metformin has been researched along with Carcinoma, Ductal, Breast in 3 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin has been associated with antitumour activity in breast cancer (BC) but its mechanism remains unclear." | 9.17 | The effect of metformin on apoptosis in a breast cancer presurgical trial. ( Bonanni, B; Bottiglieri, L; Cazzaniga, M; DeCensi, A; Dell'Orto, P; Gentilini, OD; Guerrieri-Gonzaga, A; Lazzeroni, M; Pagani, G; Pruneri, G; Puntoni, M; Serrano, D; Varricchio, C; Viale, G, 2013) |
| "Observational data suggest that metformin use decreases breast cancer (BC) incidence in women with diabetes; the impact of metformin on BC outcomes in this population is less clear." | 7.80 | The effect of metformin on breast cancer outcomes in patients with type 2 diabetes. ( Eaton, A; King, TA; Oppong, BA; Oskar, S; Patil, S; Pharmer, LA; Stempel, M, 2014) |
| "Metformin has been associated with antitumour activity in breast cancer (BC) but its mechanism remains unclear." | 5.17 | The effect of metformin on apoptosis in a breast cancer presurgical trial. ( Bonanni, B; Bottiglieri, L; Cazzaniga, M; DeCensi, A; Dell'Orto, P; Gentilini, OD; Guerrieri-Gonzaga, A; Lazzeroni, M; Pagani, G; Pruneri, G; Puntoni, M; Serrano, D; Varricchio, C; Viale, G, 2013) |
| "Observational data suggest that metformin use decreases breast cancer (BC) incidence in women with diabetes; the impact of metformin on BC outcomes in this population is less clear." | 3.80 | The effect of metformin on breast cancer outcomes in patients with type 2 diabetes. ( Eaton, A; King, TA; Oppong, BA; Oskar, S; Patil, S; Pharmer, LA; Stempel, M, 2014) |
| "Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines." | 3.77 | Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. ( Hirsch, HA; Iliopoulos, D; Struhl, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cazzaniga, M | 1 |
| DeCensi, A | 1 |
| Pruneri, G | 1 |
| Puntoni, M | 1 |
| Bottiglieri, L | 1 |
| Varricchio, C | 1 |
| Guerrieri-Gonzaga, A | 1 |
| Gentilini, OD | 1 |
| Pagani, G | 1 |
| Dell'Orto, P | 1 |
| Lazzeroni, M | 1 |
| Serrano, D | 1 |
| Viale, G | 1 |
| Bonanni, B | 1 |
| Oppong, BA | 1 |
| Pharmer, LA | 1 |
| Oskar, S | 1 |
| Eaton, A | 1 |
| Stempel, M | 1 |
| Patil, S | 1 |
| King, TA | 1 |
| Iliopoulos, D | 1 |
| Hirsch, HA | 1 |
| Struhl, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma[NCT02978547] | Phase 2 | 20 participants (Anticipated) | Interventional | 2019-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metformin and Carcinoma, Ductal, Breast
| Article | Year |
|---|---|
The effect of metformin on apoptosis in a breast cancer presurgical trial.
Topics: Apoptosis; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Double-Blind Meth | 2013 |
2 other studies available for metformin and Carcinoma, Ductal, Breast
| Article | Year |
|---|---|
The effect of metformin on breast cancer outcomes in patients with type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2014 |
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Car | 2011 |