Page last updated: 2024-10-30

metformin and Cataract

metformin has been researched along with Cataract in 7 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Recent studies suggest that the diabetes drug metformin has a protective effect on open-angle glaucoma (OAG) and age-related macular degeneration (AMD)."4.12Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study. ( Ahmadizar, F; Kavousi, M; Klaver, CCW; Ramdas, WD; Stricker, BH; Thee, EF; van Duijn, CM; Vergroesen, JE, 2022)
"Cataract is the leading cause of blindness worldwide."2.82Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. ( Chen, M; Duan, P; Gao, H; Gong, Y; Li, J; Lu, A; Xie, J; Xu, H, 2022)
"Metformin (Mtf) has been used to treat fibrosis-related diseases affecting many organs and tissues, but its effect on ocular fibrosis-related diseases is unclear."1.62Metformin attenuates the epithelial-mesenchymal transition of lens epithelial cells through the AMPK/TGF-β/Smad2/3 signalling pathway. ( Hua, X; Shang, Z; Tian, Y; Wang, L; Yuan, X; Zhang, B, 2021)
"Cataracts are the leading cause of blindness worldwide owing to the increasing proportion of elderly individuals in the population."1.62Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration. ( Chen, M; Qi, Y; Su, D; Wang, X; Zhang, C; Zhou, N, 2021)
"d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs)."1.48d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions. ( Huang, W; Li, S; Li, Y; Ma, L; Niu, H; Wei, Z; Xin, G; Xing, Z; Xu, Y; Zeng, Z, 2018)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's6 (85.71)2.80

Authors

AuthorsStudies
Wang, L1
Tian, Y1
Shang, Z1
Zhang, B1
Hua, X1
Yuan, X1
Vergroesen, JE1
Thee, EF1
Ahmadizar, F1
van Duijn, CM1
Stricker, BH1
Kavousi, M1
Klaver, CCW1
Ramdas, WD1
Chen, YY1
Wu, TT1
Ho, CY1
Yeh, TC1
Sun, GC1
Tseng, CJ1
Cheng, PW1
Lu, A1
Duan, P1
Xie, J1
Gao, H1
Chen, M2
Gong, Y1
Li, J1
Xu, H1
Chhunchha, B1
Kubo, E1
Singh, DP1
Zhang, C1
Zhou, N1
Wang, X1
Su, D1
Qi, Y1
Xu, Y1
Li, Y1
Ma, L1
Xin, G1
Wei, Z1
Zeng, Z1
Xing, Z1
Li, S1
Niu, H1
Huang, W1

Reviews

1 review available for metformin and Cataract

ArticleYear
Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
    European journal of pharmacology, 2022, Nov-05, Volume: 934

    Topics: Bibliometrics; Cataract; Curcumin; Humans; Lanosterol; Metformin; Oxysterols; Resveratrol

2022

Other Studies

6 other studies available for metformin and Cataract

ArticleYear
Metformin attenuates the epithelial-mesenchymal transition of lens epithelial cells through the AMPK/TGF-β/Smad2/3 signalling pathway.
    Experimental eye research, 2021, Volume: 212

    Topics: AMP-Activated Protein Kinases; Cataract; Cell Proliferation; Cells, Cultured; Epithelial Cells; Epit

2021
Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study.
    JAMA ophthalmology, 2022, 07-01, Volume: 140, Issue:7

    Topics: Aged; Cataract; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glaucoma, Open-Angle; Humans; Ins

2022
Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.
    International journal of molecular sciences, 2022, Jun-27, Volume: 23, Issue:13

    Topics: Animals; Cataract; Diabetes Mellitus; Fructose; Metformin; NADP; NADPH Oxidases; Oxidative Stress; R

2022
Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity.
    Cells, 2022, 09-27, Volume: 11, Issue:19

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; ARNTL Transcription Factors; Cataract; Cations

2022
Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:17

    Topics: Antioxidants; Cataract; Cell Line; Cellular Senescence; Epithelial Cells; Female; Humans; Lens, Crys

2021
d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.
    Toxicology letters, 2018, Jun-01, Volume: 289

    Topics: Adenosine Triphosphate; Antioxidants; Autophagy; Calcium Signaling; Cataract; Cell Line; Cell Prolif

2018