metformin has been researched along with Complex Regional Pain Syndromes in 1 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Complex Regional Pain Syndromes: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin injections elevated von Frey thresholds (reduced mechanical allodynia) in complex regional pain syndrome mice versus saline-treated fracture mice between days 25 and 56 (difference of mean area under the curve, 42." | 7.96 | Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. ( Buvanendran, A; Das, V; Kroin, JS; McCarthy, RJ; Moric, M, 2020) |
| "Metformin injections elevated von Frey thresholds (reduced mechanical allodynia) in complex regional pain syndrome mice versus saline-treated fracture mice between days 25 and 56 (difference of mean area under the curve, 42." | 3.96 | Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. ( Buvanendran, A; Das, V; Kroin, JS; McCarthy, RJ; Moric, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, V | 1 |
| Kroin, JS | 1 |
| Moric, M | 1 |
| McCarthy, RJ | 1 |
| Buvanendran, A | 1 |
1 other study available for metformin and Complex Regional Pain Syndromes
| Article | Year |
|---|---|
Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Female; Hypoglycemic Agents | 2020 |