Page last updated: 2024-10-30

metformin and Cholestasis

metformin has been researched along with Cholestasis in 8 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).

Research Excerpts

ExcerptRelevanceReference
"Metformin, an oral antidiabetic drug, recently demonstrated a reducing effect on bile acids (BA) plasma concentrations in one patient with intrahepatic cholestasis of pregnancy (ICP) by unknown mechanism."8.02Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. ( Cermanova, J; Faistova, H; Faradonbeh, FA; Hroch, M; Lastuvkova, H; Micuda, S; Mokry, J; Nachtigal, P; Nova, Z; Pavek, P; Sa, II; Uher, M, 2021)
"To investigate the effect of 17alpha-ethynylestradiol (EE)-induced cholestasis on the expression of organic cation transporters (Octs) in the liver and kidney, as well as the pharmacokinetics and pharmacodynamics of metformin in rats."7.75Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. ( Choi, MK; Chung, SJ; Hong, SS; Jin, HE; Kim, DD; Maeng, HJ; Shim, CK, 2009)
"Metformin, an oral antidiabetic drug, recently demonstrated a reducing effect on bile acids (BA) plasma concentrations in one patient with intrahepatic cholestasis of pregnancy (ICP) by unknown mechanism."4.02Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. ( Cermanova, J; Faistova, H; Faradonbeh, FA; Hroch, M; Lastuvkova, H; Micuda, S; Mokry, J; Nachtigal, P; Nova, Z; Pavek, P; Sa, II; Uher, M, 2021)
" Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition."3.96Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression. ( Garzel, B; Heyward, S; Hu, T; Huang, SM; Li, L; Lu, Y; Polli, J; Raufman, JP; Wang, H; Zhang, L, 2020)
"To investigate the effect of 17alpha-ethynylestradiol (EE)-induced cholestasis on the expression of organic cation transporters (Octs) in the liver and kidney, as well as the pharmacokinetics and pharmacodynamics of metformin in rats."3.75Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. ( Choi, MK; Chung, SJ; Hong, SS; Jin, HE; Kim, DD; Maeng, HJ; Shim, CK, 2009)
"Metformin treatment reduced liver injury caused by bile acid, and it suppressed ER stress, inflammation, chemokine expression, and neutrophil infiltration."1.56Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress. ( Cho, DH; Han, JH; Kim, S; Lee, CH; Lee, H; Nam, DH; Woo, CH, 2020)
"Metformin hydrochloride was discontinued, and the patient's jaundice resolved slowly over a period of several months."1.31Cholestatic jaundice associated with the use of metformin. ( Desilets, DJ; Holtzmuller, KC; Moran, KA; Shorr, AF, 2001)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Lee, CH1
Han, JH1
Kim, S2
Lee, H1
Nam, DH1
Cho, DH1
Woo, CH1
Garzel, B1
Hu, T1
Li, L1
Lu, Y1
Heyward, S1
Polli, J1
Zhang, L1
Huang, SM1
Raufman, JP1
Wang, H1
Faradonbeh, FA1
Sa, II1
Lastuvkova, H1
Cermanova, J1
Hroch, M1
Faistova, H1
Mokry, J1
Nova, Z1
Uher, M1
Nachtigal, P1
Pavek, P1
Micuda, S1
Jin, HE1
Hong, SS1
Choi, MK1
Maeng, HJ1
Kim, DD1
Chung, SJ1
Shim, CK1
Nies, AT1
Koepsell, H1
Winter, S1
Burk, O1
Klein, K1
Kerb, R1
Zanger, UM1
Keppler, D1
Schwab, M1
Schaeffeler, E1
DeGorter, MK1
Kim, RB1
Crespo Valadés, E1
Ortega Gómez, A1
Alvarado Izquierdo, MI1
Magro Ledesma, D1
Desilets, DJ1
Shorr, AF1
Moran, KA1
Holtzmuller, KC1

Other Studies

8 other studies available for metformin and Cholestasis

ArticleYear
Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress.
    BMB reports, 2020, Volume: 53, Issue:6

    Topics: Acute Disease; Animals; Bile Ducts; Cholestasis; Disease Models, Animal; Endoplasmic Reticulum Stres

2020
Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.
    Pharmaceutical research, 2020, Jan-06, Volume: 37, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile; Bile Acids and Salts; Biological Tra

2020
Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice.
    Chemico-biological interactions, 2021, Aug-25, Volume: 345

    Topics: Animals; Bile Acids and Salts; Cholestasis; Ethinyl Estradiol; Female; Hepatocytes; Homeostasis; Int

2021
Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.
    Pharmaceutical research, 2009, Volume: 26, Issue:3

    Topics: Animals; Blood Proteins; Blotting, Western; Catecholamine Plasma Membrane Transport Proteins; Choles

2009
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:4

    Topics: Biological Transport; Cholestasis; Gene Frequency; Glucose; Haplotypes; Hepatocytes; Humans; Hypogly

2009
Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:4

    Topics: Cholestasis; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Metformin; Octamer Transcript

2009
[Hepatotoxic reaction associated with metformin and chlorpropamide treatment].
    Revista clinica espanola, 1999, Volume: 199, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Cholestasis; Diabetes Mellitus, Type 2

1999
Cholestatic jaundice associated with the use of metformin.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:7

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Humans; Liver Function Tests; Male; Me

2001