metformin has been researched along with Depressive Disorder in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 5.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| " A low prevalence of AD in patients with T2D was associated with residency in urban areas, the comorbidity of hemiplegia or paraplegia, the usage of metformin and sulfonylureas, and rapid-acting insulin injection therapy." | 3.85 | Prevalence of anxiety disorder in patients with type 2 diabetes: a nationwide population-based study in Taiwan 2000-2010. ( Hsieh, HM; Huang, CJ; Jiang, HJ; Lin, CH; Tu, HP; Wang, PW, 2017) |
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 1.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| "The included 3810 patients with type 2 diabetes had their treatment intensified at baseline." | 1.43 | Incidence, characteristics and impact of hypoglycaemia in patients receiving intensified treatment for inadequately controlled type 2 diabetes mellitus. ( Bramlage, P; Gitt, AK; Schneider, S; Tschöpe, D, 2016) |
| "In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) levels were measured at the annual diabetes checkup, and deficiencies were defined as <148 and <21 pmol/L, respectively." | 1.42 | Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. ( Beulens, JW; Biemans, E; Cuellar Renteria, VG; Hart, HE; Kooijman-Buiting, AM; Rutten, GE, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Niaz, D | 1 |
| Necyk, C | 1 |
| Simpson, SH | 1 |
| Shivavedi, N | 1 |
| Kumar, M | 1 |
| Tej, GNVC | 1 |
| Nayak, PK | 1 |
| Liu, W | 2 |
| Liu, J | 1 |
| Huang, Z | 1 |
| Cui, Z | 1 |
| Li, L | 1 |
| Qi, Z | 1 |
| Poggini, S | 1 |
| Golia, MT | 1 |
| Alboni, S | 1 |
| Milior, G | 1 |
| Sciarria, LP | 1 |
| Viglione, A | 1 |
| Matte Bon, G | 1 |
| Brunello, N | 1 |
| Puglisi-Allegra, S | 1 |
| Limatola, C | 1 |
| Maggi, L | 1 |
| Branchi, I | 1 |
| Kuo, SF | 1 |
| Chuang, WY | 1 |
| Ng, S | 1 |
| Chen, CH | 1 |
| Chang, CN | 1 |
| Chou, CH | 1 |
| Weng, WC | 1 |
| Yeh, CH | 1 |
| Lin, JD | 1 |
| Biemans, E | 1 |
| Hart, HE | 1 |
| Rutten, GE | 1 |
| Cuellar Renteria, VG | 1 |
| Kooijman-Buiting, AM | 1 |
| Beulens, JW | 1 |
| Tschöpe, D | 1 |
| Bramlage, P | 1 |
| Schneider, S | 1 |
| Gitt, AK | 1 |
| Tu, HP | 1 |
| Lin, CH | 1 |
| Hsieh, HM | 1 |
| Jiang, HJ | 1 |
| Wang, PW | 1 |
| Huang, CJ | 1 |
| Aswar, U | 1 |
| Chepurwar, S | 1 |
| Shintre, S | 1 |
| Aswar, M | 1 |
9 other studies available for metformin and Depressive Disorder
| Article | Year |
|---|---|
Depression and antecedent medication adherence in a cohort of new metformin users.
Topics: Adult; Aged; Depressive Disorder; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Ma | 2021 |
Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats.
Topics: Animals; Ascorbic Acid; Biogenic Monoamines; Blood Glucose; Comorbidity; Corticosterone; Cytokines; | 2017 |
Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Corticosterone; Depression; Depressive D | 2019 |
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.
Topics: Anhedonia; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Drug Therapy | 2019 |
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent.
Topics: Adenoma; Adolescent; Adolescent Development; Antineoplastic Agents, Hormonal; Combined Modality Ther | 2013 |
Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin.
Topics: Adult; Aged; Cognition; Depressive Disorder; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Femal | 2015 |
Incidence, characteristics and impact of hypoglycaemia in patients receiving intensified treatment for inadequately controlled type 2 diabetes mellitus.
Topics: Aged; Amputation, Surgical; Angina, Stable; Asymptomatic Diseases; Blood Glucose; Depressive Disorde | 2016 |
Prevalence of anxiety disorder in patients with type 2 diabetes: a nationwide population-based study in Taiwan 2000-2010.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care; Anxiety Disorders; Cerebrovascular Dis | 2017 |
Telmisartan attenuates diabetes induced depression in rats.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depress | 2017 |