metformin has been researched along with Colonic Polyps in 10 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin may decrease the overall incidence of cancer in patients with diabetes and may decrease the incidence of colorectal cancer." | 8.12 | Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas. ( Abrams, JA; Araujo, JL; Buitrago, C; Huang, CH; Karkenny, G; Krigel, A; Lebwohl, B; Nguyen, STT; Talukder, N, 2022) |
| " Presence of colonic polyps/cancer and related risk factors, current metformin and acetylsalicylic acid intake, disease duration, therapies for acromegaly, hormonal and metabolic parameters were assessed." | 8.02 | Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study. ( Albertelli, M; Boschetti, M; Colao, AAL; Dotto, A; Ferone, D; Grasso, LF; Nazzari, E; Pirchio, R; Pivonello, R; Rebora, A; Ricci Bitti, S; Sciallero, S, 2021) |
| "Metformin has a potential role in the chemoprevention of colorectal cancer." | 6.82 | Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. ( Arimoto, J; Hata, Y; Hattori, A; Higurashi, T; Hosono, K; Inayama, Y; Kessoku, T; Komiya, Y; Matsuhashi, N; Nagase, H; Nakajima, A; Sakai, E; Taguri, M; Takahashi, H; Taniguchi, L; Uchiyama, S; Uchiyama, T; Umezawa, S; Yamanaka, S, 2016) |
| " Metformin may decrease the overall incidence of cancer in patients with diabetes and may decrease the incidence of colorectal cancer." | 4.12 | Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas. ( Abrams, JA; Araujo, JL; Buitrago, C; Huang, CH; Karkenny, G; Krigel, A; Lebwohl, B; Nguyen, STT; Talukder, N, 2022) |
| " Presence of colonic polyps/cancer and related risk factors, current metformin and acetylsalicylic acid intake, disease duration, therapies for acromegaly, hormonal and metabolic parameters were assessed." | 4.02 | Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study. ( Albertelli, M; Boschetti, M; Colao, AAL; Dotto, A; Ferone, D; Grasso, LF; Nazzari, E; Pirchio, R; Pivonello, R; Rebora, A; Ricci Bitti, S; Sciallero, S, 2021) |
| "Metformin has a potential role in the chemoprevention of colorectal cancer." | 2.82 | Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. ( Arimoto, J; Hata, Y; Hattori, A; Higurashi, T; Hosono, K; Inayama, Y; Kessoku, T; Komiya, Y; Matsuhashi, N; Nagase, H; Nakajima, A; Sakai, E; Taguri, M; Takahashi, H; Taniguchi, L; Uchiyama, S; Uchiyama, T; Umezawa, S; Yamanaka, S, 2016) |
| "Colorectal cancer is one of the major neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease." | 2.77 | Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. ( Endo, H; Ezuka, A; Fujisawa, N; Hata, Y; Higurashi, T; Hosono, K; Inayama, Y; Kessoku, T; Matsuhashi, N; Morita, S; Nagase, H; Nakajima, A; Ohkubo, H; Sakai, E; Takahashi, H; Uchiyama, S; Uchiyama, T; Yamada, E; Yamanaka, S, 2012) |
| "This observation applied separately for colon cancer [0." | 2.53 | Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis. ( Portincasa, P; Rokkas, T, 2016) |
| "Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated." | 1.48 | Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. ( Damsky, WE; Nasiri, AR; Perry, CJ; Perry, RJ; Pollak, MN; Rabin-Court, A; Shulman, GI; Wang, Y; Zhang, XM, 2018) |
| "Treatment with metformin significantly reduced ACF formation." | 1.36 | Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. ( Chihara, T; Endo, H; Fujita, K; Hosono, K; Inamori, M; Nakagama, H; Nakajima, A; Nozaki, Y; Shimpo, K; Sugiyama, M; Suzuki, K; Takahashi, H; Tomatsu, A; Uchiyama, T; Yoneda, K; Yoneda, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krigel, A | 1 |
| Nguyen, STT | 1 |
| Talukder, N | 1 |
| Huang, CH | 1 |
| Buitrago, C | 1 |
| Karkenny, G | 1 |
| Lebwohl, B | 1 |
| Abrams, JA | 1 |
| Araujo, JL | 1 |
| Albertelli, M | 1 |
| Nazzari, E | 1 |
| Dotto, A | 1 |
| Grasso, LF | 1 |
| Sciallero, S | 1 |
| Pirchio, R | 1 |
| Rebora, A | 1 |
| Boschetti, M | 1 |
| Pivonello, R | 1 |
| Ricci Bitti, S | 1 |
| Colao, AAL | 1 |
| Ferone, D | 1 |
| Niculescu, DA | 1 |
| Wang, Y | 1 |
| Nasiri, AR | 1 |
| Damsky, WE | 1 |
| Perry, CJ | 1 |
| Zhang, XM | 1 |
| Rabin-Court, A | 1 |
| Pollak, MN | 1 |
| Shulman, GI | 1 |
| Perry, RJ | 1 |
| Gravitz, L | 1 |
| Higurashi, T | 2 |
| Hosono, K | 3 |
| Takahashi, H | 3 |
| Komiya, Y | 1 |
| Umezawa, S | 1 |
| Sakai, E | 2 |
| Uchiyama, T | 3 |
| Taniguchi, L | 1 |
| Hata, Y | 2 |
| Uchiyama, S | 2 |
| Hattori, A | 1 |
| Nagase, H | 2 |
| Kessoku, T | 2 |
| Arimoto, J | 1 |
| Matsuhashi, N | 2 |
| Inayama, Y | 2 |
| Yamanaka, S | 2 |
| Taguri, M | 1 |
| Nakajima, A | 3 |
| Rokkas, T | 1 |
| Portincasa, P | 1 |
| Endo, H | 2 |
| Sugiyama, M | 1 |
| Suzuki, K | 1 |
| Nozaki, Y | 1 |
| Yoneda, K | 1 |
| Fujita, K | 1 |
| Yoneda, M | 1 |
| Inamori, M | 1 |
| Tomatsu, A | 1 |
| Chihara, T | 1 |
| Shimpo, K | 1 |
| Nakagama, H | 1 |
| Yamada, E | 1 |
| Ohkubo, H | 1 |
| Fujisawa, N | 1 |
| Ezuka, A | 1 |
| Morita, S | 1 |
| Lewis, JD | 1 |
| Capra, AM | 1 |
| Achacoso, NS | 1 |
| Ferrara, A | 1 |
| Levin, TR | 1 |
| Quesenberry, CP | 1 |
| Habel, LA | 1 |
1 review available for metformin and Colonic Polyps
| Article | Year |
|---|---|
Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis.
Topics: Colonic Neoplasms; Colonic Polyps; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2016 |
2 trials available for metformin and Colonic Polyps
| Article | Year |
|---|---|
Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Chemoprevention; Colonic Polyps; Colonoscopy; Colorectal Ne | 2016 |
Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Colonic Polyps; Colorectal Neoplasms; Doubl | 2012 |
7 other studies available for metformin and Colonic Polyps
| Article | Year |
|---|---|
Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas.
Topics: Adenoma; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Early Detection of Cancer; Humans; Metfo | 2022 |
Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study.
Topics: Acromegaly; Adult; Aged; Aged, 80 and over; Colonic Polyps; Colonoscopy; Cross-Sectional Studies; Fe | 2021 |
Metformin and colonic polyps in acromegaly: is the solution closer than we think?
Topics: Acromegaly; Colonic Polyps; Colorectal Neoplasms; Diabetes Mellitus; Human Growth Hormone; Humans; I | 2021 |
Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.
Topics: Adenomatous Polyposis Coli Protein; Animals; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co | 2018 |
Prevention: Tending the gut.
Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Cancer Vaccines; Clinical Trials as Topic; Colonic | 2015 |
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Proli | 2010 |
Medical therapy for diabetes is associated with increased use of lower endoscopy.
Topics: Aged; Bias; Cohort Studies; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Diabetes Mellitus, Ty | 2007 |