Page last updated: 2024-10-30

metformin and Colitis

metformin has been researched along with Colitis in 11 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various fields including inflammation."8.02Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt. ( Sun, KY; Xiong, W; Zhang, X; Zhou, YH; Zhu, Y; Zou, X, 2021)
"Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores."7.88New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018)
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease."7.80Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014)
"Ulcerative colitis is an inflammatory condition of the colon."5.62Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling. ( Liu, X; Sun, Z; Wang, H, 2021)
"Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various fields including inflammation."4.02Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt. ( Sun, KY; Xiong, W; Zhang, X; Zhou, YH; Zhu, Y; Zou, X, 2021)
"Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores."3.88New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018)
"These results indicate that metformin suppresses NF-κB activation in intestinal epithelial cells and ameliorates murine colitis and colitis-associated tumorigenesis in mice, suggesting that metformin could be a potential therapeutic agent for the treatment of inflammatory bowel disease."3.80Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. ( Kim, IK; Kim, JM; Kim, JS; Ko, SH; Koh, SJ, 2014)
"Ulcerative colitis is an inflammatory condition of the colon."1.62Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling. ( Liu, X; Sun, Z; Wang, H, 2021)
"Metformin has unexpected beneficial effects other than glucose-lowering effects."1.48Metformin protects against intestinal barrier dysfunction via AMPKα1-dependent inhibition of JNK signalling activation. ( Chen, Y; Deng, J; Lai, X; Li, J; Lin, Q; Liu, L; Zeng, L, 2018)
"Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed."1.46Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. ( Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD, 2017)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's5 (45.45)24.3611
2020's5 (45.45)2.80

Authors

AuthorsStudies
Xiong, W1
Sun, KY1
Zhu, Y1
Zhang, X1
Zhou, YH1
Zou, X1
Takahara, M1
Takaki, A1
Hiraoka, S1
Takei, K1
Yasutomi, E1
Igawa, S1
Yamamoto, S1
Oka, S1
Ohmori, M1
Yamasaki, Y1
Inokuchi, T1
Kinugasa, H1
Harada, K1
Udono, H1
Okada, H1
Olivier, S1
Diounou, H1
Pochard, C1
Frechin, L1
Durieu, E1
Foretz, M1
Neunlist, M1
Rolli-Derkinderen, M1
Viollet, B1
Saber, S1
El-Kader, EMA1
Liu, X1
Sun, Z1
Wang, H1
Deng, J1
Zeng, L1
Lai, X1
Li, J1
Liu, L1
Lin, Q1
Chen, Y1
Samman, FS1
Elaidy, SM1
Essawy, SS1
Hassan, MS1
Wang, SQ1
Cui, SX1
Qu, XJ1
Koh, SJ1
Kim, JM1
Kim, IK1
Ko, SH1
Kim, JS1
Chung, EJ1
Do, EJ1
Kim, SY1
Cho, EA1
Kim, DH1
Pak, S1
Hwang, SW1
Lee, HJ1
Byeon, JS1
Ye, BD1
Yang, DH1
Park, SH1
Yang, SK1
Kim, JH1
Myung, SJ1
Gould, M1
Sellin, JH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis[NCT04750135]Phase 240 participants (Anticipated)Interventional2021-02-07Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

11 other studies available for metformin and Colitis

ArticleYear
Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt.
    Cell death & disease, 2021, 10-12, Volume: 12, Issue:10

    Topics: 4-Butyrolactone; Animals; Cell Membrane; Colitis; Dextran Sulfate; Down-Regulation; Enzyme Activatio

2021
Metformin ameliorates chronic colitis in a mouse model by regulating interferon-γ-producing lamina propria CD4
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022, Volume: 36, Issue:2

    Topics: Adoptive Transfer; AMP-Activated Protein Kinases; Animals; CD4-Positive T-Lymphocytes; Colitis; Colo

2022
Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis.
    Cells, 2022, 02-09, Volume: 11, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Metformin;

2022
Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats.
    Inflammopharmacology, 2021, Volume: 29, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Colitis; Dextran Sulfate; Disease M

2021
Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2021, Volume: 96, Issue:2

    Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Metformin; Mice; Mice, Inbred C57BL; T-Lymphocy

2021
Metformin protects against intestinal barrier dysfunction via AMPKα1-dependent inhibition of JNK signalling activation.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:1

    Topics: Acute Disease; Adenylate Kinase; Animals; Bacterial Translocation; Caco-2 Cells; Colitis; Dextran Su

2018
New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Male; M

2018
Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.
    Cancer biology & therapy, 2019, Volume: 20, Issue:3

    Topics: Animals; Colitis; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic

2019
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextran Sulfat

2014
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
    European journal of pharmacology, 2017, Jan-05, Volume: 794

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplas

2017
Diabetic diarrhea.
    Current gastroenterology reports, 2009, Volume: 11, Issue:5

    Topics: Algorithms; Antidiarrheals; Celiac Disease; Clonidine; Colitis; Diabetes Complications; Diabetes Mel

2009