metformin has been researched along with Cardiac Rupture, Traumatic in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metformin improved cardiovascular function and survival in mature animals of both genders." | 5.46 | Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock. ( Hake, PW; James, J; Lahni, P; Matsiukevich, D; O'Connor, M; Piraino, G; Wolfe, V; Zingarelli, B, 2017) |
| "Dunning prostate cancer was induced in Copenhagen rats using high metastatic MAT-LyLu cells." | 1.62 | Metformin protects against diabetes-induced heart injury and dunning prostate cancer model. ( Bayrak, BB; Karabulut Bulan, O; Koroglu, P; Yanardag, R, 2021) |
| "Treatment with metformin improved cardiovascular function and survival in mature animals of both genders." | 1.46 | Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock. ( Hake, PW; James, J; Lahni, P; Matsiukevich, D; O'Connor, M; Piraino, G; Wolfe, V; Zingarelli, B, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Bayrak, BB | 1 |
| Koroglu, P | 1 |
| Karabulut Bulan, O | 1 |
| Yanardag, R | 1 |
| Matsiukevich, D | 1 |
| Piraino, G | 1 |
| Lahni, P | 1 |
| Hake, PW | 1 |
| Wolfe, V | 1 |
| O'Connor, M | 1 |
| James, J | 1 |
| Zingarelli, B | 1 |
| Al-Rasheed, NM | 2 |
| Al-Rabeeah, DA | 1 |
| Al-Barrak, HS | 1 |
| Al-Salman, SA | 1 |
| Ibrahim, SA | 1 |
| Al-Hassab, SA | 1 |
| Al-Amin, MA | 1 |
| Hasan, IH | 1 |
| Al-Ajmi, HN | 1 |
| Al-Shammari, TK | 1 |
| Cui, C | 1 |
| Huang, C | 1 |
| Liu, K | 1 |
| Xu, G | 1 |
| Yang, J | 1 |
| Zhou, Y | 1 |
| Feng, Y | 1 |
| Kararigas, G | 1 |
| Geng, B | 1 |
| Cui, Q | 1 |
| El Messaoudi, S | 1 |
| Nederlof, R | 1 |
| Zuurbier, CJ | 1 |
| van Swieten, HA | 1 |
| Pickkers, P | 1 |
| Noyez, L | 1 |
| Dieker, HJ | 1 |
| Coenen, MJ | 1 |
| Donders, AR | 1 |
| Vos, A | 1 |
| Rongen, GA | 1 |
| Riksen, NP | 1 |
| van der Horst, IC | 1 |
| Nijsten, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Metformin in CABG (MetCAB) Trial[NCT01438723] | Phase 4 | 100 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metformin and Cardiac Rupture, Traumatic
| Article | Year |
|---|---|
Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.
Topics: Aged; Coronary Artery Bypass; Double-Blind Method; Female; Heart; Heart Injuries; Humans; Hypoglycem | 2015 |
5 other studies available for metformin and Cardiac Rupture, Traumatic
| Article | Year |
|---|---|
Metformin protects against diabetes-induced heart injury and dunning prostate cancer model.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Diabetes M | 2021 |
Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Biomarkers; Cardiotonic Agents; Enzyme Activators; Fe | 2017 |
Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury.
Topics: Animals; Heart Injuries; Isoproterenol; Male; Metformin; NF-kappa B; Rats; Rats, Wistar; Signal Tran | 2018 |
Large-scale in silico identification of drugs exerting sex-specific effects in the heart.
Topics: Acebutolol; Animals; Blood Pressure; China; Computer Simulation; Drug Therapy; Female; Heart; Heart | 2018 |
Metformin in cardiac surgery: high expectations.
Topics: Coronary Artery Bypass; Female; Heart Injuries; Humans; Hypoglycemic Agents; Intraoperative Complica | 2015 |