metformin has been researched along with Depression, Involutional in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conducted the present study to compare the antidepressant efficacy of pioglitazone with another insulin-sensitizer, metformin, in obese patients with concomitant polycystic ovarian syndrome (PCOS) and major depressive disorder (MDD)." | 9.17 | Does pioglitazone improve depression through insulin-sensitization? Results of a randomized double-blind metformin-controlled trial in patients with polycystic ovarian syndrome and comorbid depression. ( Akhondzadeh, S; Ashrafi, M; Farazmand, B; Kashani, L; Modabbernia, A; Omidvar, T; Ramzanzadeh, F; Tabrizi, M; Tehraninejad, ES, 2013) |
| " We conducted the present study to compare the antidepressant efficacy of pioglitazone with another insulin-sensitizer, metformin, in obese patients with concomitant polycystic ovarian syndrome (PCOS) and major depressive disorder (MDD)." | 5.17 | Does pioglitazone improve depression through insulin-sensitization? Results of a randomized double-blind metformin-controlled trial in patients with polycystic ovarian syndrome and comorbid depression. ( Akhondzadeh, S; Ashrafi, M; Farazmand, B; Kashani, L; Modabbernia, A; Omidvar, T; Ramzanzadeh, F; Tabrizi, M; Tehraninejad, ES, 2013) |
| "Metformin (MET) has been reported to have antidepressant effects in animal models and in diabetic patients with depression, owing to its anti-inflammatory, antioxidant, and neuroprotective activity." | 2.94 | The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial. ( Abdallah, MS; Ebeid, AM; Elattar, KS; Mosalam, EM; Ramadan, AN; Zaki, SA; Zidan, AA, 2020) |
| "Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most commonly prescribed drugs in the world." | 2.82 | Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders. ( Fei, E; Li, N; Zhou, T, 2022) |
| "Metformin has the potential effect of inducing hippocampal neurogenesis, and additional studies of this drug are warranted in patients with mood or cognitive disorders." | 2.49 | A "glucose eater" drug as a therapeutic agent in psychiatry. ( Howland, RH, 2013) |
| "The patient also had untreated Polycystic Ovarian Syndrome (PCOS)." | 2.41 | Common treatment of polycystic ovarian syndrome and major depressive disorder: case report and review. ( Bauer, M; Carter, MS; Elman, S; Korenman, SG; Love, M; Rasgon, NL, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Zhou, T | 1 |
| Fei, E | 1 |
| Abdallah, MS | 1 |
| Mosalam, EM | 1 |
| Zidan, AA | 1 |
| Elattar, KS | 1 |
| Zaki, SA | 1 |
| Ramadan, AN | 1 |
| Ebeid, AM | 1 |
| Howland, RH | 1 |
| Chen, R | 1 |
| Lopes, J | 1 |
| Kashani, L | 1 |
| Omidvar, T | 1 |
| Farazmand, B | 1 |
| Modabbernia, A | 1 |
| Ramzanzadeh, F | 1 |
| Tehraninejad, ES | 1 |
| Ashrafi, M | 1 |
| Tabrizi, M | 1 |
| Akhondzadeh, S | 1 |
| Rasgon, NL | 1 |
| Carter, MS | 1 |
| Elman, S | 1 |
| Bauer, M | 1 |
| Love, M | 1 |
| Korenman, SG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Antidiabetic Metformin as a Novel Adjunct to Antidepressants in Major Depressive Disorder Patients: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial[NCT04088448] | Phase 1/Phase 2 | 80 participants (Actual) | Interventional | 2017-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Depression, Involutional
| Article | Year |
|---|---|
Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders.
Topics: Brain; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2022 |
A "glucose eater" drug as a therapeutic agent in psychiatry.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Depressive Disorder, Major; Diabetes Mellitus, Typ | 2013 |
Common treatment of polycystic ovarian syndrome and major depressive disorder: case report and review.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Drug Therapy, Combinati | 2002 |
2 trials available for metformin and Depression, Involutional
| Article | Year |
|---|---|
The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Double-Blind Method; Female; F | 2020 |
Does pioglitazone improve depression through insulin-sensitization? Results of a randomized double-blind metformin-controlled trial in patients with polycystic ovarian syndrome and comorbid depression.
Topics: Adolescent; Adult; Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Double-Blind Metho | 2013 |
1 other study available for metformin and Depression, Involutional
| Article | Year |
|---|---|
Hyperglycaemia secondary to mirtazapine therapy in a 37-year-old man.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Drug Therapy, Combination; Glic | 2008 |