metformin has been researched along with Complications, Pregnancy in 99 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "s-PROK1 was analysed using ELISA at gestational week 19 and related to pregnancy complications, fasting insulin levels, homoeostatic model assessment for insulin resistance (HOMA-IR), testosterone, or androstenedione levels, metformin use, PCOS phenotype and hyperandrogenism." | 9.69 | Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials. ( Hirschberg, AL; Trouva, A; Ujvari, D; Vanky, E, 2023) |
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 9.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| " The TSH level was not affected by metformin, whereas fT4 was significantly higher in the metformin group with less decrease throughout pregnancy compared to placebo, p<0." | 9.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| " While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects on maternal androgen levels in pregnancy are less well understood." | 9.34 | Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus. ( Abbott, D; Andræ, F; Odsæter, IH; Salvesen, Ø; Schmedes, AV; Stridsklev, S; Vanky, E, 2020) |
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 9.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| " Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group." | 9.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "Metformin-exposed children had higher BMI and increased prevalence of overweight/obesity at 4 years of age." | 9.27 | Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs. ( Carlsen, SM; Hanem, LGE; Júlíusson, PB; Roelants, M; Salvesen, Ø; Stridsklev, S; Vanky, E; Ødegård, R, 2018) |
| "Worldwide, metformin is prescribed to improve pregnancy outcome in polycystic ovary syndrome (PCOS)." | 9.27 | Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS? ( Andersen, MS; Høgetveit, K; Oppen, IH; Stridsklev, S; Underdal, MO; Vanky, E, 2018) |
| "The results of this trial will inform endocrinologists, obstetricians, family doctors, and other healthcare professionals caring for women with type 2 diabetes in pregnancy, as to the benefits of adding metformin to insulin in this high risk population." | 9.22 | Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial. ( Armson, AB; Asztalos, E; Barrett, JF; Fantus, IG; Feig, DS; Lipscombe, LL; Murphy, K; Ohlsson, A; Ryan, EA; Sanchez, J; Tomlinson, G; Zinman, B, 2016) |
| "To assess the effect of metformin and to compare it with insulin treatment in patients with type 2 diabetes in pregnancy in terms of perinatal outcome, maternal complications, additional insulin requirement, and treatment acceptability." | 9.20 | Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy. ( Ainuddin, JA; Ali, SS; Hasan, AA; Karim, N; Zaheer, S, 2015) |
| "Metformin is used to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS), although it is not approved for this indication and solid evidence is lacking." | 9.19 | Midpregnancy Doppler ultrasound of the uterine artery in metformin- versus placebo-treated PCOS women: a randomized trial. ( Carlsen, SM; Clemens, I; Salvesen, Ø; Stridsklev, S; Vanky, E, 2014) |
| "Metformin is suggested to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS)." | 9.19 | Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: data from a randomized controlled study on metformin. ( Carlsen, SM; Helseth, R; Stridsklev, S; Vanky, E; Vogt, C, 2014) |
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 9.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "To study the significance of breast size increment in pregnancy, and the impact of metformin during pregnancy on breastfeeding in women with polycystic ovary syndrome (PCOS)." | 9.16 | Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo. ( Carlsen, SM; Hjorth-Hansen, AK; Leithe, H; Martinussen, M; Nordskar, JJ; Vanky, E, 2012) |
| "The impact of metformin medication in pregnant women with polycystic ovary syndrome on weight gain during pregnancy and after delivery and the impact on growth of the offspring are essentially unexplored." | 9.16 | Metformin's effect on first-year weight gain: a follow-up study. ( Carlsen, SM; Martinussen, MP; Vanky, E, 2012) |
| "To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome." | 9.15 | The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. ( De Leo, V; Di Sabatino, A; Morgante, G; Musacchio, MC; Piomboni, P, 2011) |
| "Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt to reduce pregnancy complications." | 9.14 | Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. ( Almås, I; Berg, AH; Berg, KF; Bjerke, C; Bunford, G; Carlsen, SM; Danielson, A; Eikeland, T; Flo, K; Heimstad, R; Hjelle, S; Kleggetveit, O; Lahmami, G; Lund, A; Romundstad, P; Skogøy, K; Stridsklev, S; Vanky, E; von Brandis, P, 2010) |
| "In women with polycystic ovary syndrome, C-reactive protein levels and D-dimer, antithrombin III, activated protein C resistance, and activated partial thromboplastin time were unaffected by metformin treatment throughout pregnancy." | 9.12 | Beneficial effect of metformin on pregnancy outcome in women with polycystic ovary syndrome is not associated with major changes in C-reactive protein levels or indices of coagulation. ( Bjerve, K; Carlsen, SM; Hjorth-Hansen, H; Salvesen, KA; Vanky, E, 2006) |
| "We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months." | 9.12 | Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. ( Barnhart, HX; Carr, BR; Carson, SA; Cataldo, NA; Coutifaris, C; Diamond, MP; Giudice, LC; Gosman, GG; Legro, RS; Leppert, PC; McGovern, PG; Myers, ER; Nestler, JE; Schlaff, WD; Steinkampf, MP, 2007) |
| "Forty pregnant women with polycystic ovary syndrome (PCOS) were enrolled in a randomized, double-blind, placebo-controlled trial of metformin (1700 mg/day) during pregnancy." | 9.12 | Metformin treatment in pregnant women with polycystic ovary syndrome--is reduced complication rate mediated by changes in the uteroplacental circulation? ( Carlsen, SM; Salvesen, KA; Vanky, E, 2007) |
| "Serum homocysteine levels were unaffected by metformin treatment both in nonpregnant and pregnant women with polycystic ovary syndrome." | 9.12 | Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome. ( Carlsen, SM; Kjøtrød, S; Romundstad, P; Vanky, E, 2007) |
| "In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 +/- 4 years) with polycystic ovary syndrome (PCOS), we examined effects of metformin on maternal insulin, insulin resistance (IR), insulin secretion (IS), weight gain, development of gestational diabetes (GD), testosterone and plasminogen activator inhibitor activity." | 9.11 | Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg ( Glueck, CJ; Goldenberg, N; Loftspring, M; Sherman, A; Wang, P, 2004) |
| "We prospectively assessed growth and motor-social development during the first 18 months of life in 126 live births (122 pregnancies) to 109 women with polycystic ovary syndrome (PCOS) who conceived on and continued metformin (1." | 9.11 | Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. ( Glueck, CJ; Goldenberg, N; Loftspring, M; Pranikoff, J; Sieve, L; Wang, P, 2004) |
| "Investigation of a possible effect of metformin on androgen levels in pregnant women with polycystic ovary syndrome (PCOS)." | 9.11 | Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. ( Carlsen, SM; Fougner, KJ; Heimstad, R; Romundstad, P; Salvesen, KA; Vanky, E, 2004) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 8.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS)." | 8.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| "Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women." | 8.90 | The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). ( Nathan, N; Sullivan, SD, 2014) |
| "The role of metformin in the treatment of pregnant women with polycystic ovary syndrome (PCOS) is controversial." | 8.89 | The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials. ( Gu, W; Shan, PF; Zheng, J, 2013) |
| "Metformin is an effective oral anti-hyperglycemic agent that is widely used to manage diabetes mellitus type 2 in the general population and more recently, in pregnancy." | 8.89 | Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. ( Goulis, DG; Lautatzis, ME; Vrontakis, M, 2013) |
| "To describe the first reported cases of two women with polycystic ovary syndrome (PCOS) desirous of pregnancy who conceived trichorionic pregnancies following ovulation induction with metformin alone and metformin plus clomiphene." | 8.83 | Higher-order multiple pregnancy associated with metformin in women with polycystic ovary syndrome: two cases and review of the literature. ( Boothroyd, C; Yazdani, A, 2006) |
| " Metformin appears to reduce these risks in mothers with polycystic ovary syndrome and their children; but may increase the risk of childhood-obesity in children form women without PCOS." | 8.12 | Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. ( Brusselaers, N; Crisosto, N; Cruz, G; Engstrand, L; Fornes, R; Nguyen, MH; Simin, J; van der Schaaf, M, 2022) |
| "We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during the first trimester for different indications relative to a matched unexposed reference group." | 7.88 | Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services. ( Amar, E; Baud, D; Beau-Salinas, F; Bernard, N; Buclin, T; Cassina, M; Csajka, C; Dautriche, A; De Santis, M; Duman, MK; Dunstan, H; Eleftheriou, G; Hernandez-Diaz, S; Kaplan, YC; Klinger, G; Maňáková, E; Panchaud, A; Passier, A; Pistelli, A; Rothuizen, LE; Rousson, V; Vial, T; Winterfeld, U, 2018) |
| "The initiation of metformin in early pregnancy in Gestational Diabetes mellitus (GDM) remains controversial." | 7.88 | How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India. ( Asha, HS; Dasgupta, R; Gupta, V; Mathews, JE; Paul, T; Ramachandran, R; Regi, A; Thomas, N; Visalakshi, P, 2018) |
| "This study aimed to assess the perinatal outcome, especially foetal growth, following the continuation of metformin during the first trimester of pregnancy." | 7.75 | Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity. ( Bolton, S; Cleary, B; Dempsey, E; Turner, MJ; Walsh, J, 2009) |
| "In women with PCOS, continuous use of metformin during pregnancy significantly reduced the rate of miscarriage, gestational diabetes requiring insulin treatment and fetal growth restriction." | 7.74 | Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome? ( Khalid, R; Naru, T; Nawaz, FH; Rizvi, J, 2008) |
| "Metformin-associated lactic acidosis is a rare but serious condition and potentially even more hazardous during pregnancy." | 7.74 | Metformin-associated lactic acidosis in a pregnant patient. ( Chen, IC; Hong, YC; Hsiao, CT; Kuan, JT; O'Boyle, CP, 2008) |
| "The pharmacokinetic disposition of metformin in late pregnancy was studied together with the level of fetal exposure at birth." | 7.73 | Population pharmacokinetics of metformin in late pregnancy. ( Charles, B; Hague, W; Norris, R; Xiao, X, 2006) |
| "A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility before her pregnancy, is safe for her fetus." | 7.73 | Metformin use during the first trimester of pregnancy. Is it safe? ( Gilbert, C; Koren, G; Valois, M, 2006) |
| "To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin." | 7.73 | Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. ( Jackson, EM; Thatcher, SS, 2006) |
| "55 g metformin per day throughout pregnancy and lactation." | 7.73 | Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. ( Glueck, CJ; Salehi, M; Sieve, L; Wang, P, 2006) |
| "The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls." | 7.73 | Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy. ( Glezerman, M; Gur, D; Kovo, M; Levran, D; Rotmensch, S; Weissman, A, 2006) |
| "We sought to determine whether metformin, which had facilitated conception in 72 oligoamenorrhoeic women with polycystic ovary syndrome (PCOS), would safely reduce the rate of first trimester spontaneous abortion (SAB) and increase the number of live births without teratogenicity." | 7.71 | Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. ( Glueck, CJ; Goldenberg, N; Sieve-Smith, L; Wang, P, 2002) |
| "Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus." | 6.45 | Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. ( Falbo, A; Orio, F; Palomba, S; Zullo, F, 2009) |
| "s-PROK1 was analysed using ELISA at gestational week 19 and related to pregnancy complications, fasting insulin levels, homoeostatic model assessment for insulin resistance (HOMA-IR), testosterone, or androstenedione levels, metformin use, PCOS phenotype and hyperandrogenism." | 5.69 | Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials. ( Hirschberg, AL; Trouva, A; Ujvari, D; Vanky, E, 2023) |
| "Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications." | 5.51 | Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study. ( Ebbing, C; Grindheim, S; Karlsen, HO; Kessler, J; Lønnebotn, M; Løvvik, T; Real, FG; Skulstad, SM; Vanky, E, 2022) |
| "Our study assesses perinatal outcomes among women with type 2 diabetes, with gestational weight gain (GWG) within and outside of US Institute of Medicine (IOM) guidelines, by conducting a secondary analysis of the Metformin in Type 2 Diabetes in Pregnancy (MiTy) trial." | 5.51 | Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial. ( Feig, DS; Fu, J; Tomlinson, G, 2022) |
| " The TSH level was not affected by metformin, whereas fT4 was significantly higher in the metformin group with less decrease throughout pregnancy compared to placebo, p<0." | 5.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| "An 8-year clinical follow-up study including self-reported asthma diagnoses and spirometry of women with PCOS randomized to metformin or placebo during pregnancy in the original studies (the Pilot and the PregMet-study), compared with matched controls from a population-based cohort study (The HUNT Study)." | 5.34 | Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study. ( Andersen, M; Henriksen, AH; Salvesen, Ø; Underdal, MO; Vanky, E, 2020) |
| " While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects on maternal androgen levels in pregnancy are less well understood." | 5.34 | Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus. ( Abbott, D; Andræ, F; Odsæter, IH; Salvesen, Ø; Schmedes, AV; Stridsklev, S; Vanky, E, 2020) |
| "The addition of metformin to dietary and lifestyle advice in pregnancy for overweight and obese women has no clinically relevant effect on ultrasound measures of fetal biometry or adiposity." | 5.34 | Effect of metformin in addition to an antenatal diet and lifestyle intervention on fetal growth and adiposity: the GRoW randomised trial. ( Deussen, AR; Dodd, JM; Louise, J; Poprzeczny, AJ, 2020) |
| "Polycystic ovary syndrome is the most common form of female infertility in the United States." | 5.31 | Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. ( Iuorno, MJ; Jakubowicz, DJ; Jakubowicz, S; Nestler, JE; Roberts, KA, 2002) |
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 5.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| "Metformin is increasingly used to treat gestational diabetes and type 2 diabetes in pregnancy, and in attempts to improve pregnancy outcomes in polycystic ovary syndrome and obesity." | 5.30 | Intrauterine metformin exposure and offspring cardiometabolic risk factors (PedMet study): a 5-10 year follow-up of the PregMet randomised controlled trial. ( Carlsen, SM; Hanem, LGE; Juliusson, PB; Nossum, MCF; Salvesen, Ø; Vaage, MØ; Vanky, E; Ødegård, R, 2019) |
| " Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group." | 5.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "Metformin is used in an attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS)." | 5.27 | Fetal Growth and Birth Anthropometrics in Metformin-Exposed Offspring Born to Mothers With PCOS. ( Eggebø, T; Engen Hanem, LG; Hjorth-Hansen, A; Salvesen, KÅ; Salvesen, Ø; Vanky, E; Ødegård, R, 2018) |
| "Metformin-exposed children had higher BMI and increased prevalence of overweight/obesity at 4 years of age." | 5.27 | Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs. ( Carlsen, SM; Hanem, LGE; Júlíusson, PB; Roelants, M; Salvesen, Ø; Stridsklev, S; Vanky, E; Ødegård, R, 2018) |
| "Worldwide, metformin is prescribed to improve pregnancy outcome in polycystic ovary syndrome (PCOS)." | 5.27 | Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS? ( Andersen, MS; Høgetveit, K; Oppen, IH; Stridsklev, S; Underdal, MO; Vanky, E, 2018) |
| "Among women without diabetes who had a BMI of more than 35, the antenatal administration of metformin reduced maternal weight gain but not neonatal birth weight." | 5.22 | Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus. ( Akolekar, R; Balani, J; Hyer, S; Kotecha, R; Nicolaides, KH; Pastides, A; Shehata, H; Syngelaki, A, 2016) |
| "The results of this trial will inform endocrinologists, obstetricians, family doctors, and other healthcare professionals caring for women with type 2 diabetes in pregnancy, as to the benefits of adding metformin to insulin in this high risk population." | 5.22 | Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial. ( Armson, AB; Asztalos, E; Barrett, JF; Fantus, IG; Feig, DS; Lipscombe, LL; Murphy, K; Ohlsson, A; Ryan, EA; Sanchez, J; Tomlinson, G; Zinman, B, 2016) |
| " We present a protocol for a study to test the hypothesis that metformin will improve insulin sensitivity in obese pregnant women, thereby reducing the incidence of high birthweight babies and other pregnancy complications." | 5.20 | Efficacy of metformin in pregnant obese women: a randomised controlled trial. ( Chiswick, CA; Denison, FC; Drake, AJ; Forbes, S; Murray, GD; Newby, DE; Norman, JE; Quenby, S; Reynolds, RM; Walker, BR; Whyte, SA; Wray, S, 2015) |
| "To assess the effect of metformin and to compare it with insulin treatment in patients with type 2 diabetes in pregnancy in terms of perinatal outcome, maternal complications, additional insulin requirement, and treatment acceptability." | 5.20 | Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy. ( Ainuddin, JA; Ali, SS; Hasan, AA; Karim, N; Zaheer, S, 2015) |
| "Metformin is used to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS), although it is not approved for this indication and solid evidence is lacking." | 5.19 | Midpregnancy Doppler ultrasound of the uterine artery in metformin- versus placebo-treated PCOS women: a randomized trial. ( Carlsen, SM; Clemens, I; Salvesen, Ø; Stridsklev, S; Vanky, E, 2014) |
| "Metformin is suggested to reduce pregnancy complications in women with polycystic ovary syndrome (PCOS)." | 5.19 | Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: data from a randomized controlled study on metformin. ( Carlsen, SM; Helseth, R; Stridsklev, S; Vanky, E; Vogt, C, 2014) |
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 5.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "To estimate whether progestin-induced endometrial shedding, before ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCOS)." | 5.16 | Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. ( Brzyski, R; Carr, BR; Carson, S; Casson, P; Cataldo, NA; Christman, G; Coutifaris, C; Diamond, MP; Eisenberg, E; Gosman, GG; Kruger, M; Legro, RS; McGovern, PG; Myers, EE; Nestler, JE; Santoro, N; Schlaff, W; Steinkampf, MP; Zhang, H, 2012) |
| "To study the significance of breast size increment in pregnancy, and the impact of metformin during pregnancy on breastfeeding in women with polycystic ovary syndrome (PCOS)." | 5.16 | Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo. ( Carlsen, SM; Hjorth-Hansen, AK; Leithe, H; Martinussen, M; Nordskar, JJ; Vanky, E, 2012) |
| "The impact of metformin medication in pregnant women with polycystic ovary syndrome on weight gain during pregnancy and after delivery and the impact on growth of the offspring are essentially unexplored." | 5.16 | Metformin's effect on first-year weight gain: a follow-up study. ( Carlsen, SM; Martinussen, MP; Vanky, E, 2012) |
| "To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome." | 5.15 | The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. ( De Leo, V; Di Sabatino, A; Morgante, G; Musacchio, MC; Piomboni, P, 2011) |
| "Metformin is widely prescribed to pregnant women with polycystic ovary syndrome (PCOS) in an attempt to reduce pregnancy complications." | 5.14 | Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. ( Almås, I; Berg, AH; Berg, KF; Bjerke, C; Bunford, G; Carlsen, SM; Danielson, A; Eikeland, T; Flo, K; Heimstad, R; Hjelle, S; Kleggetveit, O; Lahmami, G; Lund, A; Romundstad, P; Skogøy, K; Stridsklev, S; Vanky, E; von Brandis, P, 2010) |
| "In women with polycystic ovary syndrome, C-reactive protein levels and D-dimer, antithrombin III, activated protein C resistance, and activated partial thromboplastin time were unaffected by metformin treatment throughout pregnancy." | 5.12 | Beneficial effect of metformin on pregnancy outcome in women with polycystic ovary syndrome is not associated with major changes in C-reactive protein levels or indices of coagulation. ( Bjerve, K; Carlsen, SM; Hjorth-Hansen, H; Salvesen, KA; Vanky, E, 2006) |
| "We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months." | 5.12 | Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. ( Barnhart, HX; Carr, BR; Carson, SA; Cataldo, NA; Coutifaris, C; Diamond, MP; Giudice, LC; Gosman, GG; Legro, RS; Leppert, PC; McGovern, PG; Myers, ER; Nestler, JE; Schlaff, WD; Steinkampf, MP, 2007) |
| "Forty pregnant women with polycystic ovary syndrome (PCOS) were enrolled in a randomized, double-blind, placebo-controlled trial of metformin (1700 mg/day) during pregnancy." | 5.12 | Metformin treatment in pregnant women with polycystic ovary syndrome--is reduced complication rate mediated by changes in the uteroplacental circulation? ( Carlsen, SM; Salvesen, KA; Vanky, E, 2007) |
| "Serum homocysteine levels were unaffected by metformin treatment both in nonpregnant and pregnant women with polycystic ovary syndrome." | 5.12 | Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome. ( Carlsen, SM; Kjøtrød, S; Romundstad, P; Vanky, E, 2007) |
| "In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 +/- 4 years) with polycystic ovary syndrome (PCOS), we examined effects of metformin on maternal insulin, insulin resistance (IR), insulin secretion (IS), weight gain, development of gestational diabetes (GD), testosterone and plasminogen activator inhibitor activity." | 5.11 | Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg ( Glueck, CJ; Goldenberg, N; Loftspring, M; Sherman, A; Wang, P, 2004) |
| "We prospectively assessed growth and motor-social development during the first 18 months of life in 126 live births (122 pregnancies) to 109 women with polycystic ovary syndrome (PCOS) who conceived on and continued metformin (1." | 5.11 | Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. ( Glueck, CJ; Goldenberg, N; Loftspring, M; Pranikoff, J; Sieve, L; Wang, P, 2004) |
| "Investigation of a possible effect of metformin on androgen levels in pregnant women with polycystic ovary syndrome (PCOS)." | 5.11 | Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. ( Carlsen, SM; Fougner, KJ; Heimstad, R; Romundstad, P; Salvesen, KA; Vanky, E, 2004) |
| " Metformin is an effective oral antihyperglycaemic agent that is considered to be effective during pregnancy." | 5.01 | Metformin reduces maternal weight gain in obese pregnant women: A systematic review and meta-analysis of two randomized controlled trials. ( Benedetti Panici, P; Boccherini, C; Brunelli, R; D'Ambrosio, V; Di Mascio, D; Giancotti, A; Marchetti, C; Piccioni, MG; Vena, F, 2019) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 4.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS)." | 4.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| "Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women." | 4.90 | The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). ( Nathan, N; Sullivan, SD, 2014) |
| "The role of metformin in the treatment of pregnant women with polycystic ovary syndrome (PCOS) is controversial." | 4.89 | The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials. ( Gu, W; Shan, PF; Zheng, J, 2013) |
| "Metformin is an effective oral anti-hyperglycemic agent that is widely used to manage diabetes mellitus type 2 in the general population and more recently, in pregnancy." | 4.89 | Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. ( Goulis, DG; Lautatzis, ME; Vrontakis, M, 2013) |
| "Metformin is a widely used and extensively studied insulin sensitising drug for the treatment of women with polycystic ovary syndrome (PCOS), with various actions in tissues responding to insulin that include the liver, skeletal muscle, adipose tissue, the endothelium of blood vessels, and the ovaries." | 4.88 | Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin. ( Hodges, P; Randeva, HS; Tan, BK; Weickert, MO, 2012) |
| "To describe the first reported cases of two women with polycystic ovary syndrome (PCOS) desirous of pregnancy who conceived trichorionic pregnancies following ovulation induction with metformin alone and metformin plus clomiphene." | 4.83 | Higher-order multiple pregnancy associated with metformin in women with polycystic ovary syndrome: two cases and review of the literature. ( Boothroyd, C; Yazdani, A, 2006) |
| " Metformin appears to reduce these risks in mothers with polycystic ovary syndrome and their children; but may increase the risk of childhood-obesity in children form women without PCOS." | 4.12 | Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. ( Brusselaers, N; Crisosto, N; Cruz, G; Engstrand, L; Fornes, R; Nguyen, MH; Simin, J; van der Schaaf, M, 2022) |
| "We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during the first trimester for different indications relative to a matched unexposed reference group." | 3.88 | Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services. ( Amar, E; Baud, D; Beau-Salinas, F; Bernard, N; Buclin, T; Cassina, M; Csajka, C; Dautriche, A; De Santis, M; Duman, MK; Dunstan, H; Eleftheriou, G; Hernandez-Diaz, S; Kaplan, YC; Klinger, G; Maňáková, E; Panchaud, A; Passier, A; Pistelli, A; Rothuizen, LE; Rousson, V; Vial, T; Winterfeld, U, 2018) |
| "The initiation of metformin in early pregnancy in Gestational Diabetes mellitus (GDM) remains controversial." | 3.88 | How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India. ( Asha, HS; Dasgupta, R; Gupta, V; Mathews, JE; Paul, T; Ramachandran, R; Regi, A; Thomas, N; Visalakshi, P, 2018) |
| " Using metformin during pregnancy and nursing to improve the metabolic status of obese mothers could prevent the sequence of events that lead to an increase in postnatal serum estradiol levels in female offspring and, hence, reproductive dysfunction." | 3.88 | Prenatal metformin treatment improves ovarian function in offspring of obese rats. ( Álvarez, D; Ceballo, K; Cruz, G; Fernandois, D; Maliqueo, M; Martinez-Pinto, J; Olguín, S; Sotomayor-Zárate, R, 2018) |
| "To evaluate retrospectively the prevalence of gestational diabetes (GD) in pregnancies obtained with myo-inositol administration in women with polycystic ovary syndrome." | 3.78 | Myo-inositol may prevent gestational diabetes in PCOS women. ( Corrado, F; D'Anna, R; Di Benedetto, A; Di Benedetto, V; Interdonato, ML; Raffone, E; Rizzo, P, 2012) |
| "This study aimed to assess the perinatal outcome, especially foetal growth, following the continuation of metformin during the first trimester of pregnancy." | 3.75 | Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity. ( Bolton, S; Cleary, B; Dempsey, E; Turner, MJ; Walsh, J, 2009) |
| "To date, among insulin-sensitizing drugs, only metformin should be used to improve reproductive function in well selected polycystic ovary syndrome patients." | 3.74 | Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients. ( Falbo, A; Orio, F; Palomba, S; Zullo, F, 2008) |
| "In women with PCOS, continuous use of metformin during pregnancy significantly reduced the rate of miscarriage, gestational diabetes requiring insulin treatment and fetal growth restriction." | 3.74 | Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome? ( Khalid, R; Naru, T; Nawaz, FH; Rizvi, J, 2008) |
| " There is no evidence-based schema for achieving pregnancy in women with PCOS, though lifestyle modification, clomiphene citrate, and metformin are the current front line therapies." | 3.74 | Pregnancy considerations in women with polycystic ovary syndrome. ( Legro, RS, 2007) |
| "Metformin-associated lactic acidosis is a rare but serious condition and potentially even more hazardous during pregnancy." | 3.74 | Metformin-associated lactic acidosis in a pregnant patient. ( Chen, IC; Hong, YC; Hsiao, CT; Kuan, JT; O'Boyle, CP, 2008) |
| "The pharmacokinetic disposition of metformin in late pregnancy was studied together with the level of fetal exposure at birth." | 3.73 | Population pharmacokinetics of metformin in late pregnancy. ( Charles, B; Hague, W; Norris, R; Xiao, X, 2006) |
| "A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility before her pregnancy, is safe for her fetus." | 3.73 | Metformin use during the first trimester of pregnancy. Is it safe? ( Gilbert, C; Koren, G; Valois, M, 2006) |
| "To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin." | 3.73 | Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. ( Jackson, EM; Thatcher, SS, 2006) |
| "55 g metformin per day throughout pregnancy and lactation." | 3.73 | Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. ( Glueck, CJ; Salehi, M; Sieve, L; Wang, P, 2006) |
| "The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls." | 3.73 | Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy. ( Glezerman, M; Gur, D; Kovo, M; Levran, D; Rotmensch, S; Weissman, A, 2006) |
| "We sought to determine whether metformin, which had facilitated conception in 72 oligoamenorrhoeic women with polycystic ovary syndrome (PCOS), would safely reduce the rate of first trimester spontaneous abortion (SAB) and increase the number of live births without teratogenicity." | 3.71 | Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. ( Glueck, CJ; Goldenberg, N; Sieve-Smith, L; Wang, P, 2002) |
| "Even normal pregnancy is characterized by relative insulin resistance and glucose intolerance." | 3.01 | Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial. ( Hong, JGS; Kamarudin, M; Omar, SZ; Tan, PC, 2021) |
| "Metformin has no significant effect on birthweight percentile in obese pregnant women." | 2.80 | Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. ( Chiswick, C; Denison, F; Drake, AJ; Forbes, S; Lashen, H; Murray, G; Newby, DE; Norman, JE; Quenby, S; Reynolds, RM; Rodriguez, A; Walker, BR; Weeks, A; Whyte, S; Wray, S, 2015) |
| "Hidradenitis suppurativa is a debilitating inflammatory skin disease with a chronic course and often disappointing response to treatment." | 2.55 | Management of hidradenitis suppurativa in pregnancy. ( Okoye, GA; Perng, P; Zampella, JG, 2017) |
| "The primary aims of the treatment of gestational diabetes (GDM) are to prevent macrosomia and pregnancy complications." | 2.53 | Is it worth treating gestational diabetes: if so, when and how? ( Vääräsmäki, M, 2016) |
| "Maternal obesity is associated with adverse perinatal outcome." | 2.52 | Placental dysfunction in obese women and antenatal surveillance strategies. ( Doshani, A; Jeve, YB; Konje, JC, 2015) |
| "Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus." | 2.45 | Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. ( Falbo, A; Orio, F; Palomba, S; Zullo, F, 2009) |
| "Polycystic ovarian syndrome is the commonest endocrine disorder of reproductive-age women." | 2.44 | Polycystic ovarian syndrome--prognosis and treatment outcomes. ( Hart, R, 2007) |
| " Evidence for the long-term use of metformin to protect against adverse cardiovascular outcomes and for the use of metformin throughout pregnancy to reduce the risk of miscarriage, gestational diabetes, pre-eclampsia and fetal macrosomia is still lacking." | 2.43 | Polycystic ovarian syndrome--prognosis and outcomes. ( Hart, R; Norman, R, 2006) |
| "Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy." | 1.62 | Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria. ( Brownfoot, F; Cannon, P; Cruickshank, T; Garcha, D; Hannan, NJ; Hyett, J; Illanes, SE; Jellins, J; Kaitu'u-Lino, TJ; Kandel, M; Keenan, E; MacDonald, TM; Masci, J; Middleton, A; Murphy, C; Murray, E; Myers, J; Nguyen, TV; Nien, JK; Pell, G; Pritchard, N; Roddy Mitchell, A; Schepeler, M; Tong, S; Walker, SP; Whigham, CA; Wong, GP, 2021) |
| "In her fifth pregnancy, treatment for gestational diabetes mellitus with metformin was associated with a lowering effect on bile acids and liver enzymes, indicating a possible role for metformin in the management of obstetric cholestasis." | 1.43 | Managing Recurring Obstetric Cholestasis With Metformin. ( Ali, A; Elfituri, A; Shehata, H, 2016) |
| "Polycystic ovary syndrome is the most common form of female infertility in the United States." | 1.31 | Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. ( Iuorno, MJ; Jakubowicz, DJ; Jakubowicz, S; Nestler, JE; Roberts, KA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 36 (36.36) | 29.6817 |
| 2010's | 52 (52.53) | 24.3611 |
| 2020's | 11 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Grindheim, S | 1 |
| Ebbing, C | 1 |
| Karlsen, HO | 1 |
| Skulstad, SM | 1 |
| Real, FG | 1 |
| Lønnebotn, M | 2 |
| Løvvik, T | 1 |
| Vanky, E | 21 |
| Kessler, J | 1 |
| Fornes, R | 1 |
| Simin, J | 1 |
| Nguyen, MH | 1 |
| Cruz, G | 2 |
| Crisosto, N | 1 |
| van der Schaaf, M | 1 |
| Engstrand, L | 1 |
| Brusselaers, N | 1 |
| Fu, J | 1 |
| Tomlinson, G | 2 |
| Feig, DS | 2 |
| Trouva, A | 3 |
| Alvarsson, M | 1 |
| Calissendorff, J | 1 |
| Åsvold, BO | 1 |
| Hirschberg, AL | 3 |
| Ujvari, D | 1 |
| Underdal, MO | 3 |
| Salvesen, Ø | 8 |
| Henriksen, AH | 1 |
| Andersen, M | 1 |
| Andræ, F | 2 |
| Abbott, D | 1 |
| Stridsklev, S | 6 |
| Schmedes, AV | 1 |
| Odsæter, IH | 1 |
| Poprzeczny, AJ | 1 |
| Louise, J | 2 |
| Deussen, AR | 2 |
| Dodd, JM | 2 |
| Hong, JGS | 1 |
| Tan, PC | 1 |
| Kamarudin, M | 1 |
| Omar, SZ | 1 |
| Noh, Y | 1 |
| Choe, SA | 1 |
| Shin, JY | 1 |
| Garcha, D | 1 |
| Walker, SP | 1 |
| MacDonald, TM | 1 |
| Hyett, J | 1 |
| Jellins, J | 1 |
| Myers, J | 1 |
| Illanes, SE | 1 |
| Nien, JK | 1 |
| Schepeler, M | 1 |
| Keenan, E | 1 |
| Whigham, CA | 1 |
| Cannon, P | 1 |
| Murray, E | 1 |
| Nguyen, TV | 1 |
| Kandel, M | 1 |
| Masci, J | 1 |
| Murphy, C | 1 |
| Cruickshank, T | 1 |
| Pritchard, N | 1 |
| Hannan, NJ | 1 |
| Brownfoot, F | 1 |
| Roddy Mitchell, A | 1 |
| Middleton, A | 1 |
| Pell, G | 1 |
| Wong, GP | 1 |
| Tong, S | 1 |
| Kaitu'u-Lino, TJ | 1 |
| Hjorth-Hansen, A | 1 |
| Engen Hanem, LG | 1 |
| Eggebø, T | 1 |
| Salvesen, KÅ | 4 |
| Ødegård, R | 3 |
| Panchaud, A | 1 |
| Rousson, V | 1 |
| Vial, T | 1 |
| Bernard, N | 1 |
| Baud, D | 1 |
| Amar, E | 1 |
| De Santis, M | 1 |
| Pistelli, A | 1 |
| Dautriche, A | 1 |
| Beau-Salinas, F | 1 |
| Cassina, M | 1 |
| Dunstan, H | 1 |
| Passier, A | 1 |
| Kaplan, YC | 1 |
| Duman, MK | 1 |
| Maňáková, E | 1 |
| Eleftheriou, G | 1 |
| Klinger, G | 1 |
| Winterfeld, U | 1 |
| Rothuizen, LE | 1 |
| Buclin, T | 1 |
| Csajka, C | 1 |
| Hernandez-Diaz, S | 1 |
| Dasgupta, R | 1 |
| Ramachandran, R | 1 |
| Mathews, JE | 1 |
| Regi, A | 1 |
| Thomas, N | 2 |
| Gupta, V | 1 |
| Visalakshi, P | 1 |
| Asha, HS | 1 |
| Paul, T | 1 |
| Hanem, LGE | 2 |
| Júlíusson, PB | 2 |
| Roelants, M | 1 |
| Carlsen, SM | 13 |
| Oppen, IH | 1 |
| Høgetveit, K | 1 |
| Andersen, MS | 2 |
| Nicodemus, NA | 1 |
| Paschou, SA | 1 |
| Wolffenbuttel, BHR | 1 |
| Nankervis, A | 1 |
| Price, S | 1 |
| Conn, J | 1 |
| Álvarez, D | 1 |
| Ceballo, K | 1 |
| Olguín, S | 1 |
| Martinez-Pinto, J | 1 |
| Maliqueo, M | 1 |
| Fernandois, D | 1 |
| Sotomayor-Zárate, R | 1 |
| Grivell, RM | 1 |
| Dekker, G | 1 |
| McPhee, AJ | 1 |
| Hague, W | 2 |
| Nossum, MCF | 1 |
| Vaage, MØ | 1 |
| Løvvik, TS | 1 |
| Steffensen, B | 1 |
| Bixo, M | 1 |
| Gómez-Real, F | 1 |
| Hestvold, KV | 1 |
| Zabielska, R | 1 |
| Thorarinsdottir, S | 1 |
| Hjelle, S | 2 |
| Berg, AH | 2 |
| Poromaa, IS | 1 |
| Mohlin, J | 1 |
| Underdal, M | 1 |
| Jainchill, AL | 1 |
| Gawrys, BL | 1 |
| Arnold, JJ | 1 |
| D'Ambrosio, V | 1 |
| Brunelli, R | 1 |
| Vena, F | 1 |
| Di Mascio, D | 1 |
| Marchetti, C | 1 |
| Boccherini, C | 1 |
| Piccioni, MG | 1 |
| Benedetti Panici, P | 1 |
| Giancotti, A | 1 |
| Schmedes, A | 1 |
| McIntyre, HD | 1 |
| Catalano, P | 1 |
| Zhang, C | 1 |
| Desoye, G | 1 |
| Mathiesen, ER | 2 |
| Damm, P | 1 |
| Gatford, KL | 1 |
| Houda, CM | 1 |
| Lu, ZX | 1 |
| Coat, S | 1 |
| Baghurst, PA | 1 |
| Owens, JA | 1 |
| Sikaris, K | 1 |
| Rowan, JA | 2 |
| Hague, WM | 1 |
| Zheng, J | 1 |
| Shan, PF | 1 |
| Gu, W | 1 |
| Lautatzis, ME | 1 |
| Goulis, DG | 1 |
| Vrontakis, M | 1 |
| Clemens, I | 1 |
| Helseth, R | 1 |
| Vogt, C | 1 |
| Nathan, N | 1 |
| Sullivan, SD | 1 |
| Pasquali, R | 1 |
| Jeve, YB | 1 |
| Konje, JC | 1 |
| Doshani, A | 1 |
| Enkhtuvshin, B | 1 |
| Nagashima, S | 1 |
| Saito, N | 1 |
| Wakabayashi, T | 1 |
| Ando, A | 1 |
| Takahashi, M | 1 |
| Sakai, K | 1 |
| Yamamuro, D | 1 |
| Nagasaka, S | 1 |
| Tamemoto, H | 1 |
| Ishibashi, S | 1 |
| Chiswick, CA | 1 |
| Reynolds, RM | 2 |
| Denison, FC | 1 |
| Whyte, SA | 1 |
| Drake, AJ | 2 |
| Newby, DE | 2 |
| Walker, BR | 2 |
| Forbes, S | 2 |
| Murray, GD | 1 |
| Quenby, S | 2 |
| Wray, S | 2 |
| Norman, JE | 2 |
| Ainuddin, JA | 1 |
| Karim, N | 1 |
| Zaheer, S | 1 |
| Ali, SS | 1 |
| Hasan, AA | 1 |
| Refuerzo, J | 1 |
| Chiswick, C | 1 |
| Denison, F | 1 |
| Weeks, A | 1 |
| Lashen, H | 1 |
| Rodriguez, A | 1 |
| Murray, G | 1 |
| Whyte, S | 1 |
| Feng, L | 1 |
| Lin, XF | 1 |
| Wan, ZH | 1 |
| Hu, D | 1 |
| Du, YK | 1 |
| Syngelaki, A | 1 |
| Nicolaides, KH | 1 |
| Balani, J | 2 |
| Hyer, S | 2 |
| Akolekar, R | 1 |
| Kotecha, R | 1 |
| Pastides, A | 1 |
| Shehata, H | 3 |
| Andrade, C | 1 |
| Vääräsmäki, M | 1 |
| Sahin, M | 1 |
| Corapcioglu, D | 1 |
| Stanford, FC | 1 |
| Alfaris, N | 1 |
| Misra, M | 1 |
| Gandica, R | 1 |
| Zeitler, P | 1 |
| Murphy, K | 1 |
| Asztalos, E | 1 |
| Sanchez, J | 1 |
| Zinman, B | 1 |
| Ohlsson, A | 1 |
| Ryan, EA | 1 |
| Fantus, IG | 1 |
| Armson, AB | 1 |
| Lipscombe, LL | 1 |
| Barrett, JF | 1 |
| Tan, X | 1 |
| Li, S | 1 |
| Chang, Y | 1 |
| Fang, C | 1 |
| Liu, H | 1 |
| Zhang, X | 1 |
| Wang, Y | 1 |
| Elfituri, A | 1 |
| Ali, A | 1 |
| Perng, P | 1 |
| Zampella, JG | 1 |
| Okoye, GA | 1 |
| Palomba, S | 2 |
| Falbo, A | 2 |
| Orio, F | 2 |
| Zullo, F | 2 |
| Nawaz, FH | 1 |
| Khalid, R | 1 |
| Naru, T | 1 |
| Rizvi, J | 1 |
| Hart, R | 3 |
| Lanker, A | 1 |
| Müller, B | 1 |
| Diem, P | 1 |
| Diamanti-Kandarakis, E | 1 |
| Christakou, CD | 1 |
| Kandaraki, E | 1 |
| Economou, FN | 1 |
| Nader, S | 1 |
| Heimstad, R | 2 |
| Romundstad, P | 3 |
| Skogøy, K | 1 |
| Kleggetveit, O | 1 |
| von Brandis, P | 1 |
| Eikeland, T | 1 |
| Flo, K | 1 |
| Berg, KF | 1 |
| Bunford, G | 1 |
| Lund, A | 1 |
| Bjerke, C | 1 |
| Almås, I | 1 |
| Danielson, A | 1 |
| Lahmami, G | 1 |
| Legro, RS | 4 |
| De Leo, V | 1 |
| Musacchio, MC | 1 |
| Piomboni, P | 1 |
| Di Sabatino, A | 1 |
| Morgante, G | 1 |
| D'Anna, R | 1 |
| Di Benedetto, V | 1 |
| Rizzo, P | 1 |
| Raffone, E | 1 |
| Interdonato, ML | 1 |
| Corrado, F | 1 |
| Di Benedetto, A | 1 |
| Weickert, MO | 1 |
| Hodges, P | 1 |
| Tan, BK | 1 |
| Randeva, HS | 1 |
| Diamond, MP | 2 |
| Kruger, M | 1 |
| Santoro, N | 1 |
| Zhang, H | 1 |
| Casson, P | 1 |
| Schlaff, W | 1 |
| Coutifaris, C | 2 |
| Brzyski, R | 1 |
| Christman, G | 1 |
| Carr, BR | 2 |
| McGovern, PG | 2 |
| Cataldo, NA | 2 |
| Steinkampf, MP | 2 |
| Gosman, GG | 2 |
| Nestler, JE | 3 |
| Carson, S | 1 |
| Myers, EE | 1 |
| Eisenberg, E | 1 |
| Nordskar, JJ | 1 |
| Leithe, H | 1 |
| Hjorth-Hansen, AK | 1 |
| Martinussen, M | 1 |
| Hawkins, JZ | 1 |
| Wing, D | 1 |
| Martinussen, MP | 1 |
| Glueck, CJ | 5 |
| Wang, P | 5 |
| Goldenberg, N | 5 |
| Sieve-Smith, L | 1 |
| Loftspring, M | 2 |
| Sherman, A | 1 |
| Guido, M | 1 |
| Romualdi, D | 1 |
| Belosi, C | 1 |
| Selvaggi, L | 1 |
| Lanzone, A | 1 |
| Pranikoff, J | 1 |
| Sieve, L | 3 |
| Fougner, KJ | 1 |
| Boothroyd, C | 1 |
| Yazdani, A | 1 |
| Charles, B | 1 |
| Norris, R | 1 |
| Xiao, X | 1 |
| Brown, FM | 1 |
| Wyckoff, J | 1 |
| Jovanovic, L | 1 |
| Sacks, DA | 1 |
| Briggs, GG | 1 |
| Hjorth-Hansen, H | 2 |
| Bjerve, K | 1 |
| Koren, G | 1 |
| Gilbert, C | 1 |
| Valois, M | 1 |
| Thatcher, SS | 1 |
| Jackson, EM | 1 |
| Golnik, KC | 1 |
| Aregawi, D | 1 |
| Liu, JH | 1 |
| Bill, AH | 1 |
| Salehi, M | 1 |
| Norman, R | 1 |
| Homburg, R | 1 |
| Lilja, AE | 1 |
| Kovo, M | 1 |
| Weissman, A | 1 |
| Gur, D | 1 |
| Levran, D | 1 |
| Rotmensch, S | 1 |
| Glezerman, M | 1 |
| Barnhart, HX | 1 |
| Schlaff, WD | 1 |
| Carson, SA | 1 |
| Giudice, LC | 1 |
| Leppert, PC | 1 |
| Myers, ER | 1 |
| Kjøtrød, S | 1 |
| Glueck, C | 1 |
| Kumar, HK | 1 |
| Bolton, S | 1 |
| Cleary, B | 1 |
| Walsh, J | 1 |
| Dempsey, E | 1 |
| Turner, MJ | 1 |
| Ecker, JL | 1 |
| Greene, MF | 1 |
| Hong, YC | 1 |
| O'Boyle, CP | 1 |
| Chen, IC | 1 |
| Hsiao, CT | 1 |
| Kuan, JT | 1 |
| Jakubowicz, DJ | 1 |
| Iuorno, MJ | 1 |
| Jakubowicz, S | 1 |
| Roberts, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome (PCOS)[NCT00159536] | Phase 3 | 257 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study[NCT03259919] | Phase 2 | 40 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| A Prospective, Randomized, Double-blind, Multi-centre Study, Where the Possible Effect of Metformin to Prevent Late Miscarriage and Preterm Delivery is Studied in Women With Polycystic Ovary Syndrome (PCOS)[NCT01587378] | 489 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Management of Intrapartum Glycemia in Gestational Diabetic Mothers: A Randomized Controlled Trial[NCT05647798] | 120 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | |||
| Long-term Effects of Flash Glucose Monitoring System in Patients With Gestational Diabetes[NCT06031987] | 100 participants (Anticipated) | Interventional | 2022-01-26 | Recruiting | |||
| Diagnostic Efficiency Analysis of Oral Glucose Tolerance Test and Prediction Model Establishment in the First Trimester for Gestational Diabetes Mellitus: a Prospective Cohort Study[NCT05487352] | 781 participants (Actual) | Observational | 2021-05-30 | Active, not recruiting | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513] | 414 participants (Anticipated) | Interventional | 2022-03-24 | Not yet recruiting | |||
| Uterine Artery Blood Flow in Pregnant Women With Polycystic Ovary Syndrome(PCOS)Treated With Metformin - a Substudy to The PregMet Study[NCT00466622] | Phase 3 | 48 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| Metformin in Gestational Diabetes and type2 Diabetes in Pregnancy in a Developing Country[NCT01855763] | Phase 2/Phase 3 | 300 participants (Actual) | Interventional | 2008-12-31 | Active, not recruiting | ||
| Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy on Glycemic Control, Fetal and Neonatal Outcomes ,Randomized Controlled Trial[NCT05479214] | Phase 4 | 150 participants (Actual) | Interventional | 2022-07-29 | Completed | ||
| Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial[NCT05580523] | 3,000 participants (Anticipated) | Interventional | 2023-07-03 | Recruiting | |||
| Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women?[NCT01273584] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial[NCT00081328] | Phase 3 | 699 participants (Actual) | Interventional | 2004-05-31 | Completed | ||
| Metformin in Women With Type 2 Diabetes in Pregnancy Trial[NCT01353391] | Phase 3 | 500 participants (Actual) | Interventional | 2011-05-25 | Completed | ||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| METformin in Intrahepatic Cholestasis of Pregnancy (METRIC) Study[NCT03056274] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2019-01-31 | Not yet recruiting | ||
| Effect of Myoinositol on Serum Asprosin Levels in PCOS Patients[NCT05951309] | 30 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility[NCT05952882] | Phase 3 | 188 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention[NCT02394158] | Phase 4 | 112 participants (Anticipated) | Interventional | 2015-01-27 | Recruiting | ||
| [NCT01511822] | Phase 4 | 0 participants | Interventional | Completed | |||
| Reduction of Insulin Therapy Under Myo-inositol for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. MYO-GDM Study[NCT03875755] | 1,080 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| Role Of Dydrogesterone Towards Oocyte and Embryo Quality in Polycystic Ovarian Syndrome (PCOS)[NCT04175990] | Phase 1 | 155 participants (Actual) | Interventional | 2018-05-10 | Completed | ||
| Circulating Anti-mullerian Hormone as Predictor of Ovarian Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome[NCT03316469] | 40 participants (Anticipated) | Interventional | 2018-07-31 | Not yet recruiting | |||
| Pregnancy in Polycystic Ovary Syndrome: A 30 Week Double-Blind Randomized Trial of Clomiphene Citrate, Metformin XR, and Combined Clomiphene Citrate/Metformin XR For the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT00068861] | Phase 3 | 678 participants | Interventional | 2002-11-30 | Completed | ||
| Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial[NCT00461643] | Phase 4 | 552 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| Effects of Metformin on Fertility and Pregnancy in Women With Polycystic Ovary Syndrome: a Randomized, Prospective, Placebo-controlled Multicenter Study[NCT00994812] | Phase 3 | 326 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531] | Phase 3 | 1,100 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Body mass index (BMI) measured in kg per meters squared. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | kg per meters squared (Mean) |
|---|---|
| 1 Metformin Alone | 36.7 |
| 2 Metformin + Rosliglitazone | 38.2 |
| 3 Metformin + Lifestyle Program | 35.3 |
Measured by DXA, both whole body scan and AP-spine scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | g/cm squared (Mean) |
|---|---|
| 1 Metformin Alone | 1.15 |
| 2 Metformin + Rosliglitazone | 1.15 |
| 3 Metformin + Lifestyle Program | 1.15 |
Determined by DXA whole body scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | kg (Mean) |
|---|---|
| 1 Metformin Alone | 36.1 |
| 2 Metformin + Rosliglitazone | 39.7 |
| 3 Metformin + Lifestyle Program | 32.2 |
Waist circumference (cm) measured at the iliac crest at its outermost point with the measuring tape placed around the participant in a horizontal plane parallel to the floor at the mark and the measurement teken at the end of normal expiration without the tape compressing the skin. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | cm (Mean) |
|---|---|
| 1 Metformin Alone | 110.8 |
| 2 Metformin + Rosliglitazone | 114.0 |
| 3 Metformin + Lifestyle Program | 108.6 |
A diagnosis was made by an out-of-range value >=95th percentile or systolic >=130 or diastolic >=80 sustained over 6 months or on an anti-hypertensive medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 57 |
| 2 Metformin + Rosliglitazone | 53 |
| 3 Metformin + Lifestyle Program | 45 |
A diagnosis was made from out-of-range value >= 130 mg/dL sustained over 6 months or put on lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 18 |
| 2 Metformin + Rosliglitazone | 16 |
| 3 Metformin + Lifestyle Program | 15 |
A diagnosis was made by an out-of-range value >=150 mg/dL sustained over 6 months or on appropriate lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 20 |
| 2 Metformin + Rosliglitazone | 28 |
| 3 Metformin + Lifestyle Program | 22 |
Insulinogenic index determined from OGTT as difference in insulin at 30 minutes minus 0 minutes divided by difference in glucose at 30 minutes minus 0 minutes. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | uU/mL divided by mg/dL (Median) |
|---|---|
| 1 Metformin Alone | .75 |
| 2 Metformin + Rosliglitazone | .83 |
| 3 Metformin + Lifestyle Program | .71 |
All participants were followed to 24 months. Insulin sensitivity is measured from OGTT as inverse of fasting insulin (mL/uU). The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | mL/uU (Median) |
|---|---|
| 1 Metformin Alone | 0.037 |
| 2 Metformin + Rosiglitazone | 0.049 |
| 3 Metformin + Lifestyle Program | 0.039 |
Number of serious adverse events reported during the trial. Participant could have multiple episodes reported. (NCT00081328)
Timeframe: Reported as occurred during study follow-up - 2 years to 6.5 years from randomization.
| Intervention | episodes of serious adverse event (Number) |
|---|---|
| 1 Metformin Alone | 42 |
| 2 Metformin + Rosiglitazone | 34 |
| 3 Metformin + Lifestyle Program | 58 |
Defined as A1c persistently >=8% over a 6-month period or persistent metabolic decompensation (inability to wean insulin within 3 months of initiation or the occurrence of a second episode within three months of discontinuing insulin) (NCT00081328)
Timeframe: Study duration - 2 years to 6.5 years of follow up from randomization
| Intervention | participants (Number) | |
|---|---|---|
| Treatment failure | Did not fail treatment during trial | |
| 1 Metformin Alone | 120 | 112 |
| 2 Metformin + Rosliglitazone | 90 | 143 |
| 3 Metformin + Lifestyle Program | 109 | 125 |
26 reviews available for metformin and Complications, Pregnancy
| Article | Year |
|---|---|
Prevention of Excessive Gestational Weight Gain and Postpartum Weight Retention.
Topics: Adult; Anti-Obesity Agents; Diet, Healthy; Diet, Reducing; Evidence-Based Medicine; Exercise; Female | 2018 |
Metformin for Improving Maternal and Infant Outcomes in Pregnant Women Who are Obese.
Topics: Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformin; Obesity; Pregnancy; Pregnancy Compl | 2019 |
Metformin reduces maternal weight gain in obese pregnant women: A systematic review and meta-analysis of two randomized controlled trials.
Topics: Female; Gestational Weight Gain; Humans; Hypoglycemic Agents; Metformin; Obesity; Pregnancy; Pregnan | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
Gestational diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; | 2019 |
The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials.
Topics: Clinical Trials as Topic; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; | 2013 |
The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials.
Topics: Clinical Trials as Topic; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; | 2013 |
The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials.
Topics: Clinical Trials as Topic; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; | 2013 |
The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials.
Topics: Clinical Trials as Topic; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; | 2013 |
Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review.
Topics: Adult; Clinical Trials as Topic; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insulin | 2013 |
The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS).
Topics: Animals; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Letrozole; Metfo | 2014 |
Placental dysfunction in obese women and antenatal surveillance strategies.
Topics: Diabetes, Gestational; Female; Fetal Development; Humans; Hypoglycemic Agents; Inflammation; Metform | 2015 |
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis.
Topics: Abortion, Spontaneous; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Age | 2015 |
Major malformation risk, pregnancy outcomes, and neurodevelopmental outcomes associated with metformin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Infan | 2016 |
Is it worth treating gestational diabetes: if so, when and how?
Topics: Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Metformin; Pregnancy; Pregnancy Com | 2016 |
Update on Youth-Onset Type 2 Diabetes: Lessons Learned from the Treatment Options for Type 2 Diabetes in Adolescents and Youth Clinical Trial.
Topics: Adolescent; Child; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Management of hidradenitis suppurativa in pregnancy.
Topics: Anti-Bacterial Agents; Biological Products; Contraindications; Cryotherapy; Female; Hidradenitis Sup | 2017 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
PCOS and infertility.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic A | 2008 |
[Insulin and type 2 diabetes mellitus].
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combina | 2009 |
Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.
Topics: Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metformin; Polycystic | 2010 |
Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin.
Topics: Adipokines; Androgens; Endocrine System; Fatty Acids, Nonesterified; Fatty Liver; Female; Hormones; | 2012 |
Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.
Topics: Ambulatory Care; Blood Glucose Self-Monitoring; Diabetes, Gestational; Diet Therapy; Exercise Therap | 2012 |
Higher-order multiple pregnancy associated with metformin in women with polycystic ovary syndrome: two cases and review of the literature.
Topics: Adult; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Hypoglycemic | 2006 |
Polycystic ovarian syndrome--prognosis and outcomes.
Topics: Adolescent; Anovulation; Cardiovascular Diseases; Clomiphene; Contraceptives, Oral; Diabetes Mellitu | 2006 |
Pregnancy complications in PCOS.
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hyperinsulinism; Hypertension, Pregnan | 2006 |
Polycystic ovary syndrome and metformin in pregnancy.
Topics: Drug Administration Schedule; Female; Humans; Metformin; Ovulation Induction; Polycystic Ovary Syndr | 2006 |
Polycystic ovarian syndrome--prognosis and treatment outcomes.
Topics: Anovulation; Cardiovascular Diseases; Combined Modality Therapy; Contraceptives, Oral; Diabetes Mell | 2007 |
Medical therapy in women with polycystic ovarian syndrome before and during pregnancy and lactation.
Topics: Adult; Clomiphene; Diabetes, Gestational; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2008 |
34 trials available for metformin and Complications, Pregnancy
| Article | Year |
|---|---|
Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Fetus; Humans; Liver Circulation; Metformin; Polycystic Ovary Sy | 2022 |
Gestational weight gain in women with type 2 diabetes and perinatal outcomes: A secondary analysis of the metformin in women with type 2 diabetes in pregnancy (MiTy) trial.
Topics: Birth Weight; Body Mass Index; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Gestational | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials.
Topics: Female; Gastrointestinal Hormones; Humans; Hyperandrogenism; Hypoglycemic Agents; Infant, Newborn; M | 2023 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus.
Topics: Adult; Androgens; Body Mass Index; Female; Fetal Blood; Fetus; Humans; Hyperandrogenism; Male; Metfo | 2020 |
Effect of metformin in addition to an antenatal diet and lifestyle intervention on fetal growth and adiposity: the GRoW randomised trial.
Topics: Adiposity; Adult; Body Mass Index; Diet; Exercise; Female; Fetal Development; Fetus; Gestational Age | 2020 |
Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial.
Topics: Adult; Dexamethasone; Diabetes, Gestational; Double-Blind Method; Female; Fetal Distress; Glucocorti | 2021 |
Fetal Growth and Birth Anthropometrics in Metformin-Exposed Offspring Born to Mothers With PCOS.
Topics: Adult; Birth Weight; Double-Blind Method; Female; Fetal Development; Humans; Infant, Newborn; Metfor | 2018 |
Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs.
Topics: Body Mass Index; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypoglyce | 2018 |
Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs.
Topics: Body Mass Index; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypoglyce | 2018 |
Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs.
Topics: Body Mass Index; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypoglyce | 2018 |
Metformin Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age: Follow-Up of Two RCTs.
Topics: Body Mass Index; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypoglyce | 2018 |
Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS?
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Female; Follow-Up Studies; Humans; Hypoglycem | 2018 |
Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS?
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Female; Follow-Up Studies; Humans; Hypoglycem | 2018 |
Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS?
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Female; Follow-Up Studies; Humans; Hypoglycem | 2018 |
Does Metformin Treatment During Pregnancy Modify the Future Metabolic Profile in Women With PCOS?
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Female; Follow-Up Studies; Humans; Hypoglycem | 2018 |
Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial.
Topics: Adult; Diet Therapy; Double-Blind Method; Exercise; Female; Fetal Macrosomia; Gestational Weight Gai | 2019 |
Intrauterine metformin exposure and offspring cardiometabolic risk factors (PedMet study): a 5-10 year follow-up of the PregMet randomised controlled trial.
Topics: Adult; Body Mass Index; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypoglycemic Age | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment.
Topics: Adult; Biomarkers; Cohort Studies; Diabetes, Gestational; Female; Homocysteine; Humans; Hyperhomocys | 2013 |
Midpregnancy Doppler ultrasound of the uterine artery in metformin- versus placebo-treated PCOS women: a randomized trial.
Topics: Adolescent; Adult; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Placebos; Polycystic | 2014 |
Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: data from a randomized controlled study on metformin.
Topics: Adult; Double-Blind Method; Female; Fetal Blood; Humans; Hyperinsulinism; Hypoglycemic Agents; Insul | 2014 |
Efficacy of metformin in pregnant obese women: a randomised controlled trial.
Topics: Adolescent; Adult; Birth Weight; Blood Glucose; Clinical Protocols; Diabetes, Gestational; Double-Bl | 2015 |
Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Gestational Age; Hu | 2015 |
Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Gestational Age; Hu | 2015 |
Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Gestational Age; Hu | 2015 |
Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Gestational Age; Hu | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adult; Diabetes, Gestational; Double-Blind Method; Female; Fetal Macrosomia; | 2015 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
Topics: Adult; Birth Weight; Body Mass Index; Double-Blind Method; Female; Fetal Macrosomia; Humans; Hypogly | 2016 |
Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial.
Topics: Adolescent; Adult; Blood Glucose; Clinical Protocols; Diabetes Mellitus, Type 2; Double-Blind Method | 2016 |
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
Topics: Adult; Blood Pressure; Delivery, Obstetric; Diabetes, Gestational; Double-Blind Method; Female; Hear | 2010 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
Topics: Abortion, Spontaneous; Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperinsulinism; | 2011 |
Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Fer | 2012 |
Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo.
Topics: Body Composition; Body Mass Index; Breast; Breast Feeding; Female; Follow-Up Studies; Humans; Hypogl | 2012 |
Metformin's effect on first-year weight gain: a follow-up study.
Topics: Adult; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Infant; Infant, | 2012 |
Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg
Topics: Adult; Body Weight; Cohort Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Insu | 2004 |
Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy.
Topics: Adult; Body Height; Body Weight; Child Development; Diabetes, Gestational; Female; Humans; Hypoglyce | 2004 |
Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study.
Topics: Adult; Androgens; Birth Weight; Diabetes, Gestational; Female; Gestational Age; Glucose Tolerance Te | 2004 |
Beneficial effect of metformin on pregnancy outcome in women with polycystic ovary syndrome is not associated with major changes in C-reactive protein levels or indices of coagulation.
Topics: Activated Protein C Resistance; Adult; Antithrombin III; Blood Coagulation; C-Reactive Protein; Fema | 2006 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Metformin treatment in pregnant women with polycystic ovary syndrome--is reduced complication rate mediated by changes in the uteroplacental circulation?
Topics: Adult; Chi-Square Distribution; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Metformin; | 2007 |
Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome.
Topics: Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Metformin; Methylenetetrahydrofolate | 2007 |
39 other studies available for metformin and Complications, Pregnancy
| Article | Year |
|---|---|
Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study.
Topics: Adult; Child; Child, Preschool; Cohort Studies; Diabetes, Gestational; Female; Humans; Infant, Newbo | 2022 |
Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea.
Topics: Adolescent; Adult; Drug Prescriptions; Female; Humans; Hypoglycemic Agents; Insulin; Metformin; Midd | 2021 |
Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria.
Topics: Adult; Area Under Curve; Birth Weight; Cell Hypoxia; Delivery, Obstetric; Diabetes, Gestational; Ele | 2021 |
Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services.
Topics: Abortion, Spontaneous; Adult; Cohort Studies; Female; Humans; Hypoglycemic Agents; Metformin; Pregna | 2018 |
How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; India; Infant, Newborn; Metformin | 2018 |
Metformin use during pregnancy: Is it really safe?
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Pregnancy; Pregnancy Complica | 2018 |
Gestational diabetes mellitus: A pragmatic approach to diagnosis and management.
Topics: Blood Glucose; Diabetes, Gestational; Disease Management; Female; Humans; Hypoglycemic Agents; Insul | 2018 |
Prenatal metformin treatment improves ovarian function in offspring of obese rats.
Topics: Animals; Diet, High-Fat; Drug Evaluation, Preclinical; Female; Hypoglycemic Agents; Lactation; Metfo | 2018 |
Prolactin and breast increase during pregnancy in PCOS: linked to long-term metabolic health?
Topics: Adolescent; Adult; Blood Pressure; Body Mass Index; Breast; Female; Follow-Up Studies; Gestational A | 2019 |
Reproductive endocrinology: Maternal and fetal insulin levels at birth in women with PCOS.
Topics: Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Metformin; Polycystic Ovary Syndrome; | 2014 |
Successful pregnancy outcomes in a patient with type A insulin resistance syndrome.
Topics: Adult; Antigens, CD; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Metform | 2015 |
Metformin and pregnancy outcomes in obese women.
Topics: Diabetes, Gestational; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Metformin; Obesity, Ab | 2015 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes.
Topics: Birth Weight; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Metformin; Obesity; Pregnancy; | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes.
Topics: Birth Weight; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Metformin; Obesity; Pregnancy; | 2016 |
Metformin versus Placebo in Obese Pregnant Women without Diabetes.
Topics: Birth Weight; Female; Fetal Macrosomia; Humans; Hypoglycemic Agents; Metformin; Obesity; Pregnancy; | 2016 |
Managing Recurring Obstetric Cholestasis With Metformin.
Topics: Adult; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Diabetes, Gesta | 2016 |
Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients.
Topics: Female; Humans; Hypoglycemic Agents; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Preg | 2008 |
Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?
Topics: Adult; Case-Control Studies; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformin; Polycy | 2008 |
Reproductive endocrinology: live birth prediction in polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Female; Live Birth; Metformin; | 2010 |
Metformin during pregnancy in polycystic ovary syndrome: another vitamin bites the dust.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2010 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Myo-inositol may prevent gestational diabetes in PCOS women.
Topics: Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic O | 2012 |
Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin.
Topics: Abortion, Spontaneous; Birth Weight; Body Height; Child Development; Female; Follow-Up Studies; Huma | 2002 |
Insulin-sensitizing drugs for polycystic ovary syndrome.
Topics: Adult; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pregnancy; Pregnan | 2003 |
Longitudinal metabolic observation of metformin effects during pregnancy in hyperinsulinemic women with polycystic ovary syndrome: a case report.
Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Glucose Tolerance Test; Humans; Hyperinsulinism | 2004 |
Population pharmacokinetics of metformin in late pregnancy.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Drug Monitoring; Female; Fetal Blood; Half- | 2006 |
Metformin in pregnancy: its time has not yet come.
Topics: Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pr | 2006 |
Metformin use during the first trimester of pregnancy. Is it safe?
Topics: Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Comp | 2006 |
Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infertility, Female; Male; Metformin; Polycystic | 2006 |
Response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia.
Topics: Diet Therapy; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Synd | 2005 |
Expanding applications for metformin in polycystic ovarian syndrome.
Topics: Child Development; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformin; Polycystic Ovary | 2006 |
Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome.
Topics: Adult; Bottle Feeding; Breast Feeding; Child Development; Female; Follow-Up Studies; Humans; Hypogly | 2006 |
Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.
Topics: Adult; Birth Weight; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hyperbilirubinemia | 2006 |
Metformin and early pregnancy?
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infertility, Female; Male; Metformin; Polycystic | 2006 |
Pregnancy considerations in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2007 |
Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovarian syndrome.
Topics: Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Comp | 2008 |
Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity.
Topics: Adult; Birth Weight; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin Resistance; Metfo | 2009 |
Gestational diabetes--setting limits, exploring treatments.
Topics: Blood Glucose; Diabetes, Gestational; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Me | 2008 |
Metformin-associated lactic acidosis in a pregnant patient.
Topics: Acidosis, Lactic; Adult; Birth Weight; Charcoal; Female; Humans; Hypoglycemic Agents; Infant, Newbor | 2008 |
Effects of metformin on early pregnancy loss in the polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Adult; Androgens; Blood Glucose; Female; Humans; Hypoglycemic Agents; Insulin | 2002 |