metformin has been researched along with Cardiac Remodeling, Ventricular in 23 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 17 (73.91) | 24.3611 |
| 2020's | 5 (21.74) | 2.80 |
| Authors | Studies |
|---|---|
| Loi, H | 1 |
| Kramar, S | 1 |
| Laborde, C | 1 |
| Marsal, D | 1 |
| Pizzinat, N | 1 |
| Cussac, D | 1 |
| Roncalli, J | 1 |
| Boal, F | 1 |
| Tronchere, H | 1 |
| Oleshchuk, O | 1 |
| Korda, M | 1 |
| Kunduzova, O | 1 |
| Ibrahim, WS | 1 |
| Ahmed, HMS | 1 |
| Mahmoud, AAA | 1 |
| Mahmoud, MF | 1 |
| Ibrahim, IAAE | 1 |
| Peterson, VR | 1 |
| Norton, GR | 1 |
| Madziva, MT | 1 |
| Makaula, S | 1 |
| McNair, BD | 1 |
| Polson, SM | 1 |
| Shorthill, SK | 1 |
| Yusifov, A | 1 |
| Walker, LA | 1 |
| Weiser-Evans, MCM | 1 |
| Kovacs, EJ | 1 |
| Bruns, DR | 1 |
| Bobenko, AI | 1 |
| Heller, S | 1 |
| Schmitt, N | 1 |
| Cherdtrakulkiat, R | 1 |
| Lawung, R | 1 |
| Nabu, S | 1 |
| Tantimavanich, S | 1 |
| Sinthupoom, N | 1 |
| Prachayasittikul, S | 1 |
| Prachayasittikul, V | 1 |
| Zhang, B | 1 |
| Wu, C | 1 |
| Zhang, Z | 2 |
| Yan, K | 1 |
| Li, C | 2 |
| Li, Y | 4 |
| Li, L | 4 |
| Zheng, C | 1 |
| Xiao, Y | 2 |
| He, D | 1 |
| Zhao, F | 1 |
| Su, JF | 1 |
| Lun, SM | 1 |
| Hou, YJ | 1 |
| Duan, LJ | 1 |
| Wang, NC | 1 |
| Shen, FF | 1 |
| Zhang, YW | 1 |
| Gao, ZW | 1 |
| Li, J | 7 |
| Du, XJ | 1 |
| Zhou, FY | 1 |
| Yin, Z | 1 |
| Zhu, J | 3 |
| Yan, D | 1 |
| Lou, H | 1 |
| Yu, H | 1 |
| Feng, C | 1 |
| Wang, Z | 1 |
| Wang, Y | 4 |
| Hu, X | 1 |
| Li, Z | 3 |
| Shen, Y | 1 |
| Hu, D | 1 |
| Chen, H | 1 |
| Wu, X | 1 |
| Duan, Y | 1 |
| Zhi, D | 1 |
| Zou, M | 2 |
| Zhao, Z | 1 |
| Zhang, X | 2 |
| Yang, X | 2 |
| Zhang, J | 4 |
| Wang, H | 1 |
| Popović, KJ | 1 |
| Popović, DJ | 1 |
| Miljković, D | 1 |
| Lalošević, D | 1 |
| Čapo, I | 1 |
| Popović, JK | 1 |
| Liu, M | 1 |
| Song, H | 2 |
| Xing, Z | 1 |
| Lu, G | 1 |
| Chen, D | 1 |
| Valentini, AM | 1 |
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| Coletta, S | 1 |
| Guerra, V | 1 |
| Armentano, R | 1 |
| Caruso, ML | 1 |
| Gong, J | 1 |
| Wang, N | 1 |
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| Ye, M | 1 |
| Wen, N | 1 |
| Fu, M | 1 |
| Fan, W | 1 |
| Meng, Y | 1 |
| Dong, G | 1 |
| Lin, XH | 1 |
| Liu, HH | 1 |
| Gao, DM | 1 |
| Cui, JF | 1 |
| Ren, ZG | 1 |
| Chen, RX | 1 |
| Önal, B | 1 |
| Özen, D | 1 |
| Demir, B | 1 |
| Akkan, AG | 1 |
| Özyazgan, S | 1 |
| Payette, G | 1 |
| Geoffroy, V | 1 |
| Martineau, C | 1 |
| Villemur, R | 1 |
| Jameel, T | 1 |
| Baig, M | 1 |
| Gazzaz, ZJ | 1 |
| Tashkandi, JM | 1 |
| Al Alhareth, NS | 1 |
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| Butt, NS | 1 |
| Wang, J | 2 |
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| Zhang, Y | 4 |
| Wang, X | 2 |
| Liu, J | 2 |
| Basit, A | 1 |
| Miao, T | 1 |
| Liu, W | 1 |
| Jiang, W | 1 |
| Yu, ZY | 1 |
| Wu, L | 2 |
| Qu, B | 1 |
| Sun, JX | 1 |
| Cai, AL | 1 |
| Xie, LM | 1 |
| Groeneveld, J | 1 |
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| Genovesi, S | 1 |
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| Contaldo, G | 1 |
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| Ciurlino, D | 1 |
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| Hwang, JK | 1 |
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| Villarino, NF | 1 |
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| Ling, M | 1 |
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| Gao, X | 1 |
| Liang, C | 2 |
| Guo, Q | 1 |
| Zhou, C | 1 |
| Ma, Z | 1 |
| Xu, J | 1 |
| Wang, C | 1 |
| Zhao, W | 3 |
| Xia, X | 1 |
| Jiang, Y | 1 |
| Peng, J | 1 |
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| Li, F | 1 |
| Chen, X | 3 |
| Mo, J | 1 |
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| Li, X | 1 |
| Huang, T | 1 |
| Zhu, Q | 1 |
| Wang, S | 1 |
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| Fortunato, G | 1 |
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| Agarwal, PK | 1 |
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| Cheatum, CM | 1 |
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| Hayman, A | 1 |
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| Stewart, I | 1 |
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| Ho, CT | 1 |
| Qi, B | 1 |
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| Chen, R | 1 |
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| Xia, JM | 1 |
| Zhang, GY | 1 |
| Chen, CH | 1 |
| Yang, XW | 1 |
| Domenech-Ximenos, B | 1 |
| Garza, MS | 1 |
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| Crispi, F | 1 |
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| Abrams, G | 1 |
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| Posecion, L | 1 |
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| D'Esposito, M | 1 |
| Chen, AJW | 1 |
| Samy El Gendy, NM | 1 |
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| Lechner, W | 1 |
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| Tedgren, AC | 1 |
| Adolfsson, E | 1 |
| Campos, AM | 1 |
| Alves, VGL | 1 |
| Suming, L | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus[NCT01761318] | Phase 4 | 50 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metformin and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P | 2019 |
Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Diabetes Mellitus; Disease | 2017 |
[Metformin and left ventricular remodeling after acute myocardial infarction: molecular mechanisms and clinical implications].
Topics: Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Myocardial Infarction; Myocardial Reperfu | 2015 |
The cardioprotective effects of metformin.
Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Cardiomyo | 2011 |
2 trials available for metformin and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes.
Topics: Activins; Adipose Tissue; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Cardiomyop | 2013 |
Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus.
Topics: Adenosine Triphosphate; Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Therapy, Combi | 2009 |
17 other studies available for metformin and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice.
Topics: Animals; Fibrosis; Hypoglycemic Agents; Inflammation; Male; Metformin; Mice; Mice, Inbred C57BL; Myo | 2021 |
Propranolol and low-dose isoproterenol ameliorate insulin resistance, enhance β-arrestin2 signaling, and reduce cardiac remodeling in high-fructose, high-fat diet-fed mice: Comparative study with metformin.
Topics: Animals; beta-Arrestin 2; Blood Glucose; Diet, High-Fat; Fructose; Glucose; Heart; Insulin; Insulin | 2021 |
Metformin Prevents Low-dose Isoproterenol-induced Cardiac Dilatation and Systolic Dysfunction in Male Sprague Dawley Rats.
Topics: Animals; Dilatation; Isoproterenol; Male; Metformin; Rats; Rats, Sprague-Dawley; Ventricular Remodel | 2022 |
Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Heart Failure; Hypertension, | 2023 |
Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats.
Topics: AMP-Activated Protein Kinases; Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, An | 2020 |
Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction.
Topics: Adenylate Kinase; Animals; Cells, Cultured; Culture Media, Conditioned; Enzyme Induction; Fibrosis; | 2018 |
Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Drug Administration Schedule; Echocardiograp | 2018 |
Metformin Enhances Autophagy and Provides Cardioprotection in δ-Sarcoglycan Deficiency-Induced Dilated Cardiomyopathy.
Topics: Animals; Autophagy; Cardiomegaly; Cardiomyopathies; Cardiomyopathy, Dilated; Diabetes Mellitus, Type | 2019 |
Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Dise | 2019 |
Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate ameliorates pressure overload-induced cardiac hypertrophy and dysfunction through inhibiting autophagy.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Autophagy; Cardiomegaly; Cell Line; Heart Fa | 2019 |
Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction.
Topics: Adamantane; Angiotensin-Converting Enzyme Inhibitors; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Pe | 2015 |
[Effect of metformin on ventricular remodeling in patients with primary hypertension and type 2 diabetes mellitus].
Topics: Diabetes Mellitus, Type 2; Echocardiography; Essential Hypertension; Heart; Humans; Hypertension; Me | 2015 |
Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction.
Topics: Adamantane; Animals; Cardiotonic Agents; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; | 2016 |
Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus | 2011 |
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Natriuretic Factor; Blood Glucose; Cardiotonic Agents | 2011 |
Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats.
Topics: Animals; Endomyocardial Fibrosis; Hypoglycemic Agents; Male; Metformin; Obesity; Rats; Rats, Wistar; | 2013 |
Metformin prevents the development of chronic heart failure in the SHHF rat model.
Topics: Animals; Blood Glucose; Blood Pressure; Chronic Disease; Gene Expression Regulation; Heart Failure; | 2012 |