metformin has been researched along with Chronic Hepatitis B in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 109 patients who had chronic hepatitis B and were receiving NA therapy were analyzed." | 1.43 | Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma. ( Arai, K; Honda, M; Kaneko, S; Kawaguchi, K; Mizukoshi, E; Nakamura, M; Oishi, N; Okada, H; Sakai, Y; Shimakami, T; Shirasaki, T; Terashima, T; Wang, X; Yamashita, T, 2016) |
| "The occurrence of HCC or a nonliver cancer was evaluated in patients who either were or were not taking statin or metformin." | 1.42 | Cancer risk in HBV patients with statin and metformin use: a population-based cohort study. ( Chang, CJ; Chen, CI; Fang, YA; Hwang, J; Kuan, CF; Liu, JC; Liu, SH; Miser, JS; Wu, LL; Wu, SY; Yang, HC, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CI | 1 |
| Kuan, CF | 1 |
| Fang, YA | 1 |
| Liu, SH | 1 |
| Liu, JC | 1 |
| Wu, LL | 1 |
| Chang, CJ | 1 |
| Yang, HC | 1 |
| Hwang, J | 1 |
| Miser, JS | 1 |
| Wu, SY | 1 |
| Honda, M | 1 |
| Shirasaki, T | 1 |
| Terashima, T | 1 |
| Kawaguchi, K | 1 |
| Nakamura, M | 1 |
| Oishi, N | 1 |
| Wang, X | 1 |
| Shimakami, T | 1 |
| Okada, H | 1 |
| Arai, K | 1 |
| Yamashita, T | 2 |
| Sakai, Y | 1 |
| Mizukoshi, E | 1 |
| Kaneko, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin as Add-on to the Standard Therapy in Patients With Chronic Hepatitis B: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT04182321] | 60 participants (Actual) | Interventional | 2020-03-13 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for metformin and Chronic Hepatitis B
| Article | Year |
|---|---|
Cancer risk in HBV patients with statin and metformin use: a population-based cohort study.
Topics: Adult; Cohort Studies; Drug Synergism; Female; Hepatitis B, Chronic; Humans; Hydroxymethylglutaryl-C | 2015 |
Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.
Topics: Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Hepatitis B Core | 2016 |