metformin and Colonic Neoplasms
metformin has been researched along with Colonic Neoplasms in 51 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Colonic Neoplasms: Tumors or cancer of the COLON.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer." | 7.83 | Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer. ( Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G, 2016) |
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease." | 7.80 | Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014) |
" Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer." | 3.83 | Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer. ( Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G, 2016) |
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease." | 3.80 | Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014) |
"Metformin use was neither associated with OS (adjusted hazard ratio [HR], 1." | 2.90 | Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis. ( Adamo, V; Aglietta, M; Antista, M; Banzi, M; Barni, S; Bidoli, P; Buonadonna, A; Cavanna, L; Ciarlo, A; Cinieri, S; Clerico, M; Damiani, A; De Placido, S; Di Bartolomeo, M; Dotti, KF; Faedi, M; Ferrari, D; Ferrari, L; Ferrario, S; Frassineti, GL; Galli, F; Giordani, P; Gori, S; Iaffaioli, RV; Labianca, RF; Leonardi, F; Lonardi, S; Maiello, E; Marchetti, P; Nicolini, M; Pavesi, L; Re, GL; Rosati, G; Tamburini, E; Tronconi, MC; Vernieri, C; Zampino, MG; Zaniboni, A, 2019) |
"In addition, metformin may reduce colon cancer risk associated with chronic obstructive pulmonary disease (a surrogate for smoking)." | 2.77 | Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan. ( Tseng, CH, 2012) |
"The management of locally advanced rectal cancer has passed a long way of developments, where total mesorectal excision and preoperative radiotherapy are crucial to secure clinical outcome." | 2.58 | Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer. ( Aerts, J; de Mey, S; De Ridder, M; Dufait, I; Engels, B; Feron, O; Gevaert, T; Jiang, H; Verovski, V; Wang, H, 2018) |
"This observation applied separately for colon cancer [0." | 2.53 | Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis. ( Portincasa, P; Rokkas, T, 2016) |
"Obesity is a known risk factor for many types of cancers and a number of endocrine factors, including adipokines and steroid hormones, are regulated by and regulate AMPK." | 2.49 | Endocrine-related cancers and the role of AMPK. ( Brown, KA; Samarajeewa, NU; Simpson, ER, 2013) |
"Metformin is a commonly used drug to treat diabetes but has been recently demonstrated to have a potential therapeutic effect on colon cancer." | 1.56 | Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells. ( Chang, H; Ding, Y; Liu, C; Liu, Q; Qiao, C; Tao, J; Yan, A, 2020) |
"Recurrence and chemoresistance in colorectal cancer remain important issues for patients treated with conventional therapeutics." | 1.51 | Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer. ( Jang, H; Kim, A; Kim, H; Kim, MJ; Kim, YH; Lee, SB; Lee, SJ; Myung, JK; Park, EH; Park, JH; Park, S; Shim, S, 2019) |
"Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated." | 1.48 | Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. ( Damsky, WE; Nasiri, AR; Perry, CJ; Perry, RJ; Pollak, MN; Rabin-Court, A; Shulman, GI; Wang, Y; Zhang, XM, 2018) |
"Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies." | 1.46 | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. ( Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC, 2017) |
"Recurrences, metastases, secondary cancers, survival and carcinoembryonic antigen levels were compared using t test and chi-squared test." | 1.46 | Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. ( Frieson, D; Henderson, D; Solomon, SS; Zuber, J, 2017) |
" A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance." | 1.46 | Design and Characterization of Metformin-Loaded Solid Lipid Nanoparticles for Colon Cancer. ( Devarajan, PV; Kotak, DJ; Ngwuluka, NC, 2017) |
"Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed." | 1.46 | Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. ( Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD, 2017) |
"Metformin treatment enhanced AMPK activation, decreasing the activity of the anabolic factors ribosomal protein S6 and p4EBP-1 and inducing mitochondrial depolarization." | 1.46 | MIF/CD74 axis is a target for novel therapies in colon carcinomatosis. ( Belfiore, A; Beznoussenko, GV; Bongarzone, I; Bozzi, F; Caccia, C; Gariboldi, M; Gloghini, A; Leo, E; Leoni, V; Manenti, G; Milione, M; Mironov, AA; Mogavero, A; Pierotti, MA; Pilotti, S; Varinelli, L; Volpi, CC, 2017) |
"Metformin use did not increase or decrease the likelihood of chemotherapy-related grade 3 or higher adverse events." | 1.43 | Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance). ( Alberts, SR; Chan, E; Foster, NR; Gill, S; Goldberg, RM; Grothey, A; Kahlenberg, MS; Nair, SG; Sargent, DJ; Shi, Q; Shields, AF; Singh, PP; Sinicrope, FA, 2016) |
"Colon cancer was induced using 1,2-dimethylhydrazine (DMH, 20 mg/kg/week, s." | 1.40 | Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. ( Moustafa, YM; Zaafar, DK; Zaitone, SA, 2014) |
"We present a model of diet-induced hyperinsulinemia associated with increased insulin receptor activation in neoplastic tissue and with increased tumor FDG-PET image intensity." | 1.37 | Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet. ( Algire, C; Aliaga, A; Bazile, M; Bedell, BJ; Birman, E; Blouin, MJ; David, S; Mashhedi, H; Pollak, M; Zakikhani, M; Zhao, Y, 2011) |
"Metformin can inhibit the growth of SW-480 cells mainly by blocking the cell cycle at G0/G1, down-regulating the expression of cyclin D1 and decreasing telomerase activity." | 1.36 | [Effects of metformin on proliferation of human colon carcinoma cell line SW-480]. ( Sha, JP; Xue, YM; Zhou, XZ; Zhu, B, 2010) |
Research
Studies (51)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.96) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (5.88) | 29.6817 |
2010's | 33 (64.71) | 24.3611 |
2020's | 14 (27.45) | 2.80 |
Authors
Authors | Studies |
---|---|
Zhang, X | 1 |
Ogihara, T | 1 |
Zhu, M | 1 |
Gantumur, D | 1 |
Li, Y | 1 |
Mizoi, K | 1 |
Kamioka, H | 1 |
Tsushima, Y | 1 |
Zhang, Y | 2 |
Chen, R | 1 |
Deng, L | 1 |
Shuai, Z | 1 |
Chen, M | 1 |
Christou, N | 1 |
Bergen, ES | 1 |
Canton, C | 1 |
Le Malicot, K | 1 |
Di Bartolomeo, M | 2 |
Galli, F | 4 |
Labianca, R | 1 |
Shi, Q | 2 |
Alberts, SR | 2 |
Goldberg, RM | 2 |
Lepage, C | 1 |
Sinicrope, FA | 2 |
Taieb, J | 1 |
Jiang, S | 1 |
Lu, Q | 1 |
Ghorbanzadeh, F | 1 |
Jafari-Gharabaghlou, D | 1 |
Dashti, MR | 1 |
Hashemi, M | 1 |
Zarghami, N | 1 |
Madka, V | 1 |
Kumar, G | 1 |
Pathuri, G | 1 |
Lightfoot, S | 1 |
Asch, AS | 1 |
Mohammed, A | 1 |
Steele, VE | 1 |
Rao, CV | 1 |
Mormile, R | 1 |
Linkeviciute-Ulinskiene, D | 1 |
Dulskas, A | 1 |
Patasius, A | 1 |
Zabuliene, L | 1 |
Urbonas, V | 1 |
Smailyte, G | 1 |
Kang, RK | 1 |
Mishr, N | 1 |
Rai, VK | 1 |
Liu, C | 1 |
Liu, Q | 1 |
Yan, A | 1 |
Chang, H | 1 |
Ding, Y | 1 |
Tao, J | 1 |
Qiao, C | 1 |
Khodaei, F | 1 |
Hosseini, SM | 1 |
Omidi, M | 1 |
Hosseini, SF | 1 |
Rezaei, M | 1 |
Erkinantti, S | 1 |
Marttila, M | 1 |
Sund, R | 1 |
Arffman, M | 1 |
Urpilainen, E | 1 |
Puistola, U | 1 |
Hautakoski, A | 1 |
Karihtala, P | 1 |
Läärä, E | 1 |
Jukkola, A | 1 |
Marciano, O | 1 |
Mehazri, L | 1 |
Shpungin, S | 1 |
Varvak, A | 1 |
Zacksenhaus, E | 1 |
Nir, U | 1 |
Berkovic, MC | 1 |
Mikulic, D | 1 |
Bilic-Curcic, I | 1 |
Mrzljak, A | 1 |
Mussin, N | 1 |
Oh, SC | 1 |
Lee, KW | 1 |
Park, MY | 1 |
Seo, S | 1 |
Yi, NJ | 1 |
Kim, H | 2 |
Yoon, KC | 1 |
Ahn, SW | 1 |
Kim, HS | 1 |
Hong, SK | 1 |
Oh, DK | 1 |
Suh, KS | 1 |
Henderson, D | 1 |
Frieson, D | 1 |
Zuber, J | 1 |
Solomon, SS | 1 |
Cuyàs, E | 1 |
Fernández-Arroyo, S | 1 |
Verdura, S | 1 |
García, RÁ | 1 |
Stursa, J | 1 |
Werner, L | 1 |
Blanco-González, E | 1 |
Montes-Bayón, M | 1 |
Joven, J | 1 |
Viollet, B | 1 |
Neuzil, J | 1 |
Menendez, JA | 1 |
Arafa, K | 1 |
Shamma, RN | 1 |
El-Gazayerly, ON | 1 |
El-Sherbiny, IM | 1 |
Sena, P | 1 |
Mancini, S | 1 |
Benincasa, M | 1 |
Mariani, F | 1 |
Palumbo, C | 1 |
Roncucci, L | 1 |
de Mey, S | 1 |
Jiang, H | 1 |
Wang, H | 1 |
Engels, B | 1 |
Gevaert, T | 1 |
Dufait, I | 1 |
Feron, O | 1 |
Aerts, J | 1 |
Verovski, V | 1 |
De Ridder, M | 1 |
Wang, Y | 1 |
Nasiri, AR | 1 |
Damsky, WE | 1 |
Perry, CJ | 1 |
Zhang, XM | 1 |
Rabin-Court, A | 1 |
Pollak, MN | 3 |
Shulman, GI | 1 |
Perry, RJ | 1 |
Wang, SQ | 1 |
Cui, SX | 1 |
Qu, XJ | 1 |
Vernieri, C | 1 |
Ferrari, L | 1 |
Marchetti, P | 1 |
Lonardi, S | 1 |
Maiello, E | 1 |
Iaffaioli, RV | 1 |
Zampino, MG | 1 |
Zaniboni, A | 1 |
De Placido, S | 1 |
Banzi, M | 1 |
Damiani, A | 1 |
Ferrari, D | 1 |
Rosati, G | 1 |
Labianca, RF | 1 |
Bidoli, P | 1 |
Frassineti, GL | 1 |
Nicolini, M | 1 |
Pavesi, L | 1 |
Tronconi, MC | 1 |
Buonadonna, A | 1 |
Ferrario, S | 1 |
Re, GL | 1 |
Adamo, V | 1 |
Tamburini, E | 1 |
Clerico, M | 1 |
Giordani, P | 1 |
Leonardi, F | 1 |
Barni, S | 1 |
Ciarlo, A | 1 |
Cavanna, L | 1 |
Gori, S | 1 |
Cinieri, S | 1 |
Faedi, M | 1 |
Aglietta, M | 1 |
Antista, M | 1 |
Dotti, KF | 1 |
Besic, N | 1 |
Povsic, MK | 1 |
Park, JH | 1 |
Kim, YH | 1 |
Park, EH | 1 |
Lee, SJ | 2 |
Kim, A | 1 |
Lee, SB | 1 |
Shim, S | 1 |
Jang, H | 1 |
Myung, JK | 1 |
Park, S | 1 |
Kim, MJ | 1 |
Moon, HS | 1 |
Mantzoros, CS | 1 |
Nangia-Makker, P | 1 |
Yu, Y | 1 |
Vasudevan, A | 1 |
Farhana, L | 1 |
Rajendra, SG | 1 |
Levi, E | 1 |
Majumdar, AP | 1 |
Koh, SJ | 1 |
Kim, JM | 1 |
Kim, IK | 1 |
Ko, SH | 1 |
Kim, JS | 1 |
Zaafar, DK | 1 |
Zaitone, SA | 1 |
Moustafa, YM | 1 |
Anisimov, VN | 2 |
Wu, X | 1 |
He, C | 1 |
Wu, Y | 1 |
Chen, X | 1 |
Abdelsatir, AA | 1 |
Husain, NE | 1 |
Hassan, AT | 1 |
Elmadhoun, WM | 1 |
Almobarak, AO | 1 |
Ahmed, MH | 1 |
Marini, C | 1 |
Bianchi, G | 1 |
Buschiazzo, A | 1 |
Ravera, S | 1 |
Martella, R | 1 |
Bottoni, G | 1 |
Petretto, A | 1 |
Emionite, L | 1 |
Monteverde, E | 1 |
Capitanio, S | 1 |
Inglese, E | 1 |
Fabbi, M | 1 |
Bongioanni, F | 1 |
Garaboldi, L | 1 |
Bruzzi, P | 1 |
Orengo, AM | 1 |
Raffaghello, L | 1 |
Sambuceti, G | 1 |
Ngwuluka, NC | 1 |
Kotak, DJ | 1 |
Devarajan, PV | 1 |
Rokkas, T | 1 |
Portincasa, P | 1 |
Bekusova, VV | 1 |
Patsanovskii, VM | 1 |
Nozdrachev, AD | 1 |
Chung, EJ | 1 |
Do, EJ | 1 |
Kim, SY | 1 |
Cho, EA | 1 |
Kim, DH | 1 |
Pak, S | 1 |
Hwang, SW | 1 |
Lee, HJ | 1 |
Byeon, JS | 1 |
Ye, BD | 1 |
Yang, DH | 1 |
Park, SH | 1 |
Yang, SK | 1 |
Kim, JH | 1 |
Myung, SJ | 1 |
Singh, PP | 1 |
Foster, NR | 1 |
Grothey, A | 1 |
Nair, SG | 1 |
Chan, E | 1 |
Shields, AF | 1 |
Gill, S | 1 |
Kahlenberg, MS | 1 |
Sargent, DJ | 1 |
Bozzi, F | 1 |
Mogavero, A | 1 |
Varinelli, L | 1 |
Belfiore, A | 1 |
Manenti, G | 1 |
Caccia, C | 1 |
Volpi, CC | 1 |
Beznoussenko, GV | 1 |
Milione, M | 1 |
Leoni, V | 1 |
Gloghini, A | 1 |
Mironov, AA | 1 |
Leo, E | 1 |
Pilotti, S | 1 |
Pierotti, MA | 1 |
Bongarzone, I | 1 |
Gariboldi, M | 1 |
Brihaye, B | 1 |
Lidove, O | 1 |
Lussato, D | 1 |
Aparicio, T | 1 |
Papo, T | 1 |
Zakikhani, M | 4 |
Dowling, RJ | 1 |
Sonenberg, N | 1 |
Algire, C | 2 |
Amrein, L | 1 |
Panasci, L | 1 |
Pollak, M | 2 |
Zhou, XZ | 1 |
Xue, YM | 1 |
Zhu, B | 1 |
Sha, JP | 1 |
Bershteĭn, LM | 1 |
Vasil'ev, DA | 1 |
Poroshina, TE | 1 |
Kovalenko, IG | 1 |
Boiarkina, MP | 1 |
Revskoĭ, SIu | 1 |
Kovalevskiĭ, AIu | 1 |
Mashhedi, H | 1 |
Blouin, MJ | 2 |
David, S | 1 |
Zhao, Y | 1 |
Bazile, M | 2 |
Birman, E | 1 |
Aliaga, A | 1 |
Bedell, BJ | 1 |
Feng, YH | 1 |
Wu, CL | 1 |
Shiau, AL | 1 |
Lee, JC | 1 |
Chang, JG | 1 |
Lu, PJ | 1 |
Tung, CL | 1 |
Feng, LY | 1 |
Huang, WT | 1 |
Tsao, CJ | 1 |
Tseng, CH | 1 |
Brown, KA | 1 |
Samarajeewa, NU | 1 |
Simpson, ER | 1 |
Javeshghani, S | 1 |
Austin, S | 1 |
Topisirovic, I | 1 |
St-Pierre, J | 1 |
Ortega Carnicer, J | 1 |
Ambrós Checa, A | 1 |
Diarte De Miguel, J | 1 |
Mountjoy, KG | 1 |
Finlay, GJ | 1 |
Holdaway, IM | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Melanoma, breAst or Lung Cancer Patients With Brain Metastases: the Phase II OPTIMAL Study[NCT04001725] | Phase 2 | 110 participants (Anticipated) | Interventional | 2019-10-15 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
9 reviews available for metformin and Colonic Neoplasms
Article | Year |
---|---|
Effect of metformin on
Topics: Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Diabetes Mellitus, Type 2; | 2022 |
Impact of diabetes and metformin use on recurrence and outcome in stage II-III colon cancer patients-A pooled analysis of three adjuvant trials.
Topics: Colonic Neoplasms; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Oxaliplatin | 2022 |
A new contribution for an old drug: Prospect of metformin in colorectal oncotherapy.
Topics: Antineoplastic Agents; Colonic Neoplasms; Colorectal Neoplasms; Humans; Hypoglycemic Agents; Metform | 2021 |
How far along are we in revealing the connection between metformin and colorectal cancer?
Topics: Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Met | 2021 |
Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.
Topics: Antineoplastic Agents; CD8-Positive T-Lymphocytes; Chemoradiotherapy; Colonic Neoplasms; Humans; Imm | 2018 |
Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Diabetes Mellitus, Type 2; Drug Repositioning; Drug | 2016 |
Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far.
Topics: Animals; Colonic Neoplasms; Humans; Hypoglycemic Agents; Metformin | 2015 |
Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis.
Topics: Colonic Neoplasms; Colonic Polyps; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2016 |
Endocrine-related cancers and the role of AMPK.
Topics: AMP-Activated Protein Kinases; Biological Factors; Cell Transformation, Neoplastic; Colonic Neoplasm | 2013 |
Trials
3 trials available for metformin and Colonic Neoplasms
Article | Year |
---|---|
Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis.
Topics: Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Diabetes Mellitus, Type 2; F | 2019 |
[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients].
Topics: Acetylcysteine; Aged; Blood Glucose; Body Mass Index; Breast Neoplasms; Colonic Neoplasms; Drug Admi | 2010 |
Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Female | 2012 |
Other Studies
39 other studies available for metformin and Colonic Neoplasms
Article | Year |
---|---|
The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p.
Topics: AC133 Antigen; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; | 2021 |
Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression.
Topics: bcl-2-Associated X Protein; Caco-2 Cells; Colonic Neoplasms; Cyclin D1; Humans; Liposomes; Metformin | 2023 |
Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model.
Topics: Administration, Oral; Alendronate; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell P | 2020 |
Metformin in colorectal cancer: A match ruled by MiR26b?
Topics: Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Humans; Metformin | 2020 |
Response to Letter to the Editor: Metformin in colorectal cancer: A match ruled by MiR26b?
Topics: Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Humans; Metformin | 2020 |
Guar Gum Micro-particles for Targeted Co-delivery of Doxorubicin and Metformin HCL for Improved Specificity and Efficacy Against Colon Cancer: In Vitro and In Vivo Studies.
Topics: Administration, Oral; Animals; Colonic Neoplasms; Doxorubicin; Drug Delivery Systems; Female; Galact | 2020 |
Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dru | 2020 |
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
Topics: Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; | 2021 |
Association of Metformin, Other Antidiabetic Medications, and Statins With Incidence of Colon Cancer in Patients With Type 2 Diabetes.
Topics: Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Humans; Hypoglycemi | 2021 |
Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.
Topics: Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Humans; Lung Neoplasms; Metformin; Mitochondria; | 2021 |
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Diseas | 2017 |
Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer.
Topics: Aged; Antineoplastic Agents; Cohort Studies; Colonic Neoplasms; Diabetes Mellitus, Type 2; Disease-F | 2017 |
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon; Colonic Neoplas | 2018 |
Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; Humans; Metformin; Na | 2018 |
Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings.
Topics: Apoptosis; Biomarkers; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; HT29 | 2018 |
Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.
Topics: Adenomatous Polyposis Coli Protein; Animals; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co | 2018 |
Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.
Topics: Animals; Colitis; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic | 2019 |
Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus - a single institution experience.
Topics: Aged; Chemotherapy, Adjuvant; Colonic Neoplasms; Diabetes Mellitus; Elective Surgical Procedures; Fe | 2019 |
Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; | 2019 |
Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer.
Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Antineopl | 2013 |
Metformin: a potential therapeutic agent for recurrent colon cancer.
Topics: Animals; Cell Movement; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; M | 2014 |
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextran Sulfat | 2014 |
Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, CD34; Antineoplastic Agents; Cell Proliferation; Colon; Co | 2014 |
Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat | 2016 |
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Energy Metabolis | 2016 |
Design and Characterization of Metformin-Loaded Solid Lipid Nanoparticles for Colon Cancer.
Topics: Cell Death; Cell Proliferation; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Carriers; Drug De | 2017 |
Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Male; Metformin | 2016 |
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplas | 2017 |
Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance).
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Colonic Neoplasms; DNA Mismatch Repair; Fema | 2016 |
MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.
Topics: AMP-Activated Protein Kinases; Antigens, Differentiation, B-Lymphocyte; Cell Proliferation; Cell Sur | 2017 |
[Metformine induces false-positive (18)F-FDG PET/CT uptake].
Topics: Colonic Neoplasms; Diabetes Mellitus, Type 2; Diagnosis, Differential; False Positive Reactions; Fem | 2009 |
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.
Topics: Adiponectin; AMP-Activated Protein Kinases; Carcinoma; Cell Proliferation; Colonic Neoplasms; Cytost | 2008 |
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma; Colonic Neopla | 2010 |
[Effects of metformin on proliferation of human colon carcinoma cell line SW-480].
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Humans; Metformin; T | 2010 |
Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet.
Topics: Animal Feed; Animals; Antineoplastic Agents; Blood Glucose; Cell Line, Tumor; Cell Proliferation; Co | 2011 |
MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fluorouracil; | 2012 |
Carbon source and myc expression influence the antiproliferative actions of metformin.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carbon; Cell Growth Processes; Cell Line, Tumor; Colonic | 2012 |
[Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenoma, Villous; Aged; Colonic Neoplasms; Colonoscopy; Diabe | 2006 |
Effects of metformin and glibenclamide on insulin receptors in fibroblasts and tumor cells in vitro.
Topics: Breast Neoplasms; Colonic Neoplasms; Fibroblasts; Glyburide; Humans; In Vitro Techniques; Insulin; M | 1987 |