metformin has been researched along with Degenerative Disc Disease in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intervertebral disc degeneration (IVDD) is a complex process involving many factors, among which excessive senescence of nucleus pulposus cells is considered to be the main factor." | 1.72 | Metformin inactivates the cGAS-STING pathway through autophagy and suppresses senescence in nucleus pulposus cells. ( Jin, J; Li, C; Ren, C; Sun, L; Tian, N; Wu, Y; Xiang, J; Zhang, X; Zhou, Y, 2022) |
| "LDH evoked persistent thermal hyperalgesia and mechanical allodynia on the ipsilateral paw, as indicated by the decreased PWL and 50% PWT." | 1.51 | AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. ( Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y, 2019) |
| "Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence." | 1.43 | Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. ( Cai, N; Chen, D; Feng, Y; Pan, Z; Tang, Q; Tian, N; Wang, C; Wang, Q; Wang, X; Wu, Y; Xia, D; Xu, D; Xu, H; Yan, M; Zhang, JJ; Zhang, X; Zhou, K; Zhou, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, C | 1 |
| Jin, J | 1 |
| Li, C | 1 |
| Xiang, J | 1 |
| Wu, Y | 2 |
| Zhou, Y | 2 |
| Sun, L | 1 |
| Zhang, X | 2 |
| Tian, N | 2 |
| Han, Y | 1 |
| Yuan, F | 1 |
| Deng, C | 1 |
| He, F | 1 |
| Zhang, Y | 2 |
| Shen, H | 1 |
| Chen, Z | 1 |
| Qian, L | 1 |
| Liao, Z | 1 |
| Li, S | 1 |
| Lu, S | 1 |
| Liu, H | 1 |
| Li, G | 1 |
| Ma, L | 1 |
| Luo, R | 1 |
| Ke, W | 1 |
| Wang, B | 1 |
| Xiang, Q | 1 |
| Song, Y | 1 |
| Feng, X | 1 |
| Wu, X | 1 |
| Hua, W | 1 |
| Yang, C | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Li, H | 1 |
| Shang, Y | 1 |
| Guo, Y | 1 |
| Li, Z | 1 |
| Liu, Z | 1 |
| Chen, D | 1 |
| Xia, D | 1 |
| Pan, Z | 1 |
| Xu, D | 1 |
| Cai, N | 1 |
| Tang, Q | 1 |
| Wang, C | 1 |
| Yan, M | 1 |
| Zhang, JJ | 1 |
| Zhou, K | 1 |
| Wang, Q | 1 |
| Feng, Y | 1 |
| Wang, X | 1 |
| Xu, H | 1 |
5 other studies available for metformin and Degenerative Disc Disease
| Article | Year |
|---|---|
Metformin inactivates the cGAS-STING pathway through autophagy and suppresses senescence in nucleus pulposus cells.
Topics: Autophagy; Cellular Senescence; Humans; Intervertebral Disc Degeneration; Membrane Proteins; Metform | 2022 |
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.
Topics: Animals; Annulus Fibrosus; Anti-Inflammatory Agents; Cellular Senescence; HMGB1 Protein; Inflammatio | 2019 |
Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration.
Topics: Extracellular Vesicles; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Mesenchymal S | 2021 |
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inter | 2019 |
Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.
Topics: Adenine; Adenylate Kinase; Animals; Apoptosis; Autophagy; Cellular Senescence; Enzyme Activation; Fe | 2016 |