with gestational diabetes treated with medication to either metformin (intervention) or placebo (control) tablets to be taken until 1 year after delivery." | 5.34 | Effectiveness and acceptability of metformin in preventing the onset of type 2 diabetes after gestational diabetes in postnatal women: a protocol for a randomised, placebo-controlled, double-blind feasibility trial—Optimising health outcomes with Metformi ( Amaefule, CE; Bolou, A; D'Amico, M; Daru, J; Dodds, J; Drymoussi, Z; Gonzalez Carreras, FJ; Harden, A; Heighway, J; Hitman, G; Huda, MS; Khan, K; Lanz, D; Pardo Llorente, MDC; Pérez, T; Pizzo, E; Robson, J; Sanghi, A; Sobhy, S; Sweeney, L; Thangaratinam, S; Thomas, A; Zamora, J, 2020) |
| "Metformin had beneficial effects on maternal serum IGFBP-1 concentrations compared to insulin, as increased IGFBP-1 related to lower total and late pregnancy maternal weight gain." | 5.34 | Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial. ( Huhtala, MS; Juhila, J; Rönnemaa, T; Sorsa, T; Tertti, K, 2020) |
| "To compare the effects of metformin and insulin treatment on maternal serum lipids in patients with gestational diabetes (GDM), and to analyse the associations between individual lipids and birth weight (BW)." | 5.34 | Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes. ( Huhtala, MS; Rönnemaa, T; Tertti, K, 2020) |
| "This study aimed to evaluate the treatment efficacy of dapagliflozin and metformin, alone and in combination, on body weight and anthropometric, cardiovascular, and metabolic parameters in overweight women with a recent history of gestational diabetes mellitus." | 5.34 | A randomized trial of dapagliflozin and metformin, alone and combined, in overweight women after gestational diabetes mellitus. ( Elkind-Hirsch, KE; Harris, R; Seidemann, E, 2020) |
| "Metformin is a logical treatment in these circumstances but there has always been concern about its safety for the fetus, particularly as it crosses the placenta and it may increase the risk of teratogenesis." | 5.33 | Metformin use and diabetic pregnancy-has its time come? ( Hawthorne, G, 2006) |
| " Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group." | 5.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "We aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR)." | 5.27 | Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study. ( Abusada, N; Candia, P; Cuellar, E; Manukian, B; Orellana, R; Sepúlveda-Martínez, A; Valdés, E, 2018) |
| "Metformin has been used in pregnancy since the 1970s." | 5.22 | Metformin for pregnancy and beyond: the pros and cons. ( Dunne, FP; Newman, C, 2022) |
| "gov for randomized controlled trials (RCTs) that compared metformin to insulin in pregnancy." | 5.22 | The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials. ( Ge, J; Guo, Q; He, K; Jing, Z; Li, C; Li, J, 2022) |
| "Less maternal weight gain was found in the metformin treated groups (9." | 5.20 | Metformin versus insulin treatment in gestational diabetes in pregnancy in a developing country: a randomized control trial. ( Ainuddin, J; Hasan, AA; Karim, N; Naqvi, SA, 2015) |
| "We sought to compare weight loss in the first 6 weeks postpartum among women with gestational diabetes mellitus (GDM) treated with metformin or placebo, a promising therapy to reduce later risk of progression to diabetes mellitus." | 5.20 | The effects of metformin on weight loss in women with gestational diabetes: a pilot randomized, placebo-controlled trial. ( Blackwell, SC; Hutchinson, M; Pedroza, C; Ramin, SM; Refuerzo, JS; Tyson, JE; Viteri, OA, 2015) |
| " We present a protocol for a study to test the hypothesis that metformin will improve insulin sensitivity in obese pregnant women, thereby reducing the incidence of high birthweight babies and other pregnancy complications." | 5.20 | Efficacy of metformin in pregnant obese women: a randomised controlled trial. ( Chiswick, CA; Denison, FC; Drake, AJ; Forbes, S; Murray, GD; Newby, DE; Norman, JE; Quenby, S; Reynolds, RM; Walker, BR; Whyte, SA; Wray, S, 2015) |
| "To determine if metformin monotherapy or metformin in combination with insulin is equally effective as insulin monotherapy at glycemic control in diabetes mellitus in pregnancy among Ghanaians." | 5.20 | Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial. ( Adjepong-Yamoah, KK; Beyuo, T; Bugyei, KA; Marfoh, K; Obed, SA; Oppong, SA, 2015) |
| "Adding metformin to insulin therapy in women with insulin-resistant diabetes mellitus with pregnancy seems to be effective in proper glycemic control in a considerable proportion of women, along with benefits of reduced hospital stay, reduced frequency of maternal hypoglycemia as well as reduced frequency of neonatal hypoglycemia, NICU admission and neonatal respiratory distress syndrome." | 5.19 | The role of adding metformin in insulin-resistant diabetic pregnant women: a randomized controlled trial. ( Anwar, M; Faris, M; Hamdy, A; Ibrahim, MI; Shafik, A; Taha, S, 2014) |
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 5.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "Metformin was found to provide adequate glycemic control with lower mean glucose levels throughout the day, less weight gain and a lower frequency of neonatal hypoglycemia." | 5.17 | Randomized trial of metformin vs insulin in the management of gestational diabetes. ( Bernardes, LS; Francisco, RP; Spaulonci, CP; Trindade, TC; Zugaib, M, 2013) |
| "To compare the efficacy of metformin with insulin in the management of pregnancy with diabetes." | 5.17 | Efficacy of metformin versus insulin in the management of pregnancy with diabetes. ( Malik, FP; Mazhar, SB; Waheed, S, 2013) |
| "We conducted a single centre randomized controlled study with non-inferiority design comparing metformin and insulin in the treatment of 217 GDM patients having birth weight as primary outcome variable." | 5.17 | Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. ( Ekblad, U; Koskinen, P; Rönnemaa, T; Tertti, K; Vahlberg, T, 2013) |
| "Metformin should be considered for treatment of overt diabetes and early A2 gestational diabetes in pregnancy." | 5.17 | Metformin compared with insulin in the treatment of pregnant women with overt diabetes: a randomized controlled trial. ( Boggess, KA; Hickman, MA; McBride, R; Strauss, R, 2013) |
| "Prospectively assess whether metformin/diet pre-conception and throughout pregnancy would safely reduce first trimester miscarriage and improve pregnancy outcomes in women with polycystic ovary syndrome (PCOS)." | 5.17 | Effects of metformin-diet intervention before and throughout pregnancy on obstetric and neonatal outcomes in patients with polycystic ovary syndrome. ( Glueck, CJ; Goldenberg, N; Khan, Z; Padda, J; Pranikoff, J; Wang, P, 2013) |
| " The neonates of metformin group had less rate of birth weight centile >90 than insulin group (RR: 0." | 5.16 | Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial. ( Akbari, S; Alavi, A; Amjadi, N; Moosavi, S; Niromanesh, S; Sharbaf, FR, 2012) |
| "To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome." | 5.15 | The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. ( De Leo, V; Di Sabatino, A; Morgante, G; Musacchio, MC; Piomboni, P, 2011) |
| "To determine how glucose control in women with GDM treated with metformin and/or insulin influenced pregnancy outcomes." | 5.14 | Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial. ( Gao, W; Hague, WM; McIntyre, HD; Rowan, JA, 2010) |
| " The modest weight loss with metformin was maintained." | 5.14 | 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. ( Brenneman, AT; Brown-Friday, JO; Christophi, CA; Fowler, SE; Goldberg, R; Hamman, RF; Hoffman, HJ; Knowler, WC; Nathan, DM; Venditti, E, 2009) |
| " 'Cases' were women with PCOS who conceived while taking Metformin and it whom it was continued throughout pregnancy." | 5.14 | Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. ( Nawaz, FH; Rizvi, J, 2010) |
| "The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10." | 5.14 | Metformin compared with glyburide for the management of gestational diabetes. ( Bertini, AM; Bizato, J; de Souza, BV; Pacheco, C; Ribeiro, TE; Silva, JC, 2010) |
| "Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt to reduce pregnancy complications." | 5.14 | Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. ( Almås, I; Berg, AH; Berg, KF; Bjerke, C; Bunford, G; Carlsen, SM; Danielson, A; Eikeland, T; Flo, K; Heimstad, R; Hjelle, S; Kleggetveit, O; Lahmami, G; Lund, A; Romundstad, P; Skogøy, K; Stridsklev, S; Vanky, E; von Brandis, P, 2010) |
| "Our first specific aim in an observational study of 431 nondiabetic women with polycystic ovary syndrome (PCOS), aged >or=20 years and with >or=11 months follow-up on metformin diet, was to prospectively assess relationships between pretreatment glucose and insulin resistance (IR) and the development of type 2 diabetes mellitus (T2DM) or gestational diabetes (GD)." | 5.13 | An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet. ( Glueck, CJ; Goldenberg, N; Sieve, L; Wang, P, 2008) |
| "Previous non-randomized and uncontrolled studies indicate major metformin effects on glucose homeostasis in pregnant women with polycystic ovary syndrome (PCOS)." | 5.13 | Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study. ( Carlsen, SM; Fougner, KJ; Vanky, E, 2008) |
| "One hundred forty-two nondiabetic women with polycystic ovary syndrome (PCOS) who had at least one live-birth (LB) pregnancy on metformin diet (172 pregnancies, 180 LBs)." | 5.13 | Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome. ( Aregawi, D; Glueck, CJ; Pranikoff, J; Wang, P, 2008) |
| "To review the current evidence for the use of metformin in pregnancy for women with type 2 diabetes." | 5.12 | Metformin in Pregnancy for Women with Type 2 Diabetes: a Review. ( Benham, JL; Donovan, LE; Yamamoto, JM, 2021) |
| " Metformin is known to decrease insulin resistance and is also associated with weight loss." | 5.12 | Postpartum Use of Weight Loss and Metformin for the Prevention of Type 2 Diabetes Mellitus: a Review of the Evidence. ( Ayala, NK; Werner, EF; Whelan, AR, 2021) |
| "To evaluate metformin's effects on pregnancy outcomes in women with polycystic ovary syndrome." | 5.12 | Gestational metformin administration in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized control studies. ( Cao, Q; Fu, J; Hu, Y; Huang, W; Huang, X; Wu, L; Zhang, J, 2021) |
| "The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicine reducing insulin resistance appears to be promising." | 5.12 | Metformin administration during pregnancy - current insight. ( Cypryk, K; Krekora, M; Skibinska, M; Zurawska-Klis, M, 2021) |
| "We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes." | 5.12 | Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2021) |
| "This review study of available literature shows that metformin can be a superior option in most neonatal and maternal adverse pregnancy outcomes in women with gestational diabetes mellitus; the results need to be further updated by including future more qualified studies." | 5.12 | Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis. ( Amiri, M; Behboudi-Gandevani, S; Bidhendi Yarandi, R; Ramezani Tehrani, F, 2021) |
| "In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 +/- 4 years) with polycystic ovary syndrome (PCOS), we examined effects of metformin on maternal insulin, insulin resistance (IR), insulin secretion (IS), weight gain, development of gestational diabetes (GD), testosterone and plasminogen activator inhibitor activity." | 5.11 | Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg ( Glueck, CJ; Goldenberg, N; Loftspring, M; Sherman, A; Wang, P, 2004) |
| "We prospectively assessed growth and motor-social development during the first 18 months of life in 126 live births (122 pregnancies) to 109 women with polycystic ovary syndrome (PCOS) who conceived on and continued metformin (1." | 5.11 | Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. ( Glueck, CJ; Goldenberg, N; Loftspring, M; Pranikoff, J; Sieve, L; Wang, P, 2004) |
| "Investigation of a possible effect of metformin on androgen levels in pregnant women with polycystic ovary syndrome (PCOS)." | 5.11 | Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. ( Carlsen, SM; Fougner, KJ; Heimstad, R; Romundstad, P; Salvesen, KA; Vanky, E, 2004) |
| "Previous randomized and observational studies on the efficacy of metformin in pregnancy to reduce incident gestational diabetes mellitus (GDM) in women at high risk (obesity, polycystic ovary syndrome [PCOS], or pregestational insulin resistance) have been conflicting and several groups are planning further randomized controlled trials (RCTs) to answer this question conclusively." | 5.05 | Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials. ( Clark, J; Doi, SAR; Furuya-Kanamori, L; Islam, N; Musa, OAH; Thalib, L; Toft, E, 2020) |
| " Metformin is taken by many patients before pregnancy due to both previously diagnosed type 2 diabetes and in the treatment of prediabetes, obesity and polycystic ovary syndrome (PCOS) as part of therapy for insulin resistance." | 5.05 | Metformin therapy in pregnancy [Zastosowanie metforminy w ciąży]. ( Cichocka, E; Gumprecht, J; Kędzierski, L; Krupej-Kędzierska, J; Okopień, B, 2020) |
| "A systematic review and meta-analysis of clinical trials or observational studies of metformin intervention in preventing symptoms of GDM during pregnancy were performed." | 5.05 | The Effect of Metformin Therapy for Preventing Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Meta-Analysis. ( Liu, X; Zhang, W; Zhao, J, 2020) |
| "It seems to have no sense to prolong the use of metformin after a pregnancy diagnosis in women with PCOS." | 5.01 | Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions. ( Alvariñas, J; Bagnes, MFG; Di Girolamo, G; Gonzalez, CD, 2019) |
| "Oral antidiabetic medication of metformin is increasingly used in pregnant women with gestational diabetes mellitus (GDM), polycystic ovary syndrome (PCOS) and obesity." | 5.01 | Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis. ( Xie, Q; Xu, Q, 2019) |
| "Following intrauterine exposure to metformin for treatment of maternal GDM, neonates are significantly smaller than neonates whose mothers were treated with insulin during pregnancy." | 5.01 | Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2019) |
| "To perform meta-analyses of studies evaluating the risk of pre-eclampsia in high-risk insulin-resistant women taking metformin prior to, or during pregnancy." | 4.98 | Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. ( Alqudah, A; Graham, U; Lyons, TJ; McClements, L; McKinley, MC; McNally, R; Watson, CJ, 2018) |
| "Metformin has been reported to reduce the risk of pre-eclampsia." | 4.98 | Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. ( Abdi, A; Kalafat, E; Khalil, A; Sukur, YE; Thilaganathan, B, 2018) |
| "Metformin use in pregnancy is increasing worldwide as randomised controlled trial (RCT) evidence is emerging demonstrating its safety and efficacy." | 4.98 | Metformin in Pregnancy: Mechanisms and Clinical Applications. ( Balani, J; Hyer, S; Shehata, H, 2018) |
| "Forty articles met inclusion criteria and were summarized into four general categories: (1) RCTs of metformin use for diabetes prevention (n=7 and n=2 follow-up analyses); (2) observational analyses examining metformin use in heterogeneous subgroups of patients with prediabetes (n=9 from the Diabetes Prevention Program, n=1 from the biguanides and the prevention of the risk of obesity [BIGPRO] trial); (3) observational analyses examining cost effectiveness of metformin use for diabetes prevention (n=11 from the Diabetes Prevention Program, n=1 from the Indian Diabetes Prevention Program); and (4) real-world assessments of metformin eligibility or use for diabetes prevention (n=9)." | 4.98 | Review of Metformin Use for Type 2 Diabetes Prevention. ( Flory, JH; Herman, WH; Karter, AJ; Kruge, LE; Mangione, CM; Moin, T; Schillinger, D; Schmittdiel, JA; Walker, EA; Yeh, J, 2018) |
| "The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s." | 4.98 | Oral Agents for the Treatment of Gestational Diabetes. ( Finneran, MM; Landon, MB, 2018) |
| "Our study concluded that metformin is fastest in glucose control, with a more favorable pregnancy outcomes-would be a better option, but its rate of glucose control is the lowest." | 4.95 | Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. ( Liang, HL; Ma, SJ; Tan, HZ; Xiao, YN, 2017) |
| "To assess the short- and long-term maternal and fetal impact of metformin in pregnancy compared with insulin." | 4.95 | Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. ( Aitken, E; Butalia, S; Donovan, L; Gutierrez, L; Lodha, A; Zakariasen, A, 2017) |
| "Metformin use during pregnancy is controversial and there is disparity in the acceptance of metformin treatment in women with gestational diabetes mellitus (GDM) in Australia." | 4.95 | The emerging role of metformin in gestational diabetes mellitus. ( Cohen, N; Gray, SG; Little, PJ; McGuire, TM, 2017) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 4.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "26); whereas, significantly reduced results were found in the metformin group in pregnancy-induced hypertension (PIH) rate (RR = 0." | 4.91 | Effect comparison of metformin with insulin treatment for gestational diabetes: a meta-analysis based on RCTs. ( Cui, S; Li, G; Li, L; Li, Y; Xu, Y; Zhao, S, 2015) |
| "In women with gestational diabetes, metformin use and insulin therapy have comparable glycemic control profile, but metformin use was associated with lower risk of neonatal hypoglycemia." | 4.91 | Metformin for the treatment of gestational diabetes: An updated meta-analysis. ( Kitwitee, P; Limwattananon, C; Limwattananon, S; Nguyen, TV; Phimphilai, M; Pongchaiyakul, C; Ratanachotpanich, T; Waleekachonlert, O, 2015) |
| "To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS)." | 4.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| " Metformin is widely used in fertility treatment of women with PCOS, due to a suggested positive effect of continued metformin treatment beyond the first trimester on pregnancy complications." | 4.91 | [Metformin and the obstetric patient]. ( Aaboe, K; Bülow, NS; Galsgaard, J; Lauenborg, J; Mathiesen, ER; Odgaard, HS; Pedersen, KD, 2015) |
| " Terms for Gestational diabetes/gestational diabetes mellitus/diabetes pregnancy AND/OR Metformin/hypoglycemic drugs/Hypoglycemic Agents/Antidiabetic Medications were used in the search." | 4.90 | Metformin vs insulin in the management of gestational diabetes: a systematic review and meta-analysis. ( Su, DF; Wang, XY, 2014) |
| "Metformin is an effective oral anti-hyperglycemic agent that is widely used to manage diabetes mellitus type 2 in the general population and more recently, in pregnancy." | 4.89 | Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. ( Goulis, DG; Lautatzis, ME; Vrontakis, M, 2013) |
| " Research suggests that glyburide and metformin can each effectively manage hyperglycemia in pregnancy." | 4.89 | Oral agents for the management of gestational diabetes. ( Berggren, EK; Boggess, KA, 2013) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 4.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "Available evidence supports the use of glyburide during pregnancy." | 4.84 | Pharmacological management of gestational diabetes: an overview. ( Coustan, DR, 2007) |
| "No adverse pregnancy outcomes with metformin use have been reported, except in one unmatched study." | 4.82 | Metformin therapy and diabetes in pregnancy. ( McIntyre, HD; Rowan, JA; Simmons, D; Walters, BN, 2004) |
| "The use of insulin sensitizing drugs such as metformin in polycystic ovary syndrome has been increasingly popular and validated by systematic reviews." | 4.82 | Should we continue or stop insulin sensitizing drugs during pregnancy? ( Hague, W; Norman, RJ; Wang, JX, 2004) |
| "Twenty female pregnant rats were used, and they were divided into four groups of control (normal pregnancy), disease (diabetic untreated), metformin (received 200 mg/kg metformin dissolved in distilled water) and tBHQ groups (received 25 mg/kg tBHQ in 1% corn oil), respectively, with five rats in each group." | 4.31 | Tert-butylhydroquinone Mitigates Renal Dysfunction in Pregnant Diabetic Rats ( Li, J; Liu, H; Shang, L, 2023) |
| " Metformin appears to reduce these risks in mothers with polycystic ovary syndrome and their children; but may increase the risk of childhood-obesity in children form women without PCOS." | 4.12 | Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. ( Brusselaers, N; Crisosto, N; Cruz, G; Engstrand, L; Fornes, R; Nguyen, MH; Simin, J; van der Schaaf, M, 2022) |
| "The main aim was to study whether the long-term incidences of type 2 diabetes, pre-diabetes and metabolic syndrome differed between women who were treated with metformin or insulin for gestational diabetes." | 4.12 | Comparison of glucose metabolism and anthropometry in women with previous gestational diabetes treated with metformin vs. insulin: 9-year follow-up of two randomized trials. ( Huhtala, M; Loo, BM; Niinikoski, H; Nikkinen, H; Paavilainen, E; Rönnemaa, T; Tertti, K; Vääräsmäki, M, 2022) |
| "To use the framework of the Health Belief Model (HBM) to explore factors associated with metformin use among adults with prediabetes." | 4.12 | Health Beliefs Associated With Metformin Use Among Insured Adults With Prediabetes. ( Herman, WH; Hurst, TE; Joiner, KL; McEwen, LN, 2022) |
| "Among individuals with prediabetes in Saudi Arabia, metformin use was very low despite the evidence supporting its safety, convenience, and efficacy." | 4.12 | The use of metformin for type 2 diabetes prevention: Observational multicenter study from Saudi Arabia. ( Al Yami, MS; Al-Azzeh, O; Alfayez, OM; Aljabri, AF; Almalki, OS; Almohammed, OA; Almutairi, FS; Alsallum, AA, 2022) |
| "Metformin is beneficial for GDM women to control total GWG compared with insulin, regulate fetal birth weight more than insulin and glyburide, and increase the risk of unmet treatment targets compared with insulin." | 4.12 | Efficacy and safety of hypoglycemic agents on gestational diabetes mellitus in women: A Bayesian network analysis of randomized controlled trials. ( Chen, H; Cui, W; Guo, H; Huang, L; Jing, Y; Liu, X; Song, L; Sun, B; Wang, M; Wang, N; Wang, T; Xu, J, 2022) |
| "To investigate effects of maternal diabetes and metformin treatment on metabolic newborn screening (NBS) results of infants born to mothers with hyperglycemia during pregnancy." | 4.02 | Effect of Maternal Metformin Treatment in Pregnancy on Neonatal Metabolism: Evidence From Newborn Metabolic Screening. ( Estrella, J; Hng, TM; McLean, M; Simmons, D; Wiley, V, 2021) |
| "This study estimated the cost-effectiveness of metformin to reduce the risk of gestational diabetes mellitus (GDM) in pregnant women with polycystic ovary syndrome (PCOS) from the US health-care payer perspective." | 4.02 | Cost-effectiveness analysis of polycystic ovary syndrome management and the risk of gestational diabetes in pregnant women: a decision-tree model. ( Alenzi, EO, 2021) |
| "Women with GDM treated with insulin plus metformin had similar obstetric and neonatal complications, weight gained and insulin dose compared to those only treated with insulin." | 4.02 | Metformin combined with insulin in women with gestational diabetes mellitus: a propensity score-matched study. ( Almeida, M; Almeida, MC; Chaves, C; Cunha, F; Estevinho, C; Figueiredo, O; Garrido, S; Martinho, M; Melo, A; Morgado, A; Silva-Vieira, M, 2021) |
| "Recent research has demonstrated the benefits of metformin treatment in gestational diabetes (GDM) on short-term pregnancy outcomes (including excessive fetal growth and pre-eclampsia), but its effects on fetal metabolism remain mostly unknown." | 4.02 | Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone. ( Huhtala, MS; Pellonperä, O; Rönnemaa, T; Tertti, K, 2021) |
| "Gestational metformin attenuated the adiposity in obese dams and increased the gestation length without correcting the offspring in utero growth restriction and catch-up growth caused by maternal obesity." | 4.02 | Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Ozanne, SE; Schoonejans, JM, 2021) |
| " The mothers of the cases/controls and their diagnoses of diabetes (DM) before/during pregnancy as well as their insulin/metformin prescriptions during pregnancy were identified." | 3.96 | Maternal diabetes and risk of childhood cancer in the offspring. ( Hirvonen, E; Leinonen, MK; Madanat-Harjuoja, LM; Pitkäniemi, J; Seppälä, LK; Vettenranta, K, 2020) |
| "Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age." | 3.96 | Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos. ( Adiga, SK; Agarwal, P; Kalthur, G; Kalthur, SG; Kumari, S; Mutalik, S; Nayak, G; Rao, A; Salian, SR; Shreya, AB; Suresh Poojary, P, 2020) |
| " This study will provide robust evidence regarding the efficacy and safety of metformin use in pregnancy, and may identify subgroups of patients who may benefit most from this treatment modality." | 3.96 | Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis. ( Burden, C; Carlsen, SM; Dodd, JM; Hague, W; Hilkka, I; Løvvik, T; Morin-Papunen, L; Mousa, A; Nicolaides, K; Norman, JE; Rönnemaa, T; Rowan, J; Shehata, H; Syngelaki, A; Teede, HJ; Tertti, K; Vanky, E, 2020) |
| " In our study, we explored the changes in metabolic health and cognitive function in mice of middle- and old- age after exposure to GDM, and whether metformin therapy during pregnancy provided long-term benefits." | 3.96 | Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes. ( Baker, PN; Chen, X; Han, TL; Qi, H; Wang, A; Yu, X; Zhang, H; Zhao, X; Zhao, Y; Zhou, X, 2020) |
| " The aims of this study were to evaluate the potential effect of metformin in GWG in overweight or obese women with GDM, to report our experience and to assess metformin's safety in this population." | 3.91 | Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study. ( Belo, S; Bettencourt-Silva, R; Carvalho, D; Ferreira, MJ; Montenegro, N; Namora, G; Neves, JS; Oliveira, AI; Queirós, J; Souteiro, P, 2019) |
| "Although metformin has traditionally been avoided in pregnancy, evidence now supports its safety and efficacy for management of gestational diabetes mellitus (GDM)." | 3.91 | Implementation and Evaluation of the "Metformin First" Protocol for Management of Gestational Diabetes. ( Halperin, I; Kumar, R; Lipscombe, L; Lowe, J; Shah, B; Steinberg, D; Thompson-Hutchison, F, 2019) |
| "We found no clear evidence of any adverse outcomes related to the use of metformin for the treatment of hyperglycemia in pregnancy." | 3.91 | Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register. ( Barzi, F; Boyle, J; Brown, A; Chitturi, S; Connors, C; Corpus, S; Cotter, M; Dowden, M; Inglis, C; Kirkham, R; Kirkwood, M; Lee, IL; Lindenmayer, G; Longmore, D; Maple-Brown, LJ; McIntyre, HD; Moore, E; O'Dea, K; Oats, J; Shaw, JE; Thomas, S; van Dokkum, P; Whitbread, C; Wicks, M; Zimmet, P, 2019) |
| "The initiation of metformin in early pregnancy in Gestational Diabetes mellitus (GDM) remains controversial." | 3.88 | How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India. ( Asha, HS; Dasgupta, R; Gupta, V; Mathews, JE; Paul, T; Ramachandran, R; Regi, A; Thomas, N; Visalakshi, P, 2018) |
| "As women with higher fasting glucose levels have higher chance of necessitating insulin in later pregnancies, appropriate addition of insulin at metformin initiation for these women could help better glycaemic control throughout pregnancy." | 3.88 | Predictors of metformin failure in gestational diabetes mellitus (GDM). ( Gates, S; Khin, MO; Saravanan, P, 2018) |
| "Studies in rodents suggest that metformin treatment during pregnancy may have harmful effects on testicular development in offspring." | 3.83 | Metformin Treatment Does Not Affect Testicular Size in Offspring Born to Mothers with Gestational Diabetes. ( Rönnemaa, T; Sadov, S; Tertti, K; Toppari, J; Virtanen, HE, 2016) |
| "The children of mothers with GDM randomised to metformin (n = 47) or insulin (n = 50) treatment during pregnancy." | 3.81 | A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: growth and development of the children at the age of 18 months. ( Ijäs, H; Keravuo, R; Raudaskoski, T; Saarela, T; Vääräsmäki, M, 2015) |
| "To assess the effect of metformin in controlling Gestational Diabetes Mellitus (GDM) in women with Polycystic Ovarian Syndrome (PCOS)." | 3.81 | Metformin for preventing gestational diabetes in women with polycystic ovarian syndrome. ( Aftab, S; Ainuddin, JA; Kamran, A; Kazi, S, 2015) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 3.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "OBJECTIVE The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention." | 3.80 | Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus. ( Christophi, CA; Dabelea, D; Dagogo-Jack, S; Florez, JC; Franks, PW; Jablonski, KA; Kim, C; Knowler, WC; Ratner, R; Sullivan, SD, 2014) |
| "To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd-M) and daughters of women who belong to a healthy comparison group (HCd)." | 3.78 | Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters. ( Crisosto, N; Echiburú, B; Ladrón de Guevara, A; Maliqueo, M; Pérez, V; Preisler, J; Sánchez, F; Sir-Petermann, T, 2012) |
| "To evaluate retrospectively the prevalence of gestational diabetes (GD) in pregnancies obtained with myo-inositol administration in women with polycystic ovary syndrome." | 3.78 | Myo-inositol may prevent gestational diabetes in PCOS women. ( Corrado, F; D'Anna, R; Di Benedetto, A; Di Benedetto, V; Interdonato, ML; Raffone, E; Rizzo, P, 2012) |
| " Metformin was tolerated throughout the pregnancy by 90% of the women in the metformin+lifestyle advice group." | 3.78 | Introduction of metformin for gestational diabetes mellitus in clinical practice: Has it had an impact? ( Bustani, R; Farrell, T; Gandhi, P; Madhuvrata, P, 2012) |
| "Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women." | 3.77 | Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. ( Aboul Foutouh, I; Ashmawi, HS; Khattab, S; Mohsen, IA; Mohsen, MN; van der Veen, F; van Wely, M; Youssef, MA, 2011) |
| "A high rate of GD or IGT already was observed in the first weeks of pregnancy in our cohort under metformin treatment." | 3.77 | Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction. ( Bals-Pratsch, M; Grosser, B; Ortmann, O; Seifarth, C; Seifert, B, 2011) |
| "In women with gestational diabetes mellitus, who were randomized to metformin or insulin treatment, pregnancy outcomes were similar (Metformin in Gestational diabetes [MiG] trial)." | 3.77 | Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. ( Battin, M; Hague, WM; Obolonkin, V; Rowan, JA; Rush, EC; Wouldes, T, 2011) |
| "The aim of the present study was to assess whether continuation of metformin therapy throughout pregnancy can reduce the development of gestational diabetes in women with polycystic ovarian syndrome (PCOS)." | 3.75 | Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome. ( Begum, A; Begum, MR; Begum, MS; Ferdous, J; Khan, F; Khanam, NN; Quadir, E, 2009) |
| "Women with GDM treated with metformin and with similar baseline risk factors for adverse pregnancy outcomes had less weight gain and improved neonatal outcomes compared with those treated with insulin." | 3.75 | Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. ( Balani, J; Hyer, SL; Rodin, DA; Shehata, H, 2009) |
| "The pharmacokinetic disposition of metformin in late pregnancy was studied together with the level of fetal exposure at birth." | 3.73 | Population pharmacokinetics of metformin in late pregnancy. ( Charles, B; Hague, W; Norris, R; Xiao, X, 2006) |
| "To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS)." | 3.73 | Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls." | 3.73 | Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy. ( Glezerman, M; Gur, D; Kovo, M; Levran, D; Rotmensch, S; Weissman, A, 2006) |
| "Before metformin therapy, after covariance adjustment for age, the two cohorts did not differ in height, weight, basal metabolic index, insulin, insulin resistance, or insulin secretion." | 3.71 | Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. ( Glueck, CJ; Kobayashi, S; Phillips, H; Sieve-Smith, L; Wang, P, 2002) |
| "The prevalence of pre-eclampsia was significantly increased in the group of women treated with metformin compared to women treated with sulphonylurea or insulin (32 vs." | 3.70 | Oral hypoglycaemic agents in 118 diabetic pregnancies. ( Damm, P; Hellmuth, E; Mølsted-Pedersen, L, 2000) |
| "Gestational diabetes is a common complication of pregnancy and the optimal management is uncertain." | 3.30 | Early Metformin in Gestational Diabetes: A Randomized Clinical Trial. ( Alvarez-Iglesias, A; Bogdanet, D; Browne, M; Devane, D; Dunne, F; Egan, A; Ferguson, J; Finn, Y; Gaffney, G; Gillespie, P; Kgosidialwa, O; Khattak, A; Liew, A; Newman, C; O'Donnell, M; O'Keeffe, D; O'Shea, P; Smyth, A, 2023) |
| "Pregnant women with gestational diabetes treated with medication." | 3.30 | Metformin in the prevention of type 2 diabetes after gestational diabetes in postnatal women (OMAhA): a UK multicentre randomised, placebo-controlled, double-blind feasibility trial with nested qualitative study. ( Amaefule, CE; Bolou, A; Dodds, J; Drymoussi, Z; Gonzalez Carreras, FJ; Harden, A; Heighway, J; Hitman, G; Huda, MSB; Lanz, D; Pardo Llorente, MDC; Pérez, T; Pizzo, E; Sanghi, A; Thangaratinam, S; Thomas, A; Zamora, J, 2023) |
| "Metformin treatment for GDM is associated with similar offspring growth and glucose metabolism but a more favourable lipid profile at the age of 9 years as compared to insulin treatment." | 3.11 | Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow-up study of two open-label, randomized controlled trials. ( Loo, BM; Niinikoski, H; Nikkinen, H; Paavilainen, E; Rönnemaa, T; Tertti, K; Tossavainen, P; Vääräsmäki, M; Veijola, R, 2022) |
| "Pregnancies affected by gestational diabetes mellitus (GDM) are associated with an increased risk of adverse maternal and foetal outcomes." | 3.11 | A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol. ( Alvarez-Iglesias, A; Browne, M; Devane, D; Dunne, F; Gillespie, P; Newman, C; O'Donnell, M; Smyth, A, 2022) |
| "Persons with gestational and pregestational diabetes during pregnancy may require pharmacologic agents to achieve pregnancy glycemic targets, and the available medications for use in pregnancy are limited." | 3.01 | Medications for Managing Preexisting and Gestational Diabetes in Pregnancy. ( Caughey, AB; Rickert, M; Valent, AM, 2023) |
| "Even normal pregnancy is characterized by relative insulin resistance and glucose intolerance." | 3.01 | Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial. ( Hong, JGS; Kamarudin, M; Omar, SZ; Tan, PC, 2021) |
| "Metformin treatment was associated with a better postprandial glycemic control than insulin for some meals, a lower risk of hypoglycemic episodes, less maternal weight gain, and a low rate of failure as an isolated treatment." | 3.01 | Metformin for gestational diabetes study: metformin vs insulin in gestational diabetes: glycemic control and obstetrical and perinatal outcomes: randomized prospective trial. ( González-Mesa, E; González-Romero, S; Molina-Vega, M; Olveira, G; Picón-César, MJ; Roldan-López, R; Romero-Narbona, F; Sola-Moyano, AP; Suárez-Arana, M; Tinahones, FJ, 2021) |
| " Data are limited regarding the pharmacodynamic effects of metformin and glyburide during pregnancy." | 2.94 | Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus. ( Ahmed, MS; Brown, LM; Brown, Z; Caritis, S; Clark, S; Easterling, TR; Flood Nichols, SK; Haas, DM; Haneline, LS; Hebert, MF; Ma, X; Manuck, TA; Quinney, SK; Ren, Z; Shen, DD; Shireman, LM; Shuster, DL; Thummel, KE; Tita, AT; Venkataramanan, R, 2020) |
| "In women with gestational diabetes mellitus (GDM) requiring pharmacotherapy, insulin was the established first-line treatment." | 2.90 | SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial. ( Akerboom, BMC; Assouiki, F; Bosmans, JE; Braams-Lisman, BAM; Brouwer, CB; Daemen-Gubbels, CRGM; de Boer, K; de Galan, BE; de Koning, EJP; de Valk, HW; de Wit, L; deVries, JH; Diekman, MJM; Dullemond, RC; Eskes, SA; Evers, IM; Franx, A; Galjaard, S; Gallas, PRJ; Groenendaal, F; Heijligenberg, R; Hermes, W; Hermsen, BB; Horree, N; Huisjes, AJM; IJzerman, RG; Jansen, HJ; Kiewiet-Kemper, RM; Klooker, TK; Kuppens, SMI; Laan, R; Mensing van Charante, NA; Mol, BW; Naaktgeboren, CA; Oosterwerff, MM; Painter, RC; Potter van Loon, BJ; Rademaker, D; Sanson-van Praag, ME; Schippers, DH; Soeters, MR; Sueters, M; van Bemmel, T; van Bon, AC; van den Akker, ES; van den Beld, AW; van der Heijden, OWH; van der Made, FW; van Houtum, WH; van Laar, JOEH; van Leeuwen, M; van Meir, CA; van Rijn, BB; Veldhuis-Vlug, AG; Vermeulen, MAR; Verwij-Didden, MAL; Vidarsdottir, S; Visser, W; Vogelvang, TE; Voormolen, DN; Wijbenga, JAM; Wouters, MGAJ; Wouters-van Poppel, P; Zandstra, M; Zwart, JJ; Zwertbroek, R, 2019) |
| " Metformin was not effective in reducing BMI and preventing GDM in obese pregnant women." | 2.87 | Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women. ( Dienstmann, G; Nascimento, IBD; Sales, WB; Silva, GDD; Silva, JC; Souza, MLR, 2018) |
| "Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy." | 2.84 | Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial. ( Alexander, CI; Bell, JL; Denison, FC; Juszczak, E; Lindsay, RS; Love, CDB; Mackenzie, F; Norman, JE; Penneycard, J; Reynolds, RM; Stenson, B; Strachan, MWJ; Whyte, S, 2017) |
| "Glyburide was started in 53 patients and metformin in 51." | 2.84 | Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. ( Gam Ze Letova, Y; Hasanein, J; Hissin, N; Nachum, Z; Salim, R; Suleiman, A; Yefet, E; Zafran, N, 2017) |
| "Oral hypoglycemic drugs for the treatment of gestational diabetes mellitus (GDM) are still controversial because they can pass through the placenta." | 2.82 | Comparison of the effectiveness and safety of insulin and oral hypoglycemic drugs in the treatment of gestational diabetes mellitus: a meta-analysis of 26 randomized controlled trials. ( Gao, C; Jia, X; Li, C; Shi, H; Zhang, L; Zhang, X, 2022) |
| "Metformin is considered to be a safe and effective alternative to insulin for the management of GDM if patients refuse insulin due to any reasons in China." | 2.82 | Efficacy and safety of metformin compared to insulin in gestational diabetes: a systemic review and meta-analysis of Chinese randomized controlled trials. ( Hu, Y; Li, F; Liu, L; Liu, W; Marx, CM, 2022) |
| "This review provides an update on gestational diabetes (GDM) and other adverse pregnancy outcomes in individuals with polycystic ovary syndrome (PCOS), one of the most common metabolic disorders and causes of infertility." | 2.82 | Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome. ( Powe, CE; Selen, DJ, 2022) |
| "Metformin is an effective and safe alternative to insulin in GDM." | 2.82 | Identification of metformin poor responders, requiring supplemental insulin, during randomization of metformin versus insulin for the control of gestational diabetes mellitus. ( Abdelnaby, M; Ashoush, S; El-Said, M; Fathi, H, 2016) |
| "In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide." | 2.80 | Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. ( Abraham, A; Antonisamy, B; Beck, M; Benjamin, SJ; George, A; Jana, AK; Mathews, JE; Sam, D; Thomas, N, 2015) |
| "Offspring born following maternal gestational diabetes are at risk of excessive childhood weight gain and Type 2 diabetes in childhood, which in turn is associated with an increased rate of hypertension." | 2.80 | Blood pressure measurement at two years in offspring of women randomized to a trial of metformin for GDM: follow up data from the MiG trial. ( Battin, MR; Coat, S; Hague, W; Obolonkin, V; Rowan, J; Rush, E, 2015) |
| "Metformin has no significant effect on birthweight percentile in obese pregnant women." | 2.80 | Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. ( Chiswick, C; Denison, F; Drake, AJ; Forbes, S; Lashen, H; Murray, G; Newby, DE; Norman, JE; Quenby, S; Reynolds, RM; Rodriguez, A; Walker, BR; Weeks, A; Whyte, S; Wray, S, 2015) |
| "Women with gestational diabetes mellitus were randomly assigned to metformin or insulin in the Metformin in Gestational Diabetes trial." | 2.78 | Maternal and neonatal circulating markers of metabolic and cardiovascular risk in the metformin in gestational diabetes (MiG) trial: responses to maternal metformin versus insulin treatment. ( Barrett, HL; Callaway, LK; Coat, S; De Blasio, MJ; Dekker Nitert, M; Gatford, KL; Hague, WM; Houda, CM; McIntyre, HD; Owens, JA; Rowan, JA, 2013) |
| "Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents." | 2.75 | Metformin compared with glyburide in gestational diabetes: a randomized controlled trial. ( Clokey, D; Curet, LB; Moore, LE; Rappaport, VJ, 2010) |
| "A past history of gestational diabetes mellitus (GDM) confers a very high risk of postpartum development of diabetes, particularly type 2 diabetes." | 2.73 | Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. ( Bennett, PH; Christophi, CA; Dabelea, D; Fowler, S; Kahn, SE; Metzger, BE; Pi-Sunyer, X; Ratner, RE, 2008) |
| " The majority (27/32) were easily controlled on the initial dosage (500 mg twice a day)." | 2.73 | Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. ( Bofill, JA; Briery, CM; Clokey, D; Martin, RW; Moore, LE; Morrison, JC; Williford, NJ, 2007) |
| "Metformin is a logical treatment for women with gestational diabetes mellitus, but randomized trials to assess the efficacy and safety of its use for this condition are lacking." | 2.73 | Metformin versus insulin for the treatment of gestational diabetes. ( Battin, MR; Gao, W; Hague, WM; Moore, MP; Rowan, JA, 2008) |
| "The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment." | 2.72 | Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women. ( Abou-Samra, AB; Bashir, M; Chivese, T; Clark, J; Doi, SA; Furuya-Kanamori, L; Mohamed, AM; Musa, OAH; Syed, A; Thalib, L; Toft, E; Xu, C, 2021) |
| "Maternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which can adversely affect the short- and long-term health of mothers and newborns." | 2.72 | Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options. ( Brunetti, A; Chiefari, E; Foti, D; Greco, E; Mirabelli, M; Tocci, V, 2021) |
| "Metformin was effective in DAP reduction and was well tolerated, but participants were on average 12 years beyond their GDM pregnancy." | 2.66 | Pharmacological intervention for diabetes after pregnancy prevention in women with prior gestational diabetes: A scoping review. ( Dasgupta, K; Mahmoud, I; Pancer, J; Wu, N, 2020) |
| "The prevalence of gestational diabetes mellitus (GDM) is increasing, with approximately 15% of pregnant women affected worldwide, varying by country, ethnicity and diagnostic thresholds." | 2.66 | Interventions to prevent women from developing gestational diabetes mellitus: an overview of Cochrane Reviews. ( Alsweiler, J; Brown, S; Crowther, CA; Griffith, RJ; Middleton, P; Moore, AE; Shepherd, E, 2020) |
| "Metformin has been a longstanding and safe treatment for the control of blood glucose in people with T2DM." | 2.66 | Metformin for Preventing Type 2 Diabetes Mellitus in Women with a Previous Diagnosis of Gestational Diabetes: A Narrative Review. ( Anjana, RM; Beks, H; Dunbar, JA; Hague, W; Khunti, K; McNamara, K; Mohan, V; Versace, VL; Wesley, H, 2020) |
| "Glyburide has been associated with increased neonatal hypoglycemia." | 2.61 | The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy. ( Blair, RA; Palermo, NE; Rosenberg, EA, 2019) |
| "Established risk factors for gestational diabetes mellitus (GDM) include ethnicity, obesity, and family history of diabetes." | 2.61 | Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review. ( Farahvar, S; Sheiner, E; Walfisch, A, 2019) |
| "Pregestational and gestational diabetes are associated with significant maternal and fetal risks; therefore, screening and treatment during pregnancy are recommended." | 2.61 | Pharmacologic Treatment of Diabetes in Pregnancy. ( Bishop, KC; Boyd, BK; Brown, L; Harris, BS; Kuller, JA; Reiff, ES, 2019) |
| " The use of antenatal steroids in mothers at risk of preterm delivery complicates management of hyperglycaemia in the immediate antepartum period and requires appropriate dosing adjustments of insulin therapy." | 2.58 | Intra-partum management of women with diabetes. ( Jacob, JJ; Jewel, R, 2018) |
| "The diagnosis and treatment of gestational diabetes mellitus (GDM) have been in a state of flux since the World Health Organization accepted and endorsed the International Diabetes and Pregnancy Study Group's diagnostic pathway and criteria in 2013." | 2.58 | Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy. ( Cohen, N; Gray, SG; Little, PJ; Mcguire, TM; Ross, GP; Sweeting, AN, 2018) |
| "Women with a history of gestational diabetes are at high risk for developing type 2 diabetes mellitus." | 2.55 | Preventing progression from gestational diabetes mellitus to diabetes: A thought-filled review. ( Grajower, MM; Kasher-Meron, M, 2017) |
| "Metformin has a molecular weight of 129 Daltons and therefore readily crosses the placenta." | 2.55 | Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. ( Conde-Agudelo, A; Erez, O; Grossman, LI; Hüttemann, M; Maymon, E; Pacora, P; Panaitescu, B; Romero, R; Yoon, BH, 2017) |
| "Metformin has also proven to be safe and may be considered as an initial single agent for milder gestational diabetes." | 2.55 | The care of pregestational and gestational diabetes and drug metabolism considerations. ( Davis, SN; Hedrington, MS, 2017) |
| "Glyburide has good efficacy and short-term data but it also crosses the placenta and may be associated with increased rates of large-for-gestational-age (LGA) infants and neonatal hypoglycaemia when compared with insulin." | 2.55 | Pharmacological Management of Gestational Diabetes Mellitus. ( Feig, DS; Mukerji, G, 2017) |
| "Metformin is an effective alternative to insulin in glycemic control in pregnant women." | 2.55 | Gestational diabetes - is diet and insulin the only solution? ( Bieniek, E; Brzozowska, M; Lewinski, A; Szosland, K, 2017) |
| "Metformin has been gradually used in the management of gestational diabetes mellitus (GDM)." | 2.55 | Metformin - a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis. ( Feng, Y; Yang, H, 2017) |
| "Metformin may be beneficial in treating gestational diabetes." | 2.53 | Metformin versus insulin in gestational diabetes mellitus: a meta-analysis of randomized clinical trials. ( Cao, YS; Fan, YY; Li, XG; Liu, T; Wang, L; Zhang, L; Zhao, ZG; Zhu, B, 2016) |
| "The primary aims of the treatment of gestational diabetes (GDM) are to prevent macrosomia and pregnancy complications." | 2.53 | Is it worth treating gestational diabetes: if so, when and how? ( Vääräsmäki, M, 2016) |
| "It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus." | 2.53 | Role of Metformin in Women's Health: Review of Its Current Place in Clinical Practice and Emerging Indications for Future. ( Sinai Talaulikar, V; Tang, T; Yasmin, E, 2016) |
| "A diagnosis of Gestational Diabetes (GDM) confers adverse risk to the health of the mother and fetus both in pregnancy and later life." | 2.53 | Prediction and prevention of Gestational Diabetes: an update of recent literature. ( Kennelly, MA; McAuliffe, FM, 2016) |
| "The overall incidence of gestational diabetes mellitus (GDM) is increasing worldwide." | 2.53 | Gestational diabetes mellitus: does an effective prevention strategy exist? ( Agha-Jaffar, R; Johnston, D; Oliver, N; Robinson, S, 2016) |
| "It is also used to delay the onset of type 2 diabetes mellitus, in treating gestational diabetes, and in women with polycystic ovary syndrome." | 2.53 | Metformin: From Research to Clinical Practice. ( Alquraini, H; MacEachern, M; Mizokami-Stout, K; Tan, MH, 2016) |
| "Maternal obesity is associated with adverse perinatal outcome." | 2.52 | Placental dysfunction in obese women and antenatal surveillance strategies. ( Doshani, A; Jeve, YB; Konje, JC, 2015) |
| " Other oral medications have not been shown to be safe in pregnancy." | 2.52 | Safety considerations with pharmacological treatment of gestational diabetes mellitus. ( Simmons, D, 2015) |
| "At short term, in women with gestational diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin." | 2.52 | Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. ( Balsells, M; Corcoy, R; García-Patterson, A; Gich, I; Roqué, M; Solà, I, 2015) |
| "Glycaemic control in women with gestational diabetes mellitus (GDM) has typically been achieved with diet, exercise and insulin therapy." | 2.52 | Metformin for the management of gestational diabetes mellitus. ( Barclay, M; Rahimpanah, F; Singh, KP, 2015) |
| "Metformin seems to be a superior choice to glyburide if oral antidiabetic drug therapy is to be initiated in GDM patients." | 2.52 | Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis. ( Amin, M; Malik, O; Poolsup, N; Suksomboon, N, 2015) |
| "Studies of the use of metformin in gestational diabetes show at least equivalent neonatal outcomes, while reporting reductions in neonatal hypoglycaemia, maternal hypoglycaemia and weight gain and improved treatment satisfaction." | 2.50 | The use of oral hypoglycaemic agents in pregnancy. ( Holt, RI; Lambert, KD, 2014) |
| "Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus." | 2.50 | Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and meta-analysis. ( Wang, A; Yu, H; Zhuo, Z, 2014) |
| "Metformin is an oral insulin-sensitizing anti-diabetic drug." | 2.50 | [Metformin in pregnancy]. ( Bijok, J; Bińkowska, M; Jakiel, G, 2014) |
| "Metformin seems to be an efficacious alternative to insulin and a better choice than glyburide especially those with mild form of disease." | 2.50 | Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis. ( Amin, M; Poolsup, N; Suksomboon, N, 2014) |
| " In this article, we review the efficacy, safety, and dosage of oral hypoglycemic agents for the treatment of gestational diabetes mellitus." | 2.50 | Gestational diabetes mellitus management with oral hypoglycemic agents. ( Hays, KE; Hebert, MF; Ryu, RJ, 2014) |
| "We used the key words "gestational diabetes" in combination with "metformin" and searched the databases including Pubmed, the Cochrane Library, Web of knowledge, and Clinical Trial Registries." | 2.49 | Metformin vs insulin in the management of gestational diabetes: a meta-analysis. ( Feng, L; Gui, J; Liu, Q, 2013) |
| "Pregnancy is an indication for intensive insulin therapy." | 2.48 | [Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges]. ( Zhelyazkova-Savova, M, 2012) |
| " In this review, our objectives were to (1) summarise the available evidence on the efficacy these medications, (2) review available data on adverse effect, (3) discuss current gaps in research, outlining limitations in current study designs that deserve attention and (4) summarise key points for the practicing clinician." | 2.47 | Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety. ( Baptiste-Roberts, K; Nicholson, W, 2011) |
| "Metformin has been found largely to be effective in the treatment of GDM." | 2.45 | Role of metformin in the treatment of gestational diabetes. ( Wensel, TM, 2009) |
| "The incidence of gestational diabetes is increasing." | 2.45 | The management of gestational diabetes. ( Cheung, NW, 2009) |
| "The prevalence of gestational diabetes mellitus (GDM) has been increasing in Australia and worldwide." | 1.91 | Predictors for pharmacological therapy and perinatal outcomes with metformin treatment in women with gestational diabetes. ( Bliuc, D; Brzozowska, MM; O'Sullivan, A; Piotrowicz, AK; Puvanendran, A; Zuschmann, A, 2023) |
| "Metformin was the most prescribed medication for GDM, with large increases over the past 2 decades." | 1.91 | Use of metformin and insulin among pregnant women with gestation diabetes in the United Kingdom: A population-based cohort study. ( Filion, KB; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2023) |
| "Metformin was offered to less than 2% of pregnancies to treat gestational diabetes (2017-2019)." | 1.91 | Antidiabetic Medication Utilisation before and during Pregnancy in Switzerland between 2012 and 2019: An Administrative Claim Database from the MAMA Cohort. ( Baud, D; Ceulemans, M; Dao, K; Favre, G; Gerbier, E; Jenkinson, SP; Maisonneuve, E; Niznik, B; Panchaud, A; Schmid, CPR; Spoendlin, J; Winterfeld, U, 2023) |
| "GDM metformin treatment was not associated with differences in offspring growth trajectories compared to insulin treatment." | 1.91 | Associations between maternal gestational diabetes metformin or insulin treatment and offspring growth trajectories from birth to 60 months of age: Findings from the Born in Bradford (BiB) study. ( Johnson, W; Martine-Edith, G; Petherick, ES, 2023) |
| "The increased prevalence of gestational diabetes mellitus (GDM) has caused a huge societal economic and healthy burden at both the population and individual levels." | 1.72 | Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus: A protocol for systematic review and meta-analysis. ( Hong, XY; Lin, J; Tu, RZ, 2022) |
| "The incidence of gestational diabetes mellitus (GDM) is increasing." | 1.72 | Metformin: A promising option for the management of gestational diabetes mellitus - Exploring the benefits, challenges and clinical needs in the current management of gestational diabetes mellitus. ( Bastian, B; Davis, W; Francois, ME; Pape, A; Smithers, LG, 2022) |
| "Metformin was more often used in patients with obesity who also required higher daily doses." | 1.72 | Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus. ( Eder, A; Eppel, D; Geissler, F; Göbl, CS; Hösli, I; Huhn, EA; Linder, T; Monod, C; Redling, K; Rosicky, I, 2022) |
| "Metformin is increasingly used to treat gestational diabetes (GDM) and pregnancies complicated by pregestational type 2 diabetes or polycystic ovary syndrome but data regarding long-term offspring outcome are lacking in both human studies and animal models." | 1.72 | Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Dearden, L; Fernandez-Twinn, DS; Ozanne, SE; Pantaleão, LC; Pellegrini Pisani, L; Schoonejans, JM; Tadross, JA, 2022) |
| "Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes Mellitus (DM2) are metabolic disorders characterized by increased insulin resistance." | 1.62 | The Use of Oral Hypoglycemic Agents during Pregnancy: An Alternative to Insulin? ( González-Rodríguez, LA; González-Sepúlveda, L; Mercado-Méndez, S; Romaguera, J, 2021) |
| "Once a woman is diagnosed with gestational diabetes mellitus (GDM), two strategies are considered for management; life-style modifications and pharmacological therapy." | 1.62 | Management of Gestational Diabetes Mellitus. ( Oskovi-Kaplan, ZA; Ozgu-Erdinc, AS, 2021) |
| "Metformin has been used in the treatment of gestational diabetes, but the evaluation of its efficacy and safety is lack of reliable evidence-based medicine evidence." | 1.62 | Efficacy and safety of metformin in the treatment of gestational diabetes: A protocol for systematic review and meta-analysis. ( Mao, W; Shen, S; Wang, L; Zhang, S, 2021) |
| "Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy." | 1.62 | Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria. ( Brownfoot, F; Cannon, P; Cruickshank, T; Garcha, D; Hannan, NJ; Hyett, J; Illanes, SE; Jellins, J; Kaitu'u-Lino, TJ; Kandel, M; Keenan, E; MacDonald, TM; Masci, J; Middleton, A; Murphy, C; Murray, E; Myers, J; Nguyen, TV; Nien, JK; Pell, G; Pritchard, N; Roddy Mitchell, A; Schepeler, M; Tong, S; Walker, SP; Whigham, CA; Wong, GP, 2021) |
| "Excess insulin resistance is considered the predominant pathophysiological mechanism in obese women who develop gestational diabetes (GDM)." | 1.56 | Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study. ( Begum, S; Lawlor, DL; Nelson, SM; Pasupathy, D; Poston, L; Sattar, N; Seed, P; Vieira, MC; Welsh, P; White, SL, 2020) |
| "Metformin treatment on male diabetic placental explant activated AMPK and stimulated PGC-1α expression, concomitant with increased H3K27 acetylation and decreased PGC-1α promoter methylation." | 1.56 | Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes. ( Chernausek, SD; Jensen, ME; Jiang, S; Teague, AM; Tryggestad, JB, 2020) |
| "<6." | 1.56 | Metformin Should Not Be Used to Treat Prediabetes. ( Davidson, MB, 2020) |
| "Pregnant women who develop gestational diabetes (GDM) are more likely to deliver by caesarean section (CS)." | 1.56 | Metformin versus insulin use for treatment of gestational diabetes and delivery by caesarean section: A nationwide Swedish cohort study. ( Abdi, L; Cesta, CE; Kieler, H; Pazzagli, L, 2020) |
| "Metformin appears to be an effective treatment for women with GDM and may reduce risk of some adverse neonatal outcomes when compared with insulin." | 1.51 | Comparative effectiveness of metformin versus insulin for gestational diabetes in New Zealand. ( Boggess, K; Engel, SM; Howe, AS; Jonsson Funk, M; Landi, SN; Radke, S; Stürmer, T, 2019) |
| "Metformin is an emerging option for treating gestational diabetes (GDM)." | 1.51 | Association of Long-term Child Growth and Developmental Outcomes With Metformin vs Insulin Treatment for Gestational Diabetes. ( Boggess, K; Engel, SM; Funk, MJ; Howe, AS; Landi, SN; Radke, S; Stürmer, T, 2019) |
| "In addition, the steps in the gestational diabetes mellitus management decision path and the current cost of the use of insulin, glyburide, or metformin are addressed." | 1.48 | Pharmacological treatment of gestational diabetes mellitus: point/counterpoint. ( Langer, O, 2018) |
| " Moreover, it should be noted that prior clinical studies have dosed glyburide in a manner inconsistent with its pharmacokinetic properties, resulting in poor glycemic control and high rates of maternal hypoglycemia." | 1.48 | A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. ( Aagaard, K; Barbour, LA; Buchanan, TA; Catalano, PM; Coustan, D; Frias, AE; Friedman, JE; Galan, HL; Hay, WW; Loeken, MR; Moses, RG; Sacks, DA; Scifres, C; Shankar, K; Simmons, RA; Thornburg, KL; Valent, AM, 2018) |
| "Metformin was thus found to be a safe, practical and cost effective medication to be offered to our population." | 1.48 | Metformin or insulin: logical treatment in women with gestational diabetes in the Middle East, our experience. ( Ashawesh, K; Beer, S; Boama, V; Christian, SJ; Dukhan, K; Elhadd, TA; Ramawat, J; Satti, H, 2018) |
| "Metformin has been increasingly popular in recent years." | 1.48 | Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin. ( Chen, C; Li, X; Zhen, XM, 2018) |
| "We compared, in 733 women with gestational diabetes mellitus treated with metformin and/or insulin, rates of neonatal hypoglycaemia in those who had received a dextrose/insulin infusion during labour and prior to delivery (n = 132) with those who did not (n = 601)." | 1.46 | The use of dextrose/insulin infusions during labour and delivery in women with gestational diabetes mellitus: Is there any point? ( Battin, M; Farrant, MT; Hague, WM; Rowan, JA; Williamson, K, 2017) |
| "The use of metformin in gestational diabetes is safe and effective, yet some women require additional insulin therapy to achieve glycaemic targets." | 1.43 | Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes. ( Fulcher, GR; Glastras, SJ; Hocking, S; McGrath, RT, 2016) |
| "In her fifth pregnancy, treatment for gestational diabetes mellitus with metformin was associated with a lowering effect on bile acids and liver enzymes, indicating a possible role for metformin in the management of obstetric cholestasis." | 1.43 | Managing Recurring Obstetric Cholestasis With Metformin. ( Ali, A; Elfituri, A; Shehata, H, 2016) |
| "Maternal obesity and gestational diabetes mellitus (GDM) are two increasingly common and important obstetric complications that are associated with severe long-term health risks to mothers and babies." | 1.42 | Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes. ( Lappas, M; Liong, S, 2015) |
| "Median maternal weight gain was 6 kg (gestational diabetes mellitus) and 10 kg (normal glucose tolerance); caesarean section rates were 25% and 11% respectively; baby birthweights were not significantly different." | 1.42 | Gestational diabetes mellitus screening, management and outcomes in the Cook Islands. ( Aung, YY; Ekeroma, A; Herman, J; Kenealy, T; Sowter, M, 2015) |
| "To compare the incidence of gestational diabetes mellitus (GDM) in Iranian infertile women with polycystic ovary syndrome (PCOS) and women without PCOS after pregnancies resulting from either assisted reproductive technology (ART) or spontaneous as well as to determine the risk factors of GDM in PCOS women." | 1.40 | Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS). ( Arabipoor, A; Ashrafi, M; Hosseini, R; Nourbakhsh, F; Sheikhan, F; Zolfaghari, Z, 2014) |
| "Women with a history of gestational diabetes mellitus (GDM) are at increased risk of future development of type 2 diabetes." | 1.39 | Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score. ( Cho, NH; Cho, YM; Choi, SH; Jang, HC; Jung, HS; Kim, K; Kim, SY; Kwak, SH; Lim, S; Park, KS, 2013) |
| "The Metformin in Gestational Diabetes (MiG) trial reported similar pregnancy outcomes for metformin versus insulin; however, supplemental insulin was required in 46% of women on metformin." | 1.39 | Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus. ( Campbell, J; Corbould, A; Dennis, A; McBeath, S; Radford, A; Swinton, F, 2013) |
| "Glyburide and metformin have been shown to be as effective as insulin for the treatment of gestational diabetes." | 1.37 | Oral hypoglycemic agents in pregnancy. ( Refuerzo, JS, 2011) |
| "There were 1269 women with gestational diabetes; treatment was diet in 371, insulin in 399 and metformin in 465 (249 metformin alone, 216 metformin and insulin)." | 1.37 | Metformin for gestational diabetes in routine clinical practice. ( Goh, JE; Rowan, J; Sadler, L, 2011) |
| "Glyburide was transported by multidrug resistance protein (43 +/- 4%); breast cancer resistance protein (25 +/- 5%); and P-glycoprotein (9 +/- 5%)." | 1.36 | Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. ( Ahmed, MS; Hankins, GD; Hemauer, SJ; Nanovskaya, TN; Patrikeeva, SL, 2010) |
| "Metformin is widely used in women with Type 2 diabetes of child-bearing age, many of whom become pregnant." | 1.36 | Metformin treatment for Type 2 diabetes in pregnancy? ( Simmons, D, 2010) |
| "Treatment of gestational diabetes mellitus is a hotly debated topic." | 1.35 | [Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic]. ( de Valk, HW, 2009) |
| "Sixty women with gestational and type 2 diabetes were enrolled, 30 each for metformin and insulin." | 1.35 | Metformin--a convenient alternative to insulin for Indian women with diabetes in pregnancy. ( Kamath, A; Meenakshi, D; Rai, L, 2009) |
| "Metformin is a logical treatment in these circumstances but there has always been concern about its safety for the fetus, particularly as it crosses the placenta and it may increase the risk of teratogenesis." | 1.33 | Metformin use and diabetic pregnancy-has its time come? ( Hawthorne, G, 2006) |
| "Impaired glucose tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL (7." | 1.32 | Impaired glucose tolerance and impaired fasting glucose. ( Disraeli, P; McGregor, T; Rao, SS, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 52 (14.36) | 29.6817 |
| 2010's | 196 (54.14) | 24.3611 |
| 2020's | 114 (31.49) | 2.80 |
| Authors | Studies |
|---|---|
| Estrella, J | 1 |
| Wiley, V | 1 |
| Simmons, D | 5 |
| Hng, TM | 1 |
| McLean, M | 1 |
| Benham, JL | 1 |
| Donovan, LE | 2 |
| Yamamoto, JM | 1 |
| Whelan, AR | 1 |
| Ayala, NK | 1 |
| Werner, EF | 2 |
| Newman, C | 4 |
| Dunne, FP | 2 |
| Cao, Q | 1 |
| Hu, Y | 2 |
| Fu, J | 2 |
| Huang, X | 1 |
| Wu, L | 1 |
| Zhang, J | 2 |
| Huang, W | 1 |
| Venkatesh, KK | 1 |
| Chiang, CW | 1 |
| Castillo, WC | 1 |
| Battarbee, AN | 1 |
| Donneyong, M | 1 |
| Harper, LM | 1 |
| Costantine, M | 1 |
| Saade, G | 1 |
| Boggess, KA | 3 |
| Landon, MB | 2 |
| Yu, DQ | 1 |
| Xu, GX | 1 |
| Teng, XY | 1 |
| Xu, JW | 1 |
| Tang, LF | 1 |
| Feng, C | 1 |
| Rao, JP | 1 |
| Jin, M | 1 |
| Wang, LQ | 1 |
| Díaz González-Colmenero, F | 1 |
| García-Campa, M | 1 |
| Rodríguez-Gutiérrez, R | 1 |
| Paavilainen, E | 4 |
| Tertti, K | 13 |
| Nikkinen, H | 4 |
| Veijola, R | 3 |
| Vääräsmäki, M | 7 |
| Loo, BM | 3 |
| Tossavainen, P | 3 |
| Rönnemaa, T | 14 |
| Niinikoski, H | 4 |
| Palatnik, A | 2 |
| Harrison, RK | 2 |
| Thakkar, MY | 1 |
| Walker, RJ | 1 |
| Egede, LE | 1 |
| Simmons, R | 1 |
| Molina-Vega, M | 3 |
| Picón-César, MJ | 3 |
| Gutiérrez-Repiso, C | 1 |
| Fernández-Valero, A | 1 |
| Lima-Rubio, F | 1 |
| González-Romero, S | 3 |
| Moreno-Indias, I | 1 |
| Tinahones, FJ | 2 |
| Li, C | 2 |
| Gao, C | 1 |
| Zhang, X | 3 |
| Zhang, L | 2 |
| Shi, H | 1 |
| Jia, X | 1 |
| Allehdan, S | 1 |
| Basha, A | 1 |
| Hyassat, D | 1 |
| Nabhan, M | 1 |
| Qasrawi, H | 1 |
| Tayyem, R | 1 |
| Tracer, H | 1 |
| Mohnot, S | 1 |
| Mercado-Méndez, S | 1 |
| González-Sepúlveda, L | 1 |
| Romaguera, J | 1 |
| González-Rodríguez, LA | 1 |
| Fornes, R | 1 |
| Simin, J | 1 |
| Nguyen, MH | 1 |
| Cruz, G | 1 |
| Crisosto, N | 2 |
| van der Schaaf, M | 1 |
| Engstrand, L | 1 |
| Brusselaers, N | 1 |
| Oliveira, MM | 1 |
| Andrade, KFO | 1 |
| Lima, GHS | 1 |
| Rocha, TC | 1 |
| Jiao, Y | 1 |
| Qiao, Z | 1 |
| Han, R | 1 |
| Du, J | 1 |
| Zhang, S | 2 |
| Tomlinson, G | 2 |
| Feig, DS | 4 |
| Trouva, A | 2 |
| Alvarsson, M | 1 |
| Calissendorff, J | 1 |
| Åsvold, BO | 1 |
| Vanky, E | 7 |
| Hirschberg, AL | 2 |
| Huhtala, M | 1 |
| van Hoorn, EGM | 1 |
| van Dijk, PR | 1 |
| Prins, JR | 1 |
| Lutgers, HL | 1 |
| Hoogenberg, K | 1 |
| Erwich, JJHM | 1 |
| Kooy, A | 1 |
| Lin, J | 1 |
| Tu, RZ | 1 |
| Hong, XY | 1 |
| Bastian, B | 1 |
| Smithers, LG | 1 |
| Davis, W | 1 |
| Pape, A | 1 |
| Francois, ME | 1 |
| Linder, T | 1 |
| Eder, A | 1 |
| Monod, C | 1 |
| Rosicky, I | 1 |
| Eppel, D | 1 |
| Redling, K | 1 |
| Geissler, F | 1 |
| Huhn, EA | 1 |
| Hösli, I | 1 |
| Göbl, CS | 1 |
| Zinman, B | 1 |
| Asztalos, E | 1 |
| Shah, PS | 1 |
| Sanchez, JJ | 1 |
| Murphy, KE | 1 |
| Li, F | 1 |
| Liu, L | 1 |
| Marx, CM | 1 |
| Liu, W | 2 |
| Lovell, H | 1 |
| Mitchell, A | 1 |
| Ovadia, C | 1 |
| Pitrelli, N | 1 |
| Briley, A | 1 |
| Singh, C | 1 |
| Marschall, HU | 1 |
| Cruickshank, K | 1 |
| Murphy, H | 1 |
| Seed, P | 2 |
| Williamson, C | 1 |
| Ramalho, D | 1 |
| Correia, S | 1 |
| Realista, R | 1 |
| Rocha, G | 1 |
| Alves, H | 1 |
| Almeida, L | 1 |
| Ferreira, E | 1 |
| Monteiro, S | 1 |
| Oliveira, MJ | 1 |
| Almeida, MC | 2 |
| McEwen, LN | 1 |
| Hurst, TE | 1 |
| Joiner, KL | 1 |
| Herman, WH | 4 |
| Selen, DJ | 1 |
| Powe, CE | 2 |
| Pilszyk, A | 1 |
| Niebrzydowska, M | 1 |
| Pilszyk, Z | 1 |
| Wierzchowska-Opoka, M | 1 |
| Kimber-Trojnar, Ż | 1 |
| Li, J | 2 |
| Liu, H | 2 |
| Shang, L | 1 |
| Schoonejans, JM | 2 |
| Blackmore, HL | 2 |
| Ashmore, TJ | 2 |
| Pantaleão, LC | 1 |
| Pellegrini Pisani, L | 1 |
| Dearden, L | 1 |
| Tadross, JA | 1 |
| Aiken, CE | 4 |
| Fernandez-Twinn, DS | 2 |
| Ozanne, SE | 4 |
| Dunne, F | 2 |
| Devane, D | 2 |
| Smyth, A | 2 |
| Alvarez-Iglesias, A | 2 |
| Gillespie, P | 2 |
| Browne, M | 2 |
| O'Donnell, M | 2 |
| Pagotto, V | 1 |
| Posadas Martínez, ML | 1 |
| Salzberg, S | 1 |
| Pochettino, PA | 1 |
| Alfayez, OM | 1 |
| Alsallum, AA | 1 |
| Aljabri, AF | 1 |
| Almutairi, FS | 1 |
| Al-Azzeh, O | 1 |
| Almalki, OS | 1 |
| Al Yami, MS | 1 |
| Almohammed, OA | 1 |
| Mansukhani, T | 1 |
| Arechvo, A | 1 |
| Cecchini, F | 1 |
| Breim, M | 1 |
| Wright, A | 1 |
| Nicolaides, KH | 1 |
| Charakida, M | 1 |
| Madievsky, R | 3 |
| Vu, A | 3 |
| Cheng, F | 3 |
| Chon, J | 3 |
| Turk, N | 3 |
| Krueger, A | 3 |
| Krong, J | 3 |
| Maranon, R | 3 |
| Liu, S | 3 |
| Han, CS | 3 |
| Norris, KC | 3 |
| Mangione, C | 3 |
| Page, J | 3 |
| Thomas, S | 4 |
| Duru, OK | 3 |
| Moin, T | 4 |
| Brand, KM | 3 |
| Thoren, R | 3 |
| Sõnajalg, J | 3 |
| Boutmy, E | 3 |
| Foch, C | 3 |
| Schlachter, J | 3 |
| Hakkarainen, KM | 3 |
| Saarelainen, L | 3 |
| Wang, T | 1 |
| Jing, Y | 1 |
| Guo, H | 1 |
| Xu, J | 1 |
| Wang, M | 1 |
| Huang, L | 2 |
| Chen, H | 2 |
| Cui, W | 1 |
| Song, L | 1 |
| Liu, X | 2 |
| Sun, B | 1 |
| Wang, N | 1 |
| Sorice, GP | 1 |
| Caporusso, M | 1 |
| Cignarelli, A | 1 |
| Perrini, S | 1 |
| Natalicchio, A | 1 |
| Giorgino, F | 1 |
| Sheng, B | 1 |
| Ni, J | 1 |
| Lv, B | 1 |
| Jiang, G | 1 |
| Lin, X | 1 |
| Li, H | 1 |
| Dingena, CF | 1 |
| Holmes, MJ | 1 |
| Campbell, MD | 1 |
| Cade, JE | 1 |
| Scott, EM | 1 |
| Zulyniak, MA | 1 |
| Brzozowska, MM | 1 |
| Puvanendran, A | 1 |
| Bliuc, D | 1 |
| Zuschmann, A | 1 |
| Piotrowicz, AK | 1 |
| O'Sullivan, A | 1 |
| Rickert, M | 1 |
| Caughey, AB | 1 |
| Valent, AM | 2 |
| Yu, YH | 1 |
| Platt, RW | 1 |
| Reynier, P | 1 |
| Yu, OHY | 1 |
| Filion, KB | 1 |
| Semertzidou, A | 1 |
| Grout-Smith, H | 1 |
| Kalliala, I | 1 |
| Garg, A | 1 |
| Terzidou, V | 1 |
| Marchesi, J | 1 |
| MacIntyre, D | 1 |
| Bennett, P | 1 |
| Tsilidis, K | 1 |
| Kyrgiou, M | 1 |
| Anness, AR | 1 |
| Nath, M | 2 |
| Osman, MW | 2 |
| Webb, D | 1 |
| Robinson, T | 1 |
| Khalil, A | 3 |
| Mousa, HA | 2 |
| Gerbier, E | 1 |
| Favre, G | 1 |
| Maisonneuve, E | 1 |
| Ceulemans, M | 1 |
| Winterfeld, U | 1 |
| Dao, K | 1 |
| Schmid, CPR | 1 |
| Jenkinson, SP | 1 |
| Niznik, B | 1 |
| Baud, D | 1 |
| Spoendlin, J | 1 |
| Panchaud, A | 1 |
| Parkkola, R | 1 |
| Koskensalo, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Implementation of a Pragmatic Approach to Lower Diabetes Mellitus Risk After a Diagnosis of Gestational Diabetes Mellitus[NCT05280496] | Phase 3 | 36 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Metformin Therapy for Gestational Diabetes - Metabolic Late Effects on Child at 9 Years of Age[NCT02417090] | 173 participants (Actual) | Observational | 2015-05-31 | Completed | |||
| Studying the Effectiveness of Carbohydrate Counting and Dietary Approach to Stop Hypertension Dietary Intervention on Glycemic Control and Maternal and Newborn Health Outcomes Among Jordanian Pregnant Women With Gestational Diabetes[NCT03244579] | 180 participants (Anticipated) | Interventional | 2017-08-20 | Recruiting | |||
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome (PCOS)[NCT00159536] | Phase 3 | 257 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study[NCT03259919] | Phase 2 | 40 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Pregnancy Outcomes: Effects of Metformin Study (POEM Study), a Long Term Randomized Controlled Study in Gestational Diabetes[NCT02947503] | Phase 3 | 500 participants (Anticipated) | Interventional | 2019-11-26 | Recruiting | ||
| Randomised Controlled Trial of Gestational Treatment With Ursodeoxycholic Acid Compared to Metformin to Reduce Effects of Diabetes Mellitus[NCT04407650] | Phase 4 | 158 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
| A Randomised Placebo Controlled Trial of the Effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE)[NCT02980276] | Phase 3 | 535 participants (Actual) | Interventional | 2017-06-06 | Completed | ||
| Pilot Study of Pharmacist-Coordinated Implementation of the Diabetes Prevention Program (DPP) for Women With a History of Gestational Diabetes Mellitus (GDM)[NCT03766256] | 33 participants (Actual) | Interventional | 2019-03-01 | Completed | |||
| Effects of Intervention With the Glucagon-like Peptide 1 (GLP-1) Analog Liraglutide Plus Metformin Versus Metformin Monotherapy in Overweight/Obese Women With Metabolic Defects and Recent History of Gestational Diabetes Mellitus (GDM)[NCT01234649] | Phase 3 | 153 participants (Actual) | Interventional | 2011-08-11 | Completed | ||
| The Effect Birth Outcome and Diabetes Management of Planned Behavior Theory Based Education Model in Women With Gestational Diabetes[NCT04874922] | 66 participants (Actual) | Interventional | 2021-05-15 | Completed | |||
| Metformin Versus Insulin in Gestational Diabetes. A Randomized Controlled Single Center Trial.[NCT01240785] | Phase 4 | 221 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Randomized Study Evaluating Dapagliflozin and Metformin, Alone and in Combination, in Overweight Women With a Recent History of Gestational Diabetes Mellitus: Effects on Anthropometric Measurements and Cardiometabolic Abnormalities[NCT02338193] | Phase 3 | 69 participants (Actual) | Interventional | 2015-09-22 | Completed | ||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513] | 414 participants (Anticipated) | Interventional | 2022-03-24 | Not yet recruiting | |||
| Comparative Studies of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta[NCT04907708] | 156 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS[NCT02080377] | Phase 3 | 23 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Maternal and Fetal Outcome With Metformin Therapy for Obese Pregnant Women a Randomized Control Trial.[NCT05554679] | Phase 4 | 178 participants (Anticipated) | Interventional | 2021-02-01 | Recruiting | ||
| A Prospective, Randomized, Double-blind, Multi-centre Study, Where the Possible Effect of Metformin to Prevent Late Miscarriage and Preterm Delivery is Studied in Women With Polycystic Ovary Syndrome (PCOS)[NCT01587378] | 489 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Management of Intrapartum Glycemia in Gestational Diabetic Mothers: A Randomized Controlled Trial[NCT05647798] | 120 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | |||
| Long-term Effects of Flash Glucose Monitoring System in Patients With Gestational Diabetes[NCT06031987] | 100 participants (Anticipated) | Interventional | 2022-01-26 | Recruiting | |||
| Diagnostic Efficiency Analysis of Oral Glucose Tolerance Test and Prediction Model Establishment in the First Trimester for Gestational Diabetes Mellitus: a Prospective Cohort Study[NCT05487352] | 781 participants (Actual) | Observational | 2021-05-30 | Active, not recruiting | |||
| Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.[NCT01998113] | 2,509 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| Non-inferiority Between Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. ACARB-GDM Study.[NCT03380546] | Phase 3 | 341 participants (Actual) | Interventional | 2018-07-04 | Active, not recruiting | ||
| [NCT00004992] | Phase 3 | 3,234 participants (Actual) | Interventional | 1996-07-31 | Completed | ||
| Diabetes Prevention Program Outcomes Study[NCT00038727] | Phase 3 | 2,779 participants (Actual) | Interventional | 2002-09-30 | Active, not recruiting | ||
| Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial[NCT05580523] | 3,000 participants (Anticipated) | Interventional | 2023-07-03 | Recruiting | |||
| Lower Vitamin D Levels During Second Trimester Are Associated With Developing Gestational Diabetes Mellitus: an Observational Cross-sectional Study[NCT03665974] | 80 participants (Actual) | Observational | 2013-01-05 | Completed | |||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| METformin in Intrahepatic Cholestasis of Pregnancy (METRIC) Study[NCT03056274] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2019-01-31 | Not yet recruiting | ||
| [NCT01563120] | Phase 4 | 108 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Face-it: A Health Promotion Intervention for Women With Prior Gestational Diabetes and Their Families - A Randomised Controlled Trial[NCT03997773] | 277 participants (Actual) | Interventional | 2019-05-21 | Active, not recruiting | |||
| Study of Awareness of Gestational Diabetes Problem Among Sohag Governorate Women[NCT05148897] | 500 participants (Anticipated) | Observational [Patient Registry] | 2021-10-01 | Recruiting | |||
| Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women?[NCT01273584] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort[NCT02910154] | 62 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| The Impact of Consumption of Eggs in the Context of Plant-Based Diets on[NCT04316429] | 35 participants (Actual) | Interventional | 2020-06-09 | Completed | |||
| WellStart Type 2 Diabetes Study[NCT03731533] | 0 participants (Actual) | Interventional | 2018-12-01 | Withdrawn (stopped due to Grantor withdrew from study) | |||
| Metabolic Syndrome and Severe Obesity: Randomized Nutritional Trial to Study Long Term Effect of Very-low-calories Ketogenic Diet (VLCKD) on Weight Control and Cardiovascular Risk Factors[NCT05781269] | 100 participants (Anticipated) | Interventional | 2022-02-20 | Recruiting | |||
| Benefits of Adding Continuous Glucose Monitoring to Glycemic Load, Exercise, and Monitoring of Blood Glucose (GEM) for Adults With Type 2 Diabetes - Phase 2[NCT03207893] | 24 participants (Actual) | Interventional | 2018-07-19 | Completed | |||
| Treating Type 2 Diabetes by Reducing Postprandial Glucose Elevations: A Paradigm Shift in Lifestyle Modification[NCT03196895] | 192 participants (Actual) | Interventional | 2017-06-28 | Completed | |||
| Personalizing Sleep Interventions to Prevent Type 2 Diabetes in Community Dwelling Adults With Pre-Diabetes[NCT03398902] | 150 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | |||
| Assessment of Designer Functional Foods on Parameters of Metabolic and Vascular Status in Individuals With Prediabetes.[NCT02400450] | 0 participants (Actual) | Interventional | 2016-09-30 | Withdrawn | |||
| A Randomized Prospective Trial of Metformin Compared to Glyburide in Gestational Diabetes[NCT00965991] | 149 participants (Actual) | Interventional | 2003-07-31 | Completed | |||
| Glyburide vs Glucovance in the Treatment of Gestational Diabetes[NCT02726490] | Early Phase 1 | 7 participants (Actual) | Interventional | 2016-07-31 | Terminated (stopped due to Lack of Recruitment) | ||
| Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus: a Randomized Controlled Study[NCT01087866] | Phase 2/Phase 3 | 97 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention[NCT02394158] | Phase 4 | 112 participants (Anticipated) | Interventional | 2015-01-27 | Recruiting | ||
| A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime Study[NCT03031821] | Phase 3 | 168 participants (Actual) | Interventional | 2018-07-12 | Terminated (stopped due to Manufacturer discontinued the production of study drugs.) | ||
| [NCT01511822] | Phase 4 | 0 participants | Interventional | Completed | |||
| Reduction of Insulin Therapy Under Myo-inositol for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. MYO-GDM Study[NCT03875755] | 1,080 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| Pilot Study of Metformin vs. Insulin in Pregnant Overt Diabetics (MIPOD)[NCT00835861] | Phase 2 | 31 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome[NCT02789488] | Phase 4 | 50 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Real-time Continuous Glucose Monitoring for the Treatment of Gestational Diabetes: a Randomized Trial[NCT03326232] | 40 participants (Anticipated) | Interventional | 2017-11-13 | Recruiting | |||
| Effects of Metformin on Fertility and Pregnancy in Women With Polycystic Ovary Syndrome: a Randomized, Prospective, Placebo-controlled Multicenter Study[NCT00994812] | Phase 3 | 326 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Body weight in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | kilograms (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 94.2 |
| Metformin XR Plus Placebo | 91.3 |
Hepatic enzyme, ALT, associated with insulin resistance, in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | U/L (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 32.3 |
| Metformin XR Plus Placebo | 31 |
ALT/AST ratio, used to assess liver function in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | ratio of ALT (U/L)/ AST (U/L) (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 1.2 |
| Metformin XR Plus Placebo | 1.18 |
The hepatic marker, AST, associated with insulin resistance in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | U/L (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 27 |
| Metformin XR Plus Placebo | 28 |
BMI, a measure of total body adiposity, in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | weight (kg) /height (m) squared (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 33.8 |
| Metformin XR Plus Placebo | 32.8 |
Change in body weight from baseline to end o f study in LIRA-MET group compared with PL-MET group. The number was derived from final weight minus baseline and normalized to a percent. (NCT01234649)
Timeframe: Change from baseline (time 0) to study end (84 weeks)
| Intervention | percent change in weight from baseline (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | -7.2 |
| Metformin XR Plus Placebo | -3.1 |
DBP in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 77.6 |
| Metformin XR Plus Placebo | 77 |
Fasting glucose levels in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 90 |
| Metformin XR Plus Placebo | 91.7 |
HDL-C levels in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 51 |
| Metformin XR Plus Placebo | 48.7 |
HOMA-IR, a measure of insulin resistance derived from fasting values, in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | index (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 2.2 |
| Metformin XR Plus Placebo | 2.45 |
IS-SI in liraglutide-metformin (LIRA-MET) therapy compared to metformin alone (PLacebo-MET) (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | index (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 418.4 |
| Metformin XR Plus Placebo | 333 |
IGI/HOMA-IR, a measure of early insulin response corrected by fasting insulin resistance, in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | index (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 0.8 |
| Metformin XR Plus Placebo | 0.62 |
LDL-Cholesterol levels in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 110 |
| Metformin XR Plus Placebo | 107 |
OGTT- derived insulin sensitivity index in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | index (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 5.9 |
| Metformin XR Plus Placebo | 5.4 |
MBG derived from average glucose measured during OGTT in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 121.6 |
| Metformin XR Plus Placebo | 118.8 |
SBP in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 122 |
| Metformin XR Plus Placebo | 123 |
CHOL levels in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 183.7 |
| Metformin XR Plus Placebo | 183.8 |
TRG concentrations in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 120 |
| Metformin XR Plus Placebo | 125 |
TRG/HDL-Cholesterol levels in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | ratio of TRG (mg/dL)/HDL-C (mg/dl) (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 2.56 |
| Metformin XR Plus Placebo | 2.95 |
Waist size (measure of truncal adiposity) with LIRA-MET compared to PL-MET (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | centimeters (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | 94.3 |
| Metformin XR Plus Placebo | 95.3 |
Waist circumference divided by height (measure of body fat distribution) in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | ratio of waist /height (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | .56 |
| Metformin XR Plus Placebo | .57 |
Waist circumference divided by hip circumference (a measure of central adiposity) in LIRA-MET group compared with PL-MET group (NCT01234649)
Timeframe: 84 weeks of treatment
| Intervention | ratio of waist/hip circumference (Mean) |
|---|---|
| Metformin XR Plus Liraglutide | .81 |
| Metformin XR Plus Placebo | .81 |
Apgar score 0-10. 0-2 points from heart rate; 0-2 points for respiratory effort; 0-2 points for skin colour; 0-2 points for muscle tone; 0-2 points for reflex response. For all items the higher the value, the better the outcome (NCT01240785)
Timeframe: 5 minutes after delivery
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | 8.7 |
| Insulin | 8.9 |
birth weight adjusted for gestational weeks expressed as standard deviation units using data from Finnish fetal growth charts in normal pregnancies (NCT01240785)
Timeframe: delivery
| Intervention | g (Mean) |
|---|---|
| Metformin | 3604 |
| Insulin | 3589 |
(NCT01240785)
Timeframe: delivery
| Intervention | weeks (Mean) |
|---|---|
| Metformin | 39.2 |
| Insulin | 39.3 |
(NCT01240785)
Timeframe: delivery
| Intervention | participants (Number) |
|---|---|
| Metformin | 42 |
| Insulin | 58 |
(NCT01240785)
Timeframe: up to on the average 40 weeks of gestation
| Intervention | kg (Mean) |
|---|---|
| Metformin | 8.0 |
| Insulin | 7.9 |
(NCT01240785)
Timeframe: delivery
| Intervention | no of cesarean section (Number) |
|---|---|
| Metformin | 15 |
| Insulin | 18 |
(NCT01240785)
Timeframe: 0-3 days after delivery
| Intervention | participants (Number) |
|---|---|
| Metformin | 9 |
| Insulin | 10 |
(NCT01240785)
Timeframe: 0-24 h after delivery
| Intervention | participants (Number) |
|---|---|
| Metformin | 18 |
| Insulin | 18 |
(NCT01240785)
Timeframe: 0-5 days after delivery
| Intervention | participants (Number) |
|---|---|
| Metformin | 34 |
| Insulin | 39 |
(NCT01240785)
Timeframe: up to on the average 40 weeks of gestation
| Intervention | participants (Number) |
|---|---|
| Metformin | 5 |
| Insulin | 10 |
Participants with pregnancy induced hypertension defined as blood pressure over 140/90 mmHg or increase in systolic blood pressure > 30 mmHg or diastolic blood pressure > 15 mmHg (NCT01240785)
Timeframe: up to on the average 40 weeks of gestation
| Intervention | participants (Number) |
|---|---|
| Metformin | 2 |
| Insulin | 4 |
(NCT01240785)
Timeframe: delivery
| Intervention | participants (Number) |
|---|---|
| Metformin | 1 |
| Insulin | 2 |
BMI (measure of overall adiposity) in combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | kg/m2 (Mean) |
|---|---|
| DAPA/MET XR | 33 |
| Dapaglifloxin | 33.7 |
| Metformin XR | 31 |
Change in absolute body weight with combination therapy compared to monotherapy from baseline to week 24 (NCT02338193)
Timeframe: Change from baseline (time 0) to study end (24 weeks)
| Intervention | kilograms (Mean) |
|---|---|
| DAPA/MET XR | -21.5 |
| Dapaglifloxin | -12.5 |
| Metformin XR | -4.4 |
Change in percent body weight with combination therapy compared to monotherapy from baseline to week 24 (NCT02338193)
Timeframe: Change from baseline (time 0) to study end (24 weeks)
| Intervention | percent weight loss from baseline (Mean) |
|---|---|
| DAPA/MET XR | -4.9 |
| Dapaglifloxin | -3.2 |
| Metformin XR | -1.1 |
Diastolic blood pressure with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment)
| Intervention | mmHG (Mean) |
|---|---|
| DAPA/MET XR | 79 |
| Dapaglifloxin | 77.8 |
| Metformin XR | 79 |
Fasting blood glucose levels with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| DAPA/MET XR | 89 |
| Dapaglifloxin | 91 |
| Metformin XR | 87 |
HOMA index of insulin resistance calculated from fasting insulin and glucose with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | Index (Mean) |
|---|---|
| DAPA/MET XR | 2.6 |
| Dapaglifloxin | 2.4 |
| Metformin XR | 1.8 |
Corrected early insulin response to glucose challenge [(insulinogenic index (IGI)/ divided by fasting insulin resistance index (HOMA-IR)] with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | Index (Mean) |
|---|---|
| DAPA/MET XR | 1.7 |
| Dapaglifloxin | 1.1 |
| Metformin XR | 0.77 |
ALT/AST ratio with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | Ratio (Mean) |
|---|---|
| DAPA/MET XR | 1.13 |
| Dapaglifloxin | 1.12 |
| Metformin XR | 1.18 |
Surrogate measure of insulin sensitivity derived from OGTT with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | Index (Mean) |
|---|---|
| DAPA/MET XR | 6.0 |
| Dapaglifloxin | 6.3 |
| Metformin XR | 5.42 |
Mean blood glucose after glucose load with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| DAPA/MET XR | 109.5 |
| Dapaglifloxin | 110.1 |
| Metformin XR | 112.5 |
Systolic blood pressure with combination therapy compared to monotherapy after 24 weeks of therapy (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| DAPA/MET XR | 125 |
| Dapaglifloxin | 124 |
| Metformin XR | 119.6 |
Cholesterol levels with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| DAPA/MET XR | 196 |
| Dapaglifloxin | 168 |
| Metformin XR | 178 |
Triglyceride levels with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | mg/dL (Mean) |
|---|---|
| DAPA/MET XR | 119 |
| Dapaglifloxin | 89.8 |
| Metformin XR | 212 |
Waist size (measure of truncal adiposity)with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | centimeters (Mean) |
|---|---|
| DAPA/MET XR | 95.6 |
| Dapaglifloxin | 95 |
| Metformin XR | 91.7 |
Waist-to-hip ratio with combination therapy compared to monotherapy after 24 weeks of treatment (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | Ratio (Mean) |
|---|---|
| DAPA/MET XR | 0.81 |
| Dapaglifloxin | 0.80 |
| Metformin XR | 0.83 |
Waist divided by height a( measure of central adiposity) with combination therapy compared to monotherapy after 24 weeks of therapy (NCT02338193)
Timeframe: 24 weeks of treatment
| Intervention | ratio (Mean) |
|---|---|
| DAPA/MET XR | 0.58 |
| Dapaglifloxin | 0.57 |
| Metformin XR | 0.56 |
Primary outcome for years 2002-2008 defined according to American Diabetes Association criteria (fasting plasma glucose level >= 126 mg/dL [7.0 mmol/L] or 2-hour plasma glucose >= 200 mg/dL [11.1 mmol/L], after a 75 gram oral glucose tolerance test (OGTT), and confirmed with a repeat test). (NCT00038727)
Timeframe: Outcomes were assessed from 1996-2008 (approximately 12 years including 6 years of DPP).
| Intervention | diabetes incidence (cases per 100 person (Number) |
|---|---|
| 1 Original Lifestyle | 5.3 |
| 2 Original Metformin | 6.4 |
| 3 Original Placebo | 7.8 |
All cause-mortality through clinic reports and National Death Index search (NCT00038727)
Timeframe: Outcomes were assessed throughout follow-up from 1996 to 2022. National Death Index search conducted in 2019 using early release data as of Dec 2018.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1 Original Lifestyle | 158 |
| 2 Original Metformin | 152 |
| 3 Original Placebo | 143 |
Aggregate microvascular disease is defined as the average prevalence of 3 components: (1) retinopathy measured by photography (ETDRS of 20 or greater); (2) neuropathy detected by Semmes Weinstein 10 gram monofilament, and (3) nephropathy based on estimated glomerular filtration rate (eGFR by chronic kidney disease (CKD-Epi) equation ) (<45 ml/min, confirmed) and albumin-to-creatinine ratio in spot urine (> 30mg/gm, confirmed). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | average percentage of participants (Number) |
|---|---|
| 1 Original Lifestyle | 11.3 |
| 2 Original Metformin | 13 |
| 3 Original Placebo | 12.4 |
Measured using coronary artery calcification (CAC). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | CAC geometric mean in AU (Geometric Mean) | |
|---|---|---|
| Men | Women | |
| 1 Original Lifestyle | 70.1 | 6.0 |
| 2 Original Metformin | 40.2 | 6.1 |
| 3 Original Placebo | 63.7 | 5.3 |
The importance of exercise in the management of blood glucose was emphasized, and 30 minutes of walking per day was recommended. Patients received instruction from a nurse educator or a certified diabetes educator regarding diet and the use of the glucometer. Number of participants with a glucose level <100 mg/dL. (NCT00965991)
Timeframe: fasting and 2 hour postprandial blood glucose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metformin | 50 |
| Glyburide | 50 |
(NCT00835861)
Timeframe: Baseline throughout pregnancy until last prenatal visit.
| Intervention | kg/week (Median) |
|---|---|
| Metformin | 0.28 |
| Insulin | 0.30 |
Resuscitation in the delivery room, preterm birth < 37 weeks, neonatal intensive care unit care, birth injury or diagnosis of neonatal complication, glucose infusion, antibiotics, or phototherapy. (NCT00835861)
Timeframe: Delivery until hospital discharge
| Intervention | number of babies (Number) |
|---|---|
| Metformin | 4 |
| Insulin | 7 |
Initial neonatal glucose < 40 mg/dL (NCT00835861)
Timeframe: Time of delivery through hospital discharge
| Intervention | Number of babies (Number) |
|---|---|
| Metformin | 2 |
| Insulin | 0 |
Maternal glucose < 60 mg/dL (NCT00835861)
Timeframe: Baseline throughout pregnancy until time of delivery
| Intervention | Number of episodes (Number) |
|---|---|
| Metformin | 1 |
| Insulin | 7 |
Maternal complications were stillbirths, major malformations, shoulder dystocia, or postpartum hemorrhage requiring transfusion. (NCT00835861)
Timeframe: Throughout pregnancy until hospital discharge following delivery.
| Intervention | participants (Number) |
|---|---|
| Metformin | 0 |
| Insulin | 0 |
Patients self monitored glucose measures throughout pregnancy to aid glycemic control. Fasting morning measures and postprandial measures were taken at 1 hour after breakfast, lunch, and dinner. (NCT00835861)
Timeframe: Daily fasting and 1-hr post prandial measures were taken from time of enrollment until delivery
| Intervention | mg/dL (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| Fasting throughout enrollment | Fasting 18-20 weeks | Fasting 28-30 weeks | Fasting 36-38 weeks | Postprandial throughout enrollment | Postprandial 18-20 weeks | Postprandial 28-30 weeks | Postprandial 36-38 weeks | |
| Insulin | 95.04 | 92.38 | 90.64 | 85.18 | 128.62 | 120.46 | 126.45 | 125.25 |
| Metformin | 97.38 | 97.00 | 92.43 | 89.49 | 120.40 | 118.40 | 119.00 | 122.59 |
(NCT00835861)
Timeframe: 1st, 2nd, and 3rd trimester
| Intervention | percentage of glycosolated hemoglobin (Median) | ||
|---|---|---|---|
| 1st trimester | 2nd trimester | 3rd trimester | |
| Insulin | 6.2 | 5.5 | 5.6 |
| Metformin | 5.8 | 5.6 | 5.9 |
NUMBER OF ASSESSMENTS OF FASTING GLUCOSE VALUES <95 (NCT00835861)
Timeframe: Baseline throughout pregnancy until time of delivery
| Intervention | percent of glucose values (Number) | |||
|---|---|---|---|---|
| Throughout enrollment; n=1634, 1432 | 18-20 weeks; n=148, 259 | 28-30 weeks; n=253, 201 | 36-38 weeks; n=115, 83 | |
| Insulin | 58 | 64 | 62 | 96 |
| Metformin | 48 | 42 | 64 | 76 |
NUMBER OF ASSESSMENTS OF POSTPRANDIAL GLUCOSE VALUES <130 (NCT00835861)
Timeframe: Baseline throughout pregnancy until time of delivery
| Intervention | percent of glucose values (Number) | |||
|---|---|---|---|---|
| Throughout enrollment; n=4195, 3796 | 18-20 weeks; n=368, 428 | 28-30 weeks; n=652, 559 | 36-38 weeks; n=272,228 | |
| Insulin | 61 | 67 | 58 | 65 |
| Metformin | 69 | 72 | 71 | 66 |
123 reviews available for metformin and Diabetes, Gestational
| Article | Year |
|---|---|
Metformin in Pregnancy for Women with Type 2 Diabetes: a Review.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents | 2021 |
Postpartum Use of Weight Loss and Metformin for the Prevention of Type 2 Diabetes Mellitus: a Review of the Evidence.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin; Postpartum Period; Preg | 2021 |
Metformin for pregnancy and beyond: the pros and cons.
Topics: Administration, Oral; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Gestational W | 2022 |
Gestational metformin administration in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized control studies.
Topics: Bayes Theorem; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformi | 2021 |
Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Glycemic Control; Humans; Hypoglycem | 2021 |
Comparison of the effectiveness and safety of insulin and oral hypoglycemic drugs in the treatment of gestational diabetes mellitus: a meta-analysis of 26 randomized controlled trials.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Met | 2022 |
Metformin versus glyburide in treatment and control of gestational diabetes mellitus: a systematic review with meta-analysis.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, Newbor | 2022 |
Efficacy and safety of metformin compared to insulin in gestational diabetes: a systemic review and meta-analysis of Chinese randomized controlled trials.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Infa | 2022 |
Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome.
Topics: Diabetes, Gestational; Female; Humans; Infertility; Metformin; Polycystic Ovary Syndrome; Pregnancy; | 2022 |
Incretins as a Potential Treatment Option for Gestational Diabetes Mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dipeptidyl-Peptidase IV Inhibitors; | 2022 |
Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials.
Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Infant, Newb | 2023 |
Medications for Managing Preexisting and Gestational Diabetes in Pregnancy.
Topics: Child; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pr | 2023 |
Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature.
Topics: Cesarean Section; Diabetes, Gestational; Female; Humans; Incidence; Infant; Metformin; Pregnancy; Sy | 2023 |
Focus on Metformin: Its Role and Safety in Pregnancy and Beyond.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant; Insul | 2023 |
Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy.
Topics: Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant | 2023 |
Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond.
Topics: Abortion, Spontaneous; Breast Feeding; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Hum | 2023 |
Metformin versus insulin for gestational diabetes: a systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Infant, Newborn; Insulin; | 2021 |
Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy; Randomized | 2020 |
Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.
Topics: Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Age | 2019 |
The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.
Topics: Acarbose; Diabetes, Gestational; Female; Glyburide; Healthy Lifestyle; Humans; Hypoglycemic Agents; | 2019 |
Pharmacological intervention for diabetes after pregnancy prevention in women with prior gestational diabetes: A scoping review.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy; Prospective | 2020 |
Metformin therapy in pregnancy [Zastosowanie metforminy w ciąży].
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2020 |
Interventions to prevent women from developing gestational diabetes mellitus: an overview of Cochrane Reviews.
Topics: Diabetes, Gestational; Diet, Diabetic; Dietary Supplements; Exercise; Fatty Acids, Omega-3; Female; | 2020 |
Gestational Diabetes Mellitus Pharmacological Prevention and Treatment.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2021 |
Metformin administration during pregnancy - current insight.
Topics: Child; Diabetes Mellitus; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Insul | 2021 |
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2021 |
Research progress of metformin in gestational diabetes mellitus: a narrative review.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2021 |
Metformin for Preventing Type 2 Diabetes Mellitus in Women with a Previous Diagnosis of Gestational Diabetes: A Narrative Review.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Life Style; Metformin; Postpartum | 2020 |
Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis.
Topics: Birth Weight; Databases, Factual; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Matern | 2021 |
Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Topics: Cesarean Section; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, New | 2021 |
Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, | 2021 |
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options.
Topics: Diabetes, Gestational; Female; Fetal Development; Glyburide; Humans; Hypoglycemic Agents; Infant, Ne | 2021 |
The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials.
Topics: Birth Weight; Diabetes Mellitus, Type 2; Diabetes, Gestational; Drug Therapy, Combination; Female; G | 2022 |
Preventing progression from gestational diabetes mellitus to diabetes: A thought-filled review.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Progression; Female; Humans; Hypogl | 2017 |
Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.
Topics: Diabetes, Gestational; Female; Fetal Development; Humans; Hypoglycemic Agents; Longevity; Maternal N | 2017 |
Treatments for gestational diabetes: a systematic review and meta-analysis.
Topics: Bayes Theorem; Cesarean Section; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agen | 2017 |
The care of pregestational and gestational diabetes and drug metabolism considerations.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic | 2017 |
Pharmacological Management of Gestational Diabetes Mellitus.
Topics: Acarbose; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemi | 2017 |
Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis.
Topics: Administration, Oral; Adult; Blood Glucose; Comparative Effectiveness Research; Diabetes, Gestationa | 2017 |
Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis.
Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemi | 2018 |
Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes.
Topics: Administration, Oral; Diabetes Mellitus; Diabetes, Gestational; Female; Glucose Intolerance; Humans; | 2017 |
Gestational diabetes - is diet and insulin the only solution?
Topics: Blood Glucose; Diabetes, Gestational; Diet, Carbohydrate-Restricted; Female; Glucose Tolerance Test; | 2017 |
Intra-partum management of women with diabetes.
Topics: Adrenal Cortex Hormones; Blood Glucose; Delivery, Obstetric; Diabetes, Gestational; Disease Manageme | 2018 |
Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Infant, Newborn; M | 2018 |
Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials.
Topics: Bayes Theorem; Diabetes, Gestational; Female; Glyburide; Humans; Hypertension, Pregnancy-Induced; In | 2018 |
The Effect of Metformin Therapy for Preventing Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Meta-Analysis.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Outcome Assessment, He | 2020 |
Metformin in Pregnancy: Mechanisms and Clinical Applications.
Topics: Adult; Animals; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Insulin; Me | 2018 |
Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review.
Topics: Bariatric Surgery; Body Mass Index; Diabetes, Gestational; Disease Management; Evidence-Based Medici | 2019 |
Meta-analysis suggests that metformin may reduce pre-eclampsia compared with insulin use during pregnancy.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulins; Metformin; Pre-Eclampsia; Preg | 2019 |
Review of Metformin Use for Type 2 Diabetes Prevention.
Topics: Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemi | 2018 |
Oral Agents for the Treatment of Gestational Diabetes.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2018 |
Metformin in Prevention of Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pr | 2018 |
[Role of metformin in gynaecology and obstetrics].
Topics: Breast Neoplasms; Diabetes, Gestational; Endometrial Neoplasms; Female; Humans; Hypoglycemic Agents; | 2018 |
Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions.
Topics: Adult; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; Hypoglycemic Agents; Metformi | 2019 |
Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis.
Topics: Child; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Long Term Adve | 2019 |
Drugs to Control Diabetes During Pregnancy.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glycated Hemogl | 2019 |
Pharmacologic Treatment of Diabetes in Pregnancy.
Topics: Diabetes, Gestational; Exercise; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis.
Topics: Child Development; Child, Preschool; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inf | 2019 |
Metformin vs insulin in the management of gestational diabetes: a meta-analysis.
Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; | 2013 |
Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review.
Topics: Adult; Clinical Trials as Topic; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin | 2013 |
Oral agents for the management of gestational diabetes.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2013 |
The use of oral hypoglycaemic agents in pregnancy.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Glycoside Hydrolase Inhibitors; Humans; | 2014 |
Metformin vs insulin in the management of gestational diabetes: a systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy; Prognosis | 2014 |
Unresolved controversies in gestational diabetes: implications on maternal and infant health.
Topics: Caloric Restriction; Diabetes, Gestational; Diet, Carbohydrate-Restricted; Diet, Diabetic; Female; F | 2014 |
Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Multicenter Studies as Topic; | 2014 |
[Metformin in pregnancy].
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycysti | 2014 |
Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2014 |
Gestational diabetes mellitus management with oral hypoglycemic agents.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2014 |
Interventions to modify the progression to type 2 diabetes mellitus in women with gestational diabetes: a systematic review of literature.
Topics: Breast Feeding; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, D | 2014 |
Placental dysfunction in obese women and antenatal surveillance strategies.
Topics: Diabetes, Gestational; Female; Fetal Development; Humans; Hypoglycemic Agents; Inflammation; Metform | 2015 |
Screening and management of gestational diabetes.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet | 2015 |
Safety considerations with pharmacological treatment of gestational diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic | 2015 |
Effect comparison of metformin with insulin treatment for gestational diabetes: a meta-analysis based on RCTs.
Topics: Birth Weight; Diabetes, Gestational; Female; Gestational Age; Humans; Insulin; Metformin; Pre-Eclamp | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Humans; Hypoglycemi | 2015 |
Using oral agents to manage gestational diabetes: what have we learned?
Topics: Acarbose; Administration, Oral; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypo | 2015 |
Comparative efficacy and safety of OADs in management of GDM: network meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic | 2015 |
Metformin for the management of gestational diabetes mellitus.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy; Pregnancy | 2015 |
Metformin versus insulin for gestational diabetes mellitus: a meta-analysis.
Topics: Diabetes, Gestational; Female; Humans; Hypertension, Pregnancy-Induced; Insulin; Metformin; Pregnanc | 2015 |
Prevention of gestational diabetes mellitus: Where are we now?
Topics: Diabetes, Gestational; Diet; Dietary Supplements; Exercise Therapy; Female; Humans; Hypoglycemic Age | 2015 |
Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis.
Topics: Adult; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Infant, | 2015 |
Metformin for the treatment of gestational diabetes: An updated meta-analysis.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agent | 2015 |
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis.
Topics: Abortion, Spontaneous; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Age | 2015 |
[Metformin and the obstetric patient].
Topics: Breast Feeding; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ov | 2015 |
Metformin versus insulin in gestational diabetes mellitus: a meta-analysis of randomized clinical trials.
Topics: Birth Weight; Cesarean Section; Diabetes, Gestational; Female; Gestational Age; Humans; Infant, Newb | 2016 |
Major malformation risk, pregnancy outcomes, and neurodevelopmental outcomes associated with metformin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Infan | 2016 |
Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fetal Development; Humans; Hypoglyc | 2017 |
Is it worth treating gestational diabetes: if so, when and how?
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Metformin; Pregnancy; Pregnancy Com | 2016 |
Role of Metformin in Women's Health: Review of Its Current Place in Clinical Practice and Emerging Indications for Future.
Topics: Anticarcinogenic Agents; Clomiphene; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Ferti | 2016 |
Prediction and prevention of Gestational Diabetes: an update of recent literature.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Pr | 2016 |
Gestational diabetes mellitus: does an effective prevention strategy exist?
Topics: Diabetes, Gestational; Dietary Supplements; Exercise; Female; Fetal Development; Humans; Insulin Res | 2016 |
Metformin - a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis.
Topics: Birth Weight; Diabetes, Gestational; Female; Gestational Age; Glycated Hemoglobin; Humans; Hypoglyce | 2017 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Pharmacological Management of Gestational Diabetes Mellitus.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2016 |
Metformin: From Research to Clinical Practice.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Po | 2016 |
Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypo | 2017 |
The emerging role of metformin in gestational diabetes mellitus.
Topics: Australia; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2017 |
Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review.
Topics: Acarbose; Administration, Oral; Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypo | 2009 |
Gestational diabetes mellitus: developments in diagnosis and treatment.
Topics: Amniotic Fluid; Diabetes, Gestational; Female; Fetal Diseases; Humans; Hyperinsulinism; Hypoglycemic | 2009 |
Role of metformin in the treatment of gestational diabetes.
Topics: Blood Glucose; Clinical Trials as Topic; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; | 2009 |
The management of gestational diabetes.
Topics: Administration, Oral; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes, Gestational; Drug Admi | 2009 |
The use of oral antidiabetic medications in gestational diabetes mellitus.
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2009 |
Should physicians prescribe metformin to women with polycystic ovary syndrome PCOS?
Topics: Adult; Body Mass Index; Clomiphene; Diabetes Mellitus; Diabetes, Gestational; Female; Fertility Agen | 2010 |
Hemoglobin A1c for the diagnosis of diabetes: practical considerations.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes, Gestational; False Negative R | 2010 |
Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metfo | 2010 |
Oral hypoglycemic agents for gestational diabetes mellitus?
Topics: Administration, Oral; Animals; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents | 2011 |
Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agent | 2011 |
Gestational diabetes: implications for cardiovascular health.
Topics: Biomarkers; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetes, Ge | 2012 |
Management of diabetes in pregnancy.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Huma | 2012 |
Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hyp | 2012 |
[Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges].
Topics: Breast Feeding; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulins; Met | 2012 |
Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.
Topics: Ambulatory Care; Blood Glucose Self-Monitoring; Diabetes, Gestational; Diet Therapy; Exercise Therap | 2012 |
The contentious nature of gestational diabetes: diet, insulin, glyburide and metformin.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Human | 2002 |
Metformin and gestational diabetes.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Humans; | 2003 |
[Insulin resistance in polycystic ovary syndrome].
Topics: Adolescent; Adult; Body Mass Index; Cardiovascular Diseases; Chromans; Controlled Clinical Trials as | 2003 |
Metformin for the treatment of the polycystic ovary syndrome.
Topics: Adolescent; Adult; Amenorrhea; Clinical Trials as Topic; Clomiphene; Diabetes Mellitus, Type 2; Diab | 2004 |
Metformin therapy and diabetes in pregnancy.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Po | 2004 |
Should we continue or stop insulin sensitizing drugs during pregnancy?
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycy | 2004 |
Pregnancy complications in PCOS.
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hyperinsulinism; Hypertension, Pregnan | 2006 |
Pharmacological management of gestational diabetes: an overview.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metformin; Pregnancy | 2007 |
Diagnosis and new approaches in the therapy of gestational diabetes mellitus.
Topics: Blood Glucose; Diabetes, Gestational; Female; Fetal Development; Fetus; Glyburide; Humans; Hypoglyce | 2006 |
Medical therapy in women with polycystic ovarian syndrome before and during pregnancy and lactation.
Topics: Adult; Clomiphene; Diabetes, Gestational; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2008 |
Critical appraisal of published research evidence: treatment of gestational diabetes.
Topics: Attitude of Health Personnel; Clinical Trials as Topic; Diabetes, Gestational; Evidence-Based Medici | 2001 |
81 trials available for metformin and Diabetes, Gestational
| Article | Year |
|---|---|
Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow-up study of two open-label, randomized controlled trials.
Topics: Anthropometry; Blood Glucose; Child; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypog | 2022 |
Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Female; Gastrointestinal Microbiome; Glycemic Control | 2022 |
Effectiveness of carbohydrate counting and Dietary Approach to Stop Hypertension dietary intervention on managing Gestational Diabetes Mellitus among pregnant women who used metformin: A randomized controlled clinical trial.
Topics: Adult; Blood Glucose; Combined Modality Therapy; Diabetes, Gestational; Diet, Carbohydrate-Restricte | 2022 |
Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial.
Topics: Birth Weight; Body Mass Index; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Gestational | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Pregnancy Outcomes: Effects of Metformin (POEM) study: a protocol for a long-term, multicentre, open-label, randomised controlled trial in gestational diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, Newbo | 2022 |
Determinants of Small for Gestational Age in Women With Type 2 Diabetes in Pregnancy: Who Should Receive Metformin?
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Gestational Age; Humans; Hypertension; Hyp | 2022 |
A multi-centered trial investigating gestational treatment with ursodeoxycholic acid compared to metformin to reduce effects of diabetes mellitus (GUARD): a randomized controlled trial protocol.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Humans; Infant, Ne | 2022 |
A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol.
Topics: Blood Glucose; Clinical Trials, Phase III as Topic; Diabetes, Gestational; Female; Galactose; Gestat | 2022 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study).
Topics: Decision Making, Shared; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Metformin | 2023 |
Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years.
Topics: Adipokines; Adiponectin; Adiposity; Child; Diabetes, Gestational; Female; Humans; Inflammation; Insu | 2023 |
Early Metformin in Gestational Diabetes: A Randomized Clinical Trial.
Topics: Adult; Birth Weight; Diabetes, Gestational; Double-Blind Method; Female; Humans; Hypoglycemic Agents | 2023 |
Metformin in the prevention of type 2 diabetes after gestational diabetes in postnatal women (OMAhA): a UK multicentre randomised, placebo-controlled, double-blind feasibility trial with nested qualitative study.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Double-Blind Method; Feasibility Studies; Female; | 2023 |
Metformin Versus Insulin for Gestational Diabetes: Cognitive and Neuropsychological Profiles of Children Aged 9 years.
Topics: Child; Cognition; Diabetes, Gestational; Female; Humans; Insulin; Metformin; Mothers; Pregnancy | 2023 |
SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial.
Topics: Administration, Oral; Blood Glucose; Cost-Benefit Analysis; Diabetes, Gestational; Drug Therapy, Com | 2019 |
Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Healthy | 2020 |
Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.
Topics: Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Glyburid | 2020 |
Postpartum treatment with liraglutide in combination with metformin versus metformin monotherapy to improve metabolic status and reduce body weight in overweight/obese women with recent gestational diabetes: A double-blind, randomized, placebo-controlled
Topics: Adolescent; Adult; Diabetes, Gestational; Double-Blind Method; Drug Therapy, Combination; Energy Met | 2020 |
Effectiveness and acceptability of metformin in preventing the onset of type 2 diabetes after gestational diabetes in postnatal women: a protocol for a randomised, placebo-controlled, double-blind feasibility trial—Optimising health outcomes with Metformi
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Feasibility Studies; Female; Humans; London; Metfo | 2020 |
Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial.
Topics: Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insuli | 2020 |
Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes.
Topics: Adult; Apolipoprotein A-I; Apolipoprotein B-100; Birth Weight; Cholesterol; Diabetes, Gestational; F | 2020 |
A randomized trial of dapagliflozin and metformin, alone and combined, in overweight women after gestational diabetes mellitus.
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucosides; Humans; | 2020 |
Effects of metformin and insulin therapy regimens on postpartum oral glucose tolerance test results in pregnant women with gestational diabetes mellitus: a comparative study.
Topics: Blood Glucose; Body Mass Index; Diabetes, Gestational; Female; Glucose Tolerance Test; Humans; Insul | 2020 |
Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial.
Topics: Adult; Dexamethasone; Diabetes, Gestational; Double-Blind Method; Female; Fetal Distress; Glucocorti | 2021 |
Efficacy of myoinositol in treatment of gestational diabetes mellitus in Asian Indian women: A pilot randomized clinical trial.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; India; Inositol; Insulin; Metformin; Pil | 2021 |
Metformin for gestational diabetes study: metformin vs insulin in gestational diabetes: glycemic control and obstetrical and perinatal outcomes: randomized prospective trial.
Topics: Adult; Cesarean Section; Diabetes, Gestational; Female; Gestational Weight Gain; Humans; Hypoglycemi | 2021 |
Metformin in gestational diabetes mellitus: A double-blind placebo-controlled randomized trial.
Topics: Blood Glucose; Diabetes, Gestational; Double-Blind Method; Drug Therapy, Combination; Female; Fetal | 2022 |
A clinical diabetes risk prediction model for prediabetic women with prior gestational diabetes.
Topics: Diabetes, Gestational; Female; Glycated Hemoglobin; Humans; Metformin; Prediabetic State; Pregnancy | 2021 |
Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Feasibility Studies; Female; | 2017 |
Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study.
Topics: Adult; Diabetes, Gestational; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin Resi | 2018 |
Metformin in women at high risk of gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Incidence; Metformin; Pregnancy; | 2018 |
SHORT-TERM SITAGLIPTIN-METFORMIN THERAPY IS MORE EFFECTIVE THAN METFORMIN OR PLACEBO IN PRIOR GESTATIONAL DIABETIC WOMEN WITH IMPAIRED GLUCOSE REGULATION.
Topics: Adolescent; Adult; Body Mass Index; Diabetes, Gestational; Female; Glucose Intolerance; Humans; Metf | 2018 |
Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women.
Topics: Adolescent; Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Incidence; Metformin; | 2018 |
The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Glycated Hemoglobin; Hu | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment.
Topics: Adult; Biomarkers; Cohort Studies; Diabetes, Gestational; Female; Homocysteine; Humans; Hyperhomocys | 2013 |
Randomized trial of metformin vs insulin in the management of gestational diabetes.
Topics: Blood Glucose; Brazil; Diabetes, Gestational; Female; Gestational Age; Humans; Hypoglycemic Agents; | 2013 |
Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria.
Topics: Adult; Analysis of Variance; Diabetes, Gestational; Double-Blind Method; Female; Humans; Hypoglycemi | 2013 |
The role of adding metformin in insulin-resistant diabetic pregnant women: a randomized controlled trial.
Topics: Administration, Oral; Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Egypt; Fasting; Fem | 2014 |
Efficacy of metformin versus insulin in the management of pregnancy with diabetes.
Topics: Adult; Blood Glucose; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Fasting; Female; Huma | 2013 |
The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, New | 2014 |
Metformin versus insulin treatment in gestational diabetes in pregnancy in a developing country: a randomized control trial.
Topics: Adult; Blood Glucose; Developing Countries; Diabetes, Gestational; Drug Therapy, Combination; Female | 2015 |
The effects of metformin on weight loss in women with gestational diabetes: a pilot randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Diabetes, Gestational; Drug Administration Schedule; Female; Follow-Up Studies; H | 2015 |
Efficacy of metformin in pregnant obese women: a randomised controlled trial.
Topics: Adolescent; Adult; Birth Weight; Blood Glucose; Clinical Protocols; Diabetes, Gestational; Double-Bl | 2015 |
Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial.
Topics: Adult; Birth Injuries; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hum | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglyc | 2015 |
Blood pressure measurement at two years in offspring of women randomized to a trial of metformin for GDM: follow up data from the MiG trial.
Topics: Blood Pressure; Body Fat Distribution; Child, Preschool; Diabetes, Gestational; Female; Follow-Up St | 2015 |
Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial.
Topics: Adolescent; Adult; Blood Glucose; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Diabetes, Gestat | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
The effects of metformin treatment of gestational diabetes on maternal weight and glucose tolerance postpartum--a prospective follow-up study.
Topics: Adult; Blood Glucose; Body Weight; Diabetes, Gestational; Female; Follow-Up Studies; Glucose Toleran | 2016 |
Identification of metformin poor responders, requiring supplemental insulin, during randomization of metformin versus insulin for the control of gestational diabetes mellitus.
Topics: Adult; Apgar Score; Blood Glucose; Body Mass Index; Diabetes, Gestational; Drug Therapy, Combination | 2016 |
[Metformin has no effect on median birth weight score in pregnant non-diabetic women with BMI >35].
Topics: Adult; Birth Weight; Body Mass Index; Diabetes, Gestational; Double-Blind Method; Female; Humans; In | 2016 |
Short-term antidiabetic treatment with insulin or metformin has a similar impact on the components of metabolic syndrome in women with gestational diabetes mellitus requiring antidiabetic agents: results of a prospective, randomised study.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglyce | 2016 |
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combina | 2017 |
An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet.
Topics: Adult; Blood Glucose; Body Mass Index; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabete | 2008 |
Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study.
Topics: Adolescent; Adult; Diabetes, Gestational; Double-Blind Method; Female; Glucose; Homeostasis; Humans; | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus; Diabetes, Gestational; Double-Blind Method; Femal | 2008 |
Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial.
Topics: Birth Weight; Diabetes Complications; Diabetes, Gestational; Female; Gestational Age; Glucose Tolera | 2010 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Topics: Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestationa | 2009 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Metform | 2010 |
Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome.
Topics: Abortion, Habitual; Adult; Body Mass Index; Case-Control Studies; Diabetes, Gestational; Female; Fet | 2010 |
Metformin compared with glyburide for the management of gestational diabetes.
Topics: Birth Weight; Blood Glucose; Diabetes, Gestational; Fasting; Female; Glyburide; Glycated Hemoglobin; | 2010 |
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
Topics: Adult; Blood Pressure; Delivery, Obstetric; Diabetes, Gestational; Double-Blind Method; Female; Hear | 2010 |
Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents | 2011 |
Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents | 2011 |
Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents | 2011 |
Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Female; Glucose Tolerance Test; Glyburide | 2012 |
Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Drug Administration Schedule; Female; Hum | 2013 |
Maternal and neonatal circulating markers of metabolic and cardiovascular risk in the metformin in gestational diabetes (MiG) trial: responses to maternal metformin versus insulin treatment.
Topics: Adult; Blood Glucose; C-Peptide; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Diab | 2013 |
Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial.
Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Fetal | 2012 |
Metformin compared with insulin in the treatment of pregnant women with overt diabetes: a randomized controlled trial.
Topics: Adult; C-Peptide; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fetal Blood; Humans; Hyp | 2013 |
Effects of metformin-diet intervention before and throughout pregnancy on obstetric and neonatal outcomes in patients with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic | 2013 |
Determinants of maternal triglycerides in women with gestational diabetes mellitus in the Metformin in Gestational Diabetes (MiG) study.
Topics: Adult; Diabetes, Gestational; Fasting; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Preg | 2013 |
Contraindications to use of metformin. Metformin may be useful in gestational diabetes.
Topics: Adult; Contraindications; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fetus; Humans; H | 2003 |
Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg
Topics: Adult; Body Weight; Cohort Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insu | 2004 |
Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy.
Topics: Adult; Body Height; Body Weight; Child Development; Diabetes, Gestational; Female; Humans; Hypoglyce | 2004 |
Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study.
Topics: Adult; Androgens; Birth Weight; Diabetes, Gestational; Female; Gestational Age; Glucose Tolerance Te | 2004 |
Continuous glucose monitoring versus self-monitoring of blood glucose in the treatment of gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes, Gestational; Drug Therapy, Combinatio | 2007 |
A trial in progress: gestational diabetes. Treatment with metformin compared with insulin (the Metformin in Gestational Diabetes [MiG] trial).
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Morbidity; Pr | 2007 |
Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome.
Topics: Adult; Blood Glucose; Body Weight; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insul | 2008 |
Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison.
Topics: Adult; Area Under Curve; Birth Weight; Blood Glucose; Diabetes, Gestational; Fasting; Female; Glucos | 2007 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
158 other studies available for metformin and Diabetes, Gestational
| Article | Year |
|---|---|
Effect of Maternal Metformin Treatment in Pregnancy on Neonatal Metabolism: Evidence From Newborn Metabolic Screening.
Topics: Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant; Infant, Ne | 2021 |
Changing patterns in medication prescription for gestational diabetes during a time of guideline change in the USA: a cross-sectional study.
Topics: Adolescent; Adult; Cross-Sectional Studies; Diabetes, Gestational; Drug Prescriptions; Female; Glybu | 2022 |
Doubts about the true effectiveness of metformin for gestational diabetes.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2022 |
Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes.
Topics: Administration, Oral; Adult; Analysis of Variance; Blood Glucose; Diabetes, Gestational; Female; Gly | 2022 |
Metformin in pregnancy: a re-examination of its safety.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy | 2022 |
Screening for Prediabetes and Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Diabetes, Gestational; Exercise; Female; Humans; Hypoglycemi | 2022 |
The Use of Oral Hypoglycemic Agents during Pregnancy: An Alternative to Insulin?
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant | 2021 |
Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study.
Topics: Adult; Child; Child, Preschool; Cohort Studies; Diabetes, Gestational; Female; Humans; Infant, Newbo | 2022 |
Effects of metformin and insulin on gestational diabetes mellitus: A dual drugs therapy approach.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Humans; Hypoglycemic | 2022 |
Comparison of glucose metabolism and anthropometry in women with previous gestational diabetes treated with metformin vs. insulin: 9-year follow-up of two randomized trials.
Topics: Anthropometry; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; | 2022 |
Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus: A protocol for systematic review and meta-analysis.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Meta-Analysis as Top | 2022 |
Metformin: A promising option for the management of gestational diabetes mellitus - Exploring the benefits, challenges and clinical needs in the current management of gestational diabetes mellitus.
Topics: Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregn | 2022 |
Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus.
Topics: Cesarean Section; Diabetes, Gestational; Female; Glucose; Humans; Insulin, Short-Acting; Metformin; | 2022 |
Impact of pharmacological treatment of gestational diabetes on the mode of delivery and birth weight: a nationwide population-based study on a subset of singleton pregnant Portuguese women.
Topics: Birth Weight; Cesarean Section; Diabetes, Gestational; Female; Humans; Infant, Newborn; Insulin; Met | 2022 |
Health Beliefs Associated With Metformin Use Among Insured Adults With Prediabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Male; | 2022 |
Tert-butylhydroquinone Mitigates Renal Dysfunction in Pregnant Diabetic Rats
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes, Gestat | 2023 |
Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring.
Topics: Adult; Animals; Body Composition; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, Hig | 2022 |
[Gestational diabetes mellitus in a hospital in the city of Buenos Aires, Argentina: incidence, treatment, and frequency of screening for reclassification after childbirth]
Topics: Argentina; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose Intolera | 2022 |
The use of metformin for type 2 diabetes prevention: Observational multicenter study from Saudi Arabia.
Topics: Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glycated Hemogl | 2022 |
Vascular phenotype at 35-37 weeks' gestation in women with gestational diabetes mellitus.
Topics: Diabetes, Gestational; Female; Humans; Insulins; Metformin; Pregnancy; Ultrasonography, Doppler; Vas | 2023 |
Metformin in pregnancy and risk of abnormal growth outcomes at birth: a register-based cohort study.
Topics: Child; Cohort Studies; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Infant, Newborn; In | 2022 |
Metformin in pregnancy and risk of abnormal growth outcomes at birth: a register-based cohort study.
Topics: Child; Cohort Studies; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Infant, Newborn; In | 2022 |
Metformin in pregnancy and risk of abnormal growth outcomes at birth: a register-based cohort study.
Topics: Child; Cohort Studies; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Infant, Newborn; In | 2022 |
Metformin in pregnancy and risk of abnormal growth outcomes at birth: a register-based cohort study.
Topics: Child; Cohort Studies; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Infant, Newborn; In | 2022 |
Efficacy and safety of hypoglycemic agents on gestational diabetes mellitus in women: A Bayesian network analysis of randomized controlled trials.
Topics: Birth Weight; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; I | 2022 |
Metformin use in pregnancy: efficacy, safety, and potential benefits.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy; Pregnancy | 2023 |
Observational assessments of the relationship of dietary and pharmacological treatment on continuous measures of dysglycemia over 24 hours in women with gestational diabetes.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Diabetes, Gestational; Diet; Female; Humans; Metformin | 2023 |
Predictors for pharmacological therapy and perinatal outcomes with metformin treatment in women with gestational diabetes.
Topics: Australia; Cesarean Section; Diabetes, Gestational; Female; Glucose; Humans; Hypoglycemic Agents; In | 2023 |
Use of metformin and insulin among pregnant women with gestation diabetes in the United Kingdom: A population-based cohort study.
Topics: Cohort Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Preg | 2023 |
Does treatment modality affect measures of arterial stiffness in women with gestational diabetes?
Topics: Diabetes, Gestational; Female; Humans; Infant; Insulin; Longitudinal Studies; Metformin; Pregnancy; | 2023 |
Antidiabetic Medication Utilisation before and during Pregnancy in Switzerland between 2012 and 2019: An Administrative Claim Database from the MAMA Cohort.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glucose; Humans; Hypoglycemic Agents; Insulin; Metform | 2023 |
Associations between maternal gestational diabetes metformin or insulin treatment and offspring growth trajectories from birth to 60 months of age: Findings from the Born in Bradford (BiB) study.
Topics: Birth Weight; Body Mass Index; Cohort Studies; Diabetes, Gestational; Female; Humans; Insulin; Metfo | 2023 |
Metformin in overweight and obese women with gestational diabetes: a propensity score-matched study.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Gestational Weight Gain; Humans; Hypoglycemic A | 2019 |
Implementation and Evaluation of the "Metformin First" Protocol for Management of Gestational Diabetes.
Topics: Adult; Clinical Protocols; Diabetes, Gestational; Female; Health Plan Implementation; Humans; Hypogl | 2019 |
Maternal and Neonatal Health Outcomes Associated with the Use of Gliclazide and Metformin for the Treatment of Diabetes in Pregnancy: A Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adult; Diabetes, Gestational; Female; Gliclazide; Hospitalization; Huma | 2020 |
Maternal diabetes and risk of childhood cancer in the offspring.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Diabetes Mellitus; Diabetes, Gestational; | 2020 |
Comparative effectiveness of metformin versus insulin for gestational diabetes in New Zealand.
Topics: Adolescent; Adult; Birth Weight; Cesarean Section; Diabetes, Gestational; Female; Humans; Hypoglycem | 2019 |
Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus.
Topics: Adult; Blood Glucose; Case-Control Studies; Diabetes, Gestational; Drug Therapy, Combination; Exerci | 2019 |
[Gestational diabetes adherence to treatment and metabolic control].
Topics: Adult; Cross-Sectional Studies; Diabetes, Gestational; Educational Status; Female; Gestational Age; | 2019 |
Case 6-2020: A 34-Year-Old Woman with Hyperglycemia.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diagnosis, Differential; | 2020 |
Impact of Disturbed Glucose Homeostasis Regulated by AMPK in Endometrium on Embryo Implantation in Diabetes Mice.
Topics: Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes, Gestational; Em | 2020 |
Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; | 2019 |
Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study.
Topics: Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Diet; Female; Humans; Hypoglycemic Agents; | 2020 |
Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos.
Topics: Adult; Animals; Blastocyst; Blood Glucose; Diabetes, Gestational; Disease Models, Animal; Embryonic | 2020 |
Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes.
Topics: Acetylation; Adult; AMP-Activated Protein Kinases; Animals; Cohort Studies; Diabetes, Gestational; D | 2020 |
Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis.
Topics: Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemia; Infant, Newborn; Meta-Analysis a | 2020 |
Management of Gestational Diabetes Mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents | 2021 |
Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes.
Topics: Animals; Cognitive Dysfunction; Diabetes, Gestational; Diet, Fat-Restricted; Diet, High-Fat; Female; | 2020 |
Characterization of women with gestational diabetes who failed to achieve glycemic control by lifestyle modifications.
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes, Gestational; Female; Glucose Tolerance Test; Glybur | 2021 |
Cost-effectiveness analysis of polycystic ovary syndrome management and the risk of gestational diabetes in pregnant women: a decision-tree model.
Topics: Adult; Cohort Studies; Cost-Benefit Analysis; Decision Trees; Diabetes, Gestational; Disease Progres | 2021 |
Metformin Should Not Be Used to Treat Prediabetes.
Topics: Adult; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dia | 2020 |
Metformin in women with type 2 diabetes in pregnancy.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pr | 2020 |
Metformin versus insulin use for treatment of gestational diabetes and delivery by caesarean section: A nationwide Swedish cohort study.
Topics: Cesarean Section; Cohort Studies; Diabetes, Gestational; Female; Humans; Infant, Newborn; Insulin; M | 2020 |
Efficacy and safety of metformin in the treatment of gestational diabetes: A protocol for systematic review and meta-analysis.
Topics: Adult; Clinical Protocols; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Meta-Analysis | 2021 |
Metformin combined with insulin in women with gestational diabetes mellitus: a propensity score-matched study.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Humans; Hypoglycemic | 2021 |
Different Gestational Diabetes Phenotypes: Which Insulin Regimen Fits Better?
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes, Gestational; Fasting; Female; Glucose Tolerance Tes | 2021 |
Diabetes: Screening, Diagnosis, and Prevention of Type 2 Diabetes.
Topics: Adult; Aged; Child; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Mass Screening | 2021 |
Current practices in gestational diabetes mellitus diagnosis and management in the United States: survey of maternal-fetal medicine specialists.
Topics: Blood Glucose; Decision Making, Shared; Diabetes, Gestational; Exercise; Female; Humans; Hypoglycemi | 2021 |
Gestational diabetes, metformin, and the risk of hypoglycemia.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Pregnancy | 2021 |
Gestational diabetes, metformin, and risk of hypoglycemia.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Pregnancy | 2021 |
Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone.
Topics: Birth Weight; Diabetes, Gestational; Diet; Female; Humans; Infant, Newborn; Insulin; Metabolome; Met | 2021 |
Risk of metformin failure in the treatment of women with gestational diabetes.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Substitution; Female; Glucose Tolerance Test; Glyc | 2021 |
Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner.
Topics: Adiposity; Animals; Animals, Newborn; Diabetes, Gestational; Female; Male; Metformin; Mice; Mice, In | 2021 |
Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria.
Topics: Adult; Area Under Curve; Birth Weight; Cell Hypoxia; Delivery, Obstetric; Diabetes, Gestational; Ele | 2021 |
Gestational diabetes mellitus: Berlin and beyond.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, Diabetic; Early Diagnosis; Female; Glycemic | 2017 |
Incidence and Contributing Factors of Persistent Hyperglycemia at 6-12 Weeks Postpartum in Iranian Women with Gestational Diabetes: Results from LAGA Cohort Study.
Topics: Adult; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Fasting; Fem | 2017 |
Patterns of glucose-lowering therapies and neonatal outcomes in the treatment of gestational diabetes in Canada, 2009-2014.
Topics: Adult; Birth Weight; Blood Glucose; Canada; Diabetes, Gestational; Drug Therapy, Combination; Female | 2017 |
Comment on Nachum et al. Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. Diabetes Care 2017;40:332-337.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; In | 2017 |
Response to Comment on Nachum et al. Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. Diabetes Care 2017;40:332-337.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; In | 2017 |
Use of a clinical-laboratory score to guide treatment of gestational diabetes.
Topics: Adult; Apgar Score; Clinical Decision-Making; Decision Support Systems, Clinical; Diabetes, Gestatio | 2018 |
Metformin in gestational diabetes mellitus.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2017 |
Efficacy of metformin in improving glycaemic control & perinatal outcome in gestational diabetes mellitus: A non-randomized study.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, Newborn; I | 2017 |
Metformin in gestational diabetes mellitus: predictors of poor response.
Topics: Adult; Age Factors; Blood Glucose; Body Mass Index; Cohort Studies; Diabetes, Gestational; Female; H | 2018 |
Gestational diabetes-Predictors of response to treatment and obstetric outcome.
Topics: Adult; Body Mass Index; Diabetes, Gestational; Diet, Carbohydrate-Restricted; Female; Humans; Hypogl | 2018 |
How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; India; Infant, Newborn; Metformin | 2018 |
The diversity of gestational diabetes: a therapeutic challenge.
Topics: Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pract | 2018 |
Pharmacological treatment of gestational diabetes mellitus: point/counterpoint.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2018 |
The effects of metformin on maternal haemodynamics in gestational diabetes mellitus: A pilot study.
Topics: Adult; Diabetes, Gestational; Female; Hemodynamics; Humans; Hypoglycemic Agents; Incidence; Metformi | 2018 |
Predictors of metformin failure in gestational diabetes mellitus (GDM).
Topics: Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Fasting; Female; | 2018 |
Combined intervention of swimming plus metformin ameliorates the insulin resistance and impaired lipid metabolism in murine gestational diabetes mellitus.
Topics: Animals; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetes, Gestat | 2018 |
Effect of well-controlled gestational diabetes on left ventricular diastolic dysfunction in neonates.
Topics: Adult; Cardiomegaly; Case-Control Studies; Cross-Sectional Studies; Diabetes, Gestational; Echocardi | 2019 |
Improving outcomes in gestational diabetes: does gestational weight gain matter?
Topics: Adult; Body Mass Index; Delivery, Obstetric; Diabetes, Gestational; Female; Fetal Macrosomia; Gestat | 2019 |
A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Obstetrics; Practice Guidelin | 2018 |
Metformin or insulin: logical treatment in women with gestational diabetes in the Middle East, our experience.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Middle East; | 2018 |
Metformin use during pregnancy: Is it really safe?
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy; Pregnancy Complica | 2018 |
Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin.
Topics: Adult; Diabetes, Gestational; Female; Fetal Macrosomia; Follow-Up Studies; Humans; Hypoglycemic Agen | 2018 |
Gestational diabetes mellitus: A pragmatic approach to diagnosis and management.
Topics: Blood Glucose; Diabetes, Gestational; Disease Management; Female; Humans; Hypoglycemic Agents; Insul | 2018 |
Diagnosis of gestational diabetes: a 'teachable moment'.
Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes, Gestational; Diet; Emotions; Female; | 2019 |
Amino acid profile in women with gestational diabetes mellitus treated with metformin or insulin.
Topics: Adult; Amino Acids; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; | 2018 |
Association of Long-term Child Growth and Developmental Outcomes With Metformin vs Insulin Treatment for Gestational Diabetes.
Topics: Adult; Child Behavior; Child Development; Child, Preschool; Diabetes, Gestational; Female; Follow-Up | 2019 |
Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.
Topics: Adult; Analysis of Variance; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypoglycem | 2018 |
Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register.
Topics: Adult; Australia; Biomarkers; Birth Weight; Blood Glucose; Case-Control Studies; Diabetes Mellitus, | 2019 |
Renal dysfunction in a mouse model of GDM is prevented by metformin through MAPKs.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Diet, High-Fat; Disease Models, Animal; Female; Gluco | 2019 |
Exercise vs metformin for gestational diabetes mellitus: Protocol for a network meta-analysis.
Topics: Diabetes, Gestational; Exercise; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Meta-Analysi | 2019 |
Should metformin be preferred over insulin therapy in the management of gestational diabetes (GDM)?
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2013 |
Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes, | 2014 |
Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score.
Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Progression; Female; Foll | 2013 |
Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Progression; | 2014 |
Re: Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus by Corbould A, Swinton F, Radford A, Campbell, McBeath S, Dennis A. Aust N Z J Obstet Gynaecol 2013; 53: 125-129.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy | 2013 |
Re: Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus by Corbould A, Swinton F, Radford A, Campbell, McBeath S, Dennis A. Aust N Z J Obstet Gynaecol 2013; 53: 125-129.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy | 2013 |
A "spoonful of sugar" and the realities of diabetes prevention!
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Life Style; M | 2014 |
Metformin use in gestational diabetes mellitus.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2014 |
Use of antidiabetic agents in the treatment of gestational diabetes mellitus in Germany, 2008-2012.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Practice Patt | 2014 |
A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: growth and development of the children at the age of 18 months.
Topics: Adult; Body Height; Body Weight; Child Development; Diabetes, Gestational; Female; Follow-Up Studies | 2015 |
Is metformin ready for prime time in pregnancy? Probably not yet.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Po | 2015 |
Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS).
Topics: Adult; Cross-Sectional Studies; Diabetes, Gestational; Female; Fertilization; Humans; Hypoglycemic A | 2014 |
Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes, Gestational; Female; Glyburide; Humans; Hypog | 2015 |
Which oral hypoglycaemic for gestational diabetes?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
Lifestyle changes or metformin reduce type 2 diabetes risk in women with gestational diabetes, US study shows.
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Life Style; M | 2015 |
Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes.
Topics: Adipose Tissue; Adult; Biomarkers; Caspase 1; Connexins; Diabetes, Gestational; Endoplasmic Reticulu | 2015 |
Diabetes: Therapy for gestational diabetes mellitus--time for a change?
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
Metformin for preventing gestational diabetes in women with polycystic ovarian syndrome.
Topics: Adolescent; Adult; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Me | 2015 |
Gestational diabetes mellitus screening, management and outcomes in the Cook Islands.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Diet, Reducing; Female; Glucose Tolerance Test; Gravidi | 2015 |
In women with gestational diabetes requiring drug treatment, glibenclamide may be inferior to insulin and metformin: metformin (plus insulin when required) performs better than insulin.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2015 |
Metformin and pregnancy outcomes in obese women.
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Metformin; Obesity, Ab | 2015 |
Relationship between Polycystic Ovarian Syndrome and Subsequent Gestational Diabetes Mellitus: A Nationwide Population-Based Study.
Topics: Adolescent; Adult; Comorbidity; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformi | 2015 |
Metformin Treatment Does Not Affect Testicular Size in Offspring Born to Mothers with Gestational Diabetes.
Topics: Adult; Child; Child, Preschool; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin; | 2016 |
Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Gly | 2016 |
The use of dextrose/insulin infusions during labour and delivery in women with gestational diabetes mellitus: Is there any point?
Topics: Blood Glucose; Diabetes, Gestational; Female; Glucose; Humans; Hypoglycemia; Hypoglycemic Agents; In | 2017 |
Non-insulin pharmacological therapy in pregnancy.
Topics: Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Pregnancy | 2016 |
Managing Recurring Obstetric Cholestasis With Metformin.
Topics: Adult; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Diabetes, Gesta | 2016 |
Should metformin be included in fertility treatment of PCOS patients?
Topics: Adenosine Triphosphate; Diabetes Mellitus, Type 2; Diabetes, Gestational; Electron Transport; Female | 2017 |
Metformin Trumps insulin in the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Gestational diabetes: an opportunity for improvement.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Disease Progression; Female; Glucose Intolerance; Human | 2008 |
Bone disease, gestational diabetes mellitus, and health care.
Topics: Bone Density; Bone Diseases; Collagen; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fra | 2009 |
Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome.
Topics: Adult; Apgar Score; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Met | 2009 |
Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study.
Topics: Birth Weight; Blood Glucose; Body Weight; Case-Control Studies; Diabetes, Gestational; Female; Human | 2009 |
Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Connecticut; Depression; Diabetes Mellitus, Type | 2009 |
[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].
Topics: Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin | 2009 |
Metformin--a convenient alternative to insulin for Indian women with diabetes in pregnancy.
Topics: Analysis of Variance; Blood Glucose; Body Mass Index; Confidence Intervals; Diabetes Mellitus, Type | 2009 |
Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.
Topics: Adenosine Triphosphate; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Polarity; | 2010 |
Metformin treatment for Type 2 diabetes in pregnancy?
Topics: Adult; Breast Feeding; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Hypoglycemi | 2010 |
Metformin during pregnancy in polycystic ovary syndrome: another vitamin bites the dust.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2010 |
Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.
Topics: Abdominal Pain; Adult; Cohort Studies; Diabetes, Gestational; Egypt; Female; Fertilization in Vitro; | 2011 |
Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction.
Topics: Adult; Age of Onset; Cohort Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inf | 2011 |
Oral hypoglycemic agents in pregnancy.
Topics: Administration, Oral; Breast Feeding; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic | 2011 |
Metformin for gestational diabetes in routine clinical practice.
Topics: Adult; Birth Weight; Body Mass Index; Cohort Studies; Diabetes, Gestational; Female; Humans; Hypogly | 2011 |
Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age.
Topics: Absorptiometry, Photon; Anthropometry; Body Composition; Child, Preschool; Diabetes, Gestational; Fe | 2011 |
Metformin therapy during pregnancy: good for the goose and good for the gosling too?
Topics: Body Composition; Diabetes, Gestational; Female; Humans; Male; Metformin; Pregnancy | 2011 |
Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.
Topics: Adult; Anti-Mullerian Hormone; Birth Weight; Diabetes, Gestational; Female; Fertility Agents, Female | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Introduction of metformin for gestational diabetes mellitus in clinical practice: Has it had an impact?
Topics: Adult; Birth Weight; Cohort Studies; Combined Modality Therapy; Diabetes, Gestational; Drug Therapy, | 2012 |
Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.
Topics: Body Composition; Diabetes, Gestational; Female; Humans; Male; Metformin; Pregnancy | 2012 |
Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.
Topics: Body Composition; Diabetes, Gestational; Female; Humans; Male; Metformin; Pregnancy | 2012 |
Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Delayed-Action Preparations; Diabetes, Gestational; Female; Glucose Tolerance | 2013 |
Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007.
Topics: Adolescent; Adult; Child; Diabetes, Gestational; Female; Humans; Hyperglycemia; Hypoglycemic Agents; | 2013 |
[News on diabetes and public health perspectives].
Topics: Administration, Oral; Adult; Chromans; Clinical Trials as Topic; Diabetes Mellitus; Diabetes Mellitu | 2002 |
Longitudinal metabolic observation of metformin effects during pregnancy in hyperinsulinemic women with polycystic ovary syndrome: a case report.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glucose Tolerance Test; Humans; Hyperinsulinism | 2004 |
Impaired glucose tolerance and impaired fasting glucose.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes, Gestational; Disease Progression; Female; Glucose Intole | 2004 |
Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome.
Topics: Adult; Birth Weight; Body Weight; Diabetes, Gestational; Female; Gestational Age; HELLP Syndrome; Hu | 2004 |
Use of metformin in pregnancies with diabetes: a case series from India.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pilot Projects; Precon | 2005 |
Population pharmacokinetics of metformin in late pregnancy.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Drug Monitoring; Female; Fetal Blood; Half- | 2006 |
Metformin in pregnancy: its time has not yet come.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2006 |
Metformin use and diabetic pregnancy-has its time come?
Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fetus; Humans; Hypoglycemic Agents; Insuli | 2006 |
Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.
Topics: Abortion, Habitual; Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Po | 2006 |
Transfer of metformin across the dually perfused human placental lobule.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Maternal-Fetal Exchange; Metformin; Perf | 2006 |
Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.
Topics: Adult; Birth Weight; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hyperbilirubinemia | 2006 |
Gestational diabetes--setting limits, exploring treatments.
Topics: Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Me | 2008 |
Oral hypoglycaemic agents in 118 diabetic pregnancies.
Topics: Abruptio Placentae; Adult; Birth Weight; Cesarean Section; Cohort Studies; Diabetes Mellitus, Type 2 | 2000 |
A comparison of glyburide and insulin in women with gestational diabetes mellitus.
Topics: Adult; Diabetes, Gestational; Female; Glucose Intolerance; Glyburide; Humans; Hypoglycemic Agents; I | 2001 |
Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome.
Topics: Adult; Blood Glucose; Body Weight; Cohort Studies; Diabetes Complications; Diabetes Mellitus; Diabet | 2002 |