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metformin and Carcinogenesis

metformin has been researched along with Carcinogenesis in 41 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
" Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents."8.89Metformin: do we finally have an anti-aging drug? ( Anisimov, VN, 2013)
"AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)."7.91Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019)
" In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC."7.83Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016)
" The chemopreventive effect of MET against DMBA-induced breast carcinogenesis was evidenced by the capability of MET to restore the induction of the mRNA levels of basic excision repair genes, 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease1 (APE1), and the level of 8-hydroxy-2-deoxyguanosine (8-OHdG)."7.81Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. ( Alhaider, AA; Ansari, MA; Denison, MS; El-Kadi, AO; Ghebeh, H; Korashy, HM; Maayah, ZH; Soshilov, AA, 2015)
"In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet."7.80Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014)
"Obesity has been linked to a higher risk of pancreatic cancer."5.91Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice. ( Dai, S; Gao, H; Gao, Y; Jiang, K; Li, M; Lu, Z; Miao, Y; Wang, G; Yin, L; Zhang, J; Zhang, K, 2023)
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process."5.72Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022)
"Metformin is a commonly used drug for the treatment of diabetes."5.72Metformin inhibits the development and metastasis of colorectal cancer. ( Hasegawa, H; Ishida, T; Kitagawa, Y; Okabayashi, K; Seishima, R; Shigeta, K; Sugiura, K; Tsuruta, M, 2022)
"To stimulate EC carcinogenesis, chronic gastroduodenal reflux esophagitis via esophagojejunostomy was induced in 120 rats in metformin-treated and non-treated (control) groups."5.72Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. ( Fushida, S; Harashima, A; Inaki, N; Miyashita, T; Munesue, S; Ninomiya, I; Ohta, T; Tajima, H; Takada, S; Takamura, H; Takei, R; Yagi, S; Yamamoto, Y, 2022)
"Treatment of metformin led to activation of AMP-activated protein kinase (AMPK) and attenuated signaling of the downstream molecules such as p-mTOR, p-p70S6K and cyclin D1 expression both in vivo and in vitro."5.51Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. ( Deng, X; Fan, H; Guo, L; Jiang, W; Lu, SH; Yu, X; Zhan, Q; Zheng, W; Zou, Z, 2019)
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated."5.48Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."5.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
" Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents."4.89Metformin: do we finally have an anti-aging drug? ( Anisimov, VN, 2013)
"AEBN and arecoline induced dyslipidemia by downregulating AMPK (Thr-172) and activating ACC (Ser-79); they also downregulated tumor suppressor p53 (Ser-15)."3.91Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model. ( Choudhury, Y; Laskar, J; Sengupta, M, 2019)
"Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC."3.85Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer. ( Cao, J; Chen, K; Cheng, L; Duan, W; Gao, L; Jiang, Z; Lei, M; Li, J; Ma, Q; Qian, W; Sun, L; Yan, B; Zhou, C, 2017)
" In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC."3.83Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016)
" The chemopreventive effect of MET against DMBA-induced breast carcinogenesis was evidenced by the capability of MET to restore the induction of the mRNA levels of basic excision repair genes, 8-oxoguanine DNA glycosylase (OGG1) and apurinic/apyrimidinic endonuclease1 (APE1), and the level of 8-hydroxy-2-deoxyguanosine (8-OHdG)."3.81Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. ( Alhaider, AA; Ansari, MA; Denison, MS; El-Kadi, AO; Ghebeh, H; Korashy, HM; Maayah, ZH; Soshilov, AA, 2015)
" Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity."3.81Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015)
"In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet."3.80Metformin inhibits skin tumor promotion in overweight and obese mice. ( Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O, 2014)
"Breast cancer is the most ubiquitous type of neoplasms among women worldwide."2.66Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. ( Manoharan, R; Natarajan, SR; Ponnusamy, L; Thangaraj, K, 2020)
"Diabetes mellitus and prostate cancer are 2 of the most important public health concerns, especially in the elderly population."2.50Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms. ( Hara, N; Hejazi, J; Marotta, F; Rastmanesh, R, 2014)
"Obesity has been linked to a higher risk of pancreatic cancer."1.91Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice. ( Dai, S; Gao, H; Gao, Y; Jiang, K; Li, M; Lu, Z; Miao, Y; Wang, G; Yin, L; Zhang, J; Zhang, K, 2023)
"The development and induction of the carcinogenesis process in the different rat models with the high-fat diet impact were also accompanied by initiation of free-radical oxidation processes, which we studied at the initial (estimated by the level of diene conjugates) and final (TBARS products) stages of this process."1.72Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet. ( Kurhaluk, N; Tkachenko, H, 2022)
"Metformin is a commonly used drug for the treatment of diabetes."1.72Metformin inhibits the development and metastasis of colorectal cancer. ( Hasegawa, H; Ishida, T; Kitagawa, Y; Okabayashi, K; Seishima, R; Shigeta, K; Sugiura, K; Tsuruta, M, 2022)
"To stimulate EC carcinogenesis, chronic gastroduodenal reflux esophagitis via esophagojejunostomy was induced in 120 rats in metformin-treated and non-treated (control) groups."1.72Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. ( Fushida, S; Harashima, A; Inaki, N; Miyashita, T; Munesue, S; Ninomiya, I; Ohta, T; Tajima, H; Takada, S; Takamura, H; Takei, R; Yagi, S; Yamamoto, Y, 2022)
"0."1.62Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes. ( Chen, X; Chen, Y; Gu, H; Li, M; Lin, S; Song, C; Xiao, T; Xu, S, 2021)
"Treatment of metformin led to activation of AMP-activated protein kinase (AMPK) and attenuated signaling of the downstream molecules such as p-mTOR, p-p70S6K and cyclin D1 expression both in vivo and in vitro."1.51Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. ( Deng, X; Fan, H; Guo, L; Jiang, W; Lu, SH; Yu, X; Zhan, Q; Zheng, W; Zou, Z, 2019)
" In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated."1.48Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis. ( Bojková, B; Kurhaluk, N; Winklewski, PJ, 2018)
"Metformin (MET) is an anti-diabetic drug used to prevent hepatic glucose release and increase tissue insulin sensitivity."1.46Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster. ( Constante, SAR; de Rezende, AAA; Nepomuceno, JC; Oliveira, VC; Orsolin, PC; Spanó, MA, 2017)
"Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed."1.46Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. ( Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD, 2017)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."1.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration."1.40Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. ( Anso, E; Budigner, GS; Chandel, NS; Dufour, E; Glasauer, A; Hamanaka, RB; Mutlu, GM; Soberanes, S; Sullivan, LB; Weinberg, SE; Wheaton, WW, 2014)
"Metformin has recently drawn attention because of its potential antitumor effect."1.39Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice. ( Aoki, K; Atsumi, T; Inoue, H; Ito, Y; Kaji, M; Nagashima, Y; Nakamura, A; Orime, K; Sakamoto, E; Sato, K; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y, 2013)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's29 (70.73)24.3611
2020's12 (29.27)2.80

Authors

AuthorsStudies
Kurhaluk, N2
Tkachenko, H1
Sugiura, K1
Okabayashi, K1
Seishima, R1
Ishida, T1
Shigeta, K1
Tsuruta, M1
Hasegawa, H1
Kitagawa, Y1
Cheng, L2
Deepak, RNVK1
Wang, G2
Meng, Z1
Tao, L1
Xie, M1
Chi, W1
Zhang, Y5
Yang, M1
Liao, Y2
Chen, R1
Liang, Y1
Zhang, J5
Huang, Y3
Wang, W2
Guo, Z2
Wang, Y3
Lin, JD1
Fan, H2
Chen, L4
Gao, H1
Dai, S1
Li, M3
Gao, Y3
Yin, L1
Zhang, K1
Jiang, K1
Miao, Y1
Lu, Z1
Laskar, J1
Sengupta, M1
Choudhury, Y1
Hart, PC1
Kenny, HA1
Grassl, N1
Watters, KM1
Litchfield, LM1
Coscia, F1
Blaženović, I1
Ploetzky, L1
Fiehn, O1
Mann, M1
Lengyel, E1
Romero, IL1
Saber, S1
Ghanim, AMH1
El-Ahwany, E1
El-Kader, EMA1
Ponnusamy, L1
Natarajan, SR1
Thangaraj, K1
Manoharan, R1
Nguépy Keubo, FR1
Mboua, PC1
Djifack Tadongfack, T1
Fokouong Tchoffo, E1
Tasson Tatang, C1
Ide Zeuna, J1
Noupoue, EM1
Tsoplifack, CB1
Folefack, GO1
Kettani, M1
Bandelier, P1
Huo, J1
Li, H5
Yu, D1
Arulsamy, N1
AlAbbad, S1
Sardot, T1
Lekashvili, O1
Decato, D1
Lelj, F1
Alexander Ross, JB1
Rosenberg, E1
Nazir, H1
Muthuswamy, N1
Louis, C1
Jose, S1
Prakash, J1
Buan, MEM1
Flox, C1
Chavan, S1
Shi, X1
Kauranen, P1
Kallio, T1
Maia, G1
Tammeveski, K1
Lymperopoulos, N1
Carcadea, E1
Veziroglu, E1
Iranzo, A1
M Kannan, A1
Arunamata, A1
Tacy, TA1
Kache, S1
Mainwaring, RD1
Ma, M1
Maeda, K1
Punn, R1
Noguchi, S1
Hahn, S3
Iwasa, Y3
Ling, J2
Voccio, JP2
Kim, Y3
Song, J3
Bascuñán, J2
Chu, Y1
Tomita, M1
Cazorla, M1
Herrera, E1
Palomeque, E1
Saud, N1
Hoplock, LB1
Lobchuk, MM1
Lemoine, J1
Li, X10
Henson, MA1
Unsihuay, D1
Qiu, J1
Swaroop, S1
Nagornov, KO1
Kozhinov, AN1
Tsybin, YO1
Kuang, S1
Laskin, J1
Zin, NNINM1
Mohamad, MN1
Roslan, K1
Abdul Wafi, S1
Abdul Moin, NI1
Alias, A1
Zakaria, Y1
Abu-Bakar, N1
Naveed, A1
Jilani, K1
Siddique, AB1
Akbar, M1
Riaz, M1
Mushtaq, Z1
Sikandar, M1
Ilyas, S1
Bibi, I1
Asghar, A1
Rasool, G1
Irfan, M1
Li, XY1
Zhao, S1
Fan, XH1
Chen, KP1
Hua, W1
Liu, ZM1
Xue, XD1
Zhou, B1
Zhang, S2
Xing, YL1
Chen, MA1
Sun, Y1
Neradilek, MB1
Wu, XT1
Zhang, D3
Huang, W1
Cui, Y1
Yang, QQ1
Li, HW1
Zhao, XQ1
Hossein Rashidi, B1
Tarafdari, A1
Ghazimirsaeed, ST1
Shahrokh Tehraninezhad, E1
Keikha, F1
Eslami, B1
Ghazimirsaeed, SM1
Jafarabadi, M1
Silvani, Y1
Lovita, AND1
Maharani, A1
Wiyasa, IWA1
Sujuti, H1
Ratnawati, R1
Raras, TYM1
Lemin, AS1
Rahman, MM1
Pangarah, CA1
Kiyu, A1
Zeng, C2
Du, H1
Lin, D1
Jalan, D1
Rubagumya, F1
Hopman, WM1
Vanderpuye, V1
Lopes, G1
Seruga, B1
Booth, CM1
Berry, S1
Hammad, N1
Sajo, EA1
Okunade, KS1
Olorunfemi, G1
Rabiu, KA1
Anorlu, RI1
Xu, C2
Xiang, Y1
Xu, X1
Zhou, L2
Dong, X1
Tang, S1
Gao, XC1
Wei, CH1
Zhang, RG1
Cai, Q1
He, Y1
Tong, F1
Dong, JH1
Wu, G1
Dong, XR1
Tang, X1
Tao, F1
Xiang, W1
Zhao, Y2
Jin, L1
Tao, H1
Lei, Y1
Gan, H1
Chen, Y5
Shan, A1
Zhao, H2
Wu, M2
Ma, Q2
Wang, J4
Zhang, E1
Li, Y6
Xue, F1
Deng, L1
Liu, L2
Yan, Z2
Meng, J1
Chen, G2
Anastassiadou, M1
Bernasconi, G1
Brancato, A1
Carrasco Cabrera, L1
Greco, L1
Jarrah, S1
Kazocina, A1
Leuschner, R1
Magrans, JO1
Miron, I1
Nave, S1
Pedersen, R1
Reich, H1
Rojas, A1
Sacchi, A1
Santos, M1
Theobald, A1
Vagenende, B1
Verani, A1
Du, L2
Liu, X1
Ren, Y1
Li, J8
Li, P1
Jiao, Q1
Meng, P1
Wang, F2
Wang, YS1
Wang, C3
Zhou, X2
Wang, S3
Hou, J1
Zhang, A1
Lv, B1
Gao, C1
Pang, D1
Lu, K1
Ahmad, NH1
Wang, L2
Zhu, J3
Zhang, L2
Zhuang, T1
Tu, J1
Zhao, Z1
Qu, Y1
Yao, H2
Wang, X5
Lee, DF1
Shen, J3
Wen, L1
Huang, G2
Xie, X1
Zhao, Q2
Hu, W1
Wu, X1
Lu, J2
Li, W3
Wu, W1
Du, F1
Ji, H1
Yang, X2
Xu, Z1
Wan, L1
Wen, Q1
Cho, CH1
Zou, C1
Xiao, Z1
Liao, J1
Su, X1
Bi, Z1
Su, Q1
Huang, H1
Wei, Y2
Na, KJ1
Choi, H1
Oh, HR1
Kim, YH1
Lee, SB1
Jung, YJ1
Koh, J1
Park, S1
Lee, HJ3
Jeon, YK1
Chung, DH1
Paeng, JC1
Park, IK1
Kang, CH1
Cheon, GJ1
Kang, KW1
Lee, DS1
Kim, YT1
Pajuelo-Lozano, N1
Alcalá, S1
Sainz, B1
Perona, R1
Sanchez-Perez, I1
Logotheti, S1
Marquardt, S1
Gupta, SK1
Richter, C1
Edelhäuser, BAH1
Engelmann, D1
Brenmoehl, J1
Söhnchen, C1
Murr, N1
Alpers, M1
Singh, KP1
Wolkenhauer, O1
Heckl, D1
Spitschak, A1
Pützer, BM1
Cheng, J1
Kong, X1
Li, S1
Zhang, M4
Zhang, H2
Yang, T2
Dong, Y1
Xu, Y1
Yuan, Z1
Cao, J2
Zheng, Y2
Luo, Z1
Mei, Z1
Yao, Y1
Liu, Z2
Liang, C1
Yang, H2
Song, Y1
Yu, K1
Zhu, C1
Huang, Z1
Qian, J1
Ge, J1
Hu, J2
Wang, H2
Liu, Y4
Mi, Y1
Kong, H1
Xi, D1
Yan, W1
Luo, X1
Ning, Q1
Chang, X2
Zhang, T2
Wang, Q2
Rathore, MG1
Reddy, K1
Chen, H1
Shin, SH1
Ma, WY1
Bode, AM1
Dong, Z1
Mu, W1
Liu, C3
Gao, F1
Qi, Y1
Lu, H1
Zhang, X5
Cai, X1
Ji, RY1
Hou, Y3
Tian, J2
Shi, Y1
Ying, S1
Tan, M1
Feng, G1
Kuang, Y1
Chen, D1
Wu, D3
Zhu, ZQ1
Tang, HX1
Shi, ZE1
Kang, J1
Liu, Q1
Qi, J2
Mu, J1
Cong, Z1
Chen, S2
Fu, D1
Li, Z2
Celestrin, CP1
Rocha, GZ1
Stein, AM1
Guadagnini, D1
Tadelle, RM1
Saad, MJA1
Oliveira, AG1
Bianconi, V1
Bronzo, P1
Banach, M1
Sahebkar, A1
Mannarino, MR1
Pirro, M1
Patsourakos, NG1
Kouvari, M1
Kotidis, A1
Kalantzi, KI1
Tsoumani, ME1
Anastasiadis, F1
Andronikos, P1
Aslanidou, T1
Efraimidis, P1
Georgiopoulos, A1
Gerakiou, K1
Grigoriadou-Skouta, E1
Grigoropoulos, P1
Hatzopoulos, D1
Kartalis, A1
Lyras, A1
Markatos, G1
Mikrogeorgiou, A1
Myroforou, I1
Orkopoulos, A1
Pavlidis, P1
Petras, C1
Riga, M1
Skouloudi, M1
Smyrnioudis, N1
Thomaidis, K1
Tsikouri, GE1
Tsikouris, EI1
Zisimos, K1
Vavoulis, P1
Vitali, MG1
Vitsas, G1
Vogiatzidis, C1
Chantanis, S1
Fousas, S1
Panagiotakos, DB1
Tselepis, AD1
Jungen, C1
Alken, FA1
Eickholt, C1
Scherschel, K1
Kuklik, P1
Klatt, N1
Schwarzl, J1
Moser, J1
Jularic, M1
Akbulak, RO1
Schaeffer, B1
Willems, S1
Meyer, C1
Nowak, JK1
Szczepanik, M1
Trypuć, M1
Pogorzelski, A1
Bobkowski, W1
Grytczuk, M1
Minarowska, A1
Wójciak, R1
Walkowiak, J1
Lu, Y1
Xi, J1
Li, C1
Chen, W2
Hu, X1
Zhang, F1
Wei, H1
Wang, Z1
Gurzu, S1
Jung, I1
Sugimura, H2
Stefan-van Staden, RI1
Yamada, H1
Natsume, H1
Iwashita, Y1
Szodorai, R1
Szederjesi, J1
Yari, D1
Ehsanbakhsh, Z1
Validad, MH1
Langroudi, FH1
Esfandiari, H1
Prager, A1
Hassanpour, K1
Kurup, SP1
Mets-Halgrimson, R1
Yoon, H1
Zeid, JL1
Mets, MB1
Rahmani, B1
Araujo-Castillo, RV1
Culquichicón, C1
Solis Condor, R1
Efendi, F1
Sebayang, SK1
Astutik, E1
Hadisuyatmana, S1
Has, EMM1
Kuswanto, H1
Foroutan, T1
Ahmadi, F1
Moayer, F1
Khalvati, S1
Zhang, Q2
Lyu, Y1
Huang, J1
Yu, N1
Wen, Z1
Hou, H1
Zhao, T1
Gupta, A1
Khosla, N1
Govindasamy, V1
Saini, A1
Annapurna, K1
Dhakate, SR1
Akkaya, Ö1
Chandgude, AL1
Dömling, A1
Harnett, J1
Oakes, K1
Carè, J1
Leach, M1
Brown, D1
Cramer, H1
Pinder, TA1
Steel, A1
Anheyer, D1
Cantu, J1
Valle, J1
Flores, K1
Gonzalez, D1
Valdes, C1
Lopez, J1
Padilla, V1
Alcoutlabi, M1
Parsons, J1
Núñez, K1
Hamed, M1
Fort, D1
Bruce, D1
Thevenot, P1
Cohen, A1
Weber, P1
Menezes, AMB1
Gonçalves, H1
Perez-Padilla, R1
Jarvis, D1
de Oliveira, PD1
Wehrmeister, FC1
Mir, S1
Wong, J1
Ryan, CM1
Bellingham, G1
Singh, M2
Waseem, R1
Eckert, DJ1
Chung, F1
Hegde, H1
Shimpi, N1
Panny, A1
Glurich, I1
Christie, P1
Acharya, A1
English, KL1
Downs, M1
Goetchius, E1
Buxton, R1
Ryder, JW1
Ploutz-Snyder, R1
Guilliams, M1
Scott, JM1
Ploutz-Snyder, LL1
Martens, C1
Goplen, FK1
Aasen, T1
Gjestad, R1
Nordfalk, KF1
Nordahl, SHG1
Inoue, T1
Soshi, S1
Kubota, M2
Marumo, K1
Mortensen, NP1
Caffaro, MM1
Patel, PR2
Uddin, MJ1
Aravamudhan, S1
Sumner, SJ1
Fennell, TR1
Gal, RL1
Cohen, NJ1
Kruger, D1
Beck, RW1
Bergenstal, RM1
Calhoun, P1
Cushman, T1
Haban, A1
Hood, K1
Johnson, ML1
McArthur, T1
Olson, BA1
Weinstock, RS1
Oser, SM1
Oser, TK1
Bugielski, B1
Strayer, H1
Aleppo, G1
Maruyama, H1
Hirayama, K1
Yamashita, M1
Ohgi, K1
Tsujimoto, R1
Takayasu, M1
Shimohata, H1
Kobayashi, M1
Buscagan, TM1
Rees, DC1
Jaborek, JR1
Zerby, HN1
Wick, MP1
Fluharty, FL1
Moeller, SJ1
Razavi, P1
Dickler, MN1
Shah, PD1
Toy, W1
Brown, DN1
Won, HH1
Li, BT1
Shen, R1
Vasan, N1
Modi, S1
Jhaveri, K1
Caravella, BA1
Patil, S1
Selenica, P1
Zamora, S1
Cowan, AM1
Comen, E1
Singh, A1
Covey, A1
Berger, MF1
Hudis, CA1
Norton, L1
Nagy, RJ1
Odegaard, JI1
Lanman, RB1
Solit, DB1
Robson, ME1
Lacouture, ME1
Brogi, E1
Reis-Filho, JS1
Moynahan, ME1
Scaltriti, M1
Chandarlapaty, S1
Papouskova, K1
Moravcova, M1
Masrati, G1
Ben-Tal, N1
Sychrova, H1
Zimmermannova, O1
Fang, J1
Fan, Y1
Luo, T2
Su, H1
Tsetseris, L1
Anthopoulos, TD1
Liu, SF1
Zhao, K1
Sacan, O1
Turkyilmaz, IB1
Bayrak, BB1
Mutlu, O1
Akev, N1
Yanardag, R1
Gruber, S1
Kamnoedboon, P1
Özcan, M1
Srinivasan, M1
Jo, YH1
Oh, HK1
Jeong, SY1
Lee, BG1
Zheng, J1
Guan, H1
Li, D2
Tan, H1
Maji, TK1
J R, A1
Mukherjee, S1
Alexander, R1
Mondal, A1
Das, S1
Sharma, RK1
Chakraborty, NK1
Dasgupta, K1
Sharma, AMR1
Hawaldar, R1
Pandey, M1
Naik, A1
Majumdar, K1
Pal, SK1
Adarsh, KV1
Ray, SK1
Karmakar, D1
Ma, Y2
Gao, W1
Ma, S1
Lin, W1
Zhou, T1
Wu, T1
Wu, Q1
Ye, C1
He, X1
Jiang, F1
Yuan, D1
Chen, Q1
Hong, M1
Chen, K2
Hussain, M1
Razi, SS1
Yildiz, EA1
Zhao, J1
Yaglioglu, HG1
Donato, MD1
Jiang, J1
Jamil, MI1
Zhan, X1
Chen, F1
Cheng, D1
Wu, CT1
Utsunomiya, T1
Ichii, T1
Fujinami, S1
Nakajima, K1
Sanchez, DM1
Raucci, U1
Ferreras, KN1
Martínez, TJ1
Mordi, NA1
Mordi, IR1
Singh, JS1
McCrimmon, RJ1
Struthers, AD1
Lang, CC1
Wang, XW1
Yuan, LJ1
Yang, Y2
Chen, WF1
Luo, R1
Yang, K1
Amarasiri, SS1
Attanayake, AP1
Arawwawala, LDAM1
Jayatilaka, KAPW1
Mudduwa, LKB1
Ogunsuyi, O2
Akanni, O1
Alabi, O1
Alimba, C1
Adaramoye, O1
Cambier, S1
Eswara, S1
Gutleb, AC1
Bakare, A1
Gu, Z1
Cong, J1
Pellegrini, M1
Palmieri, S1
Ricci, A1
Serio, A1
Paparella, A1
Lo Sterzo, C1
Jadeja, SD1
Vaishnav, J1
Mansuri, MS1
Shah, C1
Mayatra, JM1
Shah, A1
Begum, R1
Song, H2
Lian, Y1
Wan, T1
Schultz-Lebahn, A1
Skipper, MT1
Hvas, AM1
Larsen, OH1
Hijazi, Z1
Granger, CB1
Hohnloser, SH1
Westerbergh, J1
Lindbäck, J1
Alexander, JH1
Keltai, M1
Parkhomenko, A1
López-Sendón, JL1
Lopes, RD1
Siegbahn, A1
Wallentin, L1
El-Tarabany, MS1
Saleh, AA1
El-Araby, IE1
El-Magd, MA1
van Ginkel, MPH1
Schijven, MP1
van Grevenstein, WMU1
Schreuder, HWR1
Pereira, EDM1
da Silva, J1
Carvalho, PDS1
Grivicich, I1
Picada, JN1
Salgado Júnior, IB1
Vasques, GJ1
Pereira, MADS1
Reginatto, FH1
Ferraz, ABF1
Vasilenko, EA1
Gorshkova, EN1
Astrakhantseva, IV1
Drutskaya, MS1
Tillib, SV1
Nedospasov, SA1
Mokhonov, VV1
Nam, YW1
Cui, M1
Orfali, R1
Viegas, A1
Nguyen, M1
Mohammed, EHM1
Zoghebi, KA1
Rahighi, S1
Parang, K1
Patterson, KC1
Kahanovitch, U1
Gonçalves, CM1
Hablitz, JJ1
Staruschenko, A1
Mulkey, DK1
Olsen, ML1
Gu, L1
Cao, X1
Mukhtar, A1
Wu, K1
Zhang, YY1
Zhu, Y1
Lu, DZ1
Dong, W2
Bi, WJ1
Feng, XJ1
Wen, LM1
Sun, H2
Qi, MC1
Chang, CC1
Dinh, TK1
Lee, YA1
Wang, FN1
Sung, YC1
Yu, PL1
Chiu, SC1
Shih, YC1
Wu, CY1
Huang, YD1
Lu, TT1
Wan, D1
Sakizadeh, J1
Cline, JP1
Snyder, MA1
Kiely, CJ1
McIntosh, S1
Jiang, X1
Cao, JW1
Zhao, CK1
Yang, R1
Zhang, QY1
Chen, KJ2
Liu, H1
He, Z1
Chen, B1
Wu, J1
Du, X1
Moore, J1
Blank, BR1
Eksterowicz, J1
Sutimantanapi, D1
Yuen, N1
Metzger, T1
Chan, B1
Huang, T1
Chen, X2
Duong, F1
Kong, W1
Chang, JH1
Sun, J1
Zavorotinskaya, T1
Ye, Q1
Junttila, MR1
Ndubaku, C1
Friedman, LS1
Fantin, VR1
Sun, D1
Fei, P1
Xie, Q1
Jiang, Y1
Feng, H1
Chang, Y1
Kang, H1
Xing, M1
Chen, J1
Shao, Z1
Yuan, C1
Wu, Y1
Allan, R1
Canham, K1
Wallace, R1
Singh, D1
Ward, J1
Cooper, A1
Newcomb, C1
Nammour, S1
El Mobadder, M1
Maalouf, E1
Namour, M1
Namour, A1
Rey, G1
Matamba, P1
Matys, J1
Zeinoun, T1
Grzech-Leśniak, K1
Segabinazi Peserico, C1
Garozi, L1
Zagatto, AM1
Machado, FA1
Hirth, JM1
Dinehart, EE1
Lin, YL1
Kuo, YF1
Nouri, SS1
Ritchie, C1
Volow, A1
Li, B2
McSpadden, S1
Dearman, K1
Kotwal, A1
Sudore, RL1
Ward, L1
Thakur, A1
Kondadasula, SV1
Ji, K1
Schalk, DL1
Bliemeister, E1
Ung, J1
Aboukameel, A1
Casarez, E1
Sloane, BF1
Lum, LG1
Xiao, M1
Feng, X1
Gao, R1
Du, B1
Brooks, T1
Zwirner, J1
Hammer, N1
Ondruschka, B1
Jermy, M1
Luengo, A1
Marzo, I1
Reback, M1
Daubit, IM1
Fernández-Moreira, V1
Metzler-Nolte, N1
Gimeno, MC1
Tonchev, I1
Heberman, D1
Peretz, A1
Medvedovsky, AT1
Gotsman, I1
Rashi, Y1
Poles, L1
Goland, S1
Perlman, GY1
Danenberg, HD1
Beeri, R1
Shuvy, M1
Fu, Q2
Yang, D1
Sarapulova, A1
Pang, Q1
Meng, Y1
Wei, L1
Ehrenberg, H1
Kim, CC1
Jeong, SH1
Oh, KH1
Nam, KT1
Sun, JY1
Ning, J1
Duan, Z1
Kershaw, SV1
Rogach, AL1
Gao, Z1
Wang, T1
Li, Q1
Cao, T1
Guo, L2
Fu, Y1
Seeger, ZL1
Izgorodina, EI1
Hue, S1
Beldi-Ferchiou, A1
Bendib, I1
Surenaud, M1
Fourati, S1
Frapard, T1
Rivoal, S1
Razazi, K1
Carteaux, G1
Delfau-Larue, MH1
Mekontso-Dessap, A1
Audureau, E1
de Prost, N1
Gao, SS1
Duangthip, D1
Lo, ECM1
Chu, CH1
Roberts, W1
Rosenheck, RA1
Miyake, T1
Kimoto, E1
Luo, L1
Mathialagan, S1
Horlbogen, LM1
Ramanathan, R1
Wood, LS1
Johnson, JG1
Le, VH1
Vourvahis, M1
Rodrigues, AD1
Muto, C1
Furihata, K1
Sugiyama, Y1
Kusuhara, H1
Gong, Q1
Song, W1
Sun, B1
Cao, P1
Gu, S1
Sun, X1
Zhou, G1
Toma, C1
Khandhar, S1
Zalewski, AM1
D'Auria, SJ1
Tu, TM1
Jaber, WA1
Cho, J3
Suwandaratne, NS1
Razek, S1
Choi, YH1
Piper, LFJ1
Watson, DF1
Banerjee, S1
Xie, S1
Lindsay, AP1
Bates, FS1
Lodge, TP1
Hao, Y1
Chapovetsky, A1
Liu, JJ1
Welborn, M1
Luna, JM1
Do, T1
Haiges, R1
Miller Iii, TF1
Marinescu, SC1
Lopez, SA1
Compter, I1
Eekers, DBP1
Hoeben, A1
Rouschop, KMA1
Reymen, B1
Ackermans, L1
Beckervordersantforth, J1
Bauer, NJC1
Anten, MM1
Wesseling, P1
Postma, AA1
De Ruysscher, D1
Lambin, P1
Qiang, L1
Yang, S1
Cui, YH1
He, YY1
Kumar, SK1
Jacobus, SJ1
Cohen, AD1
Weiss, M1
Callander, N1
Singh, AK1
Parker, TL1
Menter, A1
Parsons, B1
Kumar, P1
Kapoor, P1
Rosenberg, A1
Zonder, JA1
Faber, E1
Lonial, S1
Anderson, KC1
Richardson, PG1
Orlowski, RZ1
Wagner, LI1
Rajkumar, SV1
Li, G1
Hou, G1
Cui, J1
Xie, H1
Sun, Z1
Fang, Z1
Dunstand-Guzmán, E1
Hallal-Calleros, C1
Hernández-Velázquez, VM1
Canales-Vargas, EJ1
Domínguez-Roldan, R1
Pedernera, M1
Peña-Chora, G1
Flores-Pérez, I1
Kim, MJ1
Han, C1
White, K1
Park, HJ1
Ding, D1
Boyd, K1
Rothenberger, C1
Bose, U1
Carmichael, P1
Linser, PJ1
Tanokura, M1
Salvi, R1
Someya, S1
Samuni, A1
Goldstein, S1
Divya, KP1
Dharuman, V1
Feng, J2
Qian, Y1
Cheng, Q1
Ma, H1
Ren, X1
Wei, Q1
Pan, W1
Guo, J1
Situ, B1
An, T1
Zheng, L1
Augusto, S1
Ratola, N1
Tarín-Carrasco, P1
Jiménez-Guerrero, P1
Turco, M1
Schuhmacher, M1
Costa, S1
Teixeira, JP1
Costa, C1
Syed, A1
Marraiki, N1
Al-Rashed, S1
Elgorban, AM1
Yassin, MT1
Chankhanittha, T1
Nanan, S1
Sorokina, KN1
Samoylova, YV1
Gromov, NV1
Ogorodnikova, OL1
Parmon, VN1
Ye, J1
Liao, W1
Zhang, P1
Nabi, M1
Cai, Y1
Li, F1
Alsbou, EM1
Omari, KW1
Adeosun, WA1
Asiri, AM1
Marwani, HM1
Barral, M1
Jemal-Turki, A1
Beuvon, F1
Soyer, P1
Camparo, P1
Cornud, F1
Atwater, BD1
Jones, WS1
Loring, Z1
Friedman, DJ1
Namburath, M1
Papirio, S1
Moscariello, C1
Di Costanzo, N1
Pirozzi, F1
Alappat, BJ1
Sreekrishnan, TR1
Volpin, F1
Woo, YC1
Kim, H1
Freguia, S1
Jeong, N1
Choi, JS1
Phuntsho, S1
Shon, HK1
Domínguez-Zambrano, E1
Pedraza-Chaverri, J1
López-Santos, AL1
Medina-Campos, ON1
Cruz-Rivera, C1
Bueno-Hernández, F1
Espinosa-Cuevas, A1
Bulavaitė, A1
Dalgediene, I1
Michailoviene, V1
Pleckaityte, M1
Sauerbier, P1
Köhler, R1
Renner, G1
Militz, H1
Souza-Neto, FP1
Marinello, PC1
Melo, GP1
Ramalho, LZN1
Cela, EM1
Campo, VE1
González-Maglio, DH1
Cecchini, R1
Cecchini, AL1
Raggi, C1
Taddei, ML1
Sacco, E1
Navari, N1
Correnti, M1
Piombanti, B1
Pastore, M1
Campani, C1
Pranzini, E1
Iorio, J1
Lori, G1
Lottini, T1
Peano, C1
Cibella, J1
Lewinska, M1
Andersen, JB1
di Tommaso, L1
Viganò, L1
Di Maira, G1
Madiai, S1
Ramazzotti, M1
Orlandi, I1
Arcangeli, A1
Chiarugi, P1
Marra, F1
Xiong, X1
Lin, Y1
Yao, Z1
Guo, Y1
Geary, K1
Pan, Y1
Zhou, F1
Gao, S1
Yeung, SJ1
Xiao, T1
Song, C1
Xu, S1
Lin, S1
Gu, H1
Takei, R1
Miyashita, T1
Takada, S1
Tajima, H1
Ninomiya, I1
Takamura, H1
Fushida, S1
Harashima, A1
Munesue, S1
Yagi, S1
Inaki, N1
Ohta, T1
Yamamoto, Y1
Zhou, Y2
Dan, S1
Su, T1
She, S1
Jia, J1
Zheng, M1
Kang, B1
Wang, YJ1
Oliveira, VC1
Constante, SAR1
Orsolin, PC1
Nepomuceno, JC1
de Rezende, AAA1
Spanó, MA1
Qian, W1
Jiang, Z1
Sun, L1
Zhou, C2
Gao, L1
Lei, M1
Yan, B1
Duan, W1
DeWaal, D1
Nogueira, V1
Terry, AR1
Patra, KC1
Jeon, SM1
Guzman, G1
Au, J1
Long, CP1
Antoniewicz, MR1
Hay, N1
Zheng, C1
Gao, J1
Hu, N1
Shao, X1
Xiong, J1
Nie, K1
Zhou, H1
Shen, L1
Fang, H1
Lyu, J1
Roos, JF1
Qudsi, M1
Samara, A1
Rahim, MM1
Al-Bayedh, SA1
Ahmed, H1
Chang, HH1
Moro, A1
Chou, CEN1
Dawson, DW1
French, S1
Schmidt, AI1
Sinnett-Smith, J1
Hao, F1
Hines, OJ1
Eibl, G1
Rozengurt, E1
Bojková, B1
Winklewski, PJ1
Yu, X1
Zou, Z1
Zheng, W1
Deng, X1
Jiang, W1
Zhan, Q1
Lu, SH1
da Veiga Moreira, J1
Hamraz, M1
Abolhassani, M1
Schwartz, L1
Jolicœur, M1
Peres, S1
El-Sisi, AE1
Sokar, SS1
El-Sayad, ME1
Moussa, EA1
Salim, EI1
Tajima, K1
Nakamura, A1
Shirakawa, J1
Togashi, Y1
Orime, K1
Sato, K1
Inoue, H1
Kaji, M1
Sakamoto, E1
Ito, Y1
Aoki, K1
Nagashima, Y1
Atsumi, T1
Terauchi, Y1
Anisimov, VN1
Checkley, LA1
Rho, O1
Angel, JM1
Blando, J1
Beltran, L1
Hursting, SD1
DiGiovanni, J1
Rastmanesh, R1
Hejazi, J1
Marotta, F1
Hara, N1
Wheaton, WW1
Weinberg, SE1
Hamanaka, RB1
Soberanes, S1
Sullivan, LB1
Anso, E1
Glasauer, A1
Dufour, E1
Mutlu, GM1
Budigner, GS1
Chandel, NS1
Maayah, ZH1
Ghebeh, H1
Alhaider, AA1
El-Kadi, AO1
Soshilov, AA1
Denison, MS1
Ansari, MA1
Korashy, HM1
Ohno, T1
Shimizu, M1
Shirakami, Y1
Baba, A1
Kochi, T1
Tsurumi, H1
Tanaka, T1
Moriwaki, H1
Peng, YF1
Ni, HM1
Shi, YH1
Ding, WX1
Fan, J1
Ma, X1
Deng, J1
Cao, N1
Geng, S1
Meng, M1
Lin, H1
Duan, Y1
Du, G1
Jo, W1
Yu, ES1
Chang, M1
Park, HK1
Choi, HJ1
Ryu, JE1
Jang, S1
Jang, JJ1
Son, WC1
Wahdan-Alaswad, R1
Harrell, JC1
Fan, Z1
Edgerton, SM1
Liu, B1
Thor, AD1
Zhang, QS1
Tang, W1
Deater, M1
Phan, N1
Marcogliese, AN1
Al-Dhalimy, M1
Major, A1
Olson, S1
Monnat, RJ1
Grompe, M1
Zhong, T1
Men, Y1
Lu, L1
Geng, T1
Zhou, J1
Mitsuhashi, A1
Shozu, M1
Maihle, NJ1
Carmichael, GG1
Taylor, HS1
Cuyàs, E1
Fernández-Arroyo, S1
Joven, J1
Menendez, JA1
Chung, EJ1
Do, EJ1
Kim, SY1
Cho, EA1
Kim, DH1
Pak, S1
Hwang, SW1
Byeon, JS1
Ye, BD1
Yang, DH1
Park, SH1
Yang, SK1
Kim, JH1
Myung, SJ1

Reviews

5 reviews available for metformin and Carcinogenesis

ArticleYear
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
    Biochimica et biophysica acta. Reviews on cancer, 2020, Volume: 1874, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Aspirin; Biological Products; Breast

2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Metformin for lung cancer prevention and improved survival: a novel approach.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2019, Volume: 28, Issue:4

    Topics: Carcinogenesis; Carcinogens; Diabetes Mellitus, Type 2; Gene Expression Regulation, Neoplastic; Huma

2019
Metformin: do we finally have an anti-aging drug?
    Cell cycle (Georgetown, Tex.), 2013, Nov-15, Volume: 12, Issue:22

    Topics: Aging; Animals; Carcinogenesis; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin

2013
Type 2 diabetes: a protective factor for prostate cancer? An overview of proposed mechanisms.
    Clinical genitourinary cancer, 2014, Volume: 12, Issue:3

    Topics: Carcinogenesis; Diabetes Mellitus, Type 2; Diet Therapy; Genetic Predisposition to Disease; Humans;

2014

Trials

1 trial available for metformin and Carcinogenesis

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021

Other Studies

36 other studies available for metformin and Carcinogenesis

ArticleYear
Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.
    Scientific reports, 2022, 03-23, Volume: 12, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autophagy; Carcinogenesis; Diet, High-Fat; Female; Humans

2022
Metformin inhibits the development and metastasis of colorectal cancer.
    Medical oncology (Northwood, London, England), 2022, Jul-02, Volume: 39, Issue:9

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Huma

2022
Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
    Hepatology (Baltimore, Md.), 2023, Dec-01, Volume: 78, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformati

2023
Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice.
    Cancer letters, 2023, 05-28, Volume: 562

    Topics: Animals; Carcinogenesis; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Extracellular Traps; Metfo

2023
Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model.
    Pharmacological reports : PR, 2019, Volume: 71, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Areca; Arecoline; Carcinogenesis; Disease Models, Animal; Dy

2019
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
    Cell reports, 2019, 12-17, Volume: 29, Issue:12

    Topics: Animals; Carcinogenesis; Female; Humans; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subu

2019
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosa

2020
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
    Journal of dermatological science, 2020, Volume: 100, Issue:2

    Topics: Aldehydes; Animals; Carcinogenesis; DNA Damage; Female; Humans; Melanoma; Metformin; Mice; Oxidative

2020
Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.
    Journal of hepatology, 2021, Volume: 74, Issue:6

    Topics: Animals; Bile Duct Neoplasms; Carcinogenesis; Cell Line, Tumor; Cholangiocarcinoma; Electron Transpo

2021
Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling.
    Oncogene, 2021, Volume: 40, Issue:11

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogenesis; Cell Line, Tumor; Dextromethorphan

2021
Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes.
    Journal of dermatological science, 2021, Volume: 102, Issue:1

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Carcinogenesis; Disease Models, Animal

2021
Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.
    Cancer immunology, immunotherapy : CII, 2022, Volume: 71, Issue:4

    Topics: Adenocarcinoma; Animals; Barrett Esophagus; Carcinogenesis; Esophageal Neoplasms; Metformin; Rats; T

2022
Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells.
    Scientific reports, 2017, 04-06, Volume: 7

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Epigenesis,

2017
Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 106, Issue:Pt A

    Topics: Animals; Carcinogenesis; Disease Models, Animal; DNA Damage; Doxorubicin; Drosophila melanogaster; F

2017
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.
    Molecular cancer, 2017, 07-24, Volume: 16, Issue:1

    Topics: Animals; Carcinogenesis; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Di

2017
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
    Nature communications, 2018, 01-31, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Glycolysis; Hep G2 Cells;

2018
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
    Cell death & disease, 2018, 02-07, Volume: 9, Issue:2

    Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Apoptosis; Carcinogenesis; Carcinoma, Pancreatic Du

2018
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model.
    Scientific reports, 2018, 04-12, Volume: 8, Issue:1

    Topics: Acyltransferases; Administration, Oral; Animals; Carcinogenesis; Carcinoma, Pancreatic Ductal; Chemo

2018
Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:8

    Topics: Aerobiosis; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carcinogenesis

2018
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
    Carcinogenesis, 2019, 07-04, Volume: 40, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Dimethylnit

2019
Metabolic therapies inhibit tumor growth in vivo and in silico.
    Scientific reports, 2019, 02-28, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon; Carcinogenesis; Carcinoma, Lewis Lu

2019
Anticancer effect of metformin against 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis is through AMPK pathway and modulation of oxidative stress markers.
    Human & experimental toxicology, 2019, Volume: 38, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinogenesis; Carcinogens; Choleste

2019
Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.
    American journal of physiology. Endocrinology and metabolism, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Adipose Tissue, White; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinoma, Hepatocellular;

2013
Metformin inhibits skin tumor promotion in overweight and obese mice.
    Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:1

    Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet;

2014
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.
    eLife, 2014, May-13, Volume: 3

    Topics: Carcinogenesis; Cell Line, Tumor; Electron Transport Complex I; Humans; Metformin; Neoplasms

2014
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.
    Toxicology and applied pharmacology, 2015, Apr-15, Volume: 284, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinogenesis

2015
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro

2015
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; H

2015
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas

2016
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
    Molecular medicine reports, 2016, Volume: 13, Issue:1

    Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular

2016
Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:8

    Topics: Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Claudins; Disease-Free Surv

2016
[Metformin - an anti-carcinogenesis drug?].
    MMW Fortschritte der Medizin, 2016, Mar-31, Volume: 158, Issue:6

    Topics: Carcinogenesis; Diabetes Complications; Humans; Metformin; Neoplasms; Octamer Transcription Factor-1

2016
Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.
    Blood, 2016, 12-15, Volume: 128, Issue:24

    Topics: Aldehydes; Animals; Blood Cell Count; Bone Marrow Cells; Carcinogenesis; Cell Cycle; Chromosome Brea

2016
Metformin alters DNA methylation genome-wide via the H19/SAHH axis.
    Oncogene, 2017, 04-27, Volume: 36, Issue:17

    Topics: Adenosylhomocysteinase; AMP-Activated Protein Kinases; Carcinogenesis; DNA (Cytosine-5-)-Methyltrans

2017
Metformin targets histone acetylation in cancer-prone epithelial cells.
    Cell cycle (Georgetown, Tex.), 2016, Dec-16, Volume: 15, Issue:24

    Topics: Acetyl Coenzyme A; Acetylation; BRCA1 Protein; Carcinogenesis; Epigenesis, Genetic; Epithelial Cells

2016
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
    European journal of pharmacology, 2017, Jan-05, Volume: 794

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplas

2017