metformin has been researched along with Carotid Stenosis in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin increased insulin sensitivity, but did not affect neointimal thickness in either the normal fat or high fat diet-fed rats." | 7.85 | High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis. ( Breen, DM; Dalvi, P; Dolinsky, VW; Giacca, A; Guo, J; Lam, L; Pereira, TJ; Swain, N; Yeung, LSN, 2017) |
| "Treatment with metformin significantly attenuates neointimal hyperplasia through inhibition of smooth muscle cell proliferation, migration, and inflammation as well as by improvement of the insulin signaling pathway." | 5.39 | The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats. ( Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D, 2013) |
| "Metformin increased insulin sensitivity, but did not affect neointimal thickness in either the normal fat or high fat diet-fed rats." | 3.85 | High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis. ( Breen, DM; Dalvi, P; Dolinsky, VW; Giacca, A; Guo, J; Lam, L; Pereira, TJ; Swain, N; Yeung, LSN, 2017) |
| " Long-term use of metformin, an AMPK activator, was previously reported to be neuroprotective, as it promotes behavioral improvement and angiogenesis following an acute ischemic injury of the brain." | 1.91 | Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice. ( Cai, B; Xie, W; Zeng, Y; Zheng, Y, 2023) |
| "Metformin treatment was associated with decreased NGAL [60." | 1.46 | Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment. ( Demyanets, S; Eilenberg, W; Huk, I; Kaider, A; Kozakowski, N; Nanobachvili, J; Neumayer, C; Piechota-Polanczyk, A; Stojkovic, S; Weninger, WJ; Wojta, J, 2017) |
| "Treatment with metformin significantly attenuates neointimal hyperplasia through inhibition of smooth muscle cell proliferation, migration, and inflammation as well as by improvement of the insulin signaling pathway." | 1.39 | The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats. ( Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, W | 3 |
| Zeng, Y | 3 |
| Zheng, Y | 3 |
| Cai, B | 3 |
| He, Y | 1 |
| Li, Z | 1 |
| Shi, X | 1 |
| Ding, J | 1 |
| Wang, X | 1 |
| Eilenberg, W | 1 |
| Stojkovic, S | 1 |
| Piechota-Polanczyk, A | 1 |
| Kaider, A | 1 |
| Kozakowski, N | 1 |
| Weninger, WJ | 1 |
| Nanobachvili, J | 1 |
| Wojta, J | 1 |
| Huk, I | 1 |
| Demyanets, S | 1 |
| Neumayer, C | 1 |
| Mantovani, A | 1 |
| Altomari, A | 1 |
| Fassio, A | 1 |
| Gatti, D | 1 |
| Bonnet, F | 1 |
| Targher, G | 1 |
| Lu, J | 1 |
| Ji, J | 1 |
| Meng, H | 1 |
| Wang, D | 1 |
| Jiang, B | 1 |
| Liu, L | 1 |
| Randell, E | 1 |
| Adeli, K | 1 |
| Meng, QH | 1 |
| Guo, J | 1 |
| Pereira, TJ | 1 |
| Dalvi, P | 1 |
| Yeung, LSN | 1 |
| Swain, N | 1 |
| Breen, DM | 1 |
| Lam, L | 1 |
| Dolinsky, VW | 1 |
| Giacca, A | 1 |
| Stiefelhagen, P | 1 |
| Rubenstein, AH | 1 |
8 other studies available for metformin and Carotid Stenosis
| Article | Year |
|---|---|
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Carotid Stenosis; Disease Models, Animal; Ma | 2023 |
Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion.
Topics: Animals; Brain Ischemia; Carotid Stenosis; Cognitive Dysfunction; Dementia, Vascular; Diabetes Melli | 2023 |
Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment.
Topics: Aged; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Diabetes Mellitus, Ty | 2017 |
Association between increased carotid intima-media thickness and higher serum C-terminal telopeptide of type 1 collagen levels in post-menopausal women with type 2 diabetes.
Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Bone Density; Bone Remodeling; C | 2020 |
The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats.
Topics: Animals; Blood Glucose; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cells, Cultured | 2013 |
High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis.
Topics: AMP-Activated Protein Kinases; Animals; Blood Pressure; Carotid Artery Injuries; Carotid Intima-Medi | 2017 |
[Stroke is not equal to stroke. Keep track of the causes].
Topics: Adult; Antihypertensive Agents; Aspirin; Carotid Artery, Common; Carotid Artery, External; Carotid S | 2003 |
A 64-year-old man with adult-onset diabetes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Glucose Self-Monitoring; Carotid Stenosis; Decision | 1996 |