Page last updated: 2024-10-30

metformin and Colonic Neoplasms

metformin has been researched along with Colonic Neoplasms in 51 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Colonic Neoplasms: Tumors or cancer of the COLON.

Research Excerpts

ExcerptRelevanceReference
" Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer."7.83Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer. ( Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G, 2016)
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease."7.80Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014)
" Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer."3.83Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer. ( Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G, 2016)
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease."3.80Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014)
"Metformin use was neither associated with OS (adjusted hazard ratio [HR], 1."2.90Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis. ( Adamo, V; Aglietta, M; Antista, M; Banzi, M; Barni, S; Bidoli, P; Buonadonna, A; Cavanna, L; Ciarlo, A; Cinieri, S; Clerico, M; Damiani, A; De Placido, S; Di Bartolomeo, M; Dotti, KF; Faedi, M; Ferrari, D; Ferrari, L; Ferrario, S; Frassineti, GL; Galli, F; Giordani, P; Gori, S; Iaffaioli, RV; Labianca, RF; Leonardi, F; Lonardi, S; Maiello, E; Marchetti, P; Nicolini, M; Pavesi, L; Re, GL; Rosati, G; Tamburini, E; Tronconi, MC; Vernieri, C; Zampino, MG; Zaniboni, A, 2019)
"In addition, metformin may reduce colon cancer risk associated with chronic obstructive pulmonary disease (a surrogate for smoking)."2.77Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan. ( Tseng, CH, 2012)
"The management of locally advanced rectal cancer has passed a long way of developments, where total mesorectal excision and preoperative radiotherapy are crucial to secure clinical outcome."2.58Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer. ( Aerts, J; de Mey, S; De Ridder, M; Dufait, I; Engels, B; Feron, O; Gevaert, T; Jiang, H; Verovski, V; Wang, H, 2018)
"This observation applied separately for colon cancer [0."2.53Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis. ( Portincasa, P; Rokkas, T, 2016)
"Obesity is a known risk factor for many types of cancers and a number of endocrine factors, including adipokines and steroid hormones, are regulated by and regulate AMPK."2.49Endocrine-related cancers and the role of AMPK. ( Brown, KA; Samarajeewa, NU; Simpson, ER, 2013)
"Metformin is a commonly used drug to treat diabetes but has been recently demonstrated to have a potential therapeutic effect on colon cancer."1.56Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells. ( Chang, H; Ding, Y; Liu, C; Liu, Q; Qiao, C; Tao, J; Yan, A, 2020)
"Recurrence and chemoresistance in colorectal cancer remain important issues for patients treated with conventional therapeutics."1.51Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer. ( Jang, H; Kim, A; Kim, H; Kim, MJ; Kim, YH; Lee, SB; Lee, SJ; Myung, JK; Park, EH; Park, JH; Park, S; Shim, S, 2019)
"Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated."1.48Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. ( Damsky, WE; Nasiri, AR; Perry, CJ; Perry, RJ; Pollak, MN; Rabin-Court, A; Shulman, GI; Wang, Y; Zhang, XM, 2018)
"Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies."1.46Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. ( Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC, 2017)
"Recurrences, metastases, secondary cancers, survival and carcinoembryonic antigen levels were compared using t test and chi-squared test."1.46Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. ( Frieson, D; Henderson, D; Solomon, SS; Zuber, J, 2017)
" A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance."1.46Design and Characterization of Metformin-Loaded Solid Lipid Nanoparticles for Colon Cancer. ( Devarajan, PV; Kotak, DJ; Ngwuluka, NC, 2017)
"Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed."1.46Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. ( Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD, 2017)
"Metformin treatment enhanced AMPK activation, decreasing the activity of the anabolic factors ribosomal protein S6 and p4EBP-1 and inducing mitochondrial depolarization."1.46MIF/CD74 axis is a target for novel therapies in colon carcinomatosis. ( Belfiore, A; Beznoussenko, GV; Bongarzone, I; Bozzi, F; Caccia, C; Gariboldi, M; Gloghini, A; Leo, E; Leoni, V; Manenti, G; Milione, M; Mironov, AA; Mogavero, A; Pierotti, MA; Pilotti, S; Varinelli, L; Volpi, CC, 2017)
"Metformin use did not increase or decrease the likelihood of chemotherapy-related grade 3 or higher adverse events."1.43Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance). ( Alberts, SR; Chan, E; Foster, NR; Gill, S; Goldberg, RM; Grothey, A; Kahlenberg, MS; Nair, SG; Sargent, DJ; Shi, Q; Shields, AF; Singh, PP; Sinicrope, FA, 2016)
"Colon cancer was induced using 1,2-dimethylhydrazine (DMH, 20 mg/kg/week, s."1.40Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. ( Moustafa, YM; Zaafar, DK; Zaitone, SA, 2014)
"We present a model of diet-induced hyperinsulinemia associated with increased insulin receptor activation in neoplastic tissue and with increased tumor FDG-PET image intensity."1.37Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet. ( Algire, C; Aliaga, A; Bazile, M; Bedell, BJ; Birman, E; Blouin, MJ; David, S; Mashhedi, H; Pollak, M; Zakikhani, M; Zhao, Y, 2011)
"Metformin can inhibit the growth of SW-480 cells mainly by blocking the cell cycle at G0/G1, down-regulating the expression of cyclin D1 and decreasing telomerase activity."1.36[Effects of metformin on proliferation of human colon carcinoma cell line SW-480]. ( Sha, JP; Xue, YM; Zhou, XZ; Zhu, B, 2010)

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.96)18.7374
1990's0 (0.00)18.2507
2000's3 (5.88)29.6817
2010's33 (64.71)24.3611
2020's14 (27.45)2.80

Authors

AuthorsStudies
Zhang, X1
Ogihara, T1
Zhu, M1
Gantumur, D1
Li, Y1
Mizoi, K1
Kamioka, H1
Tsushima, Y1
Zhang, Y2
Chen, R1
Deng, L1
Shuai, Z1
Chen, M1
Christou, N1
Bergen, ES1
Canton, C1
Le Malicot, K1
Di Bartolomeo, M2
Galli, F4
Labianca, R1
Shi, Q2
Alberts, SR2
Goldberg, RM2
Lepage, C1
Sinicrope, FA2
Taieb, J1
Jiang, S1
Lu, Q1
Ghorbanzadeh, F1
Jafari-Gharabaghlou, D1
Dashti, MR1
Hashemi, M1
Zarghami, N1
Madka, V1
Kumar, G1
Pathuri, G1
Lightfoot, S1
Asch, AS1
Mohammed, A1
Steele, VE1
Rao, CV1
Mormile, R1
Linkeviciute-Ulinskiene, D1
Dulskas, A1
Patasius, A1
Zabuliene, L1
Urbonas, V1
Smailyte, G1
Kang, RK1
Mishr, N1
Rai, VK1
Liu, C1
Liu, Q1
Yan, A1
Chang, H1
Ding, Y1
Tao, J1
Qiao, C1
Khodaei, F1
Hosseini, SM1
Omidi, M1
Hosseini, SF1
Rezaei, M1
Erkinantti, S1
Marttila, M1
Sund, R1
Arffman, M1
Urpilainen, E1
Puistola, U1
Hautakoski, A1
Karihtala, P1
Läärä, E1
Jukkola, A1
Marciano, O1
Mehazri, L1
Shpungin, S1
Varvak, A1
Zacksenhaus, E1
Nir, U1
Berkovic, MC1
Mikulic, D1
Bilic-Curcic, I1
Mrzljak, A1
Mussin, N1
Oh, SC1
Lee, KW1
Park, MY1
Seo, S1
Yi, NJ1
Kim, H2
Yoon, KC1
Ahn, SW1
Kim, HS1
Hong, SK1
Oh, DK1
Suh, KS1
Henderson, D1
Frieson, D1
Zuber, J1
Solomon, SS1
Cuyàs, E1
Fernández-Arroyo, S1
Verdura, S1
García, RÁ1
Stursa, J1
Werner, L1
Blanco-González, E1
Montes-Bayón, M1
Joven, J1
Viollet, B1
Neuzil, J1
Menendez, JA1
Arafa, K1
Shamma, RN1
El-Gazayerly, ON1
El-Sherbiny, IM1
Sena, P1
Mancini, S1
Benincasa, M1
Mariani, F1
Palumbo, C1
Roncucci, L1
de Mey, S1
Jiang, H1
Wang, H1
Engels, B1
Gevaert, T1
Dufait, I1
Feron, O1
Aerts, J1
Verovski, V1
De Ridder, M1
Wang, Y1
Nasiri, AR1
Damsky, WE1
Perry, CJ1
Zhang, XM1
Rabin-Court, A1
Pollak, MN3
Shulman, GI1
Perry, RJ1
Wang, SQ1
Cui, SX1
Qu, XJ1
Vernieri, C1
Ferrari, L1
Marchetti, P1
Lonardi, S1
Maiello, E1
Iaffaioli, RV1
Zampino, MG1
Zaniboni, A1
De Placido, S1
Banzi, M1
Damiani, A1
Ferrari, D1
Rosati, G1
Labianca, RF1
Bidoli, P1
Frassineti, GL1
Nicolini, M1
Pavesi, L1
Tronconi, MC1
Buonadonna, A1
Ferrario, S1
Re, GL1
Adamo, V1
Tamburini, E1
Clerico, M1
Giordani, P1
Leonardi, F1
Barni, S1
Ciarlo, A1
Cavanna, L1
Gori, S1
Cinieri, S1
Faedi, M1
Aglietta, M1
Antista, M1
Dotti, KF1
Besic, N1
Povsic, MK1
Park, JH1
Kim, YH1
Park, EH1
Lee, SJ2
Kim, A1
Lee, SB1
Shim, S1
Jang, H1
Myung, JK1
Park, S1
Kim, MJ1
Moon, HS1
Mantzoros, CS1
Nangia-Makker, P1
Yu, Y1
Vasudevan, A1
Farhana, L1
Rajendra, SG1
Levi, E1
Majumdar, AP1
Koh, SJ1
Kim, JM1
Kim, IK1
Ko, SH1
Kim, JS1
Zaafar, DK1
Zaitone, SA1
Moustafa, YM1
Anisimov, VN2
Wu, X1
He, C1
Wu, Y1
Chen, X1
Abdelsatir, AA1
Husain, NE1
Hassan, AT1
Elmadhoun, WM1
Almobarak, AO1
Ahmed, MH1
Marini, C1
Bianchi, G1
Buschiazzo, A1
Ravera, S1
Martella, R1
Bottoni, G1
Petretto, A1
Emionite, L1
Monteverde, E1
Capitanio, S1
Inglese, E1
Fabbi, M1
Bongioanni, F1
Garaboldi, L1
Bruzzi, P1
Orengo, AM1
Raffaghello, L1
Sambuceti, G1
Ngwuluka, NC1
Kotak, DJ1
Devarajan, PV1
Rokkas, T1
Portincasa, P1
Bekusova, VV1
Patsanovskii, VM1
Nozdrachev, AD1
Chung, EJ1
Do, EJ1
Kim, SY1
Cho, EA1
Kim, DH1
Pak, S1
Hwang, SW1
Lee, HJ1
Byeon, JS1
Ye, BD1
Yang, DH1
Park, SH1
Yang, SK1
Kim, JH1
Myung, SJ1
Singh, PP1
Foster, NR1
Grothey, A1
Nair, SG1
Chan, E1
Shields, AF1
Gill, S1
Kahlenberg, MS1
Sargent, DJ1
Bozzi, F1
Mogavero, A1
Varinelli, L1
Belfiore, A1
Manenti, G1
Caccia, C1
Volpi, CC1
Beznoussenko, GV1
Milione, M1
Leoni, V1
Gloghini, A1
Mironov, AA1
Leo, E1
Pilotti, S1
Pierotti, MA1
Bongarzone, I1
Gariboldi, M1
Brihaye, B1
Lidove, O1
Lussato, D1
Aparicio, T1
Papo, T1
Zakikhani, M4
Dowling, RJ1
Sonenberg, N1
Algire, C2
Amrein, L1
Panasci, L1
Pollak, M2
Zhou, XZ1
Xue, YM1
Zhu, B1
Sha, JP1
Bershteĭn, LM1
Vasil'ev, DA1
Poroshina, TE1
Kovalenko, IG1
Boiarkina, MP1
Revskoĭ, SIu1
Kovalevskiĭ, AIu1
Mashhedi, H1
Blouin, MJ2
David, S1
Zhao, Y1
Bazile, M2
Birman, E1
Aliaga, A1
Bedell, BJ1
Feng, YH1
Wu, CL1
Shiau, AL1
Lee, JC1
Chang, JG1
Lu, PJ1
Tung, CL1
Feng, LY1
Huang, WT1
Tsao, CJ1
Tseng, CH1
Brown, KA1
Samarajeewa, NU1
Simpson, ER1
Javeshghani, S1
Austin, S1
Topisirovic, I1
St-Pierre, J1
Ortega Carnicer, J1
Ambrós Checa, A1
Diarte De Miguel, J1
Mountjoy, KG1
Finlay, GJ1
Holdaway, IM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Melanoma, breAst or Lung Cancer Patients With Brain Metastases: the Phase II OPTIMAL Study[NCT04001725]Phase 2110 participants (Anticipated)Interventional2019-10-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for metformin and Colonic Neoplasms

ArticleYear
Effect of metformin on
    The British journal of radiology, 2022, Feb-01, Volume: 95, Issue:1130

    Topics: Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Diabetes Mellitus, Type 2;

2022
Impact of diabetes and metformin use on recurrence and outcome in stage II-III colon cancer patients-A pooled analysis of three adjuvant trials.
    European journal of cancer (Oxford, England : 1990), 2022, Volume: 166

    Topics: Colonic Neoplasms; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Oxaliplatin

2022
A new contribution for an old drug: Prospect of metformin in colorectal oncotherapy.
    Journal of cancer research and therapeutics, 2021, Volume: 17, Issue:7

    Topics: Antineoplastic Agents; Colonic Neoplasms; Colorectal Neoplasms; Humans; Hypoglycemic Agents; Metform

2021
How far along are we in revealing the connection between metformin and colorectal cancer?
    World journal of gastroenterology, 2021, Apr-14, Volume: 27, Issue:14

    Topics: Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Met

2021
Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018, Volume: 127, Issue:3

    Topics: Antineoplastic Agents; CD8-Positive T-Lymphocytes; Chemoradiotherapy; Colonic Neoplasms; Humans; Imm

2018
Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data.
    Current drug targets, 2016, Volume: 17, Issue:4

    Topics: Animals; Cell Proliferation; Colonic Neoplasms; Diabetes Mellitus, Type 2; Drug Repositioning; Drug

2016
Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:18

    Topics: Animals; Colonic Neoplasms; Humans; Hypoglycemic Agents; Metformin

2015
Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis.
    European journal of internal medicine, 2016, Volume: 33

    Topics: Colonic Neoplasms; Colonic Polyps; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin

2016
Endocrine-related cancers and the role of AMPK.
    Molecular and cellular endocrinology, 2013, Feb-25, Volume: 366, Issue:2

    Topics: AMP-Activated Protein Kinases; Biological Factors; Cell Transformation, Neoplastic; Colonic Neoplasm

2013

Trials

3 trials available for metformin and Colonic Neoplasms

ArticleYear
Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis.
    The oncologist, 2019, Volume: 24, Issue:3

    Topics: Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Diabetes Mellitus, Type 2; F

2019
[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients].
    Voprosy onkologii, 2010, Volume: 56, Issue:6

    Topics: Acetylcysteine; Aged; Blood Glucose; Body Mass Index; Breast Neoplasms; Colonic Neoplasms; Drug Admi

2010
Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.
    European journal of endocrinology, 2012, Volume: 167, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Female

2012

Other Studies

39 other studies available for metformin and Colonic Neoplasms

ArticleYear
The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: AC133 Antigen; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans;

2021
Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression.
    Medical oncology (Northwood, London, England), 2023, Jul-29, Volume: 40, Issue:9

    Topics: bcl-2-Associated X Protein; Caco-2 Cells; Colonic Neoplasms; Cyclin D1; Humans; Liposomes; Metformin

2023
Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:2

    Topics: Administration, Oral; Alendronate; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell P

2020
Metformin in colorectal cancer: A match ruled by MiR26b?
    Cancer epidemiology, 2020, Volume: 64

    Topics: Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Humans; Metformin

2020
Response to Letter to the Editor: Metformin in colorectal cancer: A match ruled by MiR26b?
    Cancer epidemiology, 2020, Volume: 64

    Topics: Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Humans; Metformin

2020
Guar Gum Micro-particles for Targeted Co-delivery of Doxorubicin and Metformin HCL for Improved Specificity and Efficacy Against Colon Cancer: In Vitro and In Vivo Studies.
    AAPS PharmSciTech, 2020, Jan-03, Volume: 21, Issue:2

    Topics: Administration, Oral; Animals; Colonic Neoplasms; Doxorubicin; Drug Delivery Systems; Female; Galact

2020
Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells.
    Cancer medicine, 2020, Volume: 9, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dru

2020
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:3

    Topics: Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic;

2021
Association of Metformin, Other Antidiabetic Medications, and Statins With Incidence of Colon Cancer in Patients With Type 2 Diabetes.
    Clinical colorectal cancer, 2021, Volume: 20, Issue:2

    Topics: Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Humans; Hypoglycemi

2021
Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.
    Cells, 2021, 01-07, Volume: 10, Issue:1

    Topics: Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Humans; Lung Neoplasms; Metformin; Mitochondria;

2021
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
    Journal of Korean medical science, 2017, Volume: 32, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Diseas

2017
Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer.
    The American journal of the medical sciences, 2017, Volume: 354, Issue:3

    Topics: Aged; Antineoplastic Agents; Cohort Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Disease-F

2017
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.
    Oncogene, 2018, 02-15, Volume: 37, Issue:7

    Topics: AMP-Activated Protein Kinases; Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon; Colonic Neoplas

2018
Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy.
    Drug development and industrial pharmacy, 2018, Volume: 44, Issue:7

    Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; Humans; Metformin; Na

2018
Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings.
    International journal of molecular sciences, 2018, May-16, Volume: 19, Issue:5

    Topics: Apoptosis; Biomarkers; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; HT29

2018
Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.
    Cell reports, 2018, 07-03, Volume: 24, Issue:1

    Topics: Adenomatous Polyposis Coli Protein; Animals; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co

2018
Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.
    Cancer biology & therapy, 2019, Volume: 20, Issue:3

    Topics: Animals; Colitis; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic

2019
Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus - a single institution experience.
    Radiology and oncology, 2019, 05-08, Volume: 53, Issue:2

    Topics: Aged; Chemotherapy, Adjuvant; Colonic Neoplasms; Diabetes Mellitus; Elective Surgical Procedures; Fe

2019
Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer.
    Cancer science, 2019, Volume: 110, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement;

2019
Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer.
    Endocrine-related cancer, 2013, Volume: 20, Issue:6

    Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Antineopl

2013
Metformin: a potential therapeutic agent for recurrent colon cancer.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Cell Movement; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; M

2014
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextran Sulfat

2014
Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Antigens, CD34; Antineoplastic Agents; Cell Proliferation; Colon; Co

2014
Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model.
    Biomaterials, 2016, Volume: 75

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat

2016
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
    Scientific reports, 2016, Jan-22, Volume: 6

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Energy Metabolis

2016
Design and Characterization of Metformin-Loaded Solid Lipid Nanoparticles for Colon Cancer.
    AAPS PharmSciTech, 2017, Volume: 18, Issue:2

    Topics: Cell Death; Cell Proliferation; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Carriers; Drug De

2017
Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2016, Volume: 468, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Male; Metformin

2016
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
    European journal of pharmacology, 2017, Jan-05, Volume: 794

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplas

2017
Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance).
    The oncologist, 2016, Volume: 21, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Colonic Neoplasms; DNA Mismatch Repair; Fema

2016
MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.
    Journal of experimental & clinical cancer research : CR, 2017, 01-23, Volume: 36, Issue:1

    Topics: AMP-Activated Protein Kinases; Antigens, Differentiation, B-Lymphocyte; Cell Proliferation; Cell Sur

2017
[Metformine induces false-positive (18)F-FDG PET/CT uptake].
    Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:4

    Topics: Colonic Neoplasms; Diabetes Mellitus, Type 2; Diagnosis, Differential; False Positive Reactions; Fem

2009
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:5

    Topics: Adiponectin; AMP-Activated Protein Kinases; Carcinoma; Cell Proliferation; Colonic Neoplasms; Cytost

2008
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
    Endocrine-related cancer, 2010, Volume: 17, Issue:2

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma; Colonic Neopla

2010
[Effects of metformin on proliferation of human colon carcinoma cell line SW-480].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010, Volume: 30, Issue:8

    Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Humans; Metformin; T

2010
Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet.
    Cell cycle (Georgetown, Tex.), 2011, Aug-15, Volume: 10, Issue:16

    Topics: Animal Feed; Animals; Antineoplastic Agents; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co

2011
MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.
    International journal of molecular medicine, 2012, Volume: 29, Issue:5

    Topics: Antimetabolites, Antineoplastic; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fluorouracil;

2012
Carbon source and myc expression influence the antiproliferative actions of metformin.
    Cancer research, 2012, Dec-01, Volume: 72, Issue:23

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Carbon; Cell Growth Processes; Cell Line, Tumor; Colonic

2012
[Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].
    Medicina intensiva, 2006, Volume: 30, Issue:8

    Topics: Acidosis, Lactic; Acute Kidney Injury; Adenoma, Villous; Aged; Colonic Neoplasms; Colonoscopy; Diabe

2006
Effects of metformin and glibenclamide on insulin receptors in fibroblasts and tumor cells in vitro.
    Journal of endocrinological investigation, 1987, Volume: 10, Issue:6

    Topics: Breast Neoplasms; Colonic Neoplasms; Fibroblasts; Glyburide; Humans; In Vitro Techniques; Insulin; M

1987
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