metformin has been researched along with Carcinogenesis in 41 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents." | 8.89 | Metformin: do we finally have an anti-aging drug? ( Anisimov, VN, 2013) |
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 7.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 7.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The chemopreventive effect of MET against DMBA-induced breast carcinogenesis was evidenced by the capability of MET to restore the induction of the mRNA levels of basic excision repair genes, 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease1 (APE1), and the level of 8-hydroxy-2-deoxyguanosine (8-OHdG)." | 7.81 | Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. ( Alhaider, AA; Ansari, MA; Denison, MS; El-Kadi, AO; Ghebeh, H; Korashy, HM; Maayah, ZH; Soshilov, AA, 2015) |
| "In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet." | 7.80 | Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014) |
| "Obesity has been linked to a higher risk of pancreatic cancer." | 5.91 | Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice. ( Dai, S; Gao, H; Gao, Y; Jiang, K; Li, M; Lu, Z; Miao, Y; Wang, G; Yin, L; Zhang, J; Zhang, K, 2023) |
| "The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 5.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
| "Metformin is a commonly used drug for the treatment of diabetes." | 5.72 | Metformin inhibits the development and metastasis of colorectal cancer. ( Hasegawa, H; Ishida, T; Kitagawa, Y; Okabayashi, K; Seishima, R; Shigeta, K; Sugiura, K; Tsuruta, M, 2022) |
| "To stimulate EC carcinogenesis, chronic gastroduodenal reflux esophagitis via esophagojejunostomy was induced in 120 rats in metformin-treated and non-treated (control) groups." | 5.72 | Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. ( Fushida, S; Harashima, A; Inaki, N; Miyashita, T; Munesue, S; Ninomiya, I; Ohta, T; Tajima, H; Takada, S; Takamura, H; Takei, R; Yagi, S; Yamamoto, Y, 2022) |
| "Treatment of metformin led to activation of AMP-activated protein kinase (AMPK) and attenuated signaling of the downstream molecules such as p-mTOR, p-p70S6K and cyclin D1 expression both in vivo and in vitro." | 5.51 | Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. ( Deng, X; Fan, H; Guo, L; Jiang, W; Lu, SH; Yu, X; Zhan, Q; Zheng, W; Zou, Z, 2019) |
| " In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated." | 5.48 | Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| " Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents." | 4.89 | Metformin: do we finally have an anti-aging drug? ( Anisimov, VN, 2013) |
| "AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)." | 3.91 | Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019) |
| "Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC." | 3.85 | Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer. ( Cao, J; Chen, K; Cheng, L; Duan, W; Gao, L; Jiang, Z; Lei, M; Li, J; Ma, Q; Qian, W; Sun, L; Yan, B; Zhou, C, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 3.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The chemopreventive effect of MET against DMBA-induced breast carcinogenesis was evidenced by the capability of MET to restore the induction of the mRNA levels of basic excision repair genes, 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease1 (APE1), and the level of 8-hydroxy-2-deoxyguanosine (8-OHdG)." | 3.81 | Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. ( Alhaider, AA; Ansari, MA; Denison, MS; El-Kadi, AO; Ghebeh, H; Korashy, HM; Maayah, ZH; Soshilov, AA, 2015) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| "In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet." | 3.80 | Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014) |
| "Breast cancer is the most ubiquitous type of neoplasms among women worldwide." | 2.66 | Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. ( Manoharan, R; Natarajan, SR; Ponnusamy, L; Thangaraj, K, 2020) |
| "Diabetes mellitus and prostate cancer are 2 of the most important public health concerns, especially in the elderly population." | 2.50 | Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms. ( Hara, N; Hejazi, J; Marotta, F; Rastmanesh, R, 2014) |
| "Obesity has been linked to a higher risk of pancreatic cancer." | 1.91 | Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice. ( Dai, S; Gao, H; Gao, Y; Jiang, K; Li, M; Lu, Z; Miao, Y; Wang, G; Yin, L; Zhang, J; Zhang, K, 2023) |
| "The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process." | 1.72 | Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022) |
| "Metformin is a commonly used drug for the treatment of diabetes." | 1.72 | Metformin inhibits the development and metastasis of colorectal cancer. ( Hasegawa, H; Ishida, T; Kitagawa, Y; Okabayashi, K; Seishima, R; Shigeta, K; Sugiura, K; Tsuruta, M, 2022) |
| "To stimulate EC carcinogenesis, chronic gastroduodenal reflux esophagitis via esophagojejunostomy was induced in 120 rats in metformin-treated and non-treated (control) groups." | 1.72 | Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. ( Fushida, S; Harashima, A; Inaki, N; Miyashita, T; Munesue, S; Ninomiya, I; Ohta, T; Tajima, H; Takada, S; Takamura, H; Takei, R; Yagi, S; Yamamoto, Y, 2022) |
| "0." | 1.62 | Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes. ( Chen, X; Chen, Y; Gu, H; Li, M; Lin, S; Song, C; Xiao, T; Xu, S, 2021) |
| "Treatment of metformin led to activation of AMP-activated protein kinase (AMPK) and attenuated signaling of the downstream molecules such as p-mTOR, p-p70S6K and cyclin D1 expression both in vivo and in vitro." | 1.51 | Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. ( Deng, X; Fan, H; Guo, L; Jiang, W; Lu, SH; Yu, X; Zhan, Q; Zheng, W; Zou, Z, 2019) |
| " In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated." | 1.48 | Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018) |
| "Metformin (MET) is an anti-diabetic drug used to prevent hepatic glucose release and increase tissue insulin sensitivity." | 1.46 | Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster. ( Constante, SAR; de Rezende, AAA; Nepomuceno, JC; Oliveira, VC; Orsolin, PC; Spanó, MA, 2017) |
| "Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed." | 1.46 | Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. ( Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration." | 1.40 | Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. ( Anso, E; Budigner, GS; Chandel, NS; Dufour, E; Glasauer, A; Hamanaka, RB; Mutlu, GM; Soberanes, S; Sullivan, LB; Weinberg, SE; Wheaton, WW, 2014) |
| "Metformin has recently drawn attention because of its potential antitumor effect." | 1.39 | Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice. ( Aoki, K; Atsumi, T; Inoue, H; Ito, Y; Kaji, M; Nagashima, Y; Nakamura, A; Orime, K; Sakamoto, E; Sato, K; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 29 (70.73) | 24.3611 |
| 2020's | 12 (29.27) | 2.80 |
| Authors | Studies |
|---|---|
| Kurhaluk, N | 2 |
| Tkachenko, H | 1 |
| Sugiura, K | 1 |
| Okabayashi, K | 1 |
| Seishima, R | 1 |
| Ishida, T | 1 |
| Shigeta, K | 1 |
| Tsuruta, M | 1 |
| Hasegawa, H | 1 |
| Kitagawa, Y | 1 |
| Cheng, L | 2 |
| Deepak, RNVK | 1 |
| Wang, G | 2 |
| Meng, Z | 1 |
| Tao, L | 1 |
| Xie, M | 1 |
| Chi, W | 1 |
| Zhang, Y | 5 |
| Yang, M | 1 |
| Liao, Y | 2 |
| Chen, R | 1 |
| Liang, Y | 1 |
| Zhang, J | 5 |
| Huang, Y | 3 |
| Wang, W | 2 |
| Guo, Z | 2 |
| Wang, Y | 3 |
| Lin, JD | 1 |
| Fan, H | 2 |
| Chen, L | 4 |
| Gao, H | 1 |
| Dai, S | 1 |
| Li, M | 3 |
| Gao, Y | 3 |
| Yin, L | 1 |
| Zhang, K | 1 |
| Jiang, K | 1 |
| Miao, Y | 1 |
| Lu, Z | 1 |
| Laskar, J | 1 |
| Sengupta, M | 1 |
| Choudhury, Y | 1 |
| Hart, PC | 1 |
| Kenny, HA | 1 |
| Grassl, N | 1 |
| Watters, KM | 1 |
| Litchfield, LM | 1 |
| Coscia, F | 1 |
| Blaženović, I | 1 |
| Ploetzky, L | 1 |
| Fiehn, O | 1 |
| Mann, M | 1 |
| Lengyel, E | 1 |
| Romero, IL | 1 |
| Saber, S | 1 |
| Ghanim, AMH | 1 |
| El-Ahwany, E | 1 |
| El-Kader, EMA | 1 |
| Ponnusamy, L | 1 |
| Natarajan, SR | 1 |
| Thangaraj, K | 1 |
| Manoharan, R | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 3 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Chen, Y | 5 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 2 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Li, Y | 6 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 2 |
| Liu, X | 1 |
| Ren, Y | 1 |
| Li, J | 8 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, S | 3 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 2 |
| Zhu, J | 3 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 2 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 2 |
| Hu, W | 1 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, W | 3 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 1 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Su, X | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 1 |
| Wei, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 3 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 2 |
| Yang, T | 2 |
| Dong, Y | 1 |
| Xu, Y | 1 |
| Yuan, Z | 1 |
| Cao, J | 2 |
| Zheng, Y | 2 |
| Luo, Z | 1 |
| Mei, Z | 1 |
| Yao, Y | 1 |
| Liu, Z | 2 |
| Liang, C | 1 |
| Yang, H | 2 |
| Song, Y | 1 |
| Yu, K | 1 |
| Zhu, C | 1 |
| Huang, Z | 1 |
| Qian, J | 1 |
| Ge, J | 1 |
| Hu, J | 2 |
| Wang, H | 2 |
| Liu, Y | 4 |
| Mi, Y | 1 |
| Kong, H | 1 |
| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
| Ning, Q | 1 |
| Chang, X | 2 |
| Zhang, T | 2 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
| Reddy, K | 1 |
| Chen, H | 1 |
| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Mu, W | 1 |
| Liu, C | 3 |
| Gao, F | 1 |
| Qi, Y | 1 |
| Lu, H | 1 |
| Zhang, X | 5 |
| Cai, X | 1 |
| Ji, RY | 1 |
| Hou, Y | 3 |
| Tian, J | 2 |
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5 reviews available for metformin and Carcinogenesis
| Article | Year |
|---|---|
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Aspirin; Biological Products; Breast | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Metformin for lung cancer prevention and improved survival: a novel approach.
Topics: Carcinogenesis; Carcinogens; Diabetes Mellitus, Type 2; Gene Expression Regulation, Neoplastic; Huma | 2019 |
Metformin: do we finally have an anti-aging drug?
Topics: Aging; Animals; Carcinogenesis; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin | 2013 |
Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms.
Topics: Carcinogenesis; Diabetes Mellitus, Type 2; Diet Therapy; Genetic Predisposition to Disease; Humans; | 2014 |
1 trial available for metformin and Carcinogenesis
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
36 other studies available for metformin and Carcinogenesis
| Article | Year |
|---|---|
Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autophagy; Carcinogenesis; Diet, High-Fat; Female; Humans | 2022 |
Metformin inhibits the development and metastasis of colorectal cancer.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Huma | 2022 |
Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformati | 2023 |
Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice.
Topics: Animals; Carcinogenesis; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Extracellular Traps; Metfo | 2023 |
Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model.
Topics: AMP-Activated Protein Kinases; Animals; Areca; Arecoline; Carcinogenesis; Disease Models, Animal; Dy | 2019 |
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Topics: Animals; Carcinogenesis; Female; Humans; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subu | 2019 |
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosa | 2020 |
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
Topics: Aldehydes; Animals; Carcinogenesis; DNA Damage; Female; Humans; Melanoma; Metformin; Mice; Oxidative | 2020 |
Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Carcinogenesis; Cell Line, Tumor; Cholangiocarcinoma; Electron Transpo | 2021 |
Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogenesis; Cell Line, Tumor; Dextromethorphan | 2021 |
Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Carcinogenesis; Disease Models, Animal | 2021 |
Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Carcinogenesis; Esophageal Neoplasms; Metformin; Rats; T | 2022 |
Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Epigenesis, | 2017 |
Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.
Topics: Animals; Carcinogenesis; Disease Models, Animal; DNA Damage; Doxorubicin; Drosophila melanogaster; F | 2017 |
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.
Topics: Animals; Carcinogenesis; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Di | 2017 |
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Glycolysis; Hep G2 Cells; | 2018 |
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Apoptosis; Carcinogenesis; Carcinoma, Pancreatic Du | 2018 |
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model.
Topics: Acyltransferases; Administration, Oral; Animals; Carcinogenesis; Carcinoma, Pancreatic Ductal; Chemo | 2018 |
Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis.
Topics: Aerobiosis; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carcinogenesis | 2018 |
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Dimethylnit | 2019 |
Metabolic therapies inhibit tumor growth in vivo and in silico.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon; Carcinogenesis; Carcinoma, Lewis Lu | 2019 |
Anticancer effect of metformin against 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis is through AMPK pathway and modulation of oxidative stress markers.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinogenesis; Carcinogens; Choleste | 2019 |
Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.
Topics: Adipose Tissue, White; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinoma, Hepatocellular; | 2013 |
Metformin inhibits skin tumor promotion in overweight and obese mice.
Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; | 2014 |
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.
Topics: Carcinogenesis; Cell Line, Tumor; Electron Transport Complex I; Humans; Metformin; Neoplasms | 2014 |
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinogenesis | 2015 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; H | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular | 2016 |
Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.
Topics: Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Claudins; Disease-Free Surv | 2016 |
[Metformin - an anti-carcinogenesis drug?].
Topics: Carcinogenesis; Diabetes Complications; Humans; Metformin; Neoplasms; Octamer Transcription Factor-1 | 2016 |
Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.
Topics: Aldehydes; Animals; Blood Cell Count; Bone Marrow Cells; Carcinogenesis; Cell Cycle; Chromosome Brea | 2016 |
Metformin alters DNA methylation genome-wide via the H19/SAHH axis.
Topics: Adenosylhomocysteinase; AMP-Activated Protein Kinases; Carcinogenesis; DNA (Cytosine-5-)-Methyltrans | 2017 |
Metformin targets histone acetylation in cancer-prone epithelial cells.
Topics: Acetyl Coenzyme A; Acetylation; BRCA1 Protein; Carcinogenesis; Epigenesis, Genetic; Epithelial Cells | 2016 |
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplas | 2017 |