metformin has been researched along with Demyelinating Diseases in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using this preclinical murine demyelination model, we discover that application of metformin, an FDA-approved drug, in this model promotes oligodendrocyte regeneration and remyelination and improves the social interaction." | 1.56 | Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation. ( De Repentigny, Y; Gouveia, A; He, L; Ilin, J; Kosaraju, J; Kothary, R; Lagace, D; Lu, KJ; Sarma, SN; Seegobin, M; Syal, C; Wang, J; Wondisford, FE, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kosaraju, J | 1 |
| Seegobin, M | 1 |
| Gouveia, A | 1 |
| Syal, C | 1 |
| Sarma, SN | 1 |
| Lu, KJ | 1 |
| Ilin, J | 1 |
| He, L | 1 |
| Wondisford, FE | 1 |
| Lagace, D | 1 |
| De Repentigny, Y | 1 |
| Kothary, R | 1 |
| Wang, J | 1 |
| Largani, SHH | 1 |
| Borhani-Haghighi, M | 1 |
| Pasbakhsh, P | 1 |
| Mahabadi, VP | 1 |
| Nekoonam, S | 1 |
| Shiri, E | 1 |
| Kashani, IR | 1 |
| Zendehdel, A | 1 |
2 other studies available for metformin and Demyelinating Diseases
| Article | Year |
|---|---|
Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation.
Topics: Animals; Demyelinating Diseases; Female; Histone Acetyltransferases; Hypoglycemic Agents; Male; Metf | 2020 |
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Axons; Cuprizone; Demyelinating Diseases; Disease Mod | 2019 |