metformin has been researched along with Cholestasis in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin, an oral antidiabetic drug, recently demonstrated a reducing effect on bile acids (BA) plasma concentrations in one patient with intrahepatic cholestasis of pregnancy (ICP) by unknown mechanism." | 8.02 | Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. ( Cermanova, J; Faistova, H; Faradonbeh, FA; Hroch, M; Lastuvkova, H; Micuda, S; Mokry, J; Nachtigal, P; Nova, Z; Pavek, P; Sa, II; Uher, M, 2021) |
| "To investigate the effect of 17alpha-ethynylestradiol (EE)-induced cholestasis on the expression of organic cation transporters (Octs) in the liver and kidney, as well as the pharmacokinetics and pharmacodynamics of metformin in rats." | 7.75 | Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. ( Choi, MK; Chung, SJ; Hong, SS; Jin, HE; Kim, DD; Maeng, HJ; Shim, CK, 2009) |
| "Metformin, an oral antidiabetic drug, recently demonstrated a reducing effect on bile acids (BA) plasma concentrations in one patient with intrahepatic cholestasis of pregnancy (ICP) by unknown mechanism." | 4.02 | Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. ( Cermanova, J; Faistova, H; Faradonbeh, FA; Hroch, M; Lastuvkova, H; Micuda, S; Mokry, J; Nachtigal, P; Nova, Z; Pavek, P; Sa, II; Uher, M, 2021) |
| " Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition." | 3.96 | Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression. ( Garzel, B; Heyward, S; Hu, T; Huang, SM; Li, L; Lu, Y; Polli, J; Raufman, JP; Wang, H; Zhang, L, 2020) |
| "To investigate the effect of 17alpha-ethynylestradiol (EE)-induced cholestasis on the expression of organic cation transporters (Octs) in the liver and kidney, as well as the pharmacokinetics and pharmacodynamics of metformin in rats." | 3.75 | Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. ( Choi, MK; Chung, SJ; Hong, SS; Jin, HE; Kim, DD; Maeng, HJ; Shim, CK, 2009) |
| "Metformin treatment reduced liver injury caused by bile acid, and it suppressed ER stress, inflammation, chemokine expression, and neutrophil infiltration." | 1.56 | Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress. ( Cho, DH; Han, JH; Kim, S; Lee, CH; Lee, H; Nam, DH; Woo, CH, 2020) |
| "Metformin hydrochloride was discontinued, and the patient's jaundice resolved slowly over a period of several months." | 1.31 | Cholestatic jaundice associated with the use of metformin. ( Desilets, DJ; Holtzmuller, KC; Moran, KA; Shorr, AF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, CH | 1 |
| Han, JH | 1 |
| Kim, S | 2 |
| Lee, H | 1 |
| Nam, DH | 1 |
| Cho, DH | 1 |
| Woo, CH | 1 |
| Garzel, B | 1 |
| Hu, T | 1 |
| Li, L | 1 |
| Lu, Y | 1 |
| Heyward, S | 1 |
| Polli, J | 1 |
| Zhang, L | 1 |
| Huang, SM | 1 |
| Raufman, JP | 1 |
| Wang, H | 1 |
| Faradonbeh, FA | 1 |
| Sa, II | 1 |
| Lastuvkova, H | 1 |
| Cermanova, J | 1 |
| Hroch, M | 1 |
| Faistova, H | 1 |
| Mokry, J | 1 |
| Nova, Z | 1 |
| Uher, M | 1 |
| Nachtigal, P | 1 |
| Pavek, P | 1 |
| Micuda, S | 1 |
| Jin, HE | 1 |
| Hong, SS | 1 |
| Choi, MK | 1 |
| Maeng, HJ | 1 |
| Kim, DD | 1 |
| Chung, SJ | 1 |
| Shim, CK | 1 |
| Nies, AT | 1 |
| Koepsell, H | 1 |
| Winter, S | 1 |
| Burk, O | 1 |
| Klein, K | 1 |
| Kerb, R | 1 |
| Zanger, UM | 1 |
| Keppler, D | 1 |
| Schwab, M | 1 |
| Schaeffeler, E | 1 |
| DeGorter, MK | 1 |
| Kim, RB | 1 |
| Crespo Valadés, E | 1 |
| Ortega Gómez, A | 1 |
| Alvarado Izquierdo, MI | 1 |
| Magro Ledesma, D | 1 |
| Desilets, DJ | 1 |
| Shorr, AF | 1 |
| Moran, KA | 1 |
| Holtzmuller, KC | 1 |
8 other studies available for metformin and Cholestasis
| Article | Year |
|---|---|
Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress.
Topics: Acute Disease; Animals; Bile Ducts; Cholestasis; Disease Models, Animal; Endoplasmic Reticulum Stres | 2020 |
Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile; Bile Acids and Salts; Biological Tra | 2020 |
Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice.
Topics: Animals; Bile Acids and Salts; Cholestasis; Ethinyl Estradiol; Female; Hepatocytes; Homeostasis; Int | 2021 |
Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.
Topics: Animals; Blood Proteins; Blotting, Western; Catecholamine Plasma Membrane Transport Proteins; Choles | 2009 |
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
Topics: Biological Transport; Cholestasis; Gene Frequency; Glucose; Haplotypes; Hepatocytes; Humans; Hypogly | 2009 |
Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance.
Topics: Cholestasis; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Metformin; Octamer Transcript | 2009 |
[Hepatotoxic reaction associated with metformin and chlorpropamide treatment].
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Cholestasis; Diabetes Mellitus, Type 2 | 1999 |
Cholestatic jaundice associated with the use of metformin.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Humans; Liver Function Tests; Male; Me | 2001 |