metformin has been researched along with Chemical and Drug Induced Liver Injury in 49 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of idiosyncratic hepatotoxicity associated with metformin in the treatment of type 2 diabetes with nonalcoholic fatty liver disease (NAFLD)." | 7.76 | Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease. ( Bachyrycz, AM; Cone, CJ; Murata, GH, 2010) |
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 7.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| "Metformin is an oral antidiabetic agent frequently used to manage type II diabetes." | 5.35 | [Constitutional syndrome associated to metformin induced hepatotoxicity]. ( Angueira Lapeña, T; Arranz de la Mata, G; Boixeda de Miquel, D; de la Poza Gómez, G; Rivero Fernández, M; Vázquez Romero, M, 2008) |
| " We aimed to elucidate the mechanism of JLD treatment, in comparison to metformin treatment, on ameliorating insulin sensitivity in insulin resistant rats and to reveal its anti-oxidant properties." | 3.81 | Jinlida reduces insulin resistance and ameliorates liver oxidative stress in high-fat fed rats. ( Duan, L; Li, L; Li, X; Liu, Y; Song, A; Song, G; Wang, C; Wang, Y; Yu, X; Zang, S; Zhu, Y, 2015) |
| "To report a case of idiosyncratic hepatotoxicity associated with metformin in the treatment of type 2 diabetes with nonalcoholic fatty liver disease (NAFLD)." | 3.76 | Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease. ( Bachyrycz, AM; Cone, CJ; Murata, GH, 2010) |
| "In this patient, lactic acidosis was promoted by erlotinib-related hepatitis with initial liver failure (decreased lactate clearance), concomitant metformin treatment (increased lactate production), and acute renal deterioration (metformin accumulation)." | 3.75 | Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer. ( Fimognari, FL; Franco, A; Pastorelli, R; Pellegrinotti, M; Repetto, L, 2009) |
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 3.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| " However, its therapeutic application is restricted by its adverse effects, particularly hepatotoxicity." | 1.91 | Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway. ( El-Beheiry, KM; El-Masry, TA; El-Sayed El-Sayad, M; Elsisi, AE, 2023) |
| "The changes that follow liver fibrosis were assessed by measurement of hepatic enzymes (ALT, AST and ALP), histopathological examination using hematoxylin and eosin stain, special stains, and α-smooth muscle actin (α-SMA) immunostaining, measuring oxidative stress markers (MDA, GSH, NOx and MnSOD) and transforming growth factor-beta 1 (TGF-β1) in liver." | 1.72 | Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride. ( Ahmed, AA; Ahmed, MA; El-Bakry, MH; Hasan, A; Omar, ZMM, 2022) |
| "Metformin (1 mmol/L) was protective against DF-induced apoptosis in hepatocytes." | 1.62 | Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC. ( Alieva, T; Arroyave Ospina, JC; Buist-Homan, M; Cheng, X; Geng, Y; Lezoualc'h, F; Mora, FAA; Moshage, H; Musheshe, N; Rodrigo, JA; Schmidt, M; Soto, JM, 2021) |
| "Metformin is currently the most prescribed oral agent for diabetes treatment; however the overdose or long-term use may cause some severe side effects such as liver injury." | 1.51 | A Turn-On Optoacoustic Probe for Imaging Metformin-Induced Upregulation of Hepatic Hydrogen Sulfide and Subsequent Liver Injury. ( Chen, J; Sun, L; Wu, S; Wu, Y; Zeng, F; Zhong, J, 2019) |
| "Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia." | 1.46 | Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I. ( Chen, K; Feng, T; Ling, S; Liu, J; Liu, P; Shan, Q; Song, P; Xiang, P; Xie, H; Xu, X; Zhang, X; Zheng, S; Zhou, L, 2017) |
| "Metformin + Con A-treated mice had elevated serum levels of pro-inflammatory cytokines TNF-α and IFN-γ, accompanied by a massive mononuclear cell infiltration in the liver." | 1.42 | Metformin aggravates immune-mediated liver injury in mice. ( Arsenijevic, N; Jakovljevic, V; Lukic, ML; Micic, D; Milovanovic, M; Misirkic, M; Paunovic, V; Simovic Markovic, B; Stojanovic, M; Trajkovic, V; Volarevic, V; Vucicevic, L, 2015) |
| "Metformin pretreatment protected against APAP toxicity with decreased liver damage, and inhibited APAP-induced prolonged hepatic JNK phosphorylation in WT mice." | 1.42 | Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. ( Choi, DH; Choi, HS; Hwang, JH; Kim, DK; Kim, KS; Kim, YH; Lee, CH; Noh, JR; Tadi, S; Yim, YH, 2015) |
| "Metformin is a commonly used anti-diabetic drug with AMP-activated protein kinase (AMPK)-dependent hypoglycemic activities." | 1.40 | Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. ( Ai, Q; Dai, J; Deng, X; Jia, M; Jing, Y; Lin, L; Liu, M; Wan, J; Wu, K; Zhang, L, 2014) |
| "Metformin pretreatment alleviated the activity of serum enzymes, and attenuated histopathological lesions caused by LPS/D-GalN injections." | 1.40 | Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury. ( Bal, F; Bekpinar, S; Gurdol, F; Kusku-Kiraz, Z; Önder, S; Unlucerci, Y; Uysal, M, 2014) |
| "Metformin is a first-line antidiabetic drug in type 2 diabetes for its hypoglycemic activity, but recently researches also revealed the anti-inflammatory properties of metformin." | 1.38 | Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. ( Ge, P; Li, H; Li, L; Wan, J; Yuan, H; Zhang, L; Zheng, W, 2012) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes." | 1.36 | [Metformin-associated hepatotoxicity]. ( Amores-Arriaga, B; de Escalante-Yangüela, B; Martín-Fortea, P; Navarro-Aguilar, ME; Olivera-González, S; Velilla-Soriano, C, 2010) |
| "Metformin is an oral antidiabetic agent frequently used to manage type II diabetes." | 1.35 | [Constitutional syndrome associated to metformin induced hepatotoxicity]. ( Angueira Lapeña, T; Arranz de la Mata, G; Boixeda de Miquel, D; de la Poza Gómez, G; Rivero Fernández, M; Vázquez Romero, M, 2008) |
| " The probability of an adverse drug reaction (ADR), as assessed using the Naranjo ADR probability scale, in this case was 4 (probable)." | 1.33 | Possible metformin-induced hepatotoxicity. ( Kutoh, E, 2005) |
| "Acute liver failure was defined as acute liver disease and (1) hepatic encephalopathy, (2) prothrombin time prolongation greater than 3 seconds or international normalized ratio greater than 1." | 1.32 | A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. ( Ackerson, L; Chan, KA; Everhart, JE; Gurwitz, JH; Hurley, JS; Martinson, B; Moseley, RH; Platt, R; Selby, JV; Terrault, N; Truman, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.04) | 18.7374 |
| 1990's | 4 (8.16) | 18.2507 |
| 2000's | 8 (16.33) | 29.6817 |
| 2010's | 28 (57.14) | 24.3611 |
| 2020's | 8 (16.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 3 |
| Shi, Q | 1 |
| Ding, D | 2 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 2 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 4 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 2 |
| Hu, C | 1 |
| Mora, FAA | 1 |
| Musheshe, N | 1 |
| Arroyave Ospina, JC | 1 |
| Geng, Y | 1 |
| Soto, JM | 1 |
| Rodrigo, JA | 1 |
| Alieva, T | 1 |
| Buist-Homan, M | 1 |
| Lezoualc'h, F | 1 |
| Cheng, X | 1 |
| Schmidt, M | 1 |
| Moshage, H | 1 |
| Omar, ZMM | 1 |
| Ahmed, AA | 1 |
| El-Bakry, MH | 1 |
| Ahmed, MA | 1 |
| Hasan, A | 1 |
| El-Beheiry, KM | 1 |
| El-Sayed El-Sayad, M | 1 |
| El-Masry, TA | 1 |
| Elsisi, AE | 1 |
| Darijani, MH | 1 |
| Aminzadeh, A | 1 |
| Rahimi, HR | 1 |
| Mandegary, A | 1 |
| Heidari, MR | 1 |
| Karami-Mohajeri, S | 1 |
| Jafari, E | 1 |
| Tripathi, SS | 1 |
| Singh, S | 1 |
| Garg, G | 1 |
| Kumar, R | 1 |
| Verma, AK | 1 |
| Singh, AK | 2 |
| Bissoyi, A | 1 |
| Rizvi, SI | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
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| Alexander Ross, JB | 1 |
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| Flox, C | 1 |
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| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
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| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
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| Mainwaring, RD | 1 |
| Ma, M | 1 |
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| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
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| Hoplock, LB | 1 |
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| Li, X | 11 |
| Henson, MA | 1 |
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| Rasool, G | 1 |
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| Li, XY | 1 |
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| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
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| Huang, W | 1 |
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| Yang, QQ | 1 |
| Li, HW | 1 |
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| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
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| Shahrokh Tehraninezhad, E | 1 |
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| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
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| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
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| Booth, CM | 1 |
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| Rabiu, KA | 1 |
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| Xu, C | 2 |
| Xiang, Y | 1 |
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| Zhou, L | 3 |
| Dong, X | 1 |
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| Gao, XC | 1 |
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| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 3 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
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| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
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| Rojas, A | 1 |
| Sacchi, A | 1 |
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| Li, J | 7 |
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4 reviews available for metformin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.
Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Drug Discovery; Drug-Related Side | 2016 |
Probable hepatotoxicity associated with the use of metformin in type 2 diabetes.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Diagnosis, Differential; F | 2011 |
1 trial available for metformin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
45 other studies available for metformin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Cells, Cultured; Chemical and Drug Induced Liver Injury | 2021 |
Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Ci | 2022 |
Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclophosph | 2023 |
Evaluating the protective effect of metformin against diclofenac-induced oxidative stress and hepatic damage: In vitro and in vivo studies.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diclofenac; Liver; Male; Metformin; O | 2023 |
Metformin ameliorates acetaminophen-induced sub-acute toxicity via antioxidant property.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Male; Metformin | 2022 |
Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Inflammation; Kidney Diseases; Male; | 2021 |
Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Ethanol; Hep G2 Cells | 2021 |
Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line; Chemical and Dru | 2017 |
A Turn-On Optoacoustic Probe for Imaging Metformin-Induced Upregulation of Hepatic Hydrogen Sulfide and Subsequent Liver Injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Hydrogen Sulfide; Hypoglycemic Agents; Metformin; M | 2019 |
Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury.
Topics: Animals; Carbon Tetrachloride Poisoning; Catalase; Chemical and Drug Induced Liver Injury; Enzyme-Li | 2014 |
Metformin aggravates immune-mediated liver injury in mice.
Topics: Animals; Apoptosis; Autophagy; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Fl | 2015 |
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chemical and | 2014 |
Carbonyl traps as potential protective agents against methimazole-induced liver injury.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and | 2015 |
Jinlida reduces insulin resistance and ameliorates liver oxidative stress in high-fat fed rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dietary Fats; Drugs, Chinese Herbal; Hypoglycemic A | 2015 |
Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.
Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity.
Topics: Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; JNK Mitogen-Activated Pr | 2015 |
Repurposing of metformin in liver injury: The JNK conundrum.
Topics: Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; JNK Mitogen-Activated Pr | 2016 |
AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Male; Metformin; Mice; Mice, Inbred BALB C; Treatme | 2015 |
Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; In | 2015 |
Reply to "Repurposing of metformin in liver injury: The JNK conundrum".
Topics: Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; JNK Mitogen-Activated Pr | 2016 |
The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hypoglycem | 2016 |
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect | 2016 |
[Constitutional syndrome associated to metformin induced hepatotoxicity].
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Humans; Hypoglycemic Agents; Male; Metfor | 2008 |
Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer.
Topics: Acidosis, Lactic; Adenocarcinoma; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injur | 2009 |
[Metformin-associated hepatotoxicity].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemic Agents; Metformin | 2010 |
Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Fatty Liver; Humans; Hypoglycemic | 2010 |
Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Gala | 2012 |
A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Cohort Studies; Female | 2003 |
Metformin protects against carbon tetrachloride hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2003 |
Metformin hepatotoxicity.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemic Agents; Metformin | 2004 |
Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver In | 2005 |
[Metformin-induced cholestatic hepatitis].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemic Agents | 2005 |
Possible metformin-induced hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agen | 2005 |
[Metformin in combination therapy of diabetes mellitus. Advantages and reservations].
Topics: Acidosis; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Drug Therapy, Combination; Huma | 1983 |
Fatal hepatic necrosis following cardiac surgery and enflurane anaesthesia.
Topics: Acidosis, Lactic; Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiac Surgical Procedures; Chem | 1996 |
Case report. Pseudohepatotoxicity of metformin.
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dia | 1998 |
Metformin-induced acute hepatitis.
Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Biopsy; Chemical and Drug Indu | 1998 |
[Hepatotoxic reaction associated with metformin and chlorpropamide treatment].
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Cholestasis; Diabetes Mellitus, Type 2 | 1999 |