metformin and Chronic Kidney Failure studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

Excerpt	Relevance	Reference
"Lactic acidosis in metformin use is a widely recognised but rare side effect."	8.84	Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. ( Bosch, FH; Bruijstens, LA; Buscher-Jungerhans, PM; van Luin, M, 2008)
"In renal failure metformin can lead to lactic acidosis."	7.85	Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. ( Eisner, F; Eller, K; Eller, P; Lind, A; Mader, JK; Pieber, TR; Plank, J; Schilcher, G; Schwetz, V, 2017)
"We report a case of metformin-associated lactic acidosis (MALA) in a 66-year-old man with end-stage renal disease on peritoneal dialysis (PD)."	7.83	Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient . ( Gao, J; Gu, Z; Na, Y; Xu, Y, 2016)
"In recent years, lactic acidosis has been described in association with metformin therapy in diabetics."	7.66	Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. ( Casey, C; Hermann, LS; Magnusson, S; Möller, B; Tucker, GT; Woods, HF, 1981)
"Improving insulin sensitivity is one of many proven favourable effects of metformin."	6.84	Protocol for a pilot randomised controlled trial of metformin in pre-diabetes after kidney transplantation: the Transplantation and Diabetes (Transdiab) study. ( Alnasrallah, B; Manley, P; Pilmore, H, 2017)
"Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus."	5.40	Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2. ( Altun, E; Karayaylalı, I; Kaya, B; Paydaş, S; Sarıakçalı, B, 2014)
"The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain."	4.90	A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014)
"Lactic acidosis in metformin use is a widely recognised but rare side effect."	4.84	Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. ( Bosch, FH; Bruijstens, LA; Buscher-Jungerhans, PM; van Luin, M, 2008)
" The secondary outcome was metformin-associated lactic acidosis."	3.96	The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease. ( An, JN; Kim, CT; Kim, DK; Kim, YC; Kim, YS; Kwon, S; Lee, J; Lee, JP; Lim, CS; Oh, S; Oh, YK; Park, JY; Park, S, 2020)
"In renal failure metformin can lead to lactic acidosis."	3.85	Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. ( Eisner, F; Eller, K; Eller, P; Lind, A; Mader, JK; Pieber, TR; Plank, J; Schilcher, G; Schwetz, V, 2017)
"We report a case of metformin-associated lactic acidosis (MALA) in a 66-year-old man with end-stage renal disease on peritoneal dialysis (PD)."	3.83	Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient . ( Gao, J; Gu, Z; Na, Y; Xu, Y, 2016)
"Over a 20-year period, patients on dapagliflozin were projected to experience relative reductions in the incidence of myocardial infarction (MI), stroke, CV death, and all-cause death of 13."	3.80	Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. ( Alperin, P; Cohen, M; Dziuba, J; Goswami, D; Grossman, HL; Hardy, E; Iloeje, U; Perlstein, I; Racketa, J, 2014)
"In a number of patients, the antidiabetic drug metformin has been associated with lactic acidosis."	3.80	Metformin in peritoneal dialysis: a pilot experience. ( Abdul-Rahman, IS; Al-Hwiesh, AK; Al-Mohanna, FA; Divino-Filho, JC; El-Deen, MA; Gupta, KL; Larbi, E, 2014)
"In recent years, lactic acidosis has been described in association with metformin therapy in diabetics."	3.66	Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. ( Casey, C; Hermann, LS; Magnusson, S; Möller, B; Tucker, GT; Woods, HF, 1981)
"Improving insulin sensitivity is one of many proven favourable effects of metformin."	2.84	Protocol for a pilot randomised controlled trial of metformin in pre-diabetes after kidney transplantation: the Transplantation and Diabetes (Transdiab) study. ( Alnasrallah, B; Manley, P; Pilmore, H, 2017)
"In the case of patients with type 2 diabetes mellitus and vascular disease or high vascular disease risk, when lifestyle changes and metformin are inadequate, the use of drugs with proven vascular benefit should be prioritised."	2.66	[Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines.] ( Alonso de Leciñana, M; Armario, P; Aznar Lain, S; Brotons, C; Castro, A; Clarà, A; Cortés, O; Díaz Rodriguez, Á; Elosua, R; Herranz, M; Justo, S; Lahoz, C; Pedro-Botet, J; Pérez Pérez, A; Royo-Bordonada, MÁ; Santamaria, R; Tresserras, R, 2020)
" The efficacy of MMF as an immunosuppressant and long-term safety in cats of this dosage regimen is unknown."	2.61	( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Metformin is a first-line therapy in patients with Type 2 diabetes, as it appears to be effective in reducing diabetes related end points and mortality in overweight patients."	2.55	Could metformin be used in patients with diabetes and advanced chronic kidney disease? ( Abraham, G; Chowdhury, TA; Fan, SL; McCafferty, K; Oei, EL; Srirathan, D; Yaqoob, MM, 2017)
" In fact, the evidence supports the safe use of appropriate doses of metformin in patients with chronic stable renal impairment, and highlights the important possible greater risks of the alternatives, most notably severe hypoglycaemia in patients taking sulphonylureas and/or insulin and fluid retention in patients taking a thiazolidinedione."	2.47	Metformin: the safest hypoglycaemic agent in chronic kidney disease? ( Herrington, WG; Nye, HJ, 2011)
"Metformin is a biguanide, insulin sensitiser that reduces blood sugar levels."	2.46	Metformin: safety in cardiac patients. ( Khurana, R; Malik, IS, 2010)
"The biguanides are a class of oral hypoglycemic agents that are commonly used in the treatment of diabetes mellitus."	2.38	Biguanide-associated lactic acidosis. Case report and review of the literature. ( Arieff, AI; Barr, J; Gan, SC; Pearl, RG, 1992)
"Colchicine led to an increase in inflammatory cells within the renal parenchyma."	1.56	Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury. ( El-Rashid, M; Ghimire, K; Julovi, S; Li, J; Meijles, DN; Minhas, N; Nguyen-Ngo, D; Rogers, NM, 2020)
"To determine the impact of dipeptidyl peptidase-4 inhibitor (DPP4i) on the risk of major cardiocerebrovascular and renal outcomes compared with sulfonylurea (SU) combined with metformin in patients with type 2 diabetes from a population-based cohort."	1.51	Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study. ( An, JH; Bae, JH; Baik, SH; Choi, J; Choi, KM; Kim, HY; Kim, KJ; Kim, NH; Kim, SG; Lee, J; Seo, JA; Yoo, HJ, 2019)
"Metformin use was independently associated with increased risks of ESRD (adjusted hazard ratio, 1."	1.51	Association of Metformin Use With End-Stage Renal Disease in Patients With Type 2 Diabetes Mellitus: A Nationwide Cohort Study Under the Pay-for-Performance Program. ( Chang, CH; Chang, LY; Chen, SM; Lee, CH; Lee, MC; Lee, MR; Wang, JY; Zhang, JF, 2019)
"The rate of GFR event or ESRD (primary outcome) was 31 versus 26 per 1000 person-years for those who added insulin versus sulfonylureas, respectively (adjusted hazard ratio, 1."	1.43	Comparative Effectiveness of Second-Line Agents for the Treatment of Diabetes Type 2 in Preventing Kidney Function Decline. ( Greevy, RA; Griffin, MR; Grijalva, CG; Hung, AM; Ikizler, TA; Liu, X; Murff, HJ; Roumie, CL, 2016)
"Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus."	1.40	Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2. ( Altun, E; Karayaylalı, I; Kaya, B; Paydaş, S; Sarıakçalı, B, 2014)
"Metformin was independently associated with lower prevalence of cardiovascular disease for any age quartile and eGFR category than all other treatments."	1.39	Age, renal dysfunction, cardiovascular disease, and antihyperglycemic treatment in type 2 diabetes mellitus: findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study. ( Bonora, E; Cavalot, F; Cignarelli, M; Ferrannini, E; Fondelli, C; Morano, S; Orsi, E; Penno, G; Pugliese, G; Solini, A; Trevisan, R; Vedovato, M, 2013)
"We should suspect metformin-induced encephalopathy and withdraw the drug when presented with diabetic patients with chronic kidney disease and neurological signs and symptoms of unknown cause."	1.39	Two additional cases of metformin-associated encephalopathy in patients with end-stage renal disease undergoing hemodialysis. ( Bae, EJ; Chang, SH; Cho, HS; Jeon, DH; Kang, YJ; Kim, HJ; Park, DJ; Seo, JW, 2013)
" These two groups did not differ significantly with respect to volume of distribution (Vd), time to peak concentration (tmax), and parameters related to metformin's appearance in the urine."	1.29	Kidney function and age are both predictors of pharmacokinetics of metformin. ( Benet, LZ; Chiang, J; Cogan, MG; Goodman, AM; Lin, ET; Liu, CY; Sambol, NC, 1995)

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (5.08)	18.7374
1990's	6 (10.17)	18.2507
2000's	7 (11.86)	29.6817
2010's	37 (62.71)	24.3611
2020's	6 (10.17)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

3 (5.08)

18.7374

1990's

6 (10.17)

18.2507

2000's

7 (11.86)

29.6817

2010's

37 (62.71)

24.3611

2020's

6 (10.17)

2.80

Authors

Authors	Studies
Okyere, P	1
Okyere, I	1
Essuman, G	1
Attakora, J	1
Serwaa, D	1
Donkoh, IE	1
Ephraim, RKD	1
Bobenko, AI	1
Heller, S	1
Schmitt, N	1
Cherdtrakulkiat, R	1
Lawung, R	1
Nabu, S	1
Tantimavanich, S	1
Sinthupoom, N	1
Prachayasittikul, S	1
Prachayasittikul, V	1
Zhang, B	1
Wu, C	1
Zhang, Z	3
Yan, K	1
Li, C	2
Li, Y	4
Li, L	3
Zheng, C	1
Xiao, Y	1
He, D	1
Zhao, F	1
Su, JF	1
Lun, SM	1
Hou, YJ	1
Duan, LJ	1
Wang, NC	1
Shen, FF	1
Zhang, YW	1
Gao, ZW	1
Li, J	6
Du, XJ	1
Zhou, FY	1
Yin, Z	1
Zhu, J	2
Yan, D	1
Lou, H	1
Yu, H	1
Feng, C	1
Wang, Z	1
Wang, Y	4
Hu, X	1
Li, Z	2
Shen, Y	1
Hu, D	1
Chen, H	1
Wu, X	1
Duan, Y	1
Zhi, D	1
Zou, M	2
Zhao, Z	1
Zhang, X	2
Yang, X	2
Zhang, J	2
Wang, H	1
Popović, KJ	1
Popović, DJ	1
Miljković, D	1
Lalošević, D	1
Čapo, I	1
Popović, JK	1
Liu, M	1
Song, H	2
Xing, Z	1
Lu, G	1
Chen, D	1
Valentini, AM	1
Di Pinto, F	1
Coletta, S	1
Guerra, V	1
Armentano, R	1
Caruso, ML	1
Gong, J	1
Wang, N	1
Bian, L	1
Wang, M	1
Ye, M	1
Wen, N	1
Fu, M	1
Fan, W	1
Meng, Y	1
Dong, G	1
Lin, XH	1
Liu, HH	1
Gao, DM	1
Cui, JF	1
Ren, ZG	1
Chen, RX	1
Önal, B	1
Özen, D	1
Demir, B	1
Akkan, AG	1
Özyazgan, S	1
Payette, G	1
Geoffroy, V	1
Martineau, C	1
Villemur, R	1
Jameel, T	1
Baig, M	1
Gazzaz, ZJ	1
Tashkandi, JM	1
Al Alhareth, NS	1
Khan, SA	1
Butt, NS	1
Wang, J	2
Geng, Y	1
Zhang, Y	3
Wang, X	2
Liu, J	2
Basit, A	1
Miao, T	1
Liu, W	1
Jiang, W	1
Yu, ZY	1
Wu, L	2
Qu, B	1
Sun, JX	1
Cai, AL	1
Xie, LM	1
Groeneveld, J	1
Ho, SL	1
Mackensen, A	1
Mohtadi, M	1
Laepple, T	1
Genovesi, S	1
Nava, E	1
Bartolucci, C	1
Severi, S	1
Vincenti, A	1
Contaldo, G	1
Bigatti, G	1
Ciurlino, D	1
Bertoli, SV	1
Slovak, JE	1
Hwang, JK	1
Rivera, SM	1
Villarino, NF	1
Li, S	1
Cao, G	1
Ling, M	1
Ji, J	1
Zhao, D	1
Sha, Y	1
Gao, X	1
Liang, C	2
Guo, Q	1
Zhou, C	1
Ma, Z	1
Xu, J	1
Wang, C	1
Zhao, W	1
Xia, X	1
Jiang, Y	1
Peng, J	1
Jia, Z	1
Li, F	1
Chen, X	2
Mo, J	1
Zhang, S	2
Li, X	1
Huang, T	1
Zhu, Q	1
Wang, S	1
Ge, RS	1
Fortunato, G	1
Lin, J	2
Agarwal, PK	1
Kohen, A	1
Singh, P	1
Cheatum, CM	1
Zhu, D	1
Hayman, A	1
Kebede, B	1
Stewart, I	1
Chen, G	1
Frew, R	1
Guo, X	1
Gong, Q	1
Borowiec, J	1
Han, S	1
Zhang, M	1
Willis, M	1
Kreouzis, T	1
Yu, K	1
Chirvony, VS	1
Sekerbayev, KS	1
Pérez-Del-Rey, D	1
Martínez-Pastor, JP	1
Palazon, F	1
Boix, PP	1
Taurbayev, TI	1
Sessolo, M	1
Bolink, HJ	1
Lu, M	1
Lan, Y	1
Xiao, J	1
Song, M	1
Chen, C	1
Huang, Q	1
Cao, Y	1
Ho, CT	1
Qi, B	1
Wang, Q	1
Zhang, W	1
Fang, L	1
Xie, CL	1
Chen, R	1
Yang, S	1
Xia, JM	1
Zhang, GY	1
Chen, CH	1
Yang, XW	1
Domenech-Ximenos, B	1
Garza, MS	1
Prat-González, S	1
Sepúlveda-Martínez, Á	1
Crispi, F	1
Perea, RJ	1
Garcia-Alvarez, A	1
Sitges, M	1
Kalumpha, M	1
Guyo, U	1
Zinyama, NP	1
Vakira, FM	1
Nyamunda, BC	1
Varga, M	1
Drácz, L	1
Kolbenheyer, E	1
Varga, F	1
Patai, ÁV	1
Solymosi, N	1
Patai, Á	1
Kiss, J	1
Gaál, V	1
Nyul, Z	1
Mosdósi, B	1
Valdez, M	1
Moosavi, L	1
Heidari, A	1
Novakovic-Agopian, T	1
Kornblith, E	1
Abrams, G	1
McQuaid, JR	1
Posecion, L	1
Burciaga, J	1
D'Esposito, M	1
Chen, AJW	1
Samy El Gendy, NM	1
Wesolowska, P	1
Georg, D	1
Lechner, W	1
Kazantsev, P	1
Bokulic, T	1
Tedgren, AC	1
Adolfsson, E	1
Campos, AM	1
Alves, VGL	1
Suming, L	1
Hao, W	1
Ekendahl, D	1
Koniarova, I	1
Bulski, W	1
Chelminski, K	1
Samper, JLA	1
Vinatha, SP	1
Rakshit, S	1
Siri, S	1
Tomsejm, M	1
Tenhunen, M	1
Povall, J	1
Kry, SF	1
Followill, DS	1
Thwaites, DI	1
Izewska, J	1
Kang, JH	1
Yoon, Y	1
Song, J	1
Van de Winckel, A	1
Gauthier, L	1
Chao, CT	1
Lee, YH	1
Li, CM	1
Han, DS	1
Huang, JW	1
Huang, KC	1
Ni, L	1
Güttinger, R	1
Triana, CA	1
Spingler, B	1
Baldridge, KK	1
Patzke, GR	1
Shen, X	1
Wang, B	1
Xie, S	1
Deng, W	1
Wu, D	1
Zhang, Q	1
Voskamp, BJ	1
Peelen, MJCS	1
Ravelli, ACJ	1
van der Lee, R	1
Mol, BWJ	1
Pajkrt, E	1
Ganzevoort, W	1
Kazemier, BM	1
Tibrewala, R	1
Bahroos, E	1
Mehrabian, H	1
Foreman, SC	1
Link, TM	1
Pedoia, V	1
Majumdar, S	1
Jablonski, CL	1
Leonard, C	1
Salo, P	1
Krawetz, RJ	1
Yoon, N	1
Hong, SN	1
Cho, JG	1
Jeong, HK	1
Lee, KH	1
Park, HW	1
Barman, S	1
Konai, MM	1
Samaddar, S	1
Haldar, J	1
Mohamed, HSH	1
Li, CF	1
Hu, ZY	1
Deng, Z	1
Chen, LH	1
Su, BL	1
Chu, K	1
Liu, YP	1
Li, YB	1
Zhang, H	1
Xu, C	1
Zou, Z	1
Wu, Z	1
Xia, Y	1
Zhao, P	1
Wang, HT	1
de Biase, S	1
Pellitteri, G	1
Gigli, GL	1
Valente, M	1
Kwon, S	1
Kim, YC	1
Park, JY	1
Lee, J	2
An, JN	1
Kim, CT	1
Oh, S	1
Park, S	1
Kim, DK	1
Oh, YK	1
Kim, YS	1
Lim, CS	1
Lee, JP	1
Armario, P	1
Brotons, C	1
Elosua, R	1
Alonso de Leciñana, M	1
Castro, A	1
Clarà, A	1
Cortés, O	1
Díaz Rodriguez, Á	1
Herranz, M	1
Justo, S	1
Lahoz, C	1
Pedro-Botet, J	1
Pérez Pérez, A	1
Santamaria, R	1
Tresserras, R	1
Aznar Lain, S	1
Royo-Bordonada, MÁ	1
El-Rashid, M	1
Nguyen-Ngo, D	1
Minhas, N	1
Meijles, DN	1
Ghimire, K	1
Julovi, S	1
Rogers, NM	1
Mariano, F	1
Biancone, L	1
Chang, YA	1
Tarng, DC	2
Yang, CY	1
Raslan, IA	1
McDonald, EG	1
Lee, TC	1
Alnasrallah, B	1
Pilmore, H	1
Manley, P	1
Schwetz, V	1
Eisner, F	1
Schilcher, G	1
Eller, K	1
Plank, J	1
Lind, A	1
Pieber, TR	1
Mader, JK	1
Eller, P	1
Muharremi, S	1
Vest, LS	1
Koraishy, FM	1
Lam, NN	1
Schnitzler, MA	1
Dharnidharka, VR	1
Axelrod, D	1
Naik, AS	1
Alhamad, TA	1
Kasiske, BL	1
Hess, GP	1
Lentine, KL	1
Kim, KJ	1
Choi, J	1
Bae, JH	1
An, JH	1
Kim, HY	1
Yoo, HJ	1
Seo, JA	1
Kim, NH	2
Choi, KM	1
Baik, SH	1
Kim, SG	1
Lee, MC	1
Lee, CH	1
Chang, LY	1
Chang, CH	1
Zhang, JF	1
Lee, MR	1
Wang, JY	1
Chen, SM	1
Süfke, S	1
Steinhoff, J	1
Schütt, M	1
Solini, A	1
Penno, G	1
Bonora, E	1
Fondelli, C	1
Orsi, E	1
Trevisan, R	1
Vedovato, M	1
Cavalot, F	1
Cignarelli, M	1
Morano, S	1
Ferrannini, E	1
Pugliese, G	1
Altun, E	1
Kaya, B	1
Paydaş, S	1
Sarıakçalı, B	1
Karayaylalı, I	1
Erpicum, P	1
Krzesinski, JM	1
Jouret, F	1
Dziuba, J	1
Alperin, P	1
Racketa, J	1
Iloeje, U	1
Goswami, D	1
Hardy, E	1
Perlstein, I	1
Grossman, HL	1
Cohen, M	1
Al-Hwiesh, AK	1
Abdul-Rahman, IS	1
El-Deen, MA	1
Larbi, E	1
Divino-Filho, JC	1
Al-Mohanna, FA	1
Gupta, KL	1
Adam, WR	2
O'Brien, RC	2
Jones, GC	1
Sainsbury, CA	1
Holman, N	1
Gadsby, R	1
Dunn, L	1
Sylvester, C	1
Young, B	1
Petrie, MC	1
Boyle, JG	1
McKay, GA	1
Stiefelhagen, P	1
Almaleki, N	1
Ashraf, M	1
Hussein, MM	1
Mohiuddin, SA	1
Zechmann, S	1
Gao, J	1
Gu, Z	1
Xu, Y	1

Studies

Okyere, P

Okyere, I

Essuman, G

Attakora, J

Serwaa, D

Donkoh, IE

Ephraim, RKD

Bobenko, AI

Heller, S

Schmitt, N

Cherdtrakulkiat, R

Lawung, R

Nabu, S

Tantimavanich, S

Sinthupoom, N

Prachayasittikul, S

Prachayasittikul, V

Zhang, B

Wu, C

Zhang, Z

Yan, K

Li, C

Li, Y

Li, L

Zheng, C

Xiao, Y

He, D

Zhao, F

Su, JF

Lun, SM

Hou, YJ

Duan, LJ

Wang, NC

Shen, FF

Zhang, YW

Gao, ZW

Li, J

Du, XJ

Zhou, FY

Yin, Z

Zhu, J

Yan, D

Lou, H

Yu, H

Feng, C

Wang, Z

Wang, Y

Hu, X

Li, Z

Shen, Y

Hu, D

Chen, H

Wu, X

Duan, Y

Zhi, D

Zou, M

Zhao, Z

Zhang, X

Yang, X

Zhang, J

Wang, H

Popović, KJ

Popović, DJ

Miljković, D

Lalošević, D

Čapo, I

Popović, JK

Liu, M

Song, H

Xing, Z

Lu, G

Chen, D

Valentini, AM

Di Pinto, F

Coletta, S

Guerra, V

Armentano, R

Caruso, ML

Gong, J

Wang, N

Bian, L

Wang, M

Ye, M

Wen, N

Fu, M

Fan, W

Meng, Y

Dong, G

Lin, XH

Liu, HH

Gao, DM

Cui, JF

Ren, ZG

Chen, RX

Önal, B

Özen, D

Demir, B

Akkan, AG

Özyazgan, S

Payette, G

Geoffroy, V

Martineau, C

Villemur, R

Jameel, T

Baig, M

Gazzaz, ZJ

Tashkandi, JM

Al Alhareth, NS

Khan, SA

Butt, NS

Wang, J

Geng, Y

Zhang, Y

Wang, X

Liu, J

Basit, A

Miao, T

Liu, W

Jiang, W

Yu, ZY

Wu, L

Qu, B

Sun, JX

Cai, AL

Xie, LM

Groeneveld, J

Ho, SL

Mackensen, A

Mohtadi, M

Laepple, T

Genovesi, S

Nava, E

Bartolucci, C

Severi, S

Vincenti, A

Contaldo, G

Bigatti, G

Ciurlino, D

Bertoli, SV

Slovak, JE

Hwang, JK

Rivera, SM

Villarino, NF

Li, S

Cao, G

Ling, M

Ji, J

Zhao, D

Sha, Y

Gao, X

Liang, C

Guo, Q

Zhou, C

Ma, Z

Xu, J

Wang, C

Zhao, W

Xia, X

Jiang, Y

Peng, J

Jia, Z

Li, F

Chen, X

Mo, J

Zhang, S

Li, X

Huang, T

Zhu, Q

Wang, S

Ge, RS

Fortunato, G

Lin, J

Agarwal, PK

Kohen, A

Singh, P

Cheatum, CM

Zhu, D

Hayman, A

Kebede, B

Stewart, I

Chen, G

Frew, R

Guo, X

Gong, Q

Borowiec, J

Han, S

Zhang, M

Willis, M

Kreouzis, T

Yu, K

Chirvony, VS

Sekerbayev, KS

Pérez-Del-Rey, D

Martínez-Pastor, JP

Palazon, F

Boix, PP

Taurbayev, TI

Sessolo, M

Bolink, HJ

Lu, M

Lan, Y

Xiao, J

Song, M

Chen, C

Huang, Q

Cao, Y

Ho, CT

Qi, B

Wang, Q

Zhang, W

Fang, L

Xie, CL

Chen, R

Yang, S

Xia, JM

Zhang, GY

Chen, CH

Yang, XW

Domenech-Ximenos, B

Garza, MS

Prat-González, S

Sepúlveda-Martínez, Á

Crispi, F

Perea, RJ

Garcia-Alvarez, A

Sitges, M

Kalumpha, M

Guyo, U

Zinyama, NP

Vakira, FM

Nyamunda, BC

Varga, M

Drácz, L

Kolbenheyer, E

Varga, F

Patai, ÁV

Solymosi, N

Patai, Á

Kiss, J

Gaál, V

Nyul, Z

Mosdósi, B

Valdez, M

Moosavi, L

Heidari, A

Novakovic-Agopian, T

Kornblith, E

Abrams, G

McQuaid, JR

Posecion, L

Burciaga, J

D'Esposito, M

Chen, AJW

Samy El Gendy, NM

Wesolowska, P

Georg, D

Lechner, W

Kazantsev, P

Bokulic, T

Tedgren, AC

Adolfsson, E

Campos, AM

Alves, VGL

Suming, L

Hao, W

Ekendahl, D

Koniarova, I

Bulski, W

Chelminski, K

Samper, JLA

Vinatha, SP

Rakshit, S

Siri, S

Tomsejm, M

Tenhunen, M

Povall, J

Kry, SF

Followill, DS

Thwaites, DI

Izewska, J

Kang, JH

Yoon, Y

Song, J

Van de Winckel, A

Gauthier, L

Chao, CT

Lee, YH

Li, CM

Han, DS

Huang, JW

Huang, KC

Ni, L

Güttinger, R

Triana, CA

Spingler, B

Baldridge, KK

Patzke, GR

Shen, X

Wang, B

Xie, S

Deng, W

Wu, D

Zhang, Q

Voskamp, BJ

Peelen, MJCS

Ravelli, ACJ

van der Lee, R

Mol, BWJ

Pajkrt, E

Ganzevoort, W

Kazemier, BM

Tibrewala, R

Bahroos, E

Mehrabian, H

Foreman, SC

Link, TM

Pedoia, V

Majumdar, S

Jablonski, CL

Leonard, C

Salo, P

Krawetz, RJ

Yoon, N

Hong, SN

Cho, JG

Jeong, HK

Lee, KH

Park, HW

Barman, S

Konai, MM

Samaddar, S

Haldar, J

Mohamed, HSH

Li, CF

Hu, ZY

Deng, Z

Chen, LH

Su, BL

Chu, K

Liu, YP

Li, YB

Zhang, H

Xu, C

Zou, Z

Wu, Z

Xia, Y

Zhao, P

Wang, HT

de Biase, S

Pellitteri, G

Gigli, GL

Valente, M

Kwon, S

Kim, YC

Park, JY

Lee, J

An, JN

Kim, CT

Oh, S

Park, S

Kim, DK

Oh, YK

Kim, YS

Lim, CS

Lee, JP

Armario, P

Brotons, C

Elosua, R

Alonso de Leciñana, M

Castro, A

Clarà, A

Cortés, O

Díaz Rodriguez, Á

Herranz, M

Justo, S

Lahoz, C

Pedro-Botet, J

Pérez Pérez, A

Santamaria, R

Tresserras, R

Aznar Lain, S

Royo-Bordonada, MÁ

El-Rashid, M

Nguyen-Ngo, D

Minhas, N

Meijles, DN

Ghimire, K

Julovi, S

Rogers, NM

Mariano, F

Biancone, L

Chang, YA

Tarng, DC

Yang, CY

Raslan, IA

McDonald, EG

Lee, TC

Alnasrallah, B

Pilmore, H

Manley, P

Schwetz, V

Eisner, F

Schilcher, G

Eller, K

Plank, J

Lind, A

Pieber, TR

Mader, JK

Eller, P

Muharremi, S

Vest, LS

Koraishy, FM

Lam, NN

Schnitzler, MA

Dharnidharka, VR

Axelrod, D

Naik, AS

Alhamad, TA

Kasiske, BL

Hess, GP

Lentine, KL

Kim, KJ

Choi, J

Bae, JH

An, JH

Kim, HY

Yoo, HJ

Seo, JA

Kim, NH

Choi, KM

Baik, SH

Kim, SG

Lee, MC

Lee, CH

Chang, LY

Chang, CH

Zhang, JF

Lee, MR

Wang, JY

Chen, SM

Süfke, S

Steinhoff, J

Schütt, M

Solini, A

Penno, G

Bonora, E

Fondelli, C

Orsi, E

Trevisan, R

Vedovato, M

Cavalot, F

Cignarelli, M

Morano, S

Ferrannini, E

Pugliese, G

Altun, E

Kaya, B

Paydaş, S

Sarıakçalı, B

Karayaylalı, I

Erpicum, P

Krzesinski, JM

Jouret, F

Dziuba, J

Alperin, P

Racketa, J

Iloeje, U

Goswami, D

Hardy, E

Perlstein, I

Grossman, HL

Cohen, M

Al-Hwiesh, AK

Abdul-Rahman, IS

El-Deen, MA

Larbi, E

Divino-Filho, JC

Al-Mohanna, FA

Gupta, KL

Adam, WR

O'Brien, RC

Jones, GC

Sainsbury, CA

Holman, N

Gadsby, R

Dunn, L

Sylvester, C

Young, B

Petrie, MC

Boyle, JG

McKay, GA

Stiefelhagen, P

Almaleki, N

Ashraf, M

Hussein, MM

Mohiuddin, SA

Zechmann, S

Gao, J

Gu, Z

Xu, Y

Na, Y

Carlson, N

Hommel, K

Olesen, JB

Gerds, TA

Soja, AM

Vilsbøll, T

Kamper, AL

Torp-Pedersen, C

Gislason, G

Chowdhury, TA

Srirathan, D

Abraham, G

Oei, EL

Fan, SL

McCafferty, K

Yaqoob, MM

Smith, FC

Kumar, SS

Furlong, TJ

Gangaram, SV

Greenfield, JR

Stocker, SL

Graham, GG

Williams, KM

Day, RO

Chen, YH

Chen, HS

Hung, AM

Roumie, CL

Greevy, RA

Grijalva, CG

Liu, X

Murff, HJ

Ikizler, TA

Griffin, MR

Mani, MK

Jung, EY

Cho, HS

Seo, JW

Kim, DW

Kim, HJ

Chang, SH

Park, DJ

Khurana, R

Malik, IS

Tsitsios, T

Sotirakopoulos, N

Armentzioiou, K

Kalogiannidou, I

Kolaggis, A

Mavromatidis, K

Weir, MA

Gomes, T

Mamdani, M

Juurlink, DN

Hackam, DG

Mahon, JL

Jain, AK

Garg, AX

Nye, HJ

Herrington, WG

Cigarrán, S

Rodriguez, ML

Pousa, M

Menéndez, H

Mendez, MJ

Martin Gómez, MA

Sánchez Martos, MD

García Marcos, SA

Serrano Carrillo de Albornoz, JL

Burtey, S

Kang, YJ

Bae, EJ

Jeon, DH

Komazawa, H

Yamaguchi, H

Hidaka, K

Ogura, J

Kobayashi, M

Iseki, K

Weekes, AJ

Thomas, MC

Gudmundsdottir, H

Brørs, O

Os, I

Bruijstens, LA

van Luin, M

Buscher-Jungerhans, PM

Bosch, FH

Zhang, YF

Ning, G

Hermann, LS

Magnusson, S

Möller, B

Casey, C

Tucker, GT

Woods, HF

Khan, IH

Catto, GR

MacLeod, AM

Sambol, NC

Chiang, J

Lin, ET

Goodman, AM

Liu, CY

Benet, LZ

Cogan, MG

Bloomgarden, ZT

Schmidt, R

Horn, E

Richards, J

Stamatakis, M

Darwich, MS

Allaf, W

Doorenbos, CJ

Bosma, RJ

Lamberts, PJ

Mirouze, J

Mion, C

Beraud, JJ

Selam, JL

Gan, SC

Barr, J

Arieff, AI

Pearl, RG

Laursen, B

Gormsen, J

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy[NCT01175486]	Phase 4	200 participants (Anticipated)	Interventional	2010-07-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy[NCT01175486]

Phase 4

200 participants (Anticipated)

Interventional

2010-07-31

Recruiting

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

14 reviews available for metformin and Chronic Kidney Failure

Article	Year
Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227 Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P	2019
[Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines.] Revista espanola de salud publica, 2020, Sep-11, Volume: 94 Topics: Cardiology; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Exercise; Humans; Kidney Failu	2020
Metformin, chronic nephropathy and lactic acidosis: a multi-faceted issue for the nephrologist. Journal of nephrology, 2021, Volume: 34, Issue:4 Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; M	2021
[Role of AMP-activated protein kinase in renal ischemic preconditioning]. Nephrologie & therapeutique, 2014, Volume: 10, Issue:1 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Enzyme Activa	2014
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:9 Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat	2014
Metformin-associated lactic acidosis in a peritoneal dialysis patient. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:2 Topics: Acidosis, Lactic; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypo	2015
[Metformin is also recommended in mild and moderate renal failure]. Praxis, 2015, Mar-25, Volume: 104, Issue:7 Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Ki	2015
Could metformin be used in patients with diabetes and advanced chronic kidney disease? Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:2 Topics: Acidosis, Lactic; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycem	2017
Metformin: safety in cardiac patients. Heart (British Cardiac Society), 2010, Volume: 96, Issue:2 Topics: Acidosis, Lactic; Contraindications; Contrast Media; Heart Failure; Humans; Hypoglycemic Agents; Iod	2010
Metformin: the safest hypoglycaemic agent in chronic kidney disease? Nephron. Clinical practice, 2011, Volume: 118, Issue:4 Topics: Acidosis, Lactic; Animals; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin	2011
[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments]. Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Chromosomes, Human, Pair 16; Clini	2011
Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. The Netherlands journal of medicine, 2008, Volume: 66, Issue:5 Topics: Acidosis, Lactic; Aged; Bicarbonates; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic;	2008
Mecobalamin. Expert opinion on investigational drugs, 2008, Volume: 17, Issue:6 Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes;	2008
Biguanide-associated lactic acidosis. Case report and review of the literature. Archives of internal medicine, 1992, Volume: 152, Issue:11 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Emigration and Immi	1992

Article

Year

Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227

Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P

2019

[Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines.]

Revista espanola de salud publica, 2020, Sep-11, Volume: 94

Topics: Cardiology; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Exercise; Humans; Kidney Failu

2020

Metformin, chronic nephropathy and lactic acidosis: a multi-faceted issue for the nephrologist.

Journal of nephrology, 2021, Volume: 34, Issue:4

Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; M

2021

[Role of AMP-activated protein kinase in renal ischemic preconditioning].

Nephrologie & therapeutique, 2014, Volume: 10, Issue:1

Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Enzyme Activa

2014

A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.

Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:9

Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat

2014

Metformin-associated lactic acidosis in a peritoneal dialysis patient.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:2

Topics: Acidosis, Lactic; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypo

2015

[Metformin is also recommended in mild and moderate renal failure].

Praxis, 2015, Mar-25, Volume: 104, Issue:7

Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Ki

2015

Could metformin be used in patients with diabetes and advanced chronic kidney disease?

Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:2

Topics: Acidosis, Lactic; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycem

2017

Metformin: safety in cardiac patients.

Heart (British Cardiac Society), 2010, Volume: 96, Issue:2

Topics: Acidosis, Lactic; Contraindications; Contrast Media; Heart Failure; Humans; Hypoglycemic Agents; Iod

2010

Metformin: the safest hypoglycaemic agent in chronic kidney disease?

Nephron. Clinical practice, 2011, Volume: 118, Issue:4

Topics: Acidosis, Lactic; Animals; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin

2011

[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].

Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11

Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Chromosomes, Human, Pair 16; Clini

2011

Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment.

The Netherlands journal of medicine, 2008, Volume: 66, Issue:5

Topics: Acidosis, Lactic; Aged; Bicarbonates; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic;

2008

Mecobalamin.

Expert opinion on investigational drugs, 2008, Volume: 17, Issue:6

Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes;

2008

Biguanide-associated lactic acidosis. Case report and review of the literature.

Archives of internal medicine, 1992, Volume: 152, Issue:11

Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Emigration and Immi

1992

Trials

2 trials available for metformin and Chronic Kidney Failure

Article	Year
Protocol for a pilot randomised controlled trial of metformin in pre-diabetes after kidney transplantation: the Transplantation and Diabetes (Transdiab) study. BMJ open, 2017, Aug-23, Volume: 7, Issue:8 Topics: Blood Glucose; Glucose Intolerance; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemi	2017
Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study. PloS one, 2016, Volume: 11, Issue:11 Topics: Acarbose; Aged; Albumins; Albuminuria; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Drug Th	2016

Article

Year

Protocol for a pilot randomised controlled trial of metformin in pre-diabetes after kidney transplantation: the Transplantation and Diabetes (Transdiab) study.

BMJ open, 2017, Aug-23, Volume: 7, Issue:8

Topics: Blood Glucose; Glucose Intolerance; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemi

2017

Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study.

PloS one, 2016, Volume: 11, Issue:11

Topics: Acarbose; Aged; Albumins; Albuminuria; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Drug Th

2016

Other Studies

43 other studies available for metformin and Chronic Kidney Failure

Article	Year
Conservative therapy is associated with worse clinical features and biochemical derangements than renal replacement therapy: a retrospective study in Kumasi, Ghana. BMC nephrology, 2022, 10-26, Volume: 23, Issue:1 Topics: Adult; Aspirin; Bisoprolol; Conservative Treatment; Furosemide; Ghana; Humans; Irbesartan; Kidney Fa	2022
The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease. Diabetes care, 2020, Volume: 43, Issue:5 Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Diabetes Mellitus, Type 2	2020
Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury. Scientific reports, 2020, 12-15, Volume: 10, Issue:1 Topics: Acute Kidney Injury; Animals; Colchicine; Drug Repositioning; Humans; Kidney Failure, Chronic; Metfo	2020
Lentiform fork sign in a uremic patient after inadvertent exposure to metformin. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:3 Topics: Brain Diseases; Female; Humans; Kidney Failure, Chronic; Magnetic Resonance Imaging; Metformin; Midd	2022
Missed Opportunities for Deprescription: A Teachable Moment. JAMA internal medicine, 2017, 07-01, Volume: 177, Issue:7 Topics: Aged, 80 and over; Deprescriptions; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combina	2017
Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. Wiener klinische Wochenschrift, 2017, Volume: 129, Issue:17-18 Topics: Acidosis, Lactic; Aged; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combi	2017
FOURNIER'S GANGRENE, A RARE COMPLICATION OF DIABETES MELLITUS (CASE REPORT). Georgian medical news, 2018, Issue:277 Topics: Diabetes Mellitus, Type 2; Fatal Outcome; Fournier Gangrene; Humans; Hypoglycemic Agents; Kidney Fai	2018
Metformin use in the first year after kidney transplant, correlates, and associated outcomes in diabetic transplant recipients: A retrospective analysis of integrated registry and pharmacy claims data. Clinical transplantation, 2018, Volume: 32, Issue:8 Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glomerular Filtratio	2018
Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study. Cardiovascular diabetology, 2019, 03-11, Volume: 18, Issue:1 Topics: Biomarkers; Blood Glucose; Cerebrovascular Disorders; Databases, Factual; Diabetes Mellitus, Type 2;	2019
Association of Metformin Use With End-Stage Renal Disease in Patients With Type 2 Diabetes Mellitus: A Nationwide Cohort Study Under the Pay-for-Performance Program. Journal of clinical pharmacology, 2019, Volume: 59, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Inci	2019
[Diabetes treatment in patients with chronic kidney disease]. Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:21 Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Substitution; Drug Therapy, Combinatio	2013
Age, renal dysfunction, cardiovascular disease, and antihyperglycemic treatment in type 2 diabetes mellitus: findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study. Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8 Topics: Age Factors; Aged; Albuminuria; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2;	2013
Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2. Hemodialysis international. International Symposium on Home Hemodialysis, 2014, Volume: 18, Issue:2 Topics: Acidosis, Lactic; Aged; Chronic Disease; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inc	2014
Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:7 Topics: Amputation, Surgical; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Cardiovascul	2014
Metformin in peritoneal dialysis: a pilot experience. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2014, Volume: 34, Issue:4 Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin	2014
Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'. Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:2 Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl	2015
How does current diabetes care compare with landmark clinical studies? Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:7 Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl	2015
Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base. Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:7 Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl	2015
[Therapy of chronic renal failure. Family practitioner and nephrologist hand in hand]. MMW Fortschritte der Medizin, 2015, Feb-05, Volume: 157, Issue:2 Topics: Contraindications; Contrast Media; Cooperative Behavior; Diabetic Nephropathies; Family Practice; Hu	2015
Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'. Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:11 Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl	2015
Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient . Clinical nephrology, 2016, Volume: 86 (2016), Issue:11 Topics: Acidosis, Lactic; Aged; Diabetic Nephropathies; Dialysis Solutions; Humans; Hypoglycemic Agents; Kid	2016
Metformin-associated risk of acute dialysis in patients with type 2 diabetes: A nationwide cohort study. Diabetes, obesity & metabolism, 2016, Volume: 18, Issue:12 Topics: Acute Kidney Injury; Aged; Cohort Studies; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Hypog	2016
Pharmacokinetics of Metformin in Patients Receiving Regular Hemodiafiltration. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016, Volume: 68, Issue:6 Topics: Diabetes Mellitus, Type 2; Hemodiafiltration; Humans; Hypoglycemic Agents; Kidney Failure, Chronic;	2016
Comparative Effectiveness of Second-Line Agents for the Treatment of Diabetes Type 2 in Preventing Kidney Function Decline. Clinical journal of the American Society of Nephrology : CJASN, 2016, 12-07, Volume: 11, Issue:12 Topics: Aged; Comparative Effectiveness Research; Creatinine; Diabetes Mellitus, Type 2; Drug Therapy, Combi	2016
Metformin in renal failure--weigh the evidence. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:7 Topics: Contraindications; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents;	2009
Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin. Hemodialysis international. International Symposium on Home Hemodialysis, 2009, Volume: 13, Issue:2 Topics: Acidosis, Lactic; Brain Diseases; Contraindications; Diabetes Mellitus, Type 1; Diabetic Nephropathi	2009
Metformin induced severe hypophosphatemia in a patient on hemodialysis. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2010, Volume: 21, Issue:5 Topics: Aged; Biomarkers; Diabetes Mellitus; Down-Regulation; Fatigue; Female; Humans; Hypoglycemic Agents;	2010
Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:6 Topics: Aged; Aged, 80 and over; Canada; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Follow-Up	2011
Transient vision loss in a patient with severe metformin-associated lactic acidosis. QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:8 Topics: Acidosis, Lactic; Acute Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Hypoglyc	2012
Metformin-induced lactic acidosis: usefulness of measuring levels and therapy with high-flux haemodialysis. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:5 Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged, 80 and over; Comorbidity; Diabetes Mellitus, Type 2;	2011
Two additional cases of metformin-associated encephalopathy in patients with end-stage renal disease undergoing hemodialysis. Hemodialysis international. International Symposium on Home Hemodialysis, 2013, Volume: 17, Issue:1 Topics: Brain Diseases; Contraindications; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Mag	2013
Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:3 Topics: Adenine; Animals; Anti-Bacterial Agents; Body Weight; Gene Expression; Hypoglycemic Agents; Kidney;	2013
The use of oral antidiabetic agents in primary care. Australian family physician, 2007, Volume: 36, Issue:6 Topics: Aged; Diabetes Mellitus, Type 2; Drug Utilization Review; Female; Glomerular Filtration Rate; Guidel	2007
[Metformin should not be used by patients with reduced renal function]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, Apr-17, Volume: 128, Issue:8 Topics: Acidosis, Lactic; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Ag	2008
Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. Acta medica Scandinavica, 1981, Volume: 209, Issue:6 Topics: Acidosis; Aged; Diabetes Mellitus; Diabetic Nephropathies; Digitoxin; Female; Humans; Kidney Failure	1981
Severe lactic acidosis in patient receiving continuous ambulatory peritoneal dialysis. BMJ (Clinical research ed.), 1993, Oct-23, Volume: 307, Issue:6911 Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Kidney Failure	1993
Kidney function and age are both predictors of pharmacokinetics of metformin. Journal of clinical pharmacology, 1995, Volume: 35, Issue:11 Topics: Adult; Age Factors; Aged; Humans; Hypoglycemic Agents; Kidney; Kidney Failure, Chronic; Metformin; M	1995
Conference report: renal disease, metformin, and the adipocyte. Diabetes care, 1996, Volume: 19, Issue:9 Topics: Adipocytes; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabet	1996
Survival after metformin-associated lactic acidosis in peritoneal dialysis--dependent renal failure. The American journal of medicine, 1997, Volume: 102, Issue:5 Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Kidney Failure, Ch	1997
Metabolic acidosis. Postgraduate medical journal, 1998, Volume: 74, Issue:873 Topics: Acidosis; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin; Middle Aged	1998
Use of urea containing dialysate to avoid disequilibrium syndrome, enabling intensive dialysis treatment of a diabetic patient with renal failure and severe metformin induced lactic acidosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:6 Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypoglyce	2001
[Letter: Lactic acidosis during renal insufficiency in two diabetic patients treated with metformin]. La Nouvelle presse medicale, 1976, Apr-10, Volume: 5, Issue:15 Topics: Aged; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Humans; Kidney Failure, Chronic; Lactates; M	1976
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity. Scandinavian journal of haematology, 1969, Volume: 6, Issue:6 Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu	1969

Article

Year

Conservative therapy is associated with worse clinical features and biochemical derangements than renal replacement therapy: a retrospective study in Kumasi, Ghana.

BMC nephrology, 2022, 10-26, Volume: 23, Issue:1

Topics: Adult; Aspirin; Bisoprolol; Conservative Treatment; Furosemide; Ghana; Humans; Irbesartan; Kidney Fa

2022

The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease.

Diabetes care, 2020, Volume: 43, Issue:5

Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Diabetes Mellitus, Type 2

2020

Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury.

Scientific reports, 2020, 12-15, Volume: 10, Issue:1

Topics: Acute Kidney Injury; Animals; Colchicine; Drug Repositioning; Humans; Kidney Failure, Chronic; Metfo

2020

Lentiform fork sign in a uremic patient after inadvertent exposure to metformin.

Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:3

Topics: Brain Diseases; Female; Humans; Kidney Failure, Chronic; Magnetic Resonance Imaging; Metformin; Midd

2022

Missed Opportunities for Deprescription: A Teachable Moment.

JAMA internal medicine, 2017, 07-01, Volume: 177, Issue:7

Topics: Aged, 80 and over; Deprescriptions; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combina

2017

Combined metformin-associated lactic acidosis and euglycemic ketoacidosis.

Wiener klinische Wochenschrift, 2017, Volume: 129, Issue:17-18

Topics: Acidosis, Lactic; Aged; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combi

2017

FOURNIER'S GANGRENE, A RARE COMPLICATION OF DIABETES MELLITUS (CASE REPORT).

Georgian medical news, 2018, Issue:277

Topics: Diabetes Mellitus, Type 2; Fatal Outcome; Fournier Gangrene; Humans; Hypoglycemic Agents; Kidney Fai

2018

Metformin use in the first year after kidney transplant, correlates, and associated outcomes in diabetic transplant recipients: A retrospective analysis of integrated registry and pharmacy claims data.

Clinical transplantation, 2018, Volume: 32, Issue:8

Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glomerular Filtratio

2018

Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study.

Cardiovascular diabetology, 2019, 03-11, Volume: 18, Issue:1

Topics: Biomarkers; Blood Glucose; Cerebrovascular Disorders; Databases, Factual; Diabetes Mellitus, Type 2;

2019

Association of Metformin Use With End-Stage Renal Disease in Patients With Type 2 Diabetes Mellitus: A Nationwide Cohort Study Under the Pay-for-Performance Program.

Journal of clinical pharmacology, 2019, Volume: 59, Issue:11

Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Inci

2019

[Diabetes treatment in patients with chronic kidney disease].

Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:21

Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Substitution; Drug Therapy, Combinatio

2013

Age, renal dysfunction, cardiovascular disease, and antihyperglycemic treatment in type 2 diabetes mellitus: findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study.

Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8

Topics: Age Factors; Aged; Albuminuria; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2;

2013

Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2.

Hemodialysis international. International Symposium on Home Hemodialysis, 2014, Volume: 18, Issue:2

Topics: Acidosis, Lactic; Aged; Chronic Disease; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inc

2014

Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes.

Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:7

Topics: Amputation, Surgical; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Cardiovascul

2014

Metformin in peritoneal dialysis: a pilot experience.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2014, Volume: 34, Issue:4

Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin

2014

Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'.

Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:2

Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl

2015

How does current diabetes care compare with landmark clinical studies?

Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:7

Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl

2015

Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base.

Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:7

Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl

2015

[Therapy of chronic renal failure. Family practitioner and nephrologist hand in hand].

MMW Fortschritte der Medizin, 2015, Feb-05, Volume: 157, Issue:2

Topics: Contraindications; Contrast Media; Cooperative Behavior; Diabetic Nephropathies; Family Practice; Hu

2015

Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'.

Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:11

Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl

2015

Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient .

Clinical nephrology, 2016, Volume: 86 (2016), Issue:11

Topics: Acidosis, Lactic; Aged; Diabetic Nephropathies; Dialysis Solutions; Humans; Hypoglycemic Agents; Kid

2016

Metformin-associated risk of acute dialysis in patients with type 2 diabetes: A nationwide cohort study.

Diabetes, obesity & metabolism, 2016, Volume: 18, Issue:12

Topics: Acute Kidney Injury; Aged; Cohort Studies; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Hypog

2016

Pharmacokinetics of Metformin in Patients Receiving Regular Hemodiafiltration.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016, Volume: 68, Issue:6

Topics: Diabetes Mellitus, Type 2; Hemodiafiltration; Humans; Hypoglycemic Agents; Kidney Failure, Chronic;

2016

Comparative Effectiveness of Second-Line Agents for the Treatment of Diabetes Type 2 in Preventing Kidney Function Decline.

Clinical journal of the American Society of Nephrology : CJASN, 2016, 12-07, Volume: 11, Issue:12

Topics: Aged; Comparative Effectiveness Research; Creatinine; Diabetes Mellitus, Type 2; Drug Therapy, Combi

2016

Metformin in renal failure--weigh the evidence.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:7

Topics: Contraindications; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents;

2009

Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin.

Hemodialysis international. International Symposium on Home Hemodialysis, 2009, Volume: 13, Issue:2

Topics: Acidosis, Lactic; Brain Diseases; Contraindications; Diabetes Mellitus, Type 1; Diabetic Nephropathi

2009

Metformin induced severe hypophosphatemia in a patient on hemodialysis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2010, Volume: 21, Issue:5

Topics: Aged; Biomarkers; Diabetes Mellitus; Down-Regulation; Fatigue; Female; Humans; Hypoglycemic Agents;

2010

Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:6

Topics: Aged; Aged, 80 and over; Canada; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Follow-Up

2011

Transient vision loss in a patient with severe metformin-associated lactic acidosis.

QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:8

Topics: Acidosis, Lactic; Acute Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Hypoglyc

2012

Metformin-induced lactic acidosis: usefulness of measuring levels and therapy with high-flux haemodialysis.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:5

Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged, 80 and over; Comorbidity; Diabetes Mellitus, Type 2;

2011

Two additional cases of metformin-associated encephalopathy in patients with end-stage renal disease undergoing hemodialysis.

Hemodialysis international. International Symposium on Home Hemodialysis, 2013, Volume: 17, Issue:1

Topics: Brain Diseases; Contraindications; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Mag

2013

Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.

Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:3

Topics: Adenine; Animals; Anti-Bacterial Agents; Body Weight; Gene Expression; Hypoglycemic Agents; Kidney;

2013

The use of oral antidiabetic agents in primary care.

Australian family physician, 2007, Volume: 36, Issue:6

Topics: Aged; Diabetes Mellitus, Type 2; Drug Utilization Review; Female; Glomerular Filtration Rate; Guidel

2007

[Metformin should not be used by patients with reduced renal function].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, Apr-17, Volume: 128, Issue:8

Topics: Acidosis, Lactic; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Ag

2008

Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function.

Acta medica Scandinavica, 1981, Volume: 209, Issue:6

Topics: Acidosis; Aged; Diabetes Mellitus; Diabetic Nephropathies; Digitoxin; Female; Humans; Kidney Failure

1981

Severe lactic acidosis in patient receiving continuous ambulatory peritoneal dialysis.

BMJ (Clinical research ed.), 1993, Oct-23, Volume: 307, Issue:6911

Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Kidney Failure

1993

Kidney function and age are both predictors of pharmacokinetics of metformin.

Journal of clinical pharmacology, 1995, Volume: 35, Issue:11

Topics: Adult; Age Factors; Aged; Humans; Hypoglycemic Agents; Kidney; Kidney Failure, Chronic; Metformin; M

1995

Conference report: renal disease, metformin, and the adipocyte.

Diabetes care, 1996, Volume: 19, Issue:9

Topics: Adipocytes; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabet

1996

Survival after metformin-associated lactic acidosis in peritoneal dialysis--dependent renal failure.

The American journal of medicine, 1997, Volume: 102, Issue:5

Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Kidney Failure, Ch

1997

Metabolic acidosis.

Postgraduate medical journal, 1998, Volume: 74, Issue:873

Topics: Acidosis; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin; Middle Aged

1998

Use of urea containing dialysate to avoid disequilibrium syndrome, enabling intensive dialysis treatment of a diabetic patient with renal failure and severe metformin induced lactic acidosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:6

Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypoglyce

2001

[Letter: Lactic acidosis during renal insufficiency in two diabetic patients treated with metformin].

La Nouvelle presse medicale, 1976, Apr-10, Volume: 5, Issue:15

Topics: Aged; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Humans; Kidney Failure, Chronic; Lactates; M

1976

Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity.

Scandinavian journal of haematology, 1969, Volume: 6, Issue:6

Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu

1969