metformin and Carcinoma, Basal Cell, Pigmented
metformin has been researched along with Carcinoma, Basal Cell, Pigmented in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Metformin was associated with a lower risk of developing BCC (OR, 0." | 1.62 | Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland. ( Adalsteinsson, JA; Feng, H; Jonasson, JG; Kristjansson, AK; Muzumdar, S; Olafsdottir, GH; Ratner, D; Silverberg, JI; Tryggvadottir, L; Ungar, J; Waldman, R; Wu, R, 2021) |
Research
Studies (8)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (25.00) | 24.3611 |
2020's | 6 (75.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Misitzis, A | 3 |
Stratigos, A | 1 |
Mastorakos, G | 2 |
Weinstock, M | 1 |
Ravishankar, A | 1 |
Zhang, T | 1 |
Lindgren, BR | 1 |
Farah, RS | 1 |
Dong, Z | 1 |
Goldfarb, NI | 1 |
Stratigos, AJ | 1 |
Beatson, M | 1 |
Dellavalle, RP | 1 |
Weinstock, MA | 2 |
Adalsteinsson, JA | 2 |
Muzumdar, S | 1 |
Waldman, R | 2 |
Wu, R | 1 |
Ratner, D | 2 |
Feng, H | 2 |
Ungar, J | 1 |
Silverberg, JI | 1 |
Olafsdottir, GH | 1 |
Kristjansson, AK | 1 |
Tryggvadottir, L | 2 |
Jonasson, JG | 2 |
Zhang, Y | 1 |
Storr, SJ | 1 |
Johnson, K | 1 |
Green, AR | 1 |
Rakha, EA | 1 |
Ellis, IO | 1 |
Morgan, DA | 1 |
Martin, SG | 1 |
Byekova, YA | 1 |
Herrmann, JL | 1 |
Xu, J | 1 |
Elmets, CA | 1 |
Athar, M | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial[NCT00847912] | Phase 4 | 954 participants (Actual) | Interventional | 2009-06-26 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Hazard Ratio for Surgically Treated KC
(NCT00847912)
Timeframe: date of randomization to last visit before end of study follow up (6/30/2013), assessed up to four years
Intervention | participants (Number) |
---|---|
Arm 1: 5-fluorouracil | 182 |
Arm 2: Placebo, Vehicle Control | 177 |
The Time to Diagnosis of the First Keratinocyte Carcinoma (KC) on the Face or Ears for Which Surgery is Performed
Diagnosis of the first Primary Basil Cell Carcinoma (BCC) or primary Squamous Cell Carcinoma (SCC) on the face or ears that was removed surgically. (NCT00847912)
Timeframe: From randomization to last visit prior to end of study date (6/30/2013), assessed up to four years
Intervention | years (Median) |
---|---|
Arm 1: 5-fluorouracil | 3.37 |
Arm 2: Placebo, Vehicle Control | 3.52 |
Trials
1 trial available for metformin and Carcinoma, Basal Cell, Pigmented
Article | Year |
---|---|
Antidiabetic Treatment in Patients at High Risk for a Subsequent Keratinocyte Carcinoma.
Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diabetes Mellitus, Type 2; Female; Humans; Hy | 2022 |
Other Studies
7 other studies available for metformin and Carcinoma, Basal Cell, Pigmented
Article | Year |
---|---|
The effect of metformin on the risk of recurrent nonmelanoma skin cancers.
Topics: Carcinoma, Basal Cell; Humans; Metformin; Neoplasm Recurrence, Local; Skin Neoplasms | 2020 |
The association of metformin use with keratinocyte carcinoma development in high-risk patients.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratinocytes; Metformin; Skin Neoplasms | 2020 |
Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland.
Topics: Aged; Aged, 80 and over; Carcinoma, Basal Cell; Case-Control Studies; Female; Hedgehog Proteins; Hum | 2021 |
Reply to: Metformin use and keratinocyte carcinoma risk.
Topics: Carcinoma, Basal Cell; Humans; Keratinocytes; Metformin; Skin Neoplasms | 2021 |
Metformin use and keratinocyte carcinoma risk.
Topics: Carcinoma, Basal Cell; Humans; Keratinocytes; Metformin; Skin Neoplasms | 2021 |
Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy.
Topics: AMP-Activated Protein Kinases; Breast Neoplasms; Carcinoma, Basal Cell; Cell Line, Tumor; Chemoradio | 2014 |
Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.
Topics: Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Carcinoma, Basal Cell; Cell Cycle Proteins | 2011 |