metformin has been researched along with Central Hypothyroidism in 43 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In women with PCOS, metformin treatment during pregnancy was associated with less decrease in fT4 compared to placebo, while it did not affect TSH." | 9.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| "Though most of the observational studies have shown that metformin can reduce serum thyroid stimulating hormone (TSH) level in patients of hypothyroidism with diabetes or polycystic ovarian disease, randomised controlled trials are sparse." | 9.30 | Effect of metformin on thyroid function tests in patients with subclinical hypothyroidism: an open-label randomised controlled trial. ( Durgia, H; Kamalanathan, S; Kar, SS; Palui, R; Patil, M; Raj, H; Sahoo, J; Sridharan, K, 2019) |
| "To evaluate whether metformin can reduce TSH levels in subjects with subclinical hypothyroidism." | 9.27 | Metformin effect on TSH in subclinical hypothyroidism: randomized, double-blind, placebo-controlled clinical trial. ( Antonio Naujorks, A; Correa Junior, V; Dornelles Severo, M; Gus, M; Schaan, BD; Stürmer Andrade, T, 2018) |
| " Fasting plasma glucose, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, the estimated glomerular filtration rate, as well as serum levels of thyrotropin, thyroid hormones, prolactin and insulin-like growth factor-1 (IGF-1) were assessed at baseline and after 4 months of metformin treatment." | 9.22 | The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study. ( Krysiak, R; Okopien, B; Szkrobka, W, 2016) |
| "Thirty-three patients with PCOS were specifically selected for being either treated with levothyroxine for a previous diagnosis of hypothyroidism (n = 7), untreated subclinically hypothyroid (n = 2) or euthyroid without levothyroxine treatment (n = 24) before the starting of metformin." | 9.15 | Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome. ( Botta, R; Cappelli, C; Castellano, M; Chiovato, L; De Cata, P; Dionisio, R; Iacobello, C; Magri, F; Nappi, RE; Rotondi, M, 2011) |
| " Objective To prospectively evaluate if administration of metformin to obese, diabetic patients with primary hypothyroidism on stable thyroxine replacement doses modifies TSH levels." | 9.12 | Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. ( Cordido, F; Isidro, ML; Nemiña, R; Penín, MA, 2007) |
| "The present study evaluates the neuroprotective effect of α-lipoic acid (ALA) and/or metformin (MET) on the behavioral and neurochemical changes induced by hypothyroidism." | 8.12 | The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat. ( Abdulla, MS; Hosny, EN; Khadrawy, YA; Khoder, NM; Sawie, HG; Sharada, HM, 2022) |
| " Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism." | 8.12 | Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " The present study compared the impact of low-grade systemic inflammation and insulin resistance on levothyroxine action in subjects with this disorder." | 8.12 | Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| "Metformin treatment decreases thyrotropin levels in individuals with hypothyroidism and this effect seems to be mediated by the 5'-adenosine monophosphate-activated protein kinase pathway in the pituitary." | 8.12 | Rosuvastatin potentiates the thyrotropin-lowering effect of metformin in men with non-autoimmune subclinical hypothyroidism and prediabetes. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " Metformin reduced glucose levels and glycated haemoglobin, improved insulin sensitivity and decreased thyrotrophin levels." | 7.96 | Different effects of metformin on hypothalamic-pituitary-thyroid axis activity in levothyroxine-treated and levothyroxine-naïve women with non-autoimmune hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " The lipid profile, fasting plasma glucose levels, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, the estimated glomerular filtration rate, as well as serum levels of thyrotropin, thyroid hormones, prolactin, insulin and insulin-like growth factor-1 (IGF-1) were assessed at baseline and after 6 months of metformin treatment (2." | 7.83 | The effect of metformin on the hypothalamic-pituitary-thyroid axis in patients with type 2 diabetes and amiodarone-induced hypothyroidism. ( Gilowska, M; Krysiak, R; Okopień, B; Szkróbka, W, 2016) |
| "The study included 23 women and 12 men with subclinical hypothyroidism, who because of coexisting diabetes or impaired fasting glucose were treated with metformin (1." | 7.83 | Sex-dependent effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with subclinical hypothyroidism. ( Krysiak, R; Okopień, B; Szkróbka, W, 2016) |
| "To evaluate the frequency with which hypothyroidism is associated with Type 2 diabetes, to examine gender and ethnic group differences, and to assess the possible impact of metformin therapy." | 7.80 | Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy. ( Distiller, LA; Joffe, BI; Polakow, ES, 2014) |
| "To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS)." | 7.77 | Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism. ( Fatemi, S; Morteza Taghavi, S; Rokni, H, 2011) |
| "In women with PCOS, metformin treatment during pregnancy was associated with less decrease in fT4 compared to placebo, while it did not affect TSH." | 5.51 | Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin. ( Alvarsson, M; Åsvold, BO; Calissendorff, J; Hirschberg, AL; Trouva, A; Vanky, E, 2022) |
| "Metformin was found to reduce elevated serum thyrotropin levels, and this effect was partially determined by endogenous dopaminergic tone." | 5.48 | Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Elderly Antipsychotic-Treated Women With Type 2 Diabetes and Subclinical Hypothyroidism: A Preliminary Study. ( Krysiak, R; Okopień, B; Szkróbka, W, 2018) |
| "Though most of the observational studies have shown that metformin can reduce serum thyroid stimulating hormone (TSH) level in patients of hypothyroidism with diabetes or polycystic ovarian disease, randomised controlled trials are sparse." | 5.30 | Effect of metformin on thyroid function tests in patients with subclinical hypothyroidism: an open-label randomised controlled trial. ( Durgia, H; Kamalanathan, S; Kar, SS; Palui, R; Patil, M; Raj, H; Sahoo, J; Sridharan, K, 2019) |
| "To evaluate whether metformin can reduce TSH levels in subjects with subclinical hypothyroidism." | 5.27 | Metformin effect on TSH in subclinical hypothyroidism: randomized, double-blind, placebo-controlled clinical trial. ( Antonio Naujorks, A; Correa Junior, V; Dornelles Severo, M; Gus, M; Schaan, BD; Stürmer Andrade, T, 2018) |
| " Fasting plasma glucose, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, the estimated glomerular filtration rate, as well as serum levels of thyrotropin, thyroid hormones, prolactin and insulin-like growth factor-1 (IGF-1) were assessed at baseline and after 4 months of metformin treatment." | 5.22 | The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study. ( Krysiak, R; Okopien, B; Szkrobka, W, 2016) |
| "Thirty-three patients with PCOS were specifically selected for being either treated with levothyroxine for a previous diagnosis of hypothyroidism (n = 7), untreated subclinically hypothyroid (n = 2) or euthyroid without levothyroxine treatment (n = 24) before the starting of metformin." | 5.15 | Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome. ( Botta, R; Cappelli, C; Castellano, M; Chiovato, L; De Cata, P; Dionisio, R; Iacobello, C; Magri, F; Nappi, RE; Rotondi, M, 2011) |
| "Metformin administration influences TSH without change of FT4 in patients with type 2 diabetes and concomitant hypothyroidism." | 5.14 | TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients. ( Agabiti-Rosei, E; Agosti, B; Cappelli, C; Castellano, M; Chiovato, L; Cimino, A; De Martino, E; Gandossi, E; Pirola, I; Rotondi, M; Valentini, U, 2009) |
| " Objective To prospectively evaluate if administration of metformin to obese, diabetic patients with primary hypothyroidism on stable thyroxine replacement doses modifies TSH levels." | 5.12 | Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. ( Cordido, F; Isidro, ML; Nemiña, R; Penín, MA, 2007) |
| "Metformin induces a reduction in TSH levels both in overt and in subclinical hypothyroidism." | 4.90 | Effects of treatment with metformin on TSH levels: a meta-analysis of literature studies. ( Ambrosino, P; Di Minno, A; Di Minno, MN; Lupoli, GA; Lupoli, R; Tortora, A, 2014) |
| "The present study evaluates the neuroprotective effect of α-lipoic acid (ALA) and/or metformin (MET) on the behavioral and neurochemical changes induced by hypothyroidism." | 4.12 | The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat. ( Abdulla, MS; Hosny, EN; Khadrawy, YA; Khoder, NM; Sawie, HG; Sharada, HM, 2022) |
| " Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism." | 4.12 | Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| " The present study compared the impact of low-grade systemic inflammation and insulin resistance on levothyroxine action in subjects with this disorder." | 4.12 | Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| "Metformin treatment decreases thyrotropin levels in individuals with hypothyroidism and this effect seems to be mediated by the 5'-adenosine monophosphate-activated protein kinase pathway in the pituitary." | 4.12 | Rosuvastatin potentiates the thyrotropin-lowering effect of metformin in men with non-autoimmune subclinical hypothyroidism and prediabetes. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " Metformin reduced glucose levels and glycated haemoglobin, improved insulin sensitivity and decreased thyrotrophin levels." | 3.96 | Different effects of metformin on hypothalamic-pituitary-thyroid axis activity in levothyroxine-treated and levothyroxine-naïve women with non-autoimmune hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2020) |
| " The lipid profile, fasting plasma glucose levels, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, the estimated glomerular filtration rate, as well as serum levels of thyrotropin, thyroid hormones, prolactin, insulin and insulin-like growth factor-1 (IGF-1) were assessed at baseline and after 6 months of metformin treatment (2." | 3.83 | The effect of metformin on the hypothalamic-pituitary-thyroid axis in patients with type 2 diabetes and amiodarone-induced hypothyroidism. ( Gilowska, M; Krysiak, R; Okopień, B; Szkróbka, W, 2016) |
| "The study included 23 women and 12 men with subclinical hypothyroidism, who because of coexisting diabetes or impaired fasting glucose were treated with metformin (1." | 3.83 | Sex-dependent effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with subclinical hypothyroidism. ( Krysiak, R; Okopień, B; Szkróbka, W, 2016) |
| "To evaluate the frequency with which hypothyroidism is associated with Type 2 diabetes, to examine gender and ethnic group differences, and to assess the possible impact of metformin therapy." | 3.80 | Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy. ( Distiller, LA; Joffe, BI; Polakow, ES, 2014) |
| "In this longitudinal population-based study, metformin use was associated with an increased incidence of low TSH levels in patients with treated hypothyroidism, but not in euthyroid patients." | 3.80 | Metformin and low levels of thyroid-stimulating hormone in patients with type 2 diabetes mellitus. ( Azoulay, L; Fournier, JP; Yin, H; Yu, OH, 2014) |
| "Our results favour screening for hypothyroidism in patients with Type 2 diabetes older than 65 years, especially in the presence of diabetic macroangiopathy or treatment with metformin." | 3.78 | An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. ( Díez, JJ; Iglesias, P, 2012) |
| "To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS)." | 3.77 | Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism. ( Fatemi, S; Morteza Taghavi, S; Rokni, H, 2011) |
| "The objective of the study was to describe the clinical and biochemical findings of four patients with chronic hypothyroidism, previously euthyroid on fixed doses of L-T4 for several years, in whom the metformin was initiated." | 3.73 | Thyrotropin suppression by metformin. ( Filmore-Nassar, A; Glass, AR; Vigersky, RA, 2006) |
| "Because of concomitant type 2 diabetes, all men were treated with metformin (2550-3000 mg daily)." | 1.56 | The Impact of Testosterone on Metformin Action on Hypothalamic-Pituitary-Thyroid Axis Activity in Men: A Pilot Study. ( Krysiak, R; Okopień, B; Szkróbka, W, 2020) |
| "Metformin was found to reduce elevated serum thyrotropin levels, and this effect was partially determined by endogenous dopaminergic tone." | 1.48 | Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Elderly Antipsychotic-Treated Women With Type 2 Diabetes and Subclinical Hypothyroidism: A Preliminary Study. ( Krysiak, R; Okopień, B; Szkróbka, W, 2018) |
| " No differences in total levothyroxine dosage were found: 114 (100-150) [median (Q1-Q3)] μg in the non-MF group versus 125 (100-142) μg in the MF group (p=0." | 1.39 | Are levothyroxine requirements lower in thyroidectomized diabetic patients on metformin treatment? ( Casteràs, A; Ciudin, A; Mesa, J; Zafon, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.98) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (16.28) | 29.6817 |
| 2010's | 22 (51.16) | 24.3611 |
| 2020's | 11 (25.58) | 2.80 |
| Authors | Studies |
|---|---|
| Trouva, A | 1 |
| Alvarsson, M | 1 |
| Calissendorff, J | 1 |
| Åsvold, BO | 1 |
| Vanky, E | 1 |
| Hirschberg, AL | 1 |
| Khadrawy, YA | 1 |
| Khoder, NM | 1 |
| Sawie, HG | 1 |
| Sharada, HM | 1 |
| Hosny, EN | 1 |
| Abdulla, MS | 1 |
| Krysiak, R | 11 |
| Kowalcze, K | 4 |
| Okopień, B | 11 |
| Amirabadizadeh, A | 1 |
| Amouzegar, A | 1 |
| Mehran, L | 1 |
| Azizi, F | 1 |
| Alahmadi, AA | 1 |
| Alzahrani, AA | 1 |
| Ali, SS | 1 |
| Alahmadi, BA | 1 |
| Arab, RA | 1 |
| El-Shitany, NAE | 1 |
| Jia, X | 1 |
| Zhai, T | 1 |
| Zhang, JA | 1 |
| Goonoo, MS | 1 |
| Morris, R | 1 |
| Raithatha, A | 1 |
| Creagh, F | 1 |
| Shpakov, AO | 1 |
| Dornelles Severo, M | 1 |
| Stürmer Andrade, T | 1 |
| Correa Junior, V | 1 |
| Antonio Naujorks, A | 1 |
| Gus, M | 1 |
| Schaan, BD | 1 |
| Szkróbka, W | 5 |
| Hilado, MA | 1 |
| Randhawa, RS | 1 |
| Kalra, S | 1 |
| Khandelwal, D | 1 |
| Palui, R | 1 |
| Sahoo, J | 1 |
| Kamalanathan, S | 1 |
| Kar, SS | 1 |
| Sridharan, K | 1 |
| Durgia, H | 1 |
| Raj, H | 1 |
| Patil, M | 1 |
| Casteràs, A | 1 |
| Zafon, C | 1 |
| Ciudin, A | 1 |
| Mesa, J | 1 |
| Morgante, G | 1 |
| Musacchio, MC | 1 |
| Orvieto, R | 1 |
| Massaro, MG | 1 |
| De Leo, V | 1 |
| Distiller, LA | 1 |
| Polakow, ES | 1 |
| Joffe, BI | 1 |
| Lupoli, R | 1 |
| Di Minno, A | 1 |
| Tortora, A | 1 |
| Ambrosino, P | 1 |
| Lupoli, GA | 1 |
| Di Minno, MN | 1 |
| Fournier, JP | 1 |
| Yin, H | 1 |
| Yu, OH | 1 |
| Azoulay, L | 1 |
| Füessl, HS | 1 |
| He, LR | 1 |
| Qiao, W | 1 |
| Liao, ZX | 1 |
| Komaki, R | 1 |
| Ho, L | 1 |
| Hofstetter, WL | 1 |
| Lin, SH | 1 |
| Gilowska, M | 1 |
| Jatwa, R | 1 |
| Kar, A | 1 |
| Cappelli, C | 3 |
| Rotondi, M | 3 |
| Pirola, I | 2 |
| Agosti, B | 2 |
| Gandossi, E | 1 |
| Valentini, U | 2 |
| De Martino, E | 1 |
| Cimino, A | 1 |
| Chiovato, L | 3 |
| Agabiti-Rosei, E | 1 |
| Castellano, M | 3 |
| Haugen, BR | 1 |
| Morteza Taghavi, S | 1 |
| Rokni, H | 1 |
| Fatemi, S | 1 |
| Magri, F | 1 |
| Botta, R | 1 |
| Dionisio, R | 1 |
| Iacobello, C | 1 |
| De Cata, P | 1 |
| Nappi, RE | 1 |
| Díez, JJ | 1 |
| Iglesias, P | 1 |
| Formenti, A | 1 |
| Zarra, E | 1 |
| Leporati, P | 1 |
| Vigersky, RA | 1 |
| Filmore-Nassar, A | 1 |
| Glass, AR | 1 |
| Isidro, ML | 1 |
| Penín, MA | 1 |
| Nemiña, R | 1 |
| Cordido, F | 1 |
| Hexeberg, S | 1 |
| Lindberg, FA | 1 |
| Wiener, K | 1 |
| Adadevoh, BK | 1 |
| Marquié, G | 2 |
| Agid, R | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome (PCOS)[NCT00159536] | Phase 3 | 257 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study[NCT03259919] | Phase 2 | 40 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metformin and Central Hypothyroidism
| Article | Year |
|---|---|
The effect of metformin therapy on serum thyrotropin and free thyroxine concentrations in patients with type 2 diabetes: a meta-analysis.
Topics: Adolescent; Adult; Diabetes Mellitus, Type 2; Humans; Hypothyroidism; Metformin; Thyroid Hormones; T | 2023 |
Metformin reduces autoimmune antibody levels in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
Topics: Autoantibodies; Hashimoto Disease; Humans; Hypothyroidism; Metformin; Observational Studies as Topic | 2020 |
[Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus].
Topics: Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Expression; Humans; Hypothy | 2017 |
Thyrovigilance in diabetes; glucovigilance in thyroidology.
Topics: Comorbidity; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Hypert | 2018 |
Effects of treatment with metformin on TSH levels: a meta-analysis of literature studies.
Topics: Hormone Replacement Therapy; Humans; Hypoglycemic Agents; Hypothyroidism; Metformin; Thyrotropin; Th | 2014 |
Drugs that suppress TSH or cause central hypothyroidism.
Topics: Aged; Bexarotene; Dopamine Agonists; Glucocorticoids; Humans; Hypothyroidism; Lymphoma, T-Cell; Male | 2009 |
8 trials available for metformin and Central Hypothyroidism
| Article | Year |
|---|---|
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.
Topics: Diabetes, Gestational; Female; Humans; Hypothyroidism; Metformin; Pilot Projects; Polycystic Ovary S | 2022 |
Metformin effect on TSH in subclinical hypothyroidism: randomized, double-blind, placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Asymptomatic Diseases; Blood Pressure; Cholesterol, HDL; Double-Blind Metho | 2018 |
Effect of metformin on thyroid function tests in patients with subclinical hypothyroidism: an open-label randomised controlled trial.
Topics: Adiponectin; Adult; Blood Glucose; Cholesterol; Female; Humans; Hypothyroidism; Insulin Resistance; | 2019 |
The effect of metformin on the hypothalamic-pituitary-thyroid axis in women with polycystic ovary syndrome and subclinical hypothyroidism.
Topics: Adult; Female; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Metformin; Middle Aged; Polyc | 2015 |
The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Hashimoto Disease; Humans; H | 2016 |
TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Hypothyroidism; Metformin; Thyroid Diseases; | 2009 |
Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome.
Topics: Adult; Female; Humans; Hypoglycemic Agents; Hypothyroidism; Metformin; Polycystic Ovary Syndrome; Th | 2011 |
Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy.
Topics: Aged; Body Weight; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agen | 2007 |
29 other studies available for metformin and Central Hypothyroidism
| Article | Year |
|---|---|
The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Brain-Derived Neurotrophic Factor; Dopamin | 2022 |
Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism.
Topics: Autoimmunity; C-Reactive Protein; Female; Glucose; Hashimoto Disease; Humans; Hypothyroidism; Inosit | 2022 |
Thyroid Antibody Titers and Hypothalamic-Pituitary-Thyroid Axis Activity in Levothyroxine-Treated Women With Autoimmune Subclinical Hypothyroidism Receiving Atorvastatin or Metformin.
Topics: Atorvastatin; C-Reactive Protein; Female; Hashimoto Disease; Humans; Hydroxymethylglutaryl-CoA Reduc | 2022 |
Rosuvastatin potentiates the thyrotropin-lowering effect of metformin in men with non-autoimmune subclinical hypothyroidism and prediabetes.
Topics: Adrenocorticotropic Hormone; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoth | 2022 |
Both
Topics: Animals; Antioxidants; Chamomile; Female; Hypothyroidism; Matricaria; Metformin; Oxidative Stress; P | 2020 |
Different effects of metformin on hypothalamic-pituitary-thyroid axis activity in levothyroxine-treated and levothyroxine-naïve women with non-autoimmune hypothyroidism.
Topics: Aged; Blood Glucose; Case-Control Studies; Female; Humans; Hypoglycemic Agents; Hypothalamo-Hypophys | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Elderly Antipsychotic-Treated Women With Type 2 Diabetes and Subclinical Hypothyroidism: A Preliminary Study.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Diabetes Mellitus, Type 2; Dopamine; Female; Humans; | 2018 |
A novel mutation in the proopiomelanocortin (POMC) gene of a Hispanic child: metformin treatment shows a beneficial impact on the body mass index.
Topics: Adrenal Insufficiency; Adult; Body Mass Index; Child; Child, Preschool; Female; Hispanic or Latino; | 2018 |
The Impact of Testosterone on Metformin Action on Hypothalamic-Pituitary-Thyroid Axis Activity in Men: A Pilot Study.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Hypogonad | 2020 |
Are levothyroxine requirements lower in thyroidectomized diabetic patients on metformin treatment?
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; | 2013 |
Alterations in thyroid function among the different polycystic ovary syndrome phenotypes.
Topics: Adult; Body Mass Index; Drug Therapy, Combination; Female; Hospitals, University; Humans; Hypoglycem | 2013 |
Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Diabetes Mellitus, Type 2; Ethnicity; Female; Hormon | 2014 |
Metformin and low levels of thyroid-stimulating hormone in patients with type 2 diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Hypothyroidism; Longitudinal S | 2014 |
[During therapy with metformin pay attention to TSH!].
Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Hypothyroidism; Male; Metformin; Thy | 2014 |
Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Anti-Inflammatory Agents, Non-Ster | 2015 |
The effect of metformin on the hypothalamic-pituitary-thyroid axis in patients with type 2 diabetes and amiodarone-induced hypothyroidism.
Topics: Aged; Amiodarone; Diabetes Mellitus, Type 2; Female; Humans; Hypothalamo-Hypophyseal System; Hypothy | 2016 |
Sex-dependent effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with subclinical hypothyroidism.
Topics: Adult; Aged; Female; Humans; Hypoglycemic Agents; Hypothalamo-Hypophyseal System; Hypothyroidism; Ma | 2016 |
Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice.
Topics: Animals; Bauhinia; Dexamethasone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female | 2009 |
Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism.
Topics: Female; Humans; Hypoglycemic Agents; Hypothyroidism; Metformin; Overweight; Polycystic Ovary Syndrom | 2011 |
Thyrotropin-lowering effect of metformin in a patient with resistance to thyroid hormone.
Topics: Adult; Diabetes Mellitus, Type 2; Humans; Hypothyroidism; Male; Metformin; Thyroid Hormone Resistanc | 2011 |
An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes.
Topics: Aged; Autoantibodies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hypoglycemic Agents; Hypot | 2012 |
Thyreotropin levels in diabetic patients on metformin treatment.
Topics: Adult; Aged; Autoantibodies; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypoglycemic | 2012 |
Thyrotropin suppression by metformin.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Interactions; Female; Goiter; Graves D | 2006 |
[Insulin-using woman with type 2 diabetes and weight problems].
Topics: C-Peptide; Caloric Restriction; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Exercise T | 2008 |
A falling HbA1c is not necessarily an indicator of improving diabetes control.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Flupenthixol; Glycated Hemoglobin; Hemoglobins; Hemol | 2001 |
Sulphonylurea and hypothyroidism in Nigerian diabetic subjects.
Topics: Adolescent; Adult; Chlorpropamide; Diabetes Mellitus; Humans; Hypothyroidism; Insulin; Metformin; Mi | 1976 |
[Protective effects of metformin (NN-dimethylbiguanide) on hypothyroidism and fatty infiltration of the adrenal cortex induced by a cholesterol diet in rabbits].
Topics: Adrenal Glands; Animals; Antidepressive Agents; Cholesterol; Diet, Atherogenic; Hypothyroidism; Insu | 1973 |
[Prevention with dimethylbiguanide of thyroid changes caused by an atherogenic diet in rabbits].
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Diet, Atherogenic; Hypercholesterolemia; Hypoth | 1972 |