metformin has been researched along with Cataract in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
Excerpt | Relevance | Reference |
---|---|---|
"Recent studies suggest that the diabetes drug metformin has a protective effect on open-angle glaucoma (OAG) and age-related macular degeneration (AMD)." | 4.12 | Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study. ( Ahmadizar, F; Kavousi, M; Klaver, CCW; Ramdas, WD; Stricker, BH; Thee, EF; van Duijn, CM; Vergroesen, JE, 2022) |
"Cataract is the leading cause of blindness worldwide." | 2.82 | Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. ( Chen, M; Duan, P; Gao, H; Gong, Y; Li, J; Lu, A; Xie, J; Xu, H, 2022) |
"Metformin (Mtf) has been used to treat fibrosis-related diseases affecting many organs and tissues, but its effect on ocular fibrosis-related diseases is unclear." | 1.62 | Metformin attenuates the epithelial-mesenchymal transition of lens epithelial cells through the AMPK/TGF-β/Smad2/3 signalling pathway. ( Hua, X; Shang, Z; Tian, Y; Wang, L; Yuan, X; Zhang, B, 2021) |
"Cataracts are the leading cause of blindness worldwide owing to the increasing proportion of elderly individuals in the population." | 1.62 | Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration. ( Chen, M; Qi, Y; Su, D; Wang, X; Zhang, C; Zhou, N, 2021) |
"d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs)." | 1.48 | d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions. ( Huang, W; Li, S; Li, Y; Ma, L; Niu, H; Wei, Z; Xin, G; Xing, Z; Xu, Y; Zeng, Z, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (14.29) | 24.3611 |
2020's | 6 (85.71) | 2.80 |
Authors | Studies |
---|---|
Wang, L | 1 |
Tian, Y | 1 |
Shang, Z | 1 |
Zhang, B | 1 |
Hua, X | 1 |
Yuan, X | 1 |
Vergroesen, JE | 1 |
Thee, EF | 1 |
Ahmadizar, F | 1 |
van Duijn, CM | 1 |
Stricker, BH | 1 |
Kavousi, M | 1 |
Klaver, CCW | 1 |
Ramdas, WD | 1 |
Chen, YY | 1 |
Wu, TT | 1 |
Ho, CY | 1 |
Yeh, TC | 1 |
Sun, GC | 1 |
Tseng, CJ | 1 |
Cheng, PW | 1 |
Lu, A | 1 |
Duan, P | 1 |
Xie, J | 1 |
Gao, H | 1 |
Chen, M | 2 |
Gong, Y | 1 |
Li, J | 1 |
Xu, H | 1 |
Chhunchha, B | 1 |
Kubo, E | 1 |
Singh, DP | 1 |
Zhang, C | 1 |
Zhou, N | 1 |
Wang, X | 1 |
Su, D | 1 |
Qi, Y | 1 |
Xu, Y | 1 |
Li, Y | 1 |
Ma, L | 1 |
Xin, G | 1 |
Wei, Z | 1 |
Zeng, Z | 1 |
Xing, Z | 1 |
Li, S | 1 |
Niu, H | 1 |
Huang, W | 1 |
1 review available for metformin and Cataract
Article | Year |
---|---|
Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
Topics: Bibliometrics; Cataract; Curcumin; Humans; Lanosterol; Metformin; Oxysterols; Resveratrol | 2022 |
6 other studies available for metformin and Cataract
Article | Year |
---|---|
Metformin attenuates the epithelial-mesenchymal transition of lens epithelial cells through the AMPK/TGF-β/Smad2/3 signalling pathway.
Topics: AMP-Activated Protein Kinases; Cataract; Cell Proliferation; Cells, Cultured; Epithelial Cells; Epit | 2021 |
Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study.
Topics: Aged; Cataract; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glaucoma, Open-Angle; Humans; Ins | 2022 |
Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.
Topics: Animals; Cataract; Diabetes Mellitus; Fructose; Metformin; NADP; NADPH Oxidases; Oxidative Stress; R | 2022 |
Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; ARNTL Transcription Factors; Cataract; Cations | 2022 |
Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration.
Topics: Antioxidants; Cataract; Cell Line; Cellular Senescence; Epithelial Cells; Female; Humans; Lens, Crys | 2021 |
d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.
Topics: Adenosine Triphosphate; Antioxidants; Autophagy; Calcium Signaling; Cataract; Cell Line; Cell Prolif | 2018 |