metformin has been researched along with Contracture in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Contracture: Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An immobilized rat model was used to determine whether metformin could inhibit myogenic contracture and myofibrosis." | 8.31 | Metformin reduces myogenic contracture and myofibrosis induced by rat knee joint immobilization via AMPK-mediated inhibition of TGF-β1/Smad signaling pathway. ( Li, DJ; Li, W; Wang, F; Zheng, Z; Zhou, CX; Zhou, Y, 2023) |
| " Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well." | 8.02 | Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021) |
| " Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well." | 4.02 | Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tokuda, K | 1 |
| Yamanaka, Y | 1 |
| Mano, Y | 1 |
| Tsukamoto, M | 1 |
| Tajima, T | 1 |
| Suzuki, H | 1 |
| Kawasaki, M | 1 |
| Uchida, S | 1 |
| Nakamura, E | 1 |
| Wang, KY | 1 |
| Sakai, A | 1 |
| Wang, F | 1 |
| Zhou, CX | 1 |
| Zheng, Z | 1 |
| Li, DJ | 1 |
| Li, W | 1 |
| Zhou, Y | 1 |
2 other studies available for metformin and Contracture
| Article | Year |
|---|---|
Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization.
Topics: Animals; Contracture; Disease Models, Animal; Fibrosis; Gene Expression; Immobilization; Immunohisto | 2021 |
Metformin reduces myogenic contracture and myofibrosis induced by rat knee joint immobilization via AMPK-mediated inhibition of TGF-β1/Smad signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Contracture; Knee Joint; Metformin; Rats; Signal Transductio | 2023 |