metformin has been researched along with Cognition Disorders in 25 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings highlight a novel pathogenic mechanism of sepsis-related cognitive impairment through activation of inflammatory factors, and these are blocked by metformin to attenuate sepsis-induced neuronal injury and cognitive impairment." | 8.02 | Metformin attenuates sepsis-induced neuronal injury and cognitive impairment. ( Guo, C; Qin, Z; Xiao, X; Zhou, C, 2021) |
| " The drug metformin has been shown to activate neural stem cells, promote differentiation, and lead to functional motor recovery in a neonatal stroke model." | 7.91 | Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. ( Adams, KV; Morshead, CM; Ruddy, RM, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 7.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| " We hypothesised that intervention with metformin would diminish the HF-feeding-evoked cognitive deficit by improving insulin sensitivity." | 7.78 | A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. ( Balfour, DJ; McNeilly, AD; Stewart, CA; Sutherland, C; Williamson, R, 2012) |
| " The mice fed with HFD were dosed with metformin (200 mg/kg) or thymol (20, 40 mg/kg) daily." | 5.46 | Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. ( Li, H; Li, M; Ma, S; Qin, T, 2017) |
| "These findings highlight a novel pathogenic mechanism of sepsis-related cognitive impairment through activation of inflammatory factors, and these are blocked by metformin to attenuate sepsis-induced neuronal injury and cognitive impairment." | 4.02 | Metformin attenuates sepsis-induced neuronal injury and cognitive impairment. ( Guo, C; Qin, Z; Xiao, X; Zhou, C, 2021) |
| " The drug metformin has been shown to activate neural stem cells, promote differentiation, and lead to functional motor recovery in a neonatal stroke model." | 3.91 | Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. ( Adams, KV; Morshead, CM; Ruddy, RM, 2019) |
| " Therefore, we have tested whether the previously proven blood-brain barrier protective agent, probucol, can prevent blood-brain barrier breakdown and cognitive decline in a dietary-induced murine model of diabetic insulin resistance." | 3.91 | Probucol prevents blood-brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet. ( Al-Salami, H; Brook, E; Fimognari, N; Lam, V; Mamo, JC; Mooranian, A; Nesbit, M; Takechi, R, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 3.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| " We hypothesised that intervention with metformin would diminish the HF-feeding-evoked cognitive deficit by improving insulin sensitivity." | 3.78 | A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. ( Balfour, DJ; McNeilly, AD; Stewart, CA; Sutherland, C; Williamson, R, 2012) |
| "Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS)." | 2.61 | A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice. ( Craig, A; Issberner, J; Parvez, F, 2019) |
| "Hypoglycemia is a frequent adverse effect of treatment with sulfonylurea, glinides, or insulin in older adults with diabetes." | 2.49 | [Attention to the use of oral anti-diabetic medication in older adults with type 2 diabetes]. ( Aso, Y; Jojima, T, 2013) |
| "Our findings reveal that neuropathic pain-related cognitive impairments in male mice are correlated to bilateral morphological changes in PV interneurons and layer 5/6 IL pyramidal neuron AIS." | 1.48 | Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin. ( Ahmad, A; Kroener, S; Mejia, G; Mwirigi, J; Pradhan, G; Price, T; Shiers, S, 2018) |
| " The mice fed with HFD were dosed with metformin (200 mg/kg) or thymol (20, 40 mg/kg) daily." | 1.46 | Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. ( Li, H; Li, M; Ma, S; Qin, T, 2017) |
| "Metformin use was associated with impaired cognitive performance." | 1.39 | Increased risk of cognitive impairment in patients with diabetes is associated with metformin. ( Ames, D; Boundy, K; Brodaty, H; Bush, AI; Carne, RP; Ellis, KA; Faux, NG; Kotowicz, MA; Mander, AG; Martins, R; Moore, EM; Rowe, C; Szoeke, C; Watters, DA; Woodward, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (92.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qin, Z | 1 |
| Zhou, C | 1 |
| Xiao, X | 1 |
| Guo, C | 1 |
| Ruddy, RM | 1 |
| Adams, KV | 1 |
| Morshead, CM | 1 |
| Areosa Sastre, A | 1 |
| Vernooij, RW | 1 |
| González-Colaço Harmand, M | 1 |
| Martínez, G | 1 |
| Campbell, JM | 1 |
| Stephenson, MD | 1 |
| de Courten, B | 1 |
| Chapman, I | 1 |
| Bellman, SM | 1 |
| Aromataris, E | 1 |
| Shiers, S | 1 |
| Pradhan, G | 1 |
| Mwirigi, J | 1 |
| Mejia, G | 1 |
| Ahmad, A | 1 |
| Kroener, S | 1 |
| Price, T | 1 |
| Wang, J | 1 |
| Wang, L | 1 |
| Zhou, J | 1 |
| Qin, A | 1 |
| Chen, Z | 1 |
| Mamo, JC | 1 |
| Lam, V | 1 |
| Brook, E | 1 |
| Mooranian, A | 1 |
| Al-Salami, H | 1 |
| Fimognari, N | 1 |
| Nesbit, M | 1 |
| Takechi, R | 1 |
| Wang, X | 1 |
| Luo, C | 1 |
| Mao, XY | 1 |
| Li, X | 1 |
| Yin, JY | 1 |
| Zhang, W | 1 |
| Zhou, HH | 1 |
| Liu, ZQ | 1 |
| Ahuja, S | 1 |
| Uniyal, A | 1 |
| Akhtar, A | 1 |
| Sah, SP | 1 |
| Craig, A | 1 |
| Parvez, F | 1 |
| Issberner, J | 1 |
| Heyer, EJ | 1 |
| Mergeche, JL | 1 |
| Bruce, SS | 1 |
| Connolly, ES | 1 |
| Moore, EM | 2 |
| Mander, AG | 2 |
| Ames, D | 2 |
| Kotowicz, MA | 2 |
| Carne, RP | 2 |
| Brodaty, H | 2 |
| Woodward, M | 2 |
| Boundy, K | 1 |
| Ellis, KA | 2 |
| Bush, AI | 2 |
| Faux, NG | 2 |
| Martins, R | 1 |
| Szoeke, C | 1 |
| Rowe, C | 1 |
| Watters, DA | 2 |
| Alagiakrishnan, K | 1 |
| Sankaralingam, S | 1 |
| Ghosh, M | 1 |
| Mereu, L | 1 |
| Senior, P | 1 |
| Jojima, T | 1 |
| Aso, Y | 1 |
| Ng, TP | 1 |
| Feng, L | 1 |
| Yap, KB | 1 |
| Lee, TS | 1 |
| Tan, CH | 1 |
| Winblad, B | 1 |
| Goodarzi, MO | 1 |
| Ying, MA | 1 |
| Maruschak, N | 1 |
| Mansur, R | 1 |
| Carvalho, AF | 1 |
| Cha, DS | 1 |
| McIntyre, RS | 1 |
| Check Hayden, E | 1 |
| Zhou, W | 1 |
| Kavelaars, A | 1 |
| Heijnen, CJ | 1 |
| Mostafa, DK | 1 |
| Ismail, CA | 1 |
| Ghareeb, DA | 1 |
| Li, H | 1 |
| Qin, T | 1 |
| Li, M | 1 |
| Ma, S | 1 |
| Ge, XH | 1 |
| Zhu, GJ | 1 |
| Geng, DQ | 1 |
| Zhang, HZ | 1 |
| He, JM | 1 |
| Guo, AZ | 1 |
| Ma, LL | 1 |
| Yu, DH | 1 |
| McNeilly, AD | 1 |
| Williamson, R | 1 |
| Balfour, DJ | 1 |
| Stewart, CA | 1 |
| Sutherland, C | 1 |
| Hanuschak, LN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813] | 200 participants (Anticipated) | Observational | 2019-09-10 | Not yet recruiting | |||
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Effect of Augmentation of Cerebral Blood Flow on Neuropsychometric Performance After Carotid Endarterectomy in Type II Diabetic Patients[NCT00597545] | 10 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Half of DM patients had EEG changes and therefore were excluded.) | |||
| Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy[NCT00597883] | 585 participants (Actual) | Observational | 2003-03-31 | Completed | |||
| "Randomized, Double-blind, Placebo-controlled Study to Assess the Effect of Metformin, an Activator of AMPK, on Cognitive Measures of Progression in Huntington's Disease Patients"[NCT04826692] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-12-10 | Recruiting | ||
| Insulin Resistance and Mild Cognitive Impairment (MCI) in Older Chinese Adults With Pre-Diabetes and Diabetes: Cognitive Effects of Lifestyle Intervention and Metformin Treatment in a Randomized Controlled Trial[NCT02409238] | Phase 4 | 105 participants (Actual) | Interventional | 2015-03-11 | Terminated (stopped due to "Limits of grant funding reached~A/Prof Ng Tze Pin (P.I. & holder of NMRC Grant (CIRG12may033) funding this study) retired in Aug 2022.~Resignations of staff and collaborators especially over the 1st 2 years of the COVID-19 pandemic") | ||
| The Effect of Metformin Treatment on Cognitive Impairment in Patients With Schizophrenia Co-morbid Metabolic Syndrome: a Prospective Cohort Study[NCT03271866] | 80 participants (Anticipated) | Interventional | 2017-08-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Battery of neuropsychometric tests to evaluate a variety of cognitive functions. (NCT00597545)
Timeframe: Post-operatively at 1 day
| Intervention | participants (Number) |
|---|---|
| Conventional Shunt | 1 |
| Prophylactic Shunt | 2 |
5 reviews available for metformin and Cognition Disorders
| Article | Year |
|---|---|
Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia.
Topics: Carbamates; Cause of Death; Cognition Disorders; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypog | 2017 |
A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition; | 2019 |
Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Clinical Trials as Topic; Cognition Diso | 2013 |
[Attention to the use of oral anti-diabetic medication in older adults with type 2 diabetes].
Topics: Cognition Disorders; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglyc | 2013 |
Metformin: repurposing opportunities for cognitive and mood dysfunction.
Topics: Cognition Disorders; Humans; Metformin; Mood Disorders; Nootropic Agents | 2014 |
20 other studies available for metformin and Cognition Disorders
| Article | Year |
|---|---|
Metformin attenuates sepsis-induced neuronal injury and cognitive impairment.
Topics: Animals; Brain; Cecum; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal | 2021 |
Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Movement; Cognition Disorders; Disease Models, | 2019 |
Metformin and Alzheimer's disease, dementia and cognitive impairment: a systematic review protocol.
Topics: Alzheimer Disease; Cognition Disorders; Diabetes Mellitus; Disease Progression; Humans; Hypoglycemic | 2017 |
Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.
Topics: Analgesics; Animals; Attention; Axons; Clonidine; Cognition Disorders; Discrimination, Psychological | 2018 |
The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
Topics: Animals; Behavior, Animal; Blood Glucose; Cell Line, Tumor; Cognition; Cognition Disorders; Diabetes | 2018 |
Probucol prevents blood-brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Blood-Brain Barrier; Cerebral Cortex; Cognition | 2019 |
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction | 2019 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Res | 2019 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hy | 2013 |
Increased risk of cognitive impairment in patients with diabetes is associated with metformin.
Topics: Aged; Aged, 80 and over; Calcium; Cognition Disorders; Diabetes Mellitus; Female; Humans; Logistic M | 2013 |
Long-term metformin usage and cognitive function among older adults with diabetes.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cross-Sectional Studies; Diabetes Mellitus; Female; Hu | 2014 |
Comment on Moore et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes care 2013;36:2981-2987.
Topics: Cognition Disorders; Diabetes Mellitus; Female; Humans; Male; Metformin | 2014 |
Response to comment on Moore et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes care 2013;36:2981-2987.
Topics: Cognition Disorders; Diabetes Mellitus; Female; Humans; Male; Metformin | 2014 |
Anti-ageing pill pushed as bona fide drug.
Topics: Aging; Animals; Caloric Restriction; Clinical Trials as Topic; Cognition Disorders; Diabetes Mellitu | 2015 |
Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Cisplatin; Cognition Disorders; Disease Models, An | 2016 |
Differential metformin dose-dependent effects on cognition in rats: role of Akt.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cogniti | 2016 |
Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.
Topics: Animals; Antioxidants; Cognition Disorders; Cytokines; Diet, High-Fat; Heme Oxygenase-1; Hypoglycemi | 2017 |
Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.
Topics: Animals; Anxiety; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders | 2017 |
A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Body Weight; Brain; Cognition Disorders; Conditioning, | 2012 |
Metformin useful in combination with exogenous insulin.
Topics: Biomarkers; Blood Glucose; Cognition Disorders; Diabetes Mellitus, Type 2; Drug Therapy, Combination | 1996 |